Published in J Biol Chem on October 06, 2006
Helminth infections: the great neglected tropical diseases. J Clin Invest (2008) 6.92
A research agenda for helminth diseases of humans: the problem of helminthiases. PLoS Negl Trop Dis (2012) 2.28
Schistosomiasis mansoni: novel chemotherapy using a cysteine protease inhibitor. PLoS Med (2007) 2.15
Anti-schistosomal intervention targets identified by lifecycle transcriptomic analyses. PLoS Negl Trop Dis (2009) 1.51
Two approaches to discovering and developing new drugs for Chagas disease. Mem Inst Oswaldo Cruz (2009) 1.41
RNA interference of Schistosoma mansoni cathepsin D, the apical enzyme of the hemoglobin proteolysis cascade. Mol Biochem Parasitol (2007) 1.38
Gene discovery for the carcinogenic human liver fluke, Opisthorchis viverrini. BMC Genomics (2007) 1.35
RNA interference in Schistosoma mansoni schistosomula: selectivity, sensitivity and operation for larger-scale screening. PLoS Negl Trop Dis (2010) 1.32
Culture for genetic manipulation of developmental stages of Schistosoma mansoni. Parasitology (2009) 1.30
RNA interference in schistosomes: machinery and methodology. Parasitology (2009) 1.27
Development of functional genomic tools in trematodes: RNA interference and luciferase reporter gene activity in Fasciola hepatica. PLoS Negl Trop Dis (2008) 1.22
Protocols for gene silencing in schistosomes. Exp Parasitol (2007) 1.17
A comparative chemogenomics strategy to predict potential drug targets in the metazoan pathogen, Schistosoma mansoni. PLoS One (2009) 1.17
Hemoglobin digestion in blood-feeding ticks: mapping a multipeptidase pathway by functional proteomics. Chem Biol (2009) 1.17
Functional analysis of the cathepsin-like cysteine protease genes in adult Brugia malayi using RNA interference. PLoS Negl Trop Dis (2009) 1.13
Tissue specific profiling of females of Schistosoma japonicum by integrated laser microdissection microscopy and microarray analysis. PLoS Negl Trop Dis (2009) 1.10
Heme and blood-feeding parasites: friends or foes? Parasit Vectors (2010) 1.07
Dynamics of digestive proteolytic system during blood feeding of the hard tick Ixodes ricinus. Parasit Vectors (2010) 1.06
Interference with hemozoin formation represents an important mechanism of schistosomicidal action of antimalarial quinoline methanols. PLoS Negl Trop Dis (2009) 1.06
The importance of pH in regulating the function of the Fasciola hepatica cathepsin L1 cysteine protease. PLoS Negl Trop Dis (2009) 1.04
IrAE: an asparaginyl endopeptidase (legumain) in the gut of the hard tick Ixodes ricinus. Int J Parasitol (2007) 1.01
Invertebrate trypsins: a review. J Comp Physiol B (2008) 0.99
Gene Atlasing of digestive and reproductive tissues in Schistosoma mansoni. PLoS Negl Trop Dis (2011) 0.98
Serum albumin and α-1 acid glycoprotein impede the killing of Schistosoma mansoni by the tyrosine kinase inhibitor Imatinib. Int J Parasitol Drugs Drug Resist (2014) 0.97
Protease allergens induce the expression of IL-25 via Erk and p38 MAPK pathway. J Korean Med Sci (2010) 0.97
Profiling of proteolytic enzymes in the gut of the tick Ixodes ricinus reveals an evolutionarily conserved network of aspartic and cysteine peptidases. Parasit Vectors (2008) 0.96
The protein composition of the digestive fluid from the venus flytrap sheds light on prey digestion mechanisms. Mol Cell Proteomics (2012) 0.95
Asparaginyl endopeptidase from the carcinogenic liver fluke, Opisthorchis viverrini, and its potential for serodiagnosis. Int J Infect Dis (2008) 0.95
Survey of transcripts expressed by the invasive juvenile stage of the liver fluke Fasciola hepatica. BMC Genomics (2010) 0.93
The functional expression and characterisation of a cysteine peptidase from the invasive stage of the neuropathogenic schistosome Trichobilharzia regenti. Int J Parasitol (2008) 0.92
A research agenda for helminth diseases of humans: basic research and enabling technologies to support control and elimination of helminthiases. PLoS Negl Trop Dis (2012) 0.91
Secreted cysteine proteases of the carcinogenic liver fluke, Opisthorchis viverrini: regulation of cathepsin F activation by autocatalysis and trans-processing by cathepsin B. Cell Microbiol (2010) 0.91
SjTPdb: integrated transcriptome and proteome database and analysis platform for Schistosoma japonicum. BMC Genomics (2008) 0.90
Molecular characterization and expression of a cysteine protease from Clonorchis sinensis and its application for serodiagnosis of clonorchiasis. Parasitol Res (2011) 0.89
Ov-APR-1, an aspartic protease from the carcinogenic liver fluke, Opisthorchis viverrini: functional expression, immunolocalization and subsite specificity. Int J Biochem Cell Biol (2008) 0.89
Proteomic analysis of adult S. mansoni gut contents. Mol Biochem Parasitol (2007) 0.89
SmCL3, a gastrodermal cysteine protease of the human blood fluke Schistosoma mansoni. PLoS Negl Trop Dis (2009) 0.89
RNAi dynamics in Juvenile Fasciola spp. Liver flukes reveals the persistence of gene silencing in vitro. PLoS Negl Trop Dis (2014) 0.89
Kicking in the Guts: Schistosoma mansoni Digestive Tract Proteins are Potential Candidates for Vaccine Development. Front Immunol (2015) 0.88
Schistosome asparaginyl endopeptidase (legumain) is not essential for cathepsin B1 activation in vivo. Mol Biochem Parasitol (2008) 0.87
Polyethyleneimine mediated DNA transfection in schistosome parasites and regulation of the WNT signaling pathway by a dominant-negative SmMef2. PLoS Negl Trop Dis (2013) 0.87
Characterization of proteinases from the midgut of Rhipicephalus (Boophilus) microplus involved in the generation of antimicrobial peptides. Parasit Vectors (2010) 0.87
Cysteine proteases from bloodfeeding arthropod ectoparasites. Adv Exp Med Biol (2011) 0.86
An improved and secreted luciferase reporter for schistosomes. Mol Biochem Parasitol (2007) 0.86
Characterization of gut-associated cathepsin D hemoglobinase from tick Ixodes ricinus (IrCD1). J Biol Chem (2012) 0.86
Characterization of cysteine proteases from the carcinogenic liver fluke, Opisthorchis viverrini. Parasitol Res (2007) 0.86
Cloning and characterization of a novel cathepsin B-like cysteine proteinase from Angiostrongylus cantonensis. Parasitol Res (2012) 0.85
Induction of protective immune responses against schistosomiasis using functionally active cysteine peptidases. Front Genet (2014) 0.84
Analysis of regulatory protease sequences identified through bioinformatic data mining of the Schistosoma mansoni genome. BMC Genomics (2009) 0.84
Trypsin- and Chymotrypsin-like serine proteases in schistosoma mansoni-- 'the undiscovered country'. PLoS Negl Trop Dis (2014) 0.83
Identification of novel aspartic proteases from Strongyloides ratti and characterisation of their evolutionary relationships, stage-specific expression and molecular structure. BMC Genomics (2009) 0.83
Functional genes and proteins of Clonorchis sinensis. Korean J Parasitol (2009) 0.83
Structural basis for inhibition of cathepsin B drug target from the human blood fluke, Schistosoma mansoni. J Biol Chem (2011) 0.82
Lipid core peptide targeting the cathepsin D hemoglobinase of Schistosoma mansoni as a component of a schistosomiasis vaccine. Hum Vaccin Immunother (2013) 0.81
Expression profile of the Schistosoma japonicum degradome reveals differential protease expression patterns and potential anti-schistosomal intervention targets. PLoS Comput Biol (2014) 0.81
Aspartic cathepsin D endopeptidase contributes to extracellular digestion in clawed lobsters Homarus americanus and Homarus gammarus. Mar Biotechnol (NY) (2010) 0.80
Biochemical, transcriptomic and proteomic analyses of digestion in the scorpion Tityus serrulatus: insights into function and evolution of digestion in an ancient arthropod. PLoS One (2015) 0.80
The cell biology of schistosomes: a window on the evolution of the early metazoa. Protoplasma (2012) 0.80
Progress with schistosome transgenesis. Mem Inst Oswaldo Cruz (2011) 0.79
A vaccine consisting of Schistosoma mansoni cathepsin B formulated in Montanide ISA 720 VG induces high level protection against murine schistosomiasis. BMC Infect Dis (2016) 0.78
Monoclonal antibody against recombinant Fasciola gigantica cathepsin L1H could detect juvenile and adult cathepsin Ls of Fasciola gigantica. Parasitol Res (2014) 0.77
Comparative Transcriptomic Exploration Reveals Unique Molecular Adaptations of Neuropathogenic Trichobilharzia to Invade and Parasitize Its Avian Definitive Host. PLoS Negl Trop Dis (2016) 0.77
Advances in mRNA silencing and transgene expression: a gateway to functional genomics in schistosomes. Biotechnol Genet Eng Rev (2010) 0.77
Interaction Between the Neglected Tropical Disease Human Schistosomiasis and HCV Infection in Egypt: a Puzzling Relationship. J Clin Transl Hepatol (2014) 0.77
The genome, transcriptome, and proteome of the nematode Steinernema carpocapsae: evolutionary signatures of a pathogenic lifestyle. Sci Rep (2016) 0.76
Complementary Proteomic and Biochemical Analysis of Peptidases in Lobster Gastric Juice Uncovers the Functional Role of Individual Enzymes in Food Digestion. Mar Biotechnol (NY) (2015) 0.76
Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: From Functional Analysis to Anti-schistosomal Inhibitors. PLoS Negl Trop Dis (2015) 0.76
Genome-wide analysis of regulatory proteases sequences identified through bioinformatics data mining in Taenia solium. BMC Genomics (2014) 0.75
Novel Non-Peptide Inhibitors against SmCL1 of Schistosoma mansoni: In Silico Elucidation, Implications and Evaluation via Knowledge Based Drug Discovery. PLoS One (2015) 0.75
Excretion/secretion products from Schistosoma mansoni adults, eggs and schistosomula have unique peptidase specificity profiles. Biochimie (2015) 0.75
Cysteine and Aspartyl Proteases Contribute to Protein Digestion in the Gut of Freshwater Planaria. PLoS Negl Trop Dis (2016) 0.75
Proteases of haematophagous arthropod vectors are involved in blood-feeding, yolk formation and immunity - a review. Parasit Vectors (2017) 0.75
Proteomic Analysis of the Schistosoma mansoni Miracidium. PLoS One (2016) 0.75
Identification and characterization of an asparaginyl endopeptidase from Angiostrongylus cantonensis. Parasitol Res (2014) 0.75
Cold-adapted digestive aspartic protease of the clawed lobsters Homarus americanus and Homarus gammarus: biochemical characterization. Mar Biotechnol (NY) (2012) 0.75
The genome of the blood fluke Schistosoma mansoni. Nature (2009) 5.94
Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain. Bioorg Med Chem Lett (2003) 2.54
IL-13 activates a mechanism of tissue fibrosis that is completely TGF-beta independent. J Immunol (2004) 2.47
Invasion of skin by Schistosoma cercariae. Trends Parasitol (2002) 2.44
A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target. Nat Med (2012) 2.39
Drug discovery and development for neglected parasitic diseases. Nat Chem Biol (2006) 2.31
Proteases in parasitic diseases. Annu Rev Pathol (2006) 2.26
Schistosomiasis mansoni: novel chemotherapy using a cysteine protease inhibitor. PLoS Med (2007) 2.15
From innovation to application: social-ecological context, diagnostics, drugs and integrated control of schistosomiasis. Acta Trop (2010) 2.01
A workshop report on wheat genome sequencing: International Genome Research on Wheat Consortium. Genetics (2004) 1.94
PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation. EMBO Rep (2009) 1.89
Tropism of dengue virus in mice and humans defined by viral nonstructural protein 3-specific immunostaining. Am J Trop Med Hyg (2009) 1.87
Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening. PLoS Negl Trop Dis (2009) 1.74
Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain. J Med Chem (2002) 1.64
Discovery of trypanocidal compounds by whole cell HTS of Trypanosoma brucei. Chem Biol Drug Des (2006) 1.61
A cathepsin B-like protease is required for host protein degradation in Trypanosoma brucei. J Biol Chem (2004) 1.57
Complementarity between a docking and a high-throughput screen in discovering new cruzain inhibitors. J Med Chem (2010) 1.54
Proteomic analysis of Schistosoma mansoni cercarial secretions. Mol Cell Proteomics (2005) 1.54
A cysteine protease inhibitor cures Chagas' disease in an immunodeficient-mouse model of infection. Antimicrob Agents Chemother (2007) 1.54
Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi. J Med Chem (2004) 1.49
IL-22+ CD4+ T cells are associated with therapeutic trichuris trichiura infection in an ulcerative colitis patient. Sci Transl Med (2010) 1.42
Image-based high-throughput drug screening targeting the intracellular stage of Trypanosoma cruzi, the agent of Chagas' disease. Antimicrob Agents Chemother (2010) 1.41
A multi-enzyme cascade of hemoglobin proteolysis in the intestine of blood-feeding hookworms. J Biol Chem (2004) 1.41
A screen against Leishmania intracellular amastigotes: comparison to a promastigote screen and identification of a host cell-specific hit. PLoS Negl Trop Dis (2011) 1.39
Blood 'n' guts: an update on schistosome digestive peptidases. Trends Parasitol (2004) 1.35
RNA interference of Trypanosoma brucei cathepsin B and L affects disease progression in a mouse model. PLoS Negl Trop Dis (2008) 1.35
Functional expression and characterization of Schistosoma mansoni cathepsin B and its trans-activation by an endogenous asparaginyl endopeptidase. Mol Biochem Parasitol (2003) 1.34
Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases. Bioorg Med Chem Lett (2009) 1.33
Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB. J Med Chem (2008) 1.32
RNA interference in Schistosoma mansoni schistosomula: selectivity, sensitivity and operation for larger-scale screening. PLoS Negl Trop Dis (2010) 1.32
Structural characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei bound to the antifungal drugs posaconazole and fluconazole. PLoS Negl Trop Dis (2010) 1.30
Host pathogen protein interactions predicted by comparative modeling. Protein Sci (2007) 1.29
Trypanosoma cruzi CYP51 inhibitor derived from a Mycobacterium tuberculosis screen hit. PLoS Negl Trop Dis (2009) 1.29
Clan CD cysteine peptidases of parasitic protozoa. Trends Parasitol (2003) 1.28
Identification of a new class of nonpeptidic inhibitors of cruzain. J Am Chem Soc (2008) 1.26
Differential use of protease families for invasion by schistosome cercariae. Biochimie (2007) 1.24
Conservation of epidermal growth factor receptor function in the human parasitic helminth Schistosoma mansoni. J Biol Chem (2004) 1.23
Cercarial elastase is encoded by a functionally conserved gene family across multiple species of schistosomes. J Biol Chem (2002) 1.22
A novel 'gene insertion/marker out' (GIMO) method for transgene expression and gene complementation in rodent malaria parasites. PLoS One (2011) 1.22
A reprofiled drug, auranofin, is effective against metronidazole-resistant Giardia lamblia. Antimicrob Agents Chemother (2013) 1.22
A nonazole CYP51 inhibitor cures Chagas' disease in a mouse model of acute infection. Antimicrob Agents Chemother (2010) 1.22
Gene expression patterns during adaptation of a helminth parasite to different environmental niches. Genome Biol (2007) 1.20
Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica. J Biol Chem (2007) 1.19
Vinyl sulfones as antiparasitic agents and a structural basis for drug design. J Biol Chem (2009) 1.18
A comparative chemogenomics strategy to predict potential drug targets in the metazoan pathogen, Schistosoma mansoni. PLoS One (2009) 1.17
Hemoglobin digestion in blood-feeding ticks: mapping a multipeptidase pathway by functional proteomics. Chem Biol (2009) 1.17
Proteomic analysis of skin invasion by blood fluke larvae. PLoS Negl Trop Dis (2008) 1.16
Global identification of peptidase specificity by multiplex substrate profiling. Nat Methods (2012) 1.14
The Plasmodium falciparum cysteine protease falcipain-2 captures its substrate, hemoglobin, via a unique motif. Proc Natl Acad Sci U S A (2005) 1.14
Diversification of the insulin receptor family in the helminth parasite Schistosoma mansoni. FEBS J (2006) 1.14
Delineation of diverse macrophage activation programs in response to intracellular parasites and cytokines. PLoS Negl Trop Dis (2010) 1.14
Proteomic identification of Drosophila melanogaster male accessory gland proteins, including a pro-cathepsin and a soluble gamma-glutamyl transpeptidase. Proteome Sci (2006) 1.14
Evolution of apoptosis-like programmed cell death in unicellular protozoan parasites. Parasit Vectors (2011) 1.13
Upregulation of retinal dehydrogenase 2 in alternatively activated macrophages during retinoid-dependent type-2 immunity to helminth infection in mice. PLoS Pathog (2012) 1.13
Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51. PLoS Negl Trop Dis (2012) 1.12
Assessing the adequacy of attenuation of genetically modified malaria parasite vaccine candidates. Vaccine (2012) 1.11
Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain. Bioorg Med Chem Lett (2005) 1.11
Cysteine proteinases from distinct cellular compartments are recruited to phagocytic vesicles by Entamoeba histolytica. Mol Biochem Parasitol (2002) 1.09
The Syk kinase SmTK4 of Schistosoma mansoni is involved in the regulation of spermatogenesis and oogenesis. PLoS Pathog (2010) 1.08
An unusual receptor tyrosine kinase of Schistosoma mansoni contains a Venus Flytrap module. Mol Biochem Parasitol (2003) 1.07
Aziridine-2,3-dicarboxylate inhibitors targeting the major cysteine protease of Trypanosoma brucei as lead trypanocidal agents. Bioorg Med Chem Lett (2006) 1.07
New insights into the machinery of blood digestion by ticks. Trends Parasitol (2013) 1.07
Involvement of the cytokine MIF in the snail host immune response to the parasite Schistosoma mansoni. PLoS Pathog (2010) 1.07
Use of recombinant Entamoeba histolytica cysteine proteinase 1 to identify a potent inhibitor of amebic invasion in a human colonic model. Eukaryot Cell (2007) 1.07
A new family of receptor tyrosine kinases with a venus flytrap binding domain in insects and other invertebrates activated by aminoacids. PLoS One (2009) 1.07
A gene family of cathepsin L-like proteases of filarial nematodes are associated with larval molting and cuticle and eggshell remodeling. Mol Biochem Parasitol (2004) 1.06
Quantification and clustering of phenotypic screening data using time-series analysis for chemotherapy of schistosomiasis. BMC Genomics (2012) 1.06
A parasite cysteine protease is key to host protein degradation and iron acquisition. J Biol Chem (2008) 1.06
Structures of falcipain-2 and falcipain-3 bound to small molecule inhibitors: implications for substrate specificity. J Med Chem (2009) 1.06
Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB. J Med Chem (2010) 1.04
Two Plasmodium 6-Cys family-related proteins have distinct and critical roles in liver-stage development. FASEB J (2014) 1.04
Trypanosoma brucei: chemical evidence that cathepsin L is essential for survival and a relevant drug target. Int J Parasitol (2012) 1.03
The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family. Structure (2007) 1.03
A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target. J Biol Chem (2010) 1.03
The global cysteine peptidase landscape in parasites. Trends Parasitol (2009) 1.02
Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease. Proc Natl Acad Sci U S A (2006) 1.02
Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB. Bioorg Med Chem Lett (2008) 1.02