Published in J Biol Chem on July 06, 2009
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RhoGDI is required for Cdc42-mediated cellular transformation. Curr Biol (2003) 1.17
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Activated Cdc42 sequesters c-Cbl and prevents EGF receptor degradation. Cell (2003) 1.61
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The molecular basis for the regulation of the cap-binding complex by the importins. Nat Struct Mol Biol (2009) 1.38
Regulation of the Cool/Pix proteins: key binding partners of the Cdc42/Rac targets, the p21-activated kinases. J Biol Chem (2001) 1.35
Epidermal growth factor-dependent regulation of Cdc42 is mediated by the Src tyrosine kinase. J Biol Chem (2003) 1.28
Dibenzophenanthridines as inhibitors of glutaminase C and cancer cell proliferation. Mol Cancer Ther (2012) 1.27
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The Cdc42 target ACK2 interacts with sorting nexin 9 (SH3PX1) to regulate epidermal growth factor receptor degradation. J Biol Chem (2002) 1.23
Tissue transglutaminase is an essential participant in the epidermal growth factor-stimulated signaling pathway leading to cancer cell migration and invasion. J Biol Chem (2009) 1.23
Tissue transglutaminase protects against apoptosis by modifying the tumor suppressor protein p110 Rb. J Biol Chem (2002) 1.22
Two isoforms of tissue transglutaminase mediate opposing cellular fates. Proc Natl Acad Sci U S A (2006) 1.20
Cdc42 and Ras cooperate to mediate cellular transformation by intersectin-L. J Biol Chem (2005) 1.18
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Novel regulatory mechanisms for the Dbl family guanine nucleotide exchange factor Cool-2/alpha-Pix. EMBO J (2004) 1.17
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Therapeutic strategies impacting cancer cell glutamine metabolism. Future Med Chem (2013) 1.12
Activation of the Ras-ERK pathway inhibits retinoic acid-induced stimulation of tissue transglutaminase expression in NIH3T3 cells. J Biol Chem (2003) 1.11
Identification of a DOCK180-related guanine nucleotide exchange factor that is capable of mediating a positive feedback activation of Cdc42. J Biol Chem (2006) 1.09
Conserved structural motifs in intracellular trafficking pathways: structure of the gammaCOP appendage domain. Mol Cell (2003) 1.06
Microvesicles as mediators of intercellular communication in cancer. Methods Mol Biol (2014) 1.06
Iqg1p links spatial and secretion landmarks to polarity and cytokinesis. J Cell Biol (2002) 1.06
EGF potentiated oncogenesis requires a tissue transglutaminase-dependent signaling pathway leading to Src activation. Proc Natl Acad Sci U S A (2010) 1.05
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Rho GTPases and their roles in cancer metabolism. Trends Mol Med (2012) 1.01
Perturbing the linker regions of the alpha-subunit of transducin: a new class of constitutively active GTP-binding proteins. J Biol Chem (2004) 1.00
A unique role for heat shock protein 70 and its binding partner tissue transglutaminase in cancer cell migration. J Biol Chem (2011) 0.99
Cdc42-mTOR signaling pathway controls Hes5 and Pax6 expression in retinoic acid-dependent neural differentiation. J Biol Chem (2008) 0.98
Activation of the Ran GTPase is subject to growth factor regulation and can give rise to cellular transformation. J Biol Chem (2009) 0.97
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Phosphorylation of the cool-1/beta-Pix protein serves as a regulatory signal for the migration and invasive activity of Src-transformed cells. J Biol Chem (2010) 0.95
A switch 3 point mutation in the alpha subunit of transducin yields a unique dominant-negative inhibitor. J Biol Chem (2005) 0.92
The bicyclic intermediate structure provides insights into the desuccinylation mechanism of human sirtuin 5 (SIRT5). J Biol Chem (2012) 0.92
Antiapoptotic Cdc42 mutants are potent activators of cellular transformation. Biochemistry (2002) 0.92
New insights into the role of conserved, essential residues in the GTP binding/GTP hydrolytic cycle of large G proteins. J Biol Chem (2006) 0.92
Influencing cellular transformation by modulating the rates of GTP hydrolysis by Cdc42. Biochemistry (2006) 0.91
A mechanism for the upregulation of EGF receptor levels in glioblastomas. Cell Rep (2013) 0.90
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Understanding the catalytic mechanism of GTPase-activating proteins: demonstration of the importance of switch domain stabilization in the stimulation of GTP hydrolysis. Biochemistry (2002) 0.89
A link between Cdc42 and syntaxin is involved in mastoparan-stimulated insulin release. Biochemistry (2002) 0.89
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Microfluidic isolation of cancer-cell-derived microvesicles from hetergeneous extracellular shed vesicle populations. Biomed Microdevices (2014) 0.88
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The adaptor protein and Arf GTPase-activating protein Cat-1/Git-1 is required for cellular transformation. J Biol Chem (2012) 0.84
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A novel mechanism by which tissue transglutaminase activates signaling events that promote cell survival. J Biol Chem (2014) 0.83
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C-terminal di-arginine motif of Cdc42 protein is essential for binding to phosphatidylinositol 4,5-bisphosphate-containing membranes and inducing cellular transformation. J Biol Chem (2012) 0.82
Inactivation of Cdc42 in embryonic brain results in hydrocephalus with ependymal cell defects in mice. Protein Cell (2012) 0.82
A minimal Rac activation domain in the unconventional guanine nucleotide exchange factor Dock180. Biochemistry (2011) 0.81
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Simultaneously targeting tissue transglutaminase and kidney type glutaminase sensitizes cancer cells to acid toxicity and offers new opportunities for therapeutic intervention. Mol Pharm (2014) 0.80
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A Cdc42 mutant specifically activated by intersectin. Biochemistry (2005) 0.80
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A dominant-negative Galpha mutant that traps a stable rhodopsin-Galpha-GTP-betagamma complex. J Biol Chem (2011) 0.79
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Characterization of a novel activated Ran GTPase mutant and its ability to induce cellular transformation. J Biol Chem (2012) 0.78
A constitutively active Gα subunit provides insights into the mechanism of G protein activation. Biochemistry (2012) 0.77
Microcrystallography, high-pressure cryocooling and BioSAXS at MacCHESS. J Synchrotron Radiat (2010) 0.77
How GPCRs hit the switch. Nat Struct Mol Biol (2006) 0.77
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A new tool for G protein analysis. ACS Chem Biol (2008) 0.75