Published in J Am Chem Soc on November 08, 2006
Ribosomal peptide natural products: bridging the ribosomal and nonribosomal worlds. Nat Prod Rep (2009) 2.32
Isolation and characterization of carnocyclin a, a novel circular bacteriocin produced by Carnobacterium maltaromaticum UAL307. Appl Environ Microbiol (2008) 1.19
Development of Class IIa Bacteriocins as Therapeutic Agents. Int J Microbiol (2011) 0.96
Synthesis and activity of thioether-containing analogues of the complement inhibitor compstatin. ACS Chem Biol (2011) 0.94
Integrating the discovery pipeline for novel compounds targeting ion channels. Curr Opin Chem Biol (2008) 0.94
Third extracellular loop (EC3)-N terminus interaction is important for seven-transmembrane domain receptor function: implications for an activation microswitch region. J Biol Chem (2010) 0.87
Class IIa bacteriocins: diversity and new developments. Int J Mol Sci (2012) 0.86
Synthesis, conformational analysis and biological properties of a dicarba derivative of the antimicrobial peptide, brevinin-1BYa. Eur Biophys J (2011) 0.80
The Role of Disulfide Bond Replacements in Analogues of the Tarantula Toxin ProTx-II and Their Effects on Inhibition of the Voltage-Gated Sodium Ion Channel Nav1.7. J Am Chem Soc (2017) 0.75
Drug discovery and natural products: end of an era or an endless frontier? Science (2009) 7.54
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep (2013) 5.38
Complete reconstitution of a highly reducing iterative polyketide synthase. Science (2009) 2.68
Thuricin CD, a posttranslationally modified bacteriocin with a narrow spectrum of activity against Clostridium difficile. Proc Natl Acad Sci U S A (2010) 1.89
Two-peptide bacteriocins produced by lactic acid bacteria. Biochimie (2002) 1.72
Structural characterization of lacticin 3147, a two-peptide lantibiotic with synergistic activity. Biochemistry (2004) 1.61
Structure of subtilosin A, a cyclic antimicrobial peptide from Bacillus subtilis with unusual sulfur to alpha-carbon cross-links: formation and reduction of alpha-thio-alpha-amino acid derivatives. Biochemistry (2004) 1.50
Enzymatic synthesis of resorcylic acid lactones by cooperation of fungal iterative polyketide synthases involved in hypothemycin biosynthesis. J Am Chem Soc (2010) 1.41
Serine and threonine beta-lactones: a new class of hepatitis A virus 3C cysteine proteinase inhibitors. J Org Chem (2002) 1.25
Isolation and characterization of carnocyclin a, a novel circular bacteriocin produced by Carnobacterium maltaromaticum UAL307. Appl Environ Microbiol (2008) 1.19
A fungal ketoreductase domain that displays substrate-dependent stereospecificity. Nat Chem Biol (2012) 1.17
Insights into radicicol biosynthesis via heterologous synthesis of intermediates and analogs. J Biol Chem (2010) 1.17
Biosynthesis of lovastatin and related metabolites formed by fungal iterative PKS enzymes. Biopolymers (2010) 1.15
Structural insights into stereochemical inversion by diaminopimelate epimerase: an antibacterial drug target. Proc Natl Acad Sci U S A (2006) 1.14
Structure of subtilosin A, an antimicrobial peptide from Bacillus subtilis with unusual posttranslational modifications linking cysteine sulfurs to alpha-carbons of phenylalanine and threonine. J Am Chem Soc (2003) 1.11
Structure and genetics of circular bacteriocins. Trends Microbiol (2011) 1.08
Solid supported chemical syntheses of both components of the lantibiotic lacticin 3147. J Am Chem Soc (2011) 1.08
Crystal structure of LL-diaminopimelate aminotransferase from Arabidopsis thaliana: a recently discovered enzyme in the biosynthesis of L-lysine by plants and Chlamydia. J Mol Biol (2007) 1.05
Isolation, structural characterization, and properties of mattacin (polymyxin M), a cyclic peptide antibiotic produced by Paenibacillus kobensis M. J Biol Chem (2003) 1.05
Loss of Apelin exacerbates myocardial infarction adverse remodeling and ischemia-reperfusion injury: therapeutic potential of synthetic Apelin analogues. J Am Heart Assoc (2013) 1.05
Synthesis of oxytocin analogues with replacement of sulfur by carbon gives potent antagonists with increased stability. J Org Chem (2005) 1.03
Membrane permeabilization, orientation, and antimicrobial mechanism of subtilosin A. Chem Phys Lipids (2005) 1.03
Fundamental functionality: recent developments in understanding the structure-activity relationships of lantibiotic peptides. J Antibiot (Tokyo) (2010) 1.02
Synthesis of the lantibiotic lactocin S using peptide cyclizations on solid phase. J Am Chem Soc (2010) 1.01
Use of a copper-chelated lipid speeds up NMR measurements from membrane proteins. J Am Chem Soc (2010) 1.01
Synthesis and evaluation of keto-glutamine analogues as potent inhibitors of severe acute respiratory syndrome 3CLpro. J Med Chem (2004) 1.01
Biosynthesis of aminovinyl-cysteine-containing peptides and its application in the production of potential drug candidates. Acc Chem Res (2011) 1.00
Synthesis of beta-cyclopropylalanines by photolysis of diacyl peroxides. Org Lett (2003) 1.00
Structural characterization of the highly cyclized lantibiotic paenicidin A via a partial desulfurization/reduction strategy. J Am Chem Soc (2012) 0.99
Photolysis of diacyl peroxides: a radical-based approach for the synthesis of functionalized amino acids. Org Lett (2003) 0.99
Identification and comparison of natural rubber from two Lactuca species. Phytochemistry (2006) 0.98
The 3D structure of thuricin CD, a two-component bacteriocin with cysteine sulfur to α-carbon cross-links. J Am Chem Soc (2011) 0.97
The three-dimensional structure of carnocyclin A reveals that many circular bacteriocins share a common structural motif. J Biol Chem (2009) 0.97
Crystal structure and biochemical studies of the trans-acting polyketide enoyl reductase LovC from lovastatin biosynthesis. Proc Natl Acad Sci U S A (2012) 0.96
Development of Class IIa Bacteriocins as Therapeutic Agents. Int J Microbiol (2011) 0.96
Structure and biosynthesis of carnolysin, a homologue of enterococcal cytolysin with D-amino acids. J Am Chem Soc (2014) 0.96
Response of methicillin-resistant Staphylococcus aureus to amicoumacin A. PLoS One (2012) 0.95
Synthesis of biologically active dicarba analogues of the peptide hormone oxytocin using ring-closing metathesis. Org Lett (2003) 0.94
The circular bacteriocin, carnocyclin A, forms anion-selective channels in lipid bilayers. Biochim Biophys Acta (2009) 0.94
Exploration of inhibitors for diaminopimelate aminotransferase. Bioorg Med Chem (2010) 0.92
Synthesis of mono- and disaccharide analogs of moenomycin and lipid II for inhibition of transglycosylase activity of penicillin-binding protein 1b. Bioorg Med Chem (2004) 0.92
Paenibacillus polymyxa PKB1 produces variants of polymyxin B-type antibiotics. Chem Biol (2011) 0.92
Double oxidation of the cyclic nonaketide dihydromonacolin L to monacolin J by a single cytochrome P450 monooxygenase, LovA. J Am Chem Soc (2011) 0.92
NMR solution structure of the precursor for carnobacteriocin B2, an antimicrobial peptide from Carnobacterium piscicola. Eur J Biochem (2004) 0.92
Biochemical, structural, and genetic characterization of tridecaptin A₁, an antagonist of Campylobacter jejuni. Chembiochem (2013) 0.92
LovG: the thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis. Angew Chem Int Ed Engl (2013) 0.92
Dual modes of modification of hepatitis A virus 3C protease by a serine-derived beta-lactone: selective crystallization and formation of a functional catalytic triad in the active site. J Mol Biol (2005) 0.91
Syntheses of conjugated pyrones for the enzymatic assay of lovastatin nonaketide synthase, an iterative polyketide synthase. Org Lett (2007) 0.90
The 3D solution structure of thurincin H, a bacteriocin with four sulfur to α-carbon crosslinks. Angew Chem Int Ed Engl (2011) 0.90
Solid-supported synthesis and biological evaluation of the lantibiotic peptide bis(desmethyl) lacticin 3147 A2. Angew Chem Int Ed Engl (2008) 0.90
NMR solution structure of ImB2, a protein conferring immunity to antimicrobial activity of the type IIa bacteriocin, carnobacteriocin B2. Biochemistry (2004) 0.89
Mechanism of substrate recognition and PLP-induced conformational changes in LL-diaminopimelate aminotransferase from Arabidopsis thaliana. J Mol Biol (2008) 0.89
Design, synthesis, and evaluation of inhibitors for severe acute respiratory syndrome 3C-like protease based on phthalhydrazide ketones or heteroaromatic esters. J Med Chem (2007) 0.89
Crystal structure of diaminopimelate epimerase from Arabidopsis thaliana, an amino acid racemase critical for L-lysine biosynthesis. J Mol Biol (2008) 0.89
Dynamic relationships among type IIa bacteriocins: temperature effects on antimicrobial activity and on structure of the C-terminal amphipathic alpha helix as a receptor-binding region. Biochemistry (2004) 0.88
Multiple on-resin olefin metathesis to form ring-expanded analogues of the lantibiotic peptide, lacticin 3147 A2. Org Lett (2007) 0.87
Structural variations in keto-glutamines for improved inhibition against hepatitis A virus 3C proteinase. Bioorg Med Chem Lett (2004) 0.85
Synthesis and biological activity of isopentenyl diphosphate analogues. Bioorg Med Chem (2004) 0.85
Identification of an N-terminal formylated, two-peptide bacteriocin from Enterococcus faecalis 710C. J Agric Food Chem (2011) 0.85
Investigation of fungal iterative polyketide synthase functions using partially assembled intermediates. J Am Chem Soc (2013) 0.84
Spermicidal bacteriocins: lacticin 3147 and subtilosin A. Bioorg Med Chem Lett (2007) 0.84
Approaches to the discovery of new antibacterial agents based on bacteriocins. Biochem Cell Biol (2008) 0.84
Isolation of a variant of subtilosin A with hemolytic activity. J Bacteriol (2009) 0.84
The structure of LL-diaminopimelate aminotransferase from Chlamydia trachomatis: implications for its broad substrate specificity. J Mol Biol (2011) 0.84
Production of piscicolin 126 by Carnobacterium maltaromaticum UAL26 is controlled by temperature and induction peptide concentration. Arch Microbiol (2006) 0.84
An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors. J Mol Biol (2006) 0.83
Characterization of DcsC, a PLP-independent racemase involved in the biosynthesis of D-cycloserine. Org Biomol Chem (2012) 0.83
Aryl methylene ketones and fluorinated methylene ketones as reversible inhibitors for severe acute respiratory syndrome (SARS) 3C-like proteinase. Bioorg Chem (2008) 0.82
Dynamics of catalysis revealed from the crystal structures of mutants of diaminopimelate epimerase. Biochem Biophys Res Commun (2007) 0.82
Functional characterization of recombinant hyoscyamine 6β-hydroxylase from Atropa belladonna. Bioorg Med Chem (2012) 0.82
Chemical synthesis and biological evaluation of gallidermin-siderophore conjugates. Org Biomol Chem (2011) 0.82
Nuclear magnetic resonance solution structure of PisI, a group B immunity protein that provides protection against the type IIa bacteriocin piscicolin 126, PisA. Biochemistry (2008) 0.81
Heteroaromatic ester inhibitors of hepatitis A virus 3C proteinase: Evaluation of mode of action. Bioorg Med Chem (2008) 0.81
Stereoselective syntheses of 4-oxa diaminopimelic acid and its protected derivatives via aziridine ring opening. Org Lett (2007) 0.81
The stereoselective synthesis of aziridine analogues of diaminopimelic acid (DAP) and their interaction with dap epimerase. Org Biomol Chem (2005) 0.81
Synthesis and structure-activity relationships of o-sulfonamido-arylhydrazides as inhibitors of LL-diaminopimelate aminotransferase (LL-DAP-AT). Org Biomol Chem (2012) 0.81
The activity of bacteriocins from Carnobacterium maltaromaticum UAL307 against gram-negative bacteria in combination with EDTA treatment. FEMS Microbiol Lett (2011) 0.81
The synthesis of active and stable diaminopimelate analogues of the lantibiotic peptide lactocin S. J Am Chem Soc (2012) 0.81
Enzymatic synthesis of valerena-4,7(11)-diene by a unique sesquiterpene synthase from the valerian plant (Valeriana officinalis). FEBS J (2012) 0.81
Hydrophobic interactions as substitutes for a conserved disulfide linkage in the type IIa bacteriocins, leucocin A and pediocin PA-1. Chembiochem (2008) 0.80
Preparation and use of cysteine orthoesters for solid-supported synthesis of peptides. Org Lett (2010) 0.80
Solution structures of the linear leaderless bacteriocins enterocin 7A and 7B resemble carnocyclin A, a circular antimicrobial peptide. Biochemistry (2013) 0.80
Synthesis and structure-activity relationship studies of N-terminal analogues of the antimicrobial peptide tridecaptin A(1). J Med Chem (2014) 0.80
A mechanistic view of enzyme inhibition and peptide hydrolysis in the active site of the SARS-CoV 3C-like peptidase. J Mol Biol (2007) 0.80
Synthesis and biological activity of oxa-lacticin A2, a lantibiotic analogue with sulfur replaced by oxygen. Org Lett (2009) 0.79
A concise stereoselective synthesis of orthogonally protected lanthionine and beta-methyllanthionine. Org Biomol Chem (2007) 0.79
Purification and characterization of brochocin A and brochocin B(10-43), a functional fragment generated by heterologous expression in Carnobacterium piscicola. Appl Environ Microbiol (2003) 0.79
Molecular docking identifies the binding of 3-chloropyridine moieties specifically to the S1 pocket of SARS-CoV Mpro. Bioorg Med Chem (2007) 0.79
Inhibitors of 3C cysteine proteinases from Picornaviridae. Curr Top Med Chem (2004) 0.79
Studies on tridecaptin B(1), a lipopeptide with activity against multidrug resistant Gram-negative bacteria. Org Biomol Chem (2015) 0.78
Highly selective but multifunctional oxygenases in secondary metabolism. Acc Chem Res (2014) 0.78
Protein farnesyltransferase inhibitors interfere with farnesyl diphosphate binding by rubber transferase. Eur J Biochem (2003) 0.77
Chemical synthesis and biological activity of the neopetrosiamides and their analogues: revision of disulfide bond connectivity. J Am Chem Soc (2010) 0.77
Structure function relationship of inducer peptide pheromones involved in bacteriocin production in Carnobacterium maltaromaticum and Enterococcus faecium. Microbiology (2007) 0.77
Key residues in octyl-tridecaptin A1 analogues linked to stable secondary structures in the membrane. Chembiochem (2014) 0.76
Synthesis and evaluation of keto-glutamine analogues as inhibitors of hepatitis A virus 3C proteinase. J Org Chem (2002) 0.76
Monacolin N, a compound resulting from derailment of type I iterative polyketide synthase function en route to lovastatin. Chem Commun (Camb) (2003) 0.76
Transformations of cyclic nonaketides by Aspergillus terreus mutants blocked for lovastatin biosynthesis at the lovA and lovC genes. Org Biomol Chem (2003) 0.76
Investigation of the ring-closing metathesis of peptides in water. Org Biomol Chem (2012) 0.76