Published in Biochemistry on November 07, 2006
Transglutaminase 2 inhibitors and their therapeutic role in disease states. Pharmacol Ther (2007) 1.60
Transglutaminase 2: a molecular Swiss army knife. Biochim Biophys Acta (2011) 1.25
Intracellular localization and conformational state of transglutaminase 2: implications for cell death. PLoS One (2009) 1.07
Transglutaminases and neurodegeneration. J Neurochem (2009) 1.03
Identification of two GTP-independent alternatively spliced forms of tissue transglutaminase in human leukocytes, vascular smooth muscle, and endothelial cells. FASEB J (2007) 1.01
A unique role for heat shock protein 70 and its binding partner tissue transglutaminase in cancer cell migration. J Biol Chem (2011) 0.99
Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug libraries. Chem Biol (2008) 0.96
GTP-binding-defective forms of tissue transglutaminase trigger cell death. Biochemistry (2007) 0.96
A mechanism for the upregulation of EGF receptor levels in glioblastomas. Cell Rep (2013) 0.90
Transglutaminase-1 protects renal epithelial cells from hydrogen peroxide-induced apoptosis through activation of STAT3 and AKT signaling pathways. Am J Physiol Renal Physiol (2009) 0.87
Structural characterization of a conserved, calcium-dependent periplasmic protease from Legionella pneumophila. J Bacteriol (2012) 0.87
Doxorubicin induces the persistent activation of intracellular transglutaminase 2 that protects from cell death. Mol Cells (2012) 0.82
Transglutaminase 2 regulates the GTPase-activating activity of Bcr. J Biol Chem (2009) 0.80
Transglutaminase activation in neurodegenerative diseases. Future Neurol (2009) 0.79
The mechanism of transglutaminase 2 inhibition with glucosamine: implications of a possible anti-inflammatory effect through transglutaminase inhibition. J Cancer Res Clin Oncol (2010) 0.79
Bcr is a substrate for Transglutaminase 2 cross-linking activity. BMC Biochem (2011) 0.78
Methylglyoxal in cells elicits a negative feedback loop entailing transglutaminase 2 and glyoxalase 1. Redox Biol (2014) 0.76
A class of extracellular vesicles from breast cancer cells activates VEGF receptors and tumour angiogenesis. Nat Commun (2017) 0.75
Strategies towards in vivo imaging of active transglutaminase type 2 using positron emission tomography. Amino Acids (2016) 0.75
The Different Conformational States of Tissue Transglutaminase Have Opposing Affects on Cell Viability. J Biol Chem (2016) 0.75
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res (1994) 392.47
Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase. Anal Biochem (1996) 8.84
Transglutaminases: crosslinking enzymes with pleiotropic functions. Nat Rev Mol Cell Biol (2003) 6.05
Transglutaminases: multifunctional cross-linking enzymes that stabilize tissues. FASEB J (1991) 3.56
Transglutaminases. Annu Rev Biochem (1980) 3.47
Tissue transglutaminase is an integrin-binding adhesion coreceptor for fibronectin. J Cell Biol (2000) 2.86
Role of retinoids in differentiation and carcinogenesis. Cancer Res (1983) 2.74
Gh: a GTP-binding protein with transglutaminase activity and receptor signaling function. Science (1994) 2.50
Structural basis for the guanine nucleotide-binding activity of tissue transglutaminase and its regulation of transamidation activity. Proc Natl Acad Sci U S A (2002) 2.15
Chemistry and biology of dihydroisoxazole derivatives: selective inhibitors of human transglutaminase 2. Chem Biol (2005) 2.00
Three-dimensional structure of a transglutaminase: human blood coagulation factor XIII. Proc Natl Acad Sci U S A (1994) 1.78
Transglutaminases: protein cross-linking enzymes in tissues and body fluids. Thromb Haemost (1994) 1.63
Identification of a guanosine triphosphate-binding site on guinea pig liver transglutaminase. Role of GTP and calcium ions in modulating activity. J Biol Chem (1987) 1.58
Fluorescent BODIPY-GTP analogs: real-time measurement of nucleotide binding to G proteins. Anal Biochem (2001) 1.50
Augmentation of tissue transglutaminase expression and activation by epidermal growth factor inhibit doxorubicin-induced apoptosis in human breast cancer cells. J Biol Chem (2004) 1.39
Tissue transglutaminase and apoptosis: sense and antisense transfection studies with human neuroblastoma cells. Mol Cell Biol (1994) 1.37
Expression of tissue transglutaminase in skeletal tissues correlates with events of terminal differentiation of chondrocytes. J Cell Biol (1993) 1.35
Cystamine increases L-cysteine levels in Huntington's disease transgenic mouse brain and in a PC12 model of polyglutamine aggregation. J Neurochem (2004) 1.33
Analysis of tissue transglutaminase function in the migration of Swiss 3T3 fibroblasts: the active-state conformation of the enzyme does not affect cell motility but is important for its secretion. J Biol Chem (2002) 1.28
Cystamine inhibits caspase activity. Implications for the treatment of polyglutamine disorders. J Biol Chem (2002) 1.22
Tissue transglutaminase protects against apoptosis by modifying the tumor suppressor protein p110 Rb. J Biol Chem (2002) 1.22
Tissue transglutaminase 2 inhibition promotes cell death and chemosensitivity in glioblastomas. Mol Cancer Ther (2005) 1.20
Tissue transglutaminase serves as an inhibitor of apoptosis by cross-linking caspase 3 in thapsigargin-treated cells. Mol Cell Biol (2006) 1.16
Tissue transglutaminase-dependent posttranslational modification of the retinoblastoma gene product in promonocytic cells undergoing apoptosis. Mol Cell Biol (1997) 1.15
Tissue transglutaminase: a possible role in neurodegenerative diseases. Prog Neurobiol (2000) 1.14
Evidence that phospholipase delta1 is the effector in the Gh (transglutaminase II)-mediated signaling. J Biol Chem (1996) 1.11
Measurement of tissue transglutaminase activity in a permeabilized cell system: its regulation by Ca2+ and nucleotides. Biochem J (1996) 1.11
GTP hydrolysis by guinea pig liver transglutaminase. Biochem Biophys Res Commun (1989) 1.11
Cystamine treatment is neuroprotective in the YAC128 mouse model of Huntington disease. J Neurochem (2005) 1.10
Tissue transglutaminase differentially modulates apoptosis in a stimuli-dependent manner. J Neurochem (2002) 1.10
The expression of "tissue" transglutaminase in two human cancer cell lines is related with the programmed cell death (apoptosis). Eur J Cell Biol (1991) 1.08
The molecular basis of retinoic acid action. Transcriptional regulation of tissue transglutaminase gene expression in macrophages. J Biol Chem (1988) 1.07
Inhibition of "tissue" transglutaminase increases cell survival by preventing apoptosis. J Biol Chem (1999) 1.07
A transglutaminase that converts interleukin-2 into a factor cytotoxic to oligodendrocytes. Science (1993) 1.05
Regulation of human tissue transglutaminase function by magnesium-nucleotide complexes. Identification of distinct binding sites for Mg-GTP and Mg-ATP. J Biol Chem (1998) 1.04
Recovery of visual response of injured adult rat optic nerves treated with transglutaminase. Science (1994) 1.04
Effects of tissue transglutaminase on retinoic acid-induced cellular differentiation and protection against apoptosis. J Biol Chem (2001) 1.03
Three-dimensional structure of the human transglutaminase 3 enzyme: binding of calcium ions changes structure for activation. EMBO J (2002) 1.03
Free and protein-conjugated polyamines in mouse epidermal cells. Effect of high calcium and retinoic acid. J Biol Chem (1988) 0.98
Identification and biochemical characterization of an 80 kilodalton GTP-binding/transglutaminase from rabbit liver nuclei. Biochemistry (1995) 0.94
A continuous spectrophotometric linked enzyme assay for transglutaminase activity. Anal Biochem (1999) 0.94
Sphingosylphosphocholine reduces the calcium ion requirement for activating tissue transglutaminase. J Biol Chem (1997) 0.88
GTP hydrolysis by human tissue transglutaminase homologue. Biochem Biophys Res Commun (1996) 0.78
Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. Cancer Cell (2010) 5.02
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase. Science (2011) 4.16
Structural basis for the guanine nucleotide-binding activity of tissue transglutaminase and its regulation of transamidation activity. Proc Natl Acad Sci U S A (2002) 2.15
Cool-1 functions as an essential regulatory node for EGF receptor- and Src-mediated cell growth. Nat Cell Biol (2006) 2.04
Cancer cell-derived microvesicles induce transformation by transferring tissue transglutaminase and fibronectin to recipient cells. Proc Natl Acad Sci U S A (2011) 2.01
Structural basis of m7GpppG binding to the nuclear cap-binding protein complex. Nat Struct Biol (2002) 1.61
Activated Cdc42 sequesters c-Cbl and prevents EGF receptor degradation. Cell (2003) 1.61
Structural elements, mechanism, and evolutionary convergence of Rho protein-guanine nucleotide exchange factor complexes. Biochemistry (2004) 1.55
Signaling to the Rho GTPases: networking with the DH domain. FEBS Lett (2002) 1.50
Cardiac developmental defects and eccentric right ventricular hypertrophy in cardiomyocyte focal adhesion kinase (FAK) conditional knockout mice. Proc Natl Acad Sci U S A (2008) 1.48
The Cool-2/alpha-Pix protein mediates a Cdc42-Rac signaling cascade. Curr Biol (2005) 1.41
Structure of the active N-terminal domain of Ezrin. Conformational and mobility changes identify keystone interactions. J Biol Chem (2002) 1.41
Augmentation of tissue transglutaminase expression and activation by epidermal growth factor inhibit doxorubicin-induced apoptosis in human breast cancer cells. J Biol Chem (2004) 1.39
The molecular basis for the regulation of the cap-binding complex by the importins. Nat Struct Mol Biol (2009) 1.38
Regulation of the Cool/Pix proteins: key binding partners of the Cdc42/Rac targets, the p21-activated kinases. J Biol Chem (2001) 1.35
Epidermal growth factor-dependent regulation of Cdc42 is mediated by the Src tyrosine kinase. J Biol Chem (2003) 1.28
Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease. EMBO Mol Med (2010) 1.27
New insights into how the Rho guanine nucleotide dissociation inhibitor regulates the interaction of Cdc42 with membranes. J Biol Chem (2009) 1.27
Dibenzophenanthridines as inhibitors of glutaminase C and cancer cell proliferation. Mol Cancer Ther (2012) 1.27
Glutaminase: a hot spot for regulation of cancer cell metabolism? Oncotarget (2010) 1.24
The Cdc42 target ACK2 interacts with sorting nexin 9 (SH3PX1) to regulate epidermal growth factor receptor degradation. J Biol Chem (2002) 1.23
Tissue transglutaminase is an essential participant in the epidermal growth factor-stimulated signaling pathway leading to cancer cell migration and invasion. J Biol Chem (2009) 1.23
Tissue transglutaminase protects against apoptosis by modifying the tumor suppressor protein p110 Rb. J Biol Chem (2002) 1.22
Two isoforms of tissue transglutaminase mediate opposing cellular fates. Proc Natl Acad Sci U S A (2006) 1.20
Cdc42 and Ras cooperate to mediate cellular transformation by intersectin-L. J Biol Chem (2005) 1.18
RhoGDI is required for Cdc42-mediated cellular transformation. Curr Biol (2003) 1.17
Novel regulatory mechanisms for the Dbl family guanine nucleotide exchange factor Cool-2/alpha-Pix. EMBO J (2004) 1.17
Establishment of a robust single axis of cell polarity by coupling multiple positive feedback loops. Nat Commun (2013) 1.13
Therapeutic strategies impacting cancer cell glutamine metabolism. Future Med Chem (2013) 1.12
Activation of the Ras-ERK pathway inhibits retinoic acid-induced stimulation of tissue transglutaminase expression in NIH3T3 cells. J Biol Chem (2003) 1.11
Identification of a DOCK180-related guanine nucleotide exchange factor that is capable of mediating a positive feedback activation of Cdc42. J Biol Chem (2006) 1.09
Iqg1p links spatial and secretion landmarks to polarity and cytokinesis. J Cell Biol (2002) 1.06
Conserved structural motifs in intracellular trafficking pathways: structure of the gammaCOP appendage domain. Mol Cell (2003) 1.06
Microvesicles as mediators of intercellular communication in cancer. Methods Mol Biol (2014) 1.06
EGF potentiated oncogenesis requires a tissue transglutaminase-dependent signaling pathway leading to Src activation. Proc Natl Acad Sci U S A (2010) 1.05
Effector proteins exert an important influence on the signaling-active state of the small GTPase Cdc42. J Biol Chem (2008) 1.02
Rho GTPases and their roles in cancer metabolism. Trends Mol Med (2012) 1.01
Perturbing the linker regions of the alpha-subunit of transducin: a new class of constitutively active GTP-binding proteins. J Biol Chem (2004) 1.00
A unique role for heat shock protein 70 and its binding partner tissue transglutaminase in cancer cell migration. J Biol Chem (2011) 0.99
Cdc42-mTOR signaling pathway controls Hes5 and Pax6 expression in retinoic acid-dependent neural differentiation. J Biol Chem (2008) 0.98
Activation of the Ran GTPase is subject to growth factor regulation and can give rise to cellular transformation. J Biol Chem (2009) 0.97
GTP-binding-defective forms of tissue transglutaminase trigger cell death. Biochemistry (2007) 0.96
Phosphorylation of the cool-1/beta-Pix protein serves as a regulatory signal for the migration and invasive activity of Src-transformed cells. J Biol Chem (2010) 0.95
A switch 3 point mutation in the alpha subunit of transducin yields a unique dominant-negative inhibitor. J Biol Chem (2005) 0.92
The bicyclic intermediate structure provides insights into the desuccinylation mechanism of human sirtuin 5 (SIRT5). J Biol Chem (2012) 0.92
Antiapoptotic Cdc42 mutants are potent activators of cellular transformation. Biochemistry (2002) 0.92
New insights into the role of conserved, essential residues in the GTP binding/GTP hydrolytic cycle of large G proteins. J Biol Chem (2006) 0.92
Influencing cellular transformation by modulating the rates of GTP hydrolysis by Cdc42. Biochemistry (2006) 0.91
A mechanism for the upregulation of EGF receptor levels in glioblastomas. Cell Rep (2013) 0.90
Small angle X-ray scattering studies of mitochondrial glutaminase C reveal extended flexible regions, and link oligomeric state with enzyme activity. PLoS One (2013) 0.90
Understanding the catalytic mechanism of GTPase-activating proteins: demonstration of the importance of switch domain stabilization in the stimulation of GTP hydrolysis. Biochemistry (2002) 0.89
A link between Cdc42 and syntaxin is involved in mastoparan-stimulated insulin release. Biochemistry (2002) 0.89
Unloading RNAs in the cytoplasm: an "importin" task. Nucleus (2009) 0.88
Microfluidic isolation of cancer-cell-derived microvesicles from hetergeneous extracellular shed vesicle populations. Biomed Microdevices (2014) 0.88
Deletion of Cdc42 enhances ADAM17-mediated vascular endothelial growth factor receptor 2 shedding and impairs vascular endothelial cell survival and vasculogenesis. Mol Cell Biol (2013) 0.87
The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins. FEBS Lett (2003) 0.87
R(h)oads to microvesicles. Small GTPases (2012) 0.86
Transglutaminase inhibition protects against oxidative stress-induced neuronal death downstream of pathological ERK activation. J Neurosci (2012) 0.86
Phosphoinositide 3-kinase activity is required for retinoic acid-induced expression and activation of the tissue transglutaminase. J Biol Chem (2002) 0.85
Prenylation and membrane localization of Cdc42 are essential for activation by DOCK7. Biochemistry (2013) 0.84
The adaptor protein and Arf GTPase-activating protein Cat-1/Git-1 is required for cellular transformation. J Biol Chem (2012) 0.84
Crystallization and preliminary crystallographic analysis of the ezrin FERM domain. Acta Crystallogr D Biol Crystallogr (2002) 0.83
A novel mechanism by which tissue transglutaminase activates signaling events that promote cell survival. J Biol Chem (2014) 0.83
Cancerous epithelial cell lines shed extracellular vesicles with a bimodal size distribution that is sensitive to glutamine inhibition. Phys Biol (2014) 0.83
C-terminal di-arginine motif of Cdc42 protein is essential for binding to phosphatidylinositol 4,5-bisphosphate-containing membranes and inducing cellular transformation. J Biol Chem (2012) 0.82
Inactivation of Cdc42 in embryonic brain results in hydrocephalus with ependymal cell defects in mice. Protein Cell (2012) 0.82
Ras and the FAK paradox. Mol Cell (2009) 0.81
A minimal Rac activation domain in the unconventional guanine nucleotide exchange factor Dock180. Biochemistry (2011) 0.81
Interaction of activated Cdc42-associated tyrosine kinase ACK2 with HSP90. Biochem J (2004) 0.81
Tissue transglutaminase and its role in human cancer progression. Adv Enzymol Relat Areas Mol Biol (2011) 0.81
Effects of tissue transglutaminase on beta -amyloid1-42-induced apoptosis. Protein J (2006) 0.81
Simultaneously targeting tissue transglutaminase and kidney type glutaminase sensitizes cancer cells to acid toxicity and offers new opportunities for therapeutic intervention. Mol Pharm (2014) 0.80
Mutations in the polybasic juxtamembrane sequence of both plasma membrane- and endoplasmic reticulum-localized epidermal growth factor receptors confer ligand-independent cell transformation. J Biol Chem (2013) 0.80
A Cdc42 mutant specifically activated by intersectin. Biochemistry (2005) 0.80
Mutational analysis of betaCOP (Sec26p) identifies an appendage domain critical for function. BMC Cell Biol (2008) 0.79
X-ray crystal structures reveal two activated states for RhoC. Biochemistry (2007) 0.79
Insulin-like growth factor-I diminishes the activation status and expression of the small GTPase Cdc42 in articular chondrocytes. J Orthop Res (2004) 0.79
A dominant-negative Galpha mutant that traps a stable rhodopsin-Galpha-GTP-betagamma complex. J Biol Chem (2011) 0.79
Stabilization of an intermediate activation state for transducin by a fluorescent GTP analogue. Biochemistry (2004) 0.79
Biochemical characterization of the Cool (Cloned-out-of-Library)/Pix (Pak-interactive exchange factor) proteins. Methods Enzymol (2006) 0.78
Measurement of epidermal growth factor receptor turnover and effects of Cdc42. Methods Enzymol (2006) 0.78
Characterization of a novel activated Ran GTPase mutant and its ability to induce cellular transformation. J Biol Chem (2012) 0.78