Published in Biochem Biophys Res Commun on October 23, 2006
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Protein misfolding, functional amyloid, and human disease. Annu Rev Biochem (2006) 22.87
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The protofilament structure of insulin amyloid fibrils. Proc Natl Acad Sci U S A (2002) 4.08
Targeting C-reactive protein for the treatment of cardiovascular disease. Nature (2006) 4.07
Long-range interactions within a nonnative protein. Science (2002) 4.06
Protein structure determination from NMR chemical shifts. Proc Natl Acad Sci U S A (2007) 3.96
An analytical solution to the kinetics of breakable filament assembly. Science (2009) 3.87
Cigarette smoking and adenomatous polyps: a meta-analysis. Gastroenterology (2007) 3.73
Predicting drug sensitivity and resistance: profiling ABC transporter genes in cancer cells. Cancer Cell (2004) 3.72
Amyloid formation by globular proteins under native conditions. Nat Chem Biol (2009) 3.72
High-resolution molecular structure of a peptide in an amyloid fibril determined by magic angle spinning NMR spectroscopy. Proc Natl Acad Sci U S A (2004) 3.58
Direct observation of the interconversion of normal and toxic forms of α-synuclein. Cell (2012) 3.39
Smoking and colorectal cancer: a meta-analysis. JAMA (2008) 3.19
Prediction of "aggregation-prone" and "aggregation-susceptible" regions in proteins associated with neurodegenerative diseases. J Mol Biol (2005) 3.18
Mapping long-range interactions in alpha-synuclein using spin-label NMR and ensemble molecular dynamics simulations. J Am Chem Soc (2005) 3.13
Role of intermolecular forces in defining material properties of protein nanofibrils. Science (2007) 2.94
Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism. Proc Natl Acad Sci U S A (2013) 2.89
Low-populated folding intermediates of Fyn SH3 characterized by relaxation dispersion NMR. Nature (2004) 2.84
The importance of sequence diversity in the aggregation and evolution of proteins. Nature (2005) 2.70
De novo designed peptide-based amyloid fibrils. Proc Natl Acad Sci U S A (2002) 2.59
The behaviour of polyamino acids reveals an inverse side chain effect in amyloid structure formation. EMBO J (2002) 2.59
Prediction of aggregation-prone regions in structured proteins. J Mol Biol (2008) 2.56
A causative link between the structure of aberrant protein oligomers and their toxicity. Nat Chem Biol (2010) 2.48
Characterization of the nanoscale properties of individual amyloid fibrils. Proc Natl Acad Sci U S A (2006) 2.46
Molecular recycling within amyloid fibrils. Nature (2005) 2.39
Kinetic partitioning of protein folding and aggregation. Nat Struct Biol (2002) 2.37
Systematic in vivo analysis of the intrinsic determinants of amyloid Beta pathogenicity. PLoS Biol (2007) 2.35
Molecular conformation of a peptide fragment of transthyretin in an amyloid fibril. Proc Natl Acad Sci U S A (2002) 2.18
Multiple tight phospholipid-binding modes of alpha-synuclein revealed by solution NMR spectroscopy. J Mol Biol (2009) 2.14
Prediction of the absolute aggregation rates of amyloidogenic polypeptide chains. J Mol Biol (2004) 2.14
Italian cross-cultural adaptation and validation of the Oxford Shoulder Score. J Shoulder Elbow Surg (2009) 2.02
Myoglobin forms amyloid fibrils by association of unfolded polypeptide segments. Proc Natl Acad Sci U S A (2003) 1.93
Prefibrillar amyloid aggregates could be generic toxins in higher organisms. J Neurosci (2006) 1.89
Life on the edge: a link between gene expression levels and aggregation rates of human proteins. Trends Biochem Sci (2007) 1.88
Short amino acid stretches can mediate amyloid formation in globular proteins: the Src homology 3 (SH3) case. Proc Natl Acad Sci U S A (2004) 1.83
Antibodies to human serum amyloid P component eliminate visceral amyloid deposits. Nature (2010) 1.81
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The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures. FASEB J (2007) 1.79
Prefibrillar amyloid protein aggregates share common features of cytotoxicity. J Biol Chem (2004) 1.79
Atomic structure and hierarchical assembly of a cross-β amyloid fibril. Proc Natl Acad Sci U S A (2013) 1.75
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From macroscopic measurements to microscopic mechanisms of protein aggregation. J Mol Biol (2012) 1.71
Structural reorganisation and potential toxicity of oligomeric species formed during the assembly of amyloid fibrils. PLoS Comput Biol (2007) 1.71
Generation of high-quality protein extracts from formalin-fixed, paraffin-embedded tissues. Proteomics (2009) 1.70
A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme. Nature (2003) 1.66
Local cooperativity in the unfolding of an amyloidogenic variant of human lysozyme. Nat Struct Biol (2002) 1.64
Novel binding partners of Ldb1 are required for haematopoietic development. Development (2006) 1.63
Glycine residues appear to be evolutionarily conserved for their ability to inhibit aggregation. Structure (2005) 1.63
The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β(1-40) peptide. Nat Struct Mol Biol (2011) 1.62
Direct characterization of amyloidogenic oligomers by single-molecule fluorescence. Proc Natl Acad Sci U S A (2008) 1.56
Nanobodies raised against monomeric α-synuclein distinguish between fibrils at different maturation stages. J Mol Biol (2013) 1.56
Exploring amyloid formation by a de novo design. Proc Natl Acad Sci U S A (2004) 1.55
Intermolecular structure determination of amyloid fibrils with magic-angle spinning and dynamic nuclear polarization NMR. J Am Chem Soc (2011) 1.54
Metastability of native proteins and the phenomenon of amyloid formation. J Am Chem Soc (2011) 1.53
Nucleated polymerization with secondary pathways. I. Time evolution of the principal moments. J Chem Phys (2011) 1.52
Differential phospholipid binding of alpha-synuclein variants implicated in Parkinson's disease revealed by solution NMR spectroscopy. Biochemistry (2010) 1.50
ANS binding reveals common features of cytotoxic amyloid species. ACS Chem Biol (2010) 1.48
beta-amyloid is different in normal aging and in Alzheimer disease. J Biol Chem (2005) 1.48
Heat shock protein 70 inhibits alpha-synuclein fibril formation via preferential binding to prefibrillar species. J Biol Chem (2005) 1.48
Evolution of emphysema in relation to smoking. Eur Radiol (2009) 1.47
Determination of a transition state at atomic resolution from protein engineering data. J Mol Biol (2002) 1.47
A coupled equilibrium shift mechanism in calmodulin-mediated signal transduction. Structure (2008) 1.45
The solution structure of human beta2-microglobulin reveals the prodromes of its amyloid transition. Protein Sci (2002) 1.44
Determination of an ensemble of structures representing the denatured state of the bovine acyl-coenzyme a binding protein. J Am Chem Soc (2004) 1.44
Observation of sequence specificity in the seeding of protein amyloid fibrils. Protein Sci (2004) 1.44
Multistep, sequential control of the trafficking and function of the multiple sulfatase deficiency gene product, SUMF1 by PDI, ERGIC-53 and ERp44. Hum Mol Genet (2008) 1.43
Comparison of detergent-based sample preparation workflows for LTQ-Orbitrap analysis of the Escherichia coli proteome. Proteomics (2013) 1.40
Hb Southern Italy: coexistence of two missence mutations (the Hb Sun Prairie alpha2 130 Ala --> Pro and Hb Caserta alpha2 26 Ala --> Thr) in a single HBA2 gene. Br J Haematol (2008) 1.39
Appropriate use of magnetic resonance imaging and ultrasound to detect early silicone gel breast implant rupture in postmastectomy reconstruction. Plast Reconstr Surg (2014) 1.39
Expression and purification of the recombinant subunits of toluene/o-xylene monooxygenase and reconstitution of the active complex. Eur J Biochem (2002) 1.39
Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic beta2-microglobulin variant. Proc Natl Acad Sci U S A (2011) 1.38
In situ measurements of the formation and morphology of intracellular β-amyloid fibrils by super-resolution fluorescence imaging. J Am Chem Soc (2011) 1.37
The formation of spherulites by amyloid fibrils of bovine insulin. Proc Natl Acad Sci U S A (2004) 1.36
Altered aggregation properties of mutant gamma-crystallins cause inherited cataract. EMBO J (2002) 1.35
Protein misfolding and disease: from the test tube to the organism. Curr Opin Chem Biol (2008) 1.35
Collagen plays an active role in the aggregation of beta2-microglobulin under physiopathological conditions of dialysis-related amyloidosis. J Biol Chem (2006) 1.33
Identification of proteins interacting with the RNAPII FCP1 phosphatase: FCP1 forms a complex with arginine methyltransferase PRMT5 and it is a substrate for PRMT5-mediated methylation. FEBS Lett (2005) 1.32
Structure and function of the long pentraxin PTX3 glycosidic moiety: fine-tuning of the interaction with C1q and complement activation. Biochemistry (2006) 1.32
Rational design of aggregation-resistant bioactive peptides: reengineering human calcitonin. Proc Natl Acad Sci U S A (2005) 1.31
Heteronuclear NMR investigations of dynamic regions of intact Escherichia coli ribosomes. Proc Natl Acad Sci U S A (2004) 1.31
Structural biology. Dynamic visions of enzymatic reactions. Science (2006) 1.30
Structure and dynamics of a ribosome-bound nascent chain by NMR spectroscopy. Proc Natl Acad Sci U S A (2007) 1.30
Kinetics and thermodynamics of amyloid formation from direct measurements of fluctuations in fibril mass. Proc Natl Acad Sci U S A (2007) 1.29
A highly amyloidogenic region of hen lysozyme. J Mol Biol (2004) 1.29
Rapid proton-detected NMR assignment for proteins with fast magic angle spinning. J Am Chem Soc (2014) 1.29
Rare fluctuations of native proteins sampled by equilibrium hydrogen exchange. J Am Chem Soc (2003) 1.27
Formation of native and non-native interactions in ensembles of denatured ACBP molecules from paramagnetic relaxation enhancement studies. J Mol Biol (2005) 1.27
Calculation of mutational free energy changes in transition states for protein folding. Biophys J (2003) 1.27
Hereditary systemic amyloidosis due to Asp76Asn variant β2-microglobulin. N Engl J Med (2012) 1.26