Published in J Neurosci on November 01, 2006
Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality. Cell Death Differ (2011) 2.60
Peptidylarginine deiminase 4 contributes to tumor necrosis factor α-induced inflammatory arthritis. Arthritis Rheumatol (2014) 2.14
Chemical mechanisms of histone lysine and arginine modifications. Biochim Biophys Acta (2008) 1.69
Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor. Am J Physiol Gastrointest Liver Physiol (2011) 1.61
Protein arginine deiminase 4: evidence for a reverse protonation mechanism. Biochemistry (2007) 1.45
Peptidylarginine deiminase 2, 3 and 4 have distinct specificities against cellular substrates: novel insights into autoantigen selection in rheumatoid arthritis. Ann Rheum Dis (2011) 1.45
Epigenome-wide differences in pathology-free regions of multiple sclerosis-affected brains. Nat Neurosci (2013) 1.39
PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures. Front Immunol (2012) 1.37
Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation. J Exp Med (2008) 1.34
Peptidylarginine deiminases in citrullination, gene regulation, health and pathogenesis. Biochim Biophys Acta (2013) 1.20
Peptidylarginine deiminase 2 (PAD2) overexpression in transgenic mice leads to myelin loss in the central nervous system. Dis Model Mech (2008) 1.14
Protein deiminases: new players in the developmentally regulated loss of neural regenerative ability. Dev Biol (2011) 1.12
Proteins derived from neutrophil extracellular traps may serve as self-antigens and mediate organ damage in autoimmune diseases. Front Immunol (2012) 1.11
Epigenetic mechanisms facilitating oligodendrocyte development, maturation, and aging. Glia (2009) 1.09
Citrullination of histone H3 interferes with HP1-mediated transcriptional repression. PLoS Genet (2012) 1.04
Bacterial and human peptidylarginine deiminases: targets for inhibiting the autoimmune response in rheumatoid arthritis? Arthritis Res Ther (2010) 1.03
Reactivation of L1 retrotransposon by benzo(a)pyrene involves complex genetic and epigenetic regulation. Epigenetics (2011) 1.03
Inhibition of peptidyl-arginine deiminases reverses protein-hypercitrullination and disease in mouse models of multiple sclerosis. Dis Model Mech (2012) 0.97
PMeS: prediction of methylation sites based on enhanced feature encoding scheme. PLoS One (2012) 0.97
Comparative gene expression analysis in mouse models for multiple sclerosis, Alzheimer's disease and stroke for identifying commonly regulated and disease-specific gene changes. Genomics (2010) 0.96
Post-translational modifications of nucleosomal histones in oligodendrocyte lineage cells in development and disease. J Mol Neurosci (2008) 0.96
Epigenetic mechanisms in multiple sclerosis: implications for pathogenesis and treatment. Lancet Neurol (2013) 0.96
Changed histone acetylation patterns in normal-appearing white matter and early multiple sclerosis lesions. J Neurosci (2011) 0.95
iMethyl-PseAAC: identification of protein methylation sites via a pseudo amino acid composition approach. Biomed Res Int (2014) 0.93
Evaluating epigenetic landmarks in the brain of multiple sclerosis patients: a contribution to the current debate on disease pathogenesis. Prog Neurobiol (2008) 0.91
Vitamin C: a novel regulator of neutrophil extracellular trap formation. Nutrients (2013) 0.86
Alterations of histone modifications by cobalt compounds. Carcinogenesis (2009) 0.86
PADI4 and tumourigenesis. Cancer Cell Int (2010) 0.85
Peptidylarginine deiminases: novel drug targets for prevention of neuronal damage following hypoxic ischemic insult (HI) in neonates. J Neurochem (2014) 0.84
Transmethylation in immunity and autoimmunity. Clin Immunol (2011) 0.84
c-Myc mediates a hypoxia-induced decrease in acetylated histone H4. Biochimie (2009) 0.81
Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis. Nat Rev Neurol (2016) 0.80
Protein Arginine Deiminases and Associated Citrullination: Physiological Functions and Diseases Associated with Dysregulation. Curr Drug Targets (2015) 0.79
Defining the chromatin landscape in demyelinating disorders. Neurobiol Dis (2009) 0.77
Dual immunofluorescence study of citrullinated proteins in Alzheimer diseased frontal cortex. Neurosci Lett (2013) 0.77
Multiple sclerosis: getting personal with induced pluripotent stem cells. Cell Death Dis (2015) 0.77
A novel role for peptidylarginine deiminases in microvesicle release reveals therapeutic potential of PAD inhibition in sensitizing prostate cancer cells to chemotherapy. J Extracell Vesicles (2015) 0.77
Intracellular Protein Shuttling: A Mechanism Relevant for Myelin Repair in Multiple Sclerosis? Int J Mol Sci (2015) 0.77
Promoting return of function in multiple sclerosis: An integrated approach. Mult Scler Relat Disord (2013) 0.76
NETosis. Autoimmune Dis (2013) 0.76
Serum anti-modified citrullinated vimentin antibody concentration is associated with liver fibrosis in patients with chronic hepatitis. Hepat Med (2011) 0.76
Tumor necrosis factor alpha, citrullination, and peptidylarginine deiminase 4 in lung and joint inflammation. Arthritis Res Ther (2016) 0.76
The effect of epigenetic modifications on the secondary structures and possible binding positions of the N-terminal tail of histone H3 in the nucleosome: a computational study. J Mol Model (2017) 0.75
Protein arginine deiminase 4 inhibition is sufficient for the amelioration of collagen-induced arthritis. Clin Exp Immunol (2017) 0.75
Epigenetic Drugs for Multiple Sclerosis. Curr Neuropharmacol (2016) 0.75
Peptidylarginine Deiminases as Drug Targets in Neonatal Hypoxic-Ischemic Encephalopathy. Front Neurol (2016) 0.75
Is anti-cyclic citrullinated Peptide antibody a good value biomarker for Alzheimer disease? Int J Prev Med (2013) 0.75
Immune recognition of citrullinated epitopes. Immunology (2016) 0.75
Protein post-translational modifications: In silico prediction tools and molecular modeling. Comput Struct Biotechnol J (2017) 0.75
Multiplex peptide stable isotope dimethyl labeling for quantitative proteomics. Nat Protoc (2009) 4.61
Dietary intervention in infancy and later signs of beta-cell autoimmunity. N Engl J Med (2010) 4.16
The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements. EMBO J (2002) 4.13
Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency. Nat Neurosci (2008) 3.24
The transcription factor Yin Yang 1 is essential for oligodendrocyte progenitor differentiation. Neuron (2007) 2.38
Histone modifications affect timing of oligodendrocyte progenitor differentiation in the developing rat brain. J Cell Biol (2005) 2.34
The role of citrullinated proteins suggests a novel mechanism in the pathogenesis of multiple sclerosis. Neurochem Res (2006) 1.71
The Yin and Yang of YY1 in the nervous system. J Neurochem (2008) 1.68
Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J Neurosci (2007) 1.58
Dis3-like 1: a novel exoribonuclease associated with the human exosome. EMBO J (2010) 1.57
Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis. Proc Natl Acad Sci U S A (2004) 1.54
Histone deacetylase 1 is essential for oligodendrocyte specification in the zebrafish CNS. Mech Dev (2005) 1.53
A molecular insight of Hes5-dependent inhibition of myelin gene expression: old partners and new players. EMBO J (2006) 1.49
Lack of the cell-cycle inhibitor p27Kip1 results in selective increase of transit-amplifying cells for adult neurogenesis. J Neurosci (2002) 1.48
Combinatorial profiles of oligodendrocyte-selective classes of transcriptional regulators differentially modulate myelin basic protein gene expression. J Neurosci (2005) 1.47
Profiling of N-acetylated protein termini provides in-depth insights into the N-terminal nature of the proteome. Mol Cell Proteomics (2010) 1.28
Receptor protein tyrosine phosphatase alpha is essential for hippocampal neuronal migration and long-term potentiation. EMBO J (2003) 1.25
MPP6 is an exosome-associated RNA-binding protein involved in 5.8S rRNA maturation. Nucleic Acids Res (2005) 1.24
The glial or neuronal fate choice of oligodendrocyte progenitors is modulated by their ability to acquire an epigenetic memory. J Neurosci (2007) 1.22
Epigenetic memory loss in aging oligodendrocytes in the corpus callosum. Neurobiol Aging (2006) 1.21
Multiple roles of Id4 in developmental myelination: predicted outcomes and unexpected findings. Glia (2006) 1.21
TNF receptor I sensitizes neurons to erythropoietin- and VEGF-mediated neuroprotection after ischemic and excitotoxic injury. Proc Natl Acad Sci U S A (2008) 1.17
Myelin localization of peptidylarginine deiminases 2 and 4: comparison of PAD2 and PAD4 activities. Lab Invest (2008) 1.15
Peptidylarginine deiminase 2 (PAD2) overexpression in transgenic mice leads to myelin loss in the central nervous system. Dis Model Mech (2008) 1.14
Oligodendrocyte process outgrowth in vitro is modulated by epigenetic regulation of cytoskeletal severing proteins. Glia (2003) 1.13
Comparative multiplexed mass spectrometric analyses of endogenously expressed yeast nuclear and cytoplasmic exosomes. J Mol Biol (2008) 1.11
Transmembrane tumour necrosis factor is neuroprotective and regulates experimental autoimmune encephalomyelitis via neuronal nuclear factor-kappaB. Brain (2011) 1.10
Epigenetic mechanisms facilitating oligodendrocyte development, maturation, and aging. Glia (2009) 1.09
Ischemic neuronal damage. Curr Pharm Des (2008) 1.07
Peptidyl argininedeiminase 2 CpG island in multiple sclerosis white matter is hypomethylated. J Neurosci Res (2007) 1.06
Abnormal T-cell reactivities in childhood inflammatory demyelinating disease and type 1 diabetes. Ann Neurol (2008) 1.05
Oligodendrocyte progenitor proliferation and maturation is differentially regulated by male and female sex steroid hormones. Dev Neurosci (2005) 1.05
Novel aspects of autoantibodies to the PM/Scl complex: clinical, genetic and diagnostic insights. Autoimmun Rev (2007) 1.03
Autoantibodies directed to novel components of the PM/Scl complex, the human exosome. Arthritis Res (2001) 1.02
Cholecalciferol plus calcium suppresses abnormal PBMC reactivity in patients with multiple sclerosis. J Clin Endocrinol Metab (2011) 1.02
p27(Kip1) enhances myelin basic protein gene promoter activity. J Neurosci Res (2002) 1.01
Attenuation of experimental autoimmune encephalomyelitis and nonimmune demyelination by IFN-beta plus vitamin B12: treatment to modify notch-1/sonic hedgehog balance. J Immunol (2004) 1.01
In vivo profiling and visualization of cellular protein-lipid interactions using bifunctional fatty acids. Angew Chem Int Ed Engl (2013) 1.01
Mapping of citrullinated fibrinogen B-cell epitopes in rheumatoid arthritis by imaging surface plasmon resonance. Arthritis Res Ther (2010) 0.99
FLIP(L) protects neurons against in vivo ischemia and in vitro glucose deprivation-induced cell death. J Neurosci (2007) 0.99
Role of astrocytes and chemokine systems in acute TNFalpha induced demyelinating syndrome: CCR2-dependent signals promote astrocyte activation and survival via NF-kappaB and Akt. Mol Cell Neurosci (2007) 0.98
Inhibition of peptidyl-arginine deiminases reverses protein-hypercitrullination and disease in mouse models of multiple sclerosis. Dis Model Mech (2012) 0.97
Clinical evaluation of autoantibodies to a novel PM/Scl peptide antigen. Arthritis Res Ther (2005) 0.97
Post-translational modifications of nucleosomal histones in oligodendrocyte lineage cells in development and disease. J Mol Neurosci (2008) 0.96
Comparative gene expression analysis in mouse models for multiple sclerosis, Alzheimer's disease and stroke for identifying commonly regulated and disease-specific gene changes. Genomics (2010) 0.96
Applications of stable isotope dimethyl labeling in quantitative proteomics. Anal Bioanal Chem (2012) 0.96
ABAP: antibody-based assay for peptidylarginine deiminase activity. Anal Biochem (2007) 0.96
Cell and molecular biology of the exosome: how to make or break an RNA. Int Rev Cytol (2006) 0.95
RockerBox: analysis and filtering of massive proteomics search results. J Proteome Res (2011) 0.95
Inhibition of p53 transcriptional activity: a potential target for future development of therapeutic strategies for primary demyelination. J Neurosci (2008) 0.95
Differences in susceptibility of MBP charge isomers to digestion by stromelysin-1 (MMP-3) and release of an immunodominant epitope. Neurochem Res (2006) 0.95
Prevention of apoptotic but not necrotic cell death following neuronal injury by neurotrophins signaling through the tyrosine kinase receptor. J Neurosurg (2004) 0.94
Exclusive tumor necrosis factor (TNF) signaling by the p75TNF receptor triggers inflammatory ischemia in the CNS of transgenic mice. Proc Natl Acad Sci U S A (2003) 0.94
BRAF(V600E) efficient transformation and induction of microsatellite instability versus KRAS(G12V) induction of senescence markers in human colon cancer cells. Neoplasia (2009) 0.94
Oxidative tissue injury in multiple sclerosis is only partly reflected in experimental disease models. Acta Neuropathol (2014) 0.93
An Arg/Lys-->Gln mutant of recombinant murine myelin basic protein as a mimic of the deiminated form implicated in multiple sclerosis. Protein Expr Purif (2002) 0.92
Cellular FLIP (long isoform) overexpression in T cells drives Th2 effector responses and promotes immunoregulation in experimental autoimmune encephalomyelitis. J Immunol (2004) 0.92
Events at the transition between cell cycle exit and oligodendrocyte progenitor differentiation: the role of HDAC and YY1. Neuron Glia Biol (2007) 0.91
Peptidylarginine deiminase expression and activity in PAD2 knock-out and PAD4-low mice. Biochimie (2012) 0.90
Erythropoietin: not just about erythropoiesis. Lancet (2010) 0.90
Antagonistic effects of human cyclic MBP(87-99) altered peptide ligands in experimental allergic encephalomyelitis and human T-cell proliferation. J Med Chem (2002) 0.90
Expression of stathmin, a developmentally controlled cytoskeleton-regulating molecule, in demyelinating disorders. J Neurosci (2005) 0.89
Number of oligodendrocyte progenitors recruited to the lesioned spinal cord is modulated by the levels of the cell cycle regulatory protein p27Kip-1. Glia (2005) 0.89
Molecules affecting myelin stability: a novel hypothesis regarding the pathogenesis of multiple sclerosis. J Neurosci Res (2005) 0.88
Autocatalytic cleavage of myelin basic protein: an alternative to molecular mimicry. Biochemistry (2005) 0.87
Evaluation of the deuterium isotope effect in zwitterionic hydrophilic interaction liquid chromatography separations for implementation in a quantitative proteomic approach. Anal Chem (2011) 0.85
Synthetic peptides: the future of patient management in systemic rheumatic diseases? Curr Med Chem (2007) 0.85
Targeting of pancreatic glia in type 1 diabetes. Diabetes (2008) 0.85
Kinetics of human peptidylarginine deiminase 2 (hPAD2)--reduction of Ca2+ dependence by phospholipids and assessment of proposed inhibition by paclitaxel side chains. Biochem Cell Biol (2008) 0.84
Enolase and arrestin are novel nonmyelin autoantigens in multiple sclerosis. J Clin Immunol (2007) 0.84
Autoantigenicity of nucleolar complexes. Autoimmun Rev (2003) 0.84
The amount of sonic hedgehog in multiple sclerosis white matter is decreased and cleavage to the signaling peptide is deficient. Mult Scler (2003) 0.84
The up-regulation of stromelysin-1 (MMP-3) in a spontaneously demyelinating transgenic mouse precedes onset of disease. J Biol Chem (2002) 0.84
Quantifying cross-tissue diversity in proteasome complexes by mass spectrometry. Mol Biosyst (2010) 0.83
Increased peptidylarginine deiminase type II in hypoxic astrocytes. Biochem Biophys Res Commun (2004) 0.82
TNFRI is a positive T-cell costimulatory molecule important for the timing of cytokine responses. Immunol Cell Biol (2010) 0.81
Cellular FLIP long isoform transgenic mice overcome inherent Th2-biased immune responses to efficiently resolve Leishmania major infection. Int Immunol (2007) 0.81
S-phase entry of oligodendrocyte lineage cells is associated with increased levels of p21Cip1. J Neurosci Res (2005) 0.81
Novel inhibitors of protein arginine deiminase with potential activity in multiple sclerosis animal model. J Med Chem (2013) 0.80
A role for neuronal NF-κB in suppressing neuroinflammation and promoting neuroprotection in the CNS. Adv Exp Med Biol (2011) 0.80
Islet glia, neurons, and beta cells. Ann N Y Acad Sci (2008) 0.80
Deep proteome profiling of circulating granulocytes reveals bactericidal/permeability-increasing protein as a biomarker for severe atherosclerotic coronary stenosis. J Proteome Res (2012) 0.80
Expression and properties of the recombinant murine Golli-myelin basic protein isoform J37. J Neurosci Res (2003) 0.80
Caspase-mediated cleavage of the exosome subunit PM/Scl-75 during apoptosis. Arthritis Res Ther (2007) 0.79
Site-specific methionine oxidation in calmodulin affects structural integrity and interaction with Ca2+/calmodulin-dependent protein kinase II. J Struct Biol (2010) 0.79
Interplay of hormones and p53 in modulating gender dimorphism of subventricular zone cell number. J Neurosci Res (2009) 0.78
Differential contributions of microglial and neuronal IKKβ to synaptic plasticity and associative learning in alert behaving mice. Glia (2014) 0.78