The circular bacteriocin, carnocyclin A, forms anion-selective channels in lipid bilayers.

PubWeight™: 0.94‹?›

🔗 View Article (PMID 19463781)

Published in Biochim Biophys Acta on May 20, 2009

Authors

Xiandi Gong1, Leah A Martin-Visscher, Drew Nahirney, John C Vederas, Marek Duszyk

Author Affiliations

1: Department of Physiology, University of Alberta, Edmonton, Alberta, Canada T6G 2H7.

Articles by these authors

Drug discovery and natural products: end of an era or an endless frontier? Science (2009) 7.54

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep (2013) 5.38

Complete reconstitution of a highly reducing iterative polyketide synthase. Science (2009) 2.68

Thuricin CD, a posttranslationally modified bacteriocin with a narrow spectrum of activity against Clostridium difficile. Proc Natl Acad Sci U S A (2010) 1.89

Two-peptide bacteriocins produced by lactic acid bacteria. Biochimie (2002) 1.72

Structural characterization of lacticin 3147, a two-peptide lantibiotic with synergistic activity. Biochemistry (2004) 1.61

Structure of subtilosin A, a cyclic antimicrobial peptide from Bacillus subtilis with unusual sulfur to alpha-carbon cross-links: formation and reduction of alpha-thio-alpha-amino acid derivatives. Biochemistry (2004) 1.50

Enzymatic synthesis of resorcylic acid lactones by cooperation of fungal iterative polyketide synthases involved in hypothemycin biosynthesis. J Am Chem Soc (2010) 1.41

Serine and threonine beta-lactones: a new class of hepatitis A virus 3C cysteine proteinase inhibitors. J Org Chem (2002) 1.25

Syk tyrosine kinase participates in beta1-integrin signaling and inflammatory responses in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol (2004) 1.21

Isolation and characterization of carnocyclin a, a novel circular bacteriocin produced by Carnobacterium maltaromaticum UAL307. Appl Environ Microbiol (2008) 1.19

Insights into radicicol biosynthesis via heterologous synthesis of intermediates and analogs. J Biol Chem (2010) 1.17

A fungal ketoreductase domain that displays substrate-dependent stereospecificity. Nat Chem Biol (2012) 1.17

Biosynthesis of lovastatin and related metabolites formed by fungal iterative PKS enzymes. Biopolymers (2010) 1.15

Structural insights into stereochemical inversion by diaminopimelate epimerase: an antibacterial drug target. Proc Natl Acad Sci U S A (2006) 1.14

Structure of subtilosin A, an antimicrobial peptide from Bacillus subtilis with unusual posttranslational modifications linking cysteine sulfurs to alpha-carbons of phenylalanine and threonine. J Am Chem Soc (2003) 1.11

Structure and genetics of circular bacteriocins. Trends Microbiol (2011) 1.08

Solid supported chemical syntheses of both components of the lantibiotic lacticin 3147. J Am Chem Soc (2011) 1.08

Isolation, structural characterization, and properties of mattacin (polymyxin M), a cyclic peptide antibiotic produced by Paenibacillus kobensis M. J Biol Chem (2003) 1.05

Crystal structure of LL-diaminopimelate aminotransferase from Arabidopsis thaliana: a recently discovered enzyme in the biosynthesis of L-lysine by plants and Chlamydia. J Mol Biol (2007) 1.05

Loss of Apelin exacerbates myocardial infarction adverse remodeling and ischemia-reperfusion injury: therapeutic potential of synthetic Apelin analogues. J Am Heart Assoc (2013) 1.05

Membrane permeabilization, orientation, and antimicrobial mechanism of subtilosin A. Chem Phys Lipids (2005) 1.03

Synthesis of oxytocin analogues with replacement of sulfur by carbon gives potent antagonists with increased stability. J Org Chem (2005) 1.03

Membrane cholesterol content modulates activation of BK channels in colonic epithelia. Biochim Biophys Acta (2004) 1.02

Fundamental functionality: recent developments in understanding the structure-activity relationships of lantibiotic peptides. J Antibiot (Tokyo) (2010) 1.02

Synthesis of the lantibiotic lactocin S using peptide cyclizations on solid phase. J Am Chem Soc (2010) 1.01

Use of a copper-chelated lipid speeds up NMR measurements from membrane proteins. J Am Chem Soc (2010) 1.01

Synthesis and evaluation of keto-glutamine analogues as potent inhibitors of severe acute respiratory syndrome 3CLpro. J Med Chem (2004) 1.01

Biosynthesis of aminovinyl-cysteine-containing peptides and its application in the production of potential drug candidates. Acc Chem Res (2011) 1.00

Synthesis of beta-cyclopropylalanines by photolysis of diacyl peroxides. Org Lett (2003) 1.00

Structural characterization of the highly cyclized lantibiotic paenicidin A via a partial desulfurization/reduction strategy. J Am Chem Soc (2012) 0.99

Photolysis of diacyl peroxides: a radical-based approach for the synthesis of functionalized amino acids. Org Lett (2003) 0.99

Identification and comparison of natural rubber from two Lactuca species. Phytochemistry (2006) 0.98

The 3D structure of thuricin CD, a two-component bacteriocin with cysteine sulfur to α-carbon cross-links. J Am Chem Soc (2011) 0.97

The three-dimensional structure of carnocyclin A reveals that many circular bacteriocins share a common structural motif. J Biol Chem (2009) 0.97

Crystal structure and biochemical studies of the trans-acting polyketide enoyl reductase LovC from lovastatin biosynthesis. Proc Natl Acad Sci U S A (2012) 0.96

Development of Class IIa Bacteriocins as Therapeutic Agents. Int J Microbiol (2011) 0.96

Structure and biosynthesis of carnolysin, a homologue of enterococcal cytolysin with D-amino acids. J Am Chem Soc (2014) 0.96

House dust mite interactions with airway epithelium: role in allergic airway inflammation. Curr Allergy Asthma Rep (2013) 0.95

Airway delivery of soluble factors from plastic-adherent bone marrow cells prevents murine asthma. Am J Respir Cell Mol Biol (2011) 0.95

Response of methicillin-resistant Staphylococcus aureus to amicoumacin A. PLoS One (2012) 0.95

Synthesis of biologically active dicarba analogues of the peptide hormone oxytocin using ring-closing metathesis. Org Lett (2003) 0.94

Exploration of inhibitors for diaminopimelate aminotransferase. Bioorg Med Chem (2010) 0.92

Paenibacillus polymyxa PKB1 produces variants of polymyxin B-type antibiotics. Chem Biol (2011) 0.92

Synthesis of mono- and disaccharide analogs of moenomycin and lipid II for inhibition of transglycosylase activity of penicillin-binding protein 1b. Bioorg Med Chem (2004) 0.92

Biochemical, structural, and genetic characterization of tridecaptin A₁, an antagonist of Campylobacter jejuni. Chembiochem (2013) 0.92

Double oxidation of the cyclic nonaketide dihydromonacolin L to monacolin J by a single cytochrome P450 monooxygenase, LovA. J Am Chem Soc (2011) 0.92

NMR solution structure of the precursor for carnobacteriocin B2, an antimicrobial peptide from Carnobacterium piscicola. Eur J Biochem (2004) 0.92

LovG: the thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis. Angew Chem Int Ed Engl (2013) 0.92

Dual modes of modification of hepatitis A virus 3C protease by a serine-derived beta-lactone: selective crystallization and formation of a functional catalytic triad in the active site. J Mol Biol (2005) 0.91

The 3D solution structure of thurincin H, a bacteriocin with four sulfur to α-carbon crosslinks. Angew Chem Int Ed Engl (2011) 0.90

Syntheses of conjugated pyrones for the enzymatic assay of lovastatin nonaketide synthase, an iterative polyketide synthase. Org Lett (2007) 0.90

Role of calnexin in the ER quality control and productive folding of CFTR; differential effect of calnexin knockout on wild-type and DeltaF508 CFTR. Biochim Biophys Acta (2008) 0.90

Solid-supported synthesis and biological evaluation of the lantibiotic peptide bis(desmethyl) lacticin 3147 A2. Angew Chem Int Ed Engl (2008) 0.90

NMR solution structure of ImB2, a protein conferring immunity to antimicrobial activity of the type IIa bacteriocin, carnobacteriocin B2. Biochemistry (2004) 0.89

Chemotherapy drugs form ion pores in membranes due to physical interactions with lipids. Chem Biol Drug Des (2012) 0.89

Crystal structure of diaminopimelate epimerase from Arabidopsis thaliana, an amino acid racemase critical for L-lysine biosynthesis. J Mol Biol (2008) 0.89

Design, synthesis, and evaluation of inhibitors for severe acute respiratory syndrome 3C-like protease based on phthalhydrazide ketones or heteroaromatic esters. J Med Chem (2007) 0.89

Mechanism of substrate recognition and PLP-induced conformational changes in LL-diaminopimelate aminotransferase from Arabidopsis thaliana. J Mol Biol (2008) 0.89

Dynamic relationships among type IIa bacteriocins: temperature effects on antimicrobial activity and on structure of the C-terminal amphipathic alpha helix as a receptor-binding region. Biochemistry (2004) 0.88

Differential regulation of cystic fibrosis transmembrane conductance regulator by interferon gamma in mast cells and epithelial cells. J Pharmacol Exp Ther (2005) 0.88

Multiple on-resin olefin metathesis to form ring-expanded analogues of the lantibiotic peptide, lacticin 3147 A2. Org Lett (2007) 0.87

Regulation of basolateral Cl(-) channels in airway epithelial cells: the role of nitric oxide. J Membr Biol (2007) 0.87

The role of bestrophin in airway epithelial ion transport. FEBS Lett (2004) 0.86

Structural variations in keto-glutamines for improved inhibition against hepatitis A virus 3C proteinase. Bioorg Med Chem Lett (2004) 0.85

Nitric oxide activates ATP-dependent K+ channels in human eosinophils. J Leukoc Biol (2002) 0.85

Identification of an N-terminal formylated, two-peptide bacteriocin from Enterococcus faecalis 710C. J Agric Food Chem (2011) 0.85

Synthesis and biological activity of isopentenyl diphosphate analogues. Bioorg Med Chem (2004) 0.85

Antimicrobial leucocin analogues with a disulfide bridge replaced by a carbocycle or by noncovalent interactions of allyl glycine residues. J Am Chem Soc (2006) 0.85

Investigation of fungal iterative polyketide synthase functions using partially assembled intermediates. J Am Chem Soc (2013) 0.84

Spermicidal bacteriocins: lacticin 3147 and subtilosin A. Bioorg Med Chem Lett (2007) 0.84

Approaches to the discovery of new antibacterial agents based on bacteriocins. Biochem Cell Biol (2008) 0.84

The structure of LL-diaminopimelate aminotransferase from Chlamydia trachomatis: implications for its broad substrate specificity. J Mol Biol (2011) 0.84

Isolation of a variant of subtilosin A with hemolytic activity. J Bacteriol (2009) 0.84

Regulation of Cl- secretion by alpha2-adrenergic receptors in mouse colonic epithelium. J Physiol (2003) 0.84

Production of piscicolin 126 by Carnobacterium maltaromaticum UAL26 is controlled by temperature and induction peptide concentration. Arch Microbiol (2006) 0.84

Sodium 4-phenylbutyrate upregulates ENaC and sodium absorption in T84 cells. Exp Cell Res (2006) 0.83

Characterization of DcsC, a PLP-independent racemase involved in the biosynthesis of D-cycloserine. Org Biomol Chem (2012) 0.83

A protein export pathway involving Escherichia coli porins. Structure (2012) 0.83

An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors. J Mol Biol (2006) 0.83

Chemical synthesis and biological evaluation of gallidermin-siderophore conjugates. Org Biomol Chem (2011) 0.82

Dynamics of catalysis revealed from the crystal structures of mutants of diaminopimelate epimerase. Biochem Biophys Res Commun (2007) 0.82

Allergic sensitization enhances anion current responsiveness of murine trachea to PAR-2 activation. Pflugers Arch (2011) 0.82

Aryl methylene ketones and fluorinated methylene ketones as reversible inhibitors for severe acute respiratory syndrome (SARS) 3C-like proteinase. Bioorg Chem (2008) 0.82

Functional characterization of recombinant hyoscyamine 6β-hydroxylase from Atropa belladonna. Bioorg Med Chem (2012) 0.82

Nuclear magnetic resonance solution structure of PisI, a group B immunity protein that provides protection against the type IIa bacteriocin piscicolin 126, PisA. Biochemistry (2008) 0.81

Enzymatic synthesis of valerena-4,7(11)-diene by a unique sesquiterpene synthase from the valerian plant (Valeriana officinalis). FEBS J (2012) 0.81

Synthesis and structure-activity relationships of o-sulfonamido-arylhydrazides as inhibitors of LL-diaminopimelate aminotransferase (LL-DAP-AT). Org Biomol Chem (2012) 0.81

The activity of bacteriocins from Carnobacterium maltaromaticum UAL307 against gram-negative bacteria in combination with EDTA treatment. FEMS Microbiol Lett (2011) 0.81

Heteroaromatic ester inhibitors of hepatitis A virus 3C proteinase: Evaluation of mode of action. Bioorg Med Chem (2008) 0.81

Cholesterol-dependent regulation of adenosine A(2A) receptor-mediated anion secretion in colon epithelial cells. Exp Cell Res (2009) 0.81

Stereoselective syntheses of 4-oxa diaminopimelic acid and its protected derivatives via aziridine ring opening. Org Lett (2007) 0.81

The synthesis of active and stable diaminopimelate analogues of the lantibiotic peptide lactocin S. J Am Chem Soc (2012) 0.81

The stereoselective synthesis of aziridine analogues of diaminopimelic acid (DAP) and their interaction with dap epimerase. Org Biomol Chem (2005) 0.81