Published in J Biol Chem on January 17, 2002
SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis. Mol Biol Cell (2005) 2.08
The PX-BAR membrane-remodeling unit of sorting nexin 9. EMBO J (2007) 1.59
Activated Cdc42-associated kinase 1 is a component of EGF receptor signaling complex and regulates EGF receptor degradation. Mol Biol Cell (2006) 1.37
Activation of the nonreceptor protein tyrosine kinase Ack by multiple extracellular stimuli. Proc Natl Acad Sci U S A (2006) 1.37
Regulation of endocytic traffic by Rho GTPases. Biochem J (2003) 1.31
Interaction of the Wiskott-Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cells. Proc Natl Acad Sci U S A (2007) 1.22
HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK. Mol Cell Biol (2010) 1.13
Down-regulation of active ACK1 is mediated by association with the E3 ubiquitin ligase Nedd4-2. J Biol Chem (2009) 1.13
TNK2 preserves epidermal growth factor receptor expression on the cell surface and enhances migration and invasion of human breast cancer cells. Breast Cancer Res (2008) 1.12
ARAP1 regulates endocytosis of EGFR. Traffic (2008) 1.10
Constitutive activated Cdc42-associated kinase (Ack) phosphorylation at arrested endocytic clathrin-coated pits of cells that lack dynamin. Mol Biol Cell (2010) 1.00
Dimerization is required for SH3PX1 tyrosine phosphorylation in response to epidermal growth factor signalling and interaction with ACK2. Biochem J (2006) 0.93
Regulation of ack-family nonreceptor tyrosine kinases. J Signal Transduct (2011) 0.92
Sorting nexin 33 induces mammalian cell micronucleated phenotype and actin polymerization by interacting with Wiskott-Aldrich syndrome protein. J Biol Chem (2009) 0.89
Cortactin is a substrate of activated Cdc42-associated kinase 1 (ACK1) during ligand-induced epidermal growth factor receptor downregulation. PLoS One (2012) 0.84
Steroid hormone control of cell death and cell survival: molecular insights using RNAi. PLoS Genet (2009) 0.83
Characterization of PXK as a protein involved in epidermal growth factor receptor trafficking. Mol Cell Biol (2010) 0.83
An epidermal growth factor (EGF) -dependent interaction between GIT1 and sorting nexin 6 promotes degradation of the EGF receptor. FASEB J (2008) 0.82
Regulation of Ack1 localization and activity by the amino-terminal SAM domain. BMC Biochem (2010) 0.82
Interaction of activated Cdc42-associated tyrosine kinase ACK2 with HSP90. Biochem J (2004) 0.81
Sorting nexin 9 negatively regulates invadopodia formation and function in cancer cells. J Cell Sci (2016) 0.80
Modulation of morphogenesis by Egfr during dorsal closure in Drosophila. PLoS One (2013) 0.79
SNX9 promotes metastasis by enhancing cancer cell invasion via differential regulation of RhoGTPases. Mol Biol Cell (2016) 0.79
Identification of SH3 domain proteins interacting with the cytoplasmic tail of the a disintegrin and metalloprotease 10 (ADAM10). PLoS One (2014) 0.78
Endocytosis, Metastasis and Beyond: Multiple Facets of SNX9. Trends Cell Biol (2016) 0.76
The unique mechanism of SNX9 BAR domain for inducing membrane tubulation. Mol Cells (2014) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature (2004) 12.72
Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. Cancer Cell (2010) 5.02
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase. Science (2011) 4.16
S1P1 receptor signaling overrides retention mediated by G alpha i-coupled receptors to promote T cell egress. Immunity (2007) 3.05
Structural basis for the guanine nucleotide-binding activity of tissue transglutaminase and its regulation of transamidation activity. Proc Natl Acad Sci U S A (2002) 2.15
Cool-1 functions as an essential regulatory node for EGF receptor- and Src-mediated cell growth. Nat Cell Biol (2006) 2.04
Cancer cell-derived microvesicles induce transformation by transferring tissue transglutaminase and fibronectin to recipient cells. Proc Natl Acad Sci U S A (2011) 2.01
Arabidopsis relatives of the human lysine-specific Demethylase1 repress the expression of FWA and FLOWERING LOCUS C and thus promote the floral transition. Plant Cell (2007) 1.64
Structural basis of m7GpppG binding to the nuclear cap-binding protein complex. Nat Struct Biol (2002) 1.61
Activated Cdc42 sequesters c-Cbl and prevents EGF receptor degradation. Cell (2003) 1.61
Phosphatidylinositol-3-kinase-atypical protein kinase C signaling is required for Wnt attraction and anterior-posterior axon guidance. J Neurosci (2008) 1.55
Structural elements, mechanism, and evolutionary convergence of Rho protein-guanine nucleotide exchange factor complexes. Biochemistry (2004) 1.55
Signaling to the Rho GTPases: networking with the DH domain. FEBS Lett (2002) 1.50
Cardiac developmental defects and eccentric right ventricular hypertrophy in cardiomyocyte focal adhesion kinase (FAK) conditional knockout mice. Proc Natl Acad Sci U S A (2008) 1.48
The Cool-2/alpha-Pix protein mediates a Cdc42-Rac signaling cascade. Curr Biol (2005) 1.41
Structure of the active N-terminal domain of Ezrin. Conformational and mobility changes identify keystone interactions. J Biol Chem (2002) 1.41
Augmentation of tissue transglutaminase expression and activation by epidermal growth factor inhibit doxorubicin-induced apoptosis in human breast cancer cells. J Biol Chem (2004) 1.39
The molecular basis for the regulation of the cap-binding complex by the importins. Nat Struct Mol Biol (2009) 1.38
Activated Cdc42-associated kinase 1 is a component of EGF receptor signaling complex and regulates EGF receptor degradation. Mol Biol Cell (2006) 1.37
Regulation of the Cool/Pix proteins: key binding partners of the Cdc42/Rac targets, the p21-activated kinases. J Biol Chem (2001) 1.35
Cellular signaling for activation of Rho GTPase Cdc42. Cell Signal (2008) 1.32
Epidermal growth factor-dependent regulation of Cdc42 is mediated by the Src tyrosine kinase. J Biol Chem (2003) 1.28
New insights into how the Rho guanine nucleotide dissociation inhibitor regulates the interaction of Cdc42 with membranes. J Biol Chem (2009) 1.27
High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors. Chem Biol (2011) 1.27
Dibenzophenanthridines as inhibitors of glutaminase C and cancer cell proliferation. Mol Cancer Ther (2012) 1.27
Calcium activates Nedd4 E3 ubiquitin ligases by releasing the C2 domain-mediated auto-inhibition. J Biol Chem (2010) 1.25
Glutaminase: a hot spot for regulation of cancer cell metabolism? Oncotarget (2010) 1.24
Tissue transglutaminase is an essential participant in the epidermal growth factor-stimulated signaling pathway leading to cancer cell migration and invasion. J Biol Chem (2009) 1.23
Tissue transglutaminase protects against apoptosis by modifying the tumor suppressor protein p110 Rb. J Biol Chem (2002) 1.22
Two isoforms of tissue transglutaminase mediate opposing cellular fates. Proc Natl Acad Sci U S A (2006) 1.20
Cdc42 and Ras cooperate to mediate cellular transformation by intersectin-L. J Biol Chem (2005) 1.18
RhoGDI is required for Cdc42-mediated cellular transformation. Curr Biol (2003) 1.17
Novel regulatory mechanisms for the Dbl family guanine nucleotide exchange factor Cool-2/alpha-Pix. EMBO J (2004) 1.17
HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK. Mol Cell Biol (2010) 1.13
Establishment of a robust single axis of cell polarity by coupling multiple positive feedback loops. Nat Commun (2013) 1.13
Therapeutic strategies impacting cancer cell glutamine metabolism. Future Med Chem (2013) 1.12
Activation of the Ras-ERK pathway inhibits retinoic acid-induced stimulation of tissue transglutaminase expression in NIH3T3 cells. J Biol Chem (2003) 1.11
Identification of a DOCK180-related guanine nucleotide exchange factor that is capable of mediating a positive feedback activation of Cdc42. J Biol Chem (2006) 1.09
Conserved structural motifs in intracellular trafficking pathways: structure of the gammaCOP appendage domain. Mol Cell (2003) 1.06
Microvesicles as mediators of intercellular communication in cancer. Methods Mol Biol (2014) 1.06
Statin-induced autophagy by inhibition of geranylgeranyl biosynthesis in prostate cancer PC3 cells. Prostate (2010) 1.06
Iqg1p links spatial and secretion landmarks to polarity and cytokinesis. J Cell Biol (2002) 1.06
EGF potentiated oncogenesis requires a tissue transglutaminase-dependent signaling pathway leading to Src activation. Proc Natl Acad Sci U S A (2010) 1.05
Arabidopsis homologs of retinoblastoma-associated protein 46/48 associate with a histone deacetylase to act redundantly in chromatin silencing. PLoS Genet (2011) 1.04
Effector proteins exert an important influence on the signaling-active state of the small GTPase Cdc42. J Biol Chem (2008) 1.02
Importance of Ca(2+)-dependent transamidation activity in the protection afforded by tissue transglutaminase against doxorubicin-induced apoptosis. Biochemistry (2006) 1.02
Rho GTPases and their roles in cancer metabolism. Trends Mol Med (2012) 1.01
Perturbing the linker regions of the alpha-subunit of transducin: a new class of constitutively active GTP-binding proteins. J Biol Chem (2004) 1.00
A unique role for heat shock protein 70 and its binding partner tissue transglutaminase in cancer cell migration. J Biol Chem (2011) 0.99
Cdc42-mTOR signaling pathway controls Hes5 and Pax6 expression in retinoic acid-dependent neural differentiation. J Biol Chem (2008) 0.98
Activation of the Ran GTPase is subject to growth factor regulation and can give rise to cellular transformation. J Biol Chem (2009) 0.97
GTP-binding-defective forms of tissue transglutaminase trigger cell death. Biochemistry (2007) 0.96
Expression of S-100 protein in renal cell neoplasms. Hum Pathol (2006) 0.95
Phosphorylation of the cool-1/beta-Pix protein serves as a regulatory signal for the migration and invasive activity of Src-transformed cells. J Biol Chem (2010) 0.95
Dimerization is required for SH3PX1 tyrosine phosphorylation in response to epidermal growth factor signalling and interaction with ACK2. Biochem J (2006) 0.93
Antiapoptotic Cdc42 mutants are potent activators of cellular transformation. Biochemistry (2002) 0.92
The bicyclic intermediate structure provides insights into the desuccinylation mechanism of human sirtuin 5 (SIRT5). J Biol Chem (2012) 0.92
New insights into the role of conserved, essential residues in the GTP binding/GTP hydrolytic cycle of large G proteins. J Biol Chem (2006) 0.92
A switch 3 point mutation in the alpha subunit of transducin yields a unique dominant-negative inhibitor. J Biol Chem (2005) 0.92
Influencing cellular transformation by modulating the rates of GTP hydrolysis by Cdc42. Biochemistry (2006) 0.91
Atorvastatin induces autophagy in prostate cancer PC3 cells through activation of LC3 transcription. Cancer Biol Ther (2011) 0.91
A mechanism for the upregulation of EGF receptor levels in glioblastomas. Cell Rep (2013) 0.90
Small angle X-ray scattering studies of mitochondrial glutaminase C reveal extended flexible regions, and link oligomeric state with enzyme activity. PLoS One (2013) 0.90
Synapses of amphids defective (SAD-A) kinase promotes glucose-stimulated insulin secretion through activation of p21-activated kinase (PAK1) in pancreatic β-Cells. J Biol Chem (2012) 0.89
Understanding the catalytic mechanism of GTPase-activating proteins: demonstration of the importance of switch domain stabilization in the stimulation of GTP hydrolysis. Biochemistry (2002) 0.89
A link between Cdc42 and syntaxin is involved in mastoparan-stimulated insulin release. Biochemistry (2002) 0.89
Unloading RNAs in the cytoplasm: an "importin" task. Nucleus (2009) 0.88
Microfluidic isolation of cancer-cell-derived microvesicles from hetergeneous extracellular shed vesicle populations. Biomed Microdevices (2014) 0.88
The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins. FEBS Lett (2003) 0.87
Deletion of Cdc42 enhances ADAM17-mediated vascular endothelial growth factor receptor 2 shedding and impairs vascular endothelial cell survival and vasculogenesis. Mol Cell Biol (2013) 0.87
Transglutaminase inhibition protects against oxidative stress-induced neuronal death downstream of pathological ERK activation. J Neurosci (2012) 0.86
R(h)oads to microvesicles. Small GTPases (2012) 0.86
Phosphoinositide 3-kinase activity is required for retinoic acid-induced expression and activation of the tissue transglutaminase. J Biol Chem (2002) 0.85
Prenylation and membrane localization of Cdc42 are essential for activation by DOCK7. Biochemistry (2013) 0.84
The activation mechanism of ACK1 (activated Cdc42-associated tyrosine kinase 1). Biochem J (2012) 0.84
The adaptor protein and Arf GTPase-activating protein Cat-1/Git-1 is required for cellular transformation. J Biol Chem (2012) 0.84
A novel mechanism by which tissue transglutaminase activates signaling events that promote cell survival. J Biol Chem (2014) 0.83
Crystallization and preliminary crystallographic analysis of the ezrin FERM domain. Acta Crystallogr D Biol Crystallogr (2002) 0.83
Cancerous epithelial cell lines shed extracellular vesicles with a bimodal size distribution that is sensitive to glutamine inhibition. Phys Biol (2014) 0.83
Identification of the domain in ErbB2 that restricts ligand-induced degradation. Cell Signal (2008) 0.82
C-terminal di-arginine motif of Cdc42 protein is essential for binding to phosphatidylinositol 4,5-bisphosphate-containing membranes and inducing cellular transformation. J Biol Chem (2012) 0.82
Inactivation of Cdc42 in embryonic brain results in hydrocephalus with ependymal cell defects in mice. Protein Cell (2012) 0.82
Tissue transglutaminase and its role in human cancer progression. Adv Enzymol Relat Areas Mol Biol (2011) 0.81
Interaction of activated Cdc42-associated tyrosine kinase ACK2 with HSP90. Biochem J (2004) 0.81
Effects of tissue transglutaminase on beta -amyloid1-42-induced apoptosis. Protein J (2006) 0.81
Ras and the FAK paradox. Mol Cell (2009) 0.81
A minimal Rac activation domain in the unconventional guanine nucleotide exchange factor Dock180. Biochemistry (2011) 0.81
Simultaneously targeting tissue transglutaminase and kidney type glutaminase sensitizes cancer cells to acid toxicity and offers new opportunities for therapeutic intervention. Mol Pharm (2014) 0.80
A Cdc42 mutant specifically activated by intersectin. Biochemistry (2005) 0.80
Mutations in the polybasic juxtamembrane sequence of both plasma membrane- and endoplasmic reticulum-localized epidermal growth factor receptors confer ligand-independent cell transformation. J Biol Chem (2013) 0.80
COX-2 inhibitors arrest prostate cancer cell cycle progression by down-regulation of kinetochore/centromere proteins. Prostate (2014) 0.80
Insulin-like growth factor-I diminishes the activation status and expression of the small GTPase Cdc42 in articular chondrocytes. J Orthop Res (2004) 0.79
X-ray crystal structures reveal two activated states for RhoC. Biochemistry (2007) 0.79
Stabilization of an intermediate activation state for transducin by a fluorescent GTP analogue. Biochemistry (2004) 0.79
Mutational analysis of betaCOP (Sec26p) identifies an appendage domain critical for function. BMC Cell Biol (2008) 0.79