Published in EMBO J on January 15, 2002
Stress granules and processing bodies are dynamically linked sites of mRNP remodeling. J Cell Biol (2005) 9.25
AU-rich elements and associated factors: are there unifying principles? Nucleic Acids Res (2006) 6.22
Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures. EMBO J (2002) 6.08
Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay. Mol Cell Biol (2002) 5.80
Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1. Genes Dev (2005) 4.43
Decay rates of human mRNAs: correlation with functional characteristics and sequence attributes. Genome Res (2003) 4.07
The hDcp2 protein is a mammalian mRNA decapping enzyme. Proc Natl Acad Sci U S A (2002) 3.97
Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'. Genes Dev (2008) 3.30
TTP and BRF proteins nucleate processing body formation to silence mRNAs with AU-rich elements. Genes Dev (2007) 3.14
ARE-mRNA degradation requires the 5'-3' decay pathway. EMBO Rep (2006) 3.01
Tristetraprolin and its family members can promote the cell-free deadenylation of AU-rich element-containing mRNAs by poly(A) ribonuclease. Mol Cell Biol (2003) 2.61
Posttranscriptional regulation of cancer traits by HuR. Wiley Interdiscip Rev RNA (2010) 2.59
A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay. J Cell Biol (2005) 2.51
The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases. EMBO J (2002) 2.46
A protein interaction framework for human mRNA degradation. Genome Res (2004) 2.25
MicroRNA targets in immune genes and the Dicer/Argonaute and ARE machinery components. Mol Immunol (2007) 2.24
The zinc-finger antiviral protein recruits the RNA processing exosome to degrade the target mRNA. Proc Natl Acad Sci U S A (2006) 2.12
Highly selective actions of HuR in antagonizing AU-rich element-mediated mRNA destabilization. Mol Cell Biol (2002) 2.08
The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L. EMBO J (2010) 2.07
Roles of AUF1 isoforms, HuR and BRF1 in ARE-dependent mRNA turnover studied by RNA interference. Nucleic Acids Res (2004) 1.99
CUG-BP binds to RNA substrates and recruits PARN deadenylase. RNA (2006) 1.78
The RNA-binding protein Elavl1/HuR is essential for placental branching morphogenesis and embryonic development. Mol Cell Biol (2009) 1.78
Overexpression of nucleolin in chronic lymphocytic leukemia cells induces stabilization of bcl2 mRNA. Blood (2007) 1.62
The herpes simplex virus 1 UL41 gene-dependent destabilization of cellular RNAs is selective and may be sequence-specific. Proc Natl Acad Sci U S A (2004) 1.62
Nutritional control of mRNA stability is mediated by a conserved AU-rich element that binds the cytoplasmic shuttling protein HuR. J Biol Chem (2002) 1.61
Decoding ARE-mediated decay: is microRNA part of the equation? J Cell Biol (2008) 1.60
Rapid deadenylation triggered by a nonsense codon precedes decay of the RNA body in a mammalian cytoplasmic nonsense-mediated decay pathway. Mol Cell Biol (2003) 1.60
Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolin. Nucleic Acids Res (2011) 1.57
Crystal structure of Dcp1p and its functional implications in mRNA decapping. Nat Struct Mol Biol (2004) 1.57
The ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase B. EMBO J (2004) 1.55
Evidence for core exosome independent function of the nuclear exoribonuclease Rrp6p. Nucleic Acids Res (2008) 1.55
The decapping activator Lsm1p-7p-Pat1p complex has the intrinsic ability to distinguish between oligoadenylated and polyadenylated RNAs. RNA (2007) 1.54
Distinct domains of AU-rich elements exert different functions in mRNA destabilization and stabilization by p38 mitogen-activated protein kinase or HuR. Mol Cell Biol (2004) 1.52
Degradation of YRA1 Pre-mRNA in the cytoplasm requires translational repression, multiple modular intronic elements, Edc3p, and Mex67p. PLoS Biol (2010) 1.51
Interaction between Ski7p and Upf1p is required for nonsense-mediated 3'-to-5' mRNA decay in yeast. EMBO J (2003) 1.47
The regulation of mRNA stability in mammalian cells: 2.0. Gene (2012) 1.46
Tethering KSRP, a decay-promoting AU-rich element-binding protein, to mRNAs elicits mRNA decay. Mol Cell Biol (2006) 1.44
DcpS can act in the 5'-3' mRNA decay pathway in addition to the 3'-5' pathway. Proc Natl Acad Sci U S A (2003) 1.44
Polyadenylation and degradation of incomplete RNA polymerase I transcripts in mammalian cells. EMBO Rep (2010) 1.43
XRN 5'→3' exoribonucleases: structure, mechanisms and functions. Biochim Biophys Acta (2013) 1.42
Contribution of domain structure to the RNA 3' end processing and degradation functions of the nuclear exosome subunit Rrp6p. RNA (2003) 1.41
A conserved virus-induced cytoplasmic TRAMP-like complex recruits the exosome to target viral RNA for degradation. Genes Dev (2016) 1.40
A+U-rich instability elements differentially activate 5'-3' and 3'-5' mRNA decay. Mol Cell Biol (2007) 1.38
The 5'-3' exoribonuclease xrn-1 is essential for ventral epithelial enclosure during C. elegans embryogenesis. RNA (2004) 1.36
RNA-binding protein Csx1 mediates global control of gene expression in response to oxidative stress. EMBO J (2003) 1.35
Poly(A)-binding-protein-mediated regulation of hDcp2 decapping in vitro. EMBO J (2004) 1.33
A noncoding RNA produced by arthropod-borne flaviviruses inhibits the cellular exoribonuclease XRN1 and alters host mRNA stability. RNA (2012) 1.32
Caenorhabditis elegans decapping proteins: localization and functional analysis of Dcp1, Dcp2, and DcpS during embryogenesis. Mol Biol Cell (2005) 1.32
The UL41 protein of herpes simplex virus mediates selective stabilization or degradation of cellular mRNAs. Proc Natl Acad Sci U S A (2004) 1.32
The Herpesvirus saimiri small nuclear RNAs recruit AU-rich element-binding proteins but do not alter host AU-rich element-containing mRNA levels in virally transformed T cells. Mol Cell Biol (2004) 1.30
Differential utilization of decapping enzymes in mammalian mRNA decay pathways. RNA (2011) 1.29
RNA recognition by 3'-to-5' exonucleases: the substrate perspective. Biochim Biophys Acta (2007) 1.27
Cytoplasmic RNA: a case of the tail wagging the dog. Nat Rev Mol Cell Biol (2013) 1.24
MPP6 is an exosome-associated RNA-binding protein involved in 5.8S rRNA maturation. Nucleic Acids Res (2005) 1.24
Chaperone Hsp27, a novel subunit of AUF1 protein complexes, functions in AU-rich element-mediated mRNA decay. Mol Cell Biol (2008) 1.23
Assembly of AUF1 with eIF4G-poly(A) binding protein complex suggests a translation function in AU-rich mRNA decay. RNA (2006) 1.22
mRNA decay enzymes: decappers conserved between yeast and mammals. Proc Natl Acad Sci U S A (2002) 1.22
Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways. RNA (2007) 1.22
Expression of COX-2 in platelet-monocyte interactions occurs via combinatorial regulation involving adhesion and cytokine signaling. J Clin Invest (2006) 1.18
Roles of a Trypanosoma brucei 5'->3' exoribonuclease homolog in mRNA degradation. RNA (2006) 1.17
Post-transcriptional control of gene expression by AUF1: mechanisms, physiological targets, and regulation. Biochim Biophys Acta (2012) 1.16
RNA-binding proteins implicated in the hypoxic response. J Cell Mol Med (2009) 1.15
Expression of the human RNA-binding protein HuR in Trypanosoma brucei increases the abundance of mRNAs containing AU-rich regulatory elements. Nucleic Acids Res (2002) 1.15
A role for the exosome in the in vivo degradation of unstable mRNAs. RNA (2003) 1.15
The mRNA decay factor tristetraprolin (TTP) induces senescence in human papillomavirus-transformed cervical cancer cells by targeting E6-AP ubiquitin ligase. Aging (Albany NY) (2009) 1.14
Nematode m7GpppG and m3(2,2,7)GpppG decapping: activities in Ascaris embryos and characterization of C. elegans scavenger DcpS. RNA (2004) 1.13
Mechanism of regulation of bcl-2 mRNA by nucleolin and A+U-rich element-binding factor 1 (AUF1). J Biol Chem (2010) 1.12
Domain analysis of the chloroplast polynucleotide phosphorylase reveals discrete functions in RNA degradation, polyadenylation, and sequence homology with exosome proteins. Plant Cell (2003) 1.09
To polyadenylate or to deadenylate: that is the question. Cell Cycle (2010) 1.09
Growth-regulated expression and G0-specific turnover of the mRNA that encodes URH49, a mammalian DExH/D box protein that is highly related to the mRNA export protein UAP56. Nucleic Acids Res (2004) 1.08
The RNA helicase DHH1 is central to the correct expression of many developmentally regulated mRNAs in trypanosomes. J Cell Sci (2010) 1.06
Post-Transcriptional Control of the Hypoxic Response by RNA-Binding Proteins and MicroRNAs. Front Mol Neurosci (2011) 1.06
Sequence-specific RNA binding mediated by the RNase PH domain of components of the exosome. RNA (2006) 1.06
Nucleolin stabilizes Bcl-X L messenger RNA in response to UVA irradiation. Cancer Res (2008) 1.05
Modulation of utrophin A mRNA stability in fast versus slow muscles via an AU-rich element and calcineurin signaling. Nucleic Acids Res (2007) 1.05
AU-rich-element-dependent translation repression requires the cooperation of tristetraprolin and RCK/P54. Mol Cell Biol (2011) 1.03
Translational repression precedes and is required for ZAP-mediated mRNA decay. EMBO J (2012) 1.02
The nuclear exosome contributes to autogenous control of NAB2 mRNA levels. Mol Cell Biol (2005) 1.01
Regulation of the enzymes of hepatic microsomal triacylglycerol lipolysis and re-esterification by the glucocorticoid dexamethasone. Biochem J (2004) 1.01
A yeast homologue of Hsp70, Ssa1p, regulates turnover of the MFA2 transcript through its AU-rich 3' untranslated region. Mol Cell Biol (2003) 1.01
Regulated alpha-globin mRNA decay is a cytoplasmic event proceeding through 3'-to-5' exosome-dependent decapping. RNA (2002) 1.00
Crystal structure of Ski8p, a WD-repeat protein with dual roles in mRNA metabolism and meiotic recombination. Protein Sci (2004) 1.00
c-Src activates endonuclease-mediated mRNA decay. Mol Cell (2007) 0.99
Regulation of ARE transcript 3' end processing by the yeast Cth2 mRNA decay factor. EMBO J (2008) 0.99
mRNAs containing the histone 3' stem-loop are degraded primarily by decapping mediated by oligouridylation of the 3' end. RNA (2012) 0.98
Polysome-bound endonuclease PMR1 is targeted to stress granules via stress-specific binding to TIA-1. Mol Cell Biol (2006) 0.98
Identification of mRNA decapping activities and an ARE-regulated 3' to 5' exonuclease activity in trypanosome extracts. Nucleic Acids Res (2002) 0.98
Association of the von Hippel-Lindau protein with AUF1 and posttranscriptional regulation of VEGFA mRNA. Mol Cancer Res (2011) 0.97
Characterization of deadenylation in trypanosome extracts and its inhibition by poly(A)-binding protein Pab1p. RNA (2004) 0.96
Domain interactions within the Ski2/3/8 complex and between the Ski complex and Ski7p. RNA (2005) 0.96
Temperature-sensitive mutants of the exosome subunit Rrp43p show a deficiency in mRNA degradation and no longer interact with the exosome. Nucleic Acids Res (2002) 0.95
Chapter 3. Assays of adenylate uridylate-rich element-mediated mRNA decay in cells. Methods Enzymol (2008) 0.95
Phosphorothioate cap analogs stabilize mRNA and increase translational efficiency in mammalian cells. RNA (2007) 0.93
More than 1 + 2 in mRNA decapping. Nat Struct Mol Biol (2006) 0.93
LSm1-7 complexes bind to specific sites in viral RNA genomes and regulate their translation and replication. RNA (2010) 0.93
Multiple myeloma-associated hDIS3 mutations cause perturbations in cellular RNA metabolism and suggest hDIS3 PIN domain as a potential drug target. Nucleic Acids Res (2013) 0.93
Deadenylation-independent stage-specific mRNA degradation in Leishmania. Nucleic Acids Res (2008) 0.92
Inflammation: cytokines and RNA-based regulation. Wiley Interdiscip Rev RNA (2010) 0.92
AUF1 cell cycle variations define genomic DNA methylation by regulation of DNMT1 mRNA stability. Mol Cell Biol (2006) 0.90
A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell (1986) 36.96
AU-rich elements: characterization and importance in mRNA degradation. Trends Biochem Sci (1995) 14.81
The exosome: a conserved eukaryotic RNA processing complex containing multiple 3'-->5' exoribonucleases. Cell (1997) 8.94
The 3' to 5' degradation of yeast mRNAs is a general mechanism for mRNA turnover that requires the SKI2 DEVH box protein and 3' to 5' exonucleases of the exosome complex. EMBO J (1998) 7.83
Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the in vivo stability of ARE-containing mRNAs. EMBO J (1998) 7.62
Deadenylation of the unstable mRNA encoded by the yeast MFA2 gene leads to decapping followed by 5'-->3' digestion of the transcript. Genes Dev (1994) 7.57
Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay. Genes Dev (1991) 7.51
RNA stabilization by the AU-rich element binding protein, HuR, an ELAV protein. EMBO J (1998) 6.68
The cap-to-tail guide to mRNA turnover. Nat Rev Mol Cell Biol (2001) 6.67
Removal of poly(A) and consequent degradation of c-fos mRNA facilitated by 3' AU-rich sequences. Nature (1988) 6.35
The transcription factor associated Ccr4 and Caf1 proteins are components of the major cytoplasmic mRNA deadenylase in Saccharomyces cerevisiae. Cell (2001) 5.86
Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein. J Biol Chem (1996) 5.82
Functions of the exosome in rRNA, snoRNA and snRNA synthesis. EMBO J (1999) 5.68
Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA. Mol Cell Biol (1999) 5.55
The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism. EMBO J (1999) 5.47
The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases. Genes Dev (1999) 4.95
Hel-N1: an autoimmune RNA-binding protein with specificity for 3' uridylate-rich untranslated regions of growth factor mRNAs. Mol Cell Biol (1993) 4.63
Yeast exosome mutants accumulate 3'-extended polyadenylated forms of U4 small nuclear RNA and small nucleolar RNAs. Mol Cell Biol (2000) 4.57
Regulation of mRNA stability in mammalian cells. Gene (2001) 4.55
Identification of a regulated pathway for nuclear pre-mRNA turnover. Cell (2000) 4.38
Mechanisms and control of mRNA turnover in Saccharomyces cerevisiae. Microbiol Rev (1996) 4.34
An A + U-rich element RNA-binding factor regulates c-myc mRNA stability in vitro. Mol Cell Biol (1991) 4.31
Control of mRNA decay by heat shock-ubiquitin-proteasome pathway. Science (1999) 4.10
Dob1p (Mtr4p) is a putative ATP-dependent RNA helicase required for the 3' end formation of 5.8S rRNA in Saccharomyces cerevisiae. EMBO J (1998) 3.88
The poly(A)-poly(A)-binding protein complex is a major determinant of mRNA stability in vitro. Mol Cell Biol (1989) 3.69
Unraveling a cytoplasmic role for hnRNP D in the in vivo mRNA destabilization directed by the AU-rich element. Genes Dev (1999) 3.59
Rrp6p, the yeast homologue of the human PM-Scl 100-kDa autoantigen, is essential for efficient 5.8 S rRNA 3' end formation. J Biol Chem (1998) 3.45
ELAV proteins stabilize deadenylated intermediates in a novel in vitro mRNA deadenylation/degradation system. Genes Dev (1999) 3.45
A 64 kd nuclear protein binds to RNA segments that include the AAUAAA polyadenylation motif. Cell (1988) 3.44
mRNA stability in eukaryotes. Curr Opin Genet Dev (2000) 3.01
Isolation and characterization of Dcp1p, the yeast mRNA decapping enzyme. EMBO J (1998) 2.82
The yeast POP2 gene encodes a nuclease involved in mRNA deadenylation. Nucleic Acids Res (2001) 2.76
The exosome: a proteasome for RNA? Cell (1999) 2.72
Function of the ski4p (Csl4p) and Ski7p proteins in 3'-to-5' degradation of mRNA. Mol Cell Biol (2000) 2.71
Autoantibody profiles in the sera of European patients with myositis. Ann Rheum Dis (2001) 2.69
Mechanisms and control of mRNA decapping in Saccharomyces cerevisiae. Annu Rev Biochem (2000) 2.66
A novel mRNA-decapping activity in HeLa cytoplasmic extracts is regulated by AU-rich elements. EMBO J (2001) 2.63
A nuclear 3'-5' exonuclease involved in mRNA degradation interacts with Poly(A) polymerase and the hnRNA protein Npl3p. Mol Cell Biol (2000) 2.56
Nucleolin and YB-1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activation. Genes Dev (2000) 2.54
The exosome of Trypanosoma brucei. EMBO J (2001) 2.48
Degradation of ribosomal RNA precursors by the exosome. Nucleic Acids Res (2000) 2.47
Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits. Nucleic Acids Res (2000) 2.13
Parallel and independent regulation of interleukin-3 mRNA turnover by phosphatidylinositol 3-kinase and p38 mitogen-activated protein kinase. Mol Cell Biol (2001) 2.06
Joining of RNAs by splinted ligation. Methods Enzymol (2000) 2.06
Cap-dependent deadenylation of mRNA. EMBO J (2000) 1.96
Musing on the structural organization of the exosome complex. Nat Struct Biol (2000) 1.92
Precursors to the U3 small nucleolar RNA lack small nucleolar RNP proteins but are stabilized by La binding. Mol Cell Biol (2000) 1.90
AU-rich elements target small nuclear RNAs as well as mRNAs for rapid degradation. Genes Dev (1997) 1.81
Interaction between a poly(A)-specific ribonuclease and the 5' cap influences mRNA deadenylation rates in vitro. Mol Cell (2000) 1.75
Three novel components of the human exosome. J Biol Chem (2000) 1.72
The poly(A) tail inhibits the assembly of a 3'-to-5' exonuclease in an in vitro RNA stability system. Mol Cell Biol (1997) 1.71
Interactions of CCCH zinc finger proteins with mRNA: tristetraprolin-mediated AU-rich element-dependent mRNA degradation can occur in the absence of a poly(A) tail. J Biol Chem (2001) 1.63
Poly(A) tail-dependent exonuclease AtRrp41p from Arabidopsis thaliana rescues 5.8 S rRNA processing and mRNA decay defects of the yeast ski6 mutant and is found in an exosome-sized complex in plant and yeast cells. J Biol Chem (2000) 1.60
DSEF-1 is a member of the hnRNP H family of RNA-binding proteins and stimulates pre-mRNA cleavage and polyadenylation in vitro. Nucleic Acids Res (1998) 1.59
Poly(A)-binding proteins regulate both mRNA deadenylation and decapping in yeast cytoplasmic extracts. RNA (2001) 1.59
AUUUA sequences direct mRNA deadenylation uncoupled from decay during Xenopus early development. Mol Cell Biol (1998) 1.39
An in vitro system using HeLa cytoplasmic extracts that reproduces regulated mRNA stability. Methods (1999) 1.36
The exosome subunit Rrp43p is required for the efficient maturation of 5.8S, 18S and 25S rRNA. Nucleic Acids Res (1999) 1.35
The mRNA cap structure stimulates rate of poly(A) removal and amplifies processivity of degradation. J Biol Chem (2001) 1.17
Update on myositis-specific and myositis-associated autoantibodies. Curr Opin Rheumatol (2000) 1.16
Identification and developmental expression of a 5'-3' exoribonuclease from Drosophila melanogaster. Mech Dev (1998) 1.11
Protein-protein interactions of hCsl4p with other human exosome subunits. J Mol Biol (2002) 1.05
Evidence for a 3'-5' decay pathway for c-myc mRNA in mammalian cells. J Biol Chem (1999) 1.00
The human exosome: an autoantigenic complex of exoribonucleases in myositis and scleroderma. Arthritis Res (2000) 1.00
Cloning and characterization of mouse Dhm2 cDNA, a functional homolog of budding yeast SEP1. Gene (1997) 0.89
Daclatasvir plus sofosbuvir for previously treated or untreated chronic HCV infection. N Engl J Med (2014) 9.25
The highways and byways of mRNA decay. Nat Rev Mol Cell Biol (2007) 8.42
A large-scale analysis of mRNA polyadenylation of human and mouse genes. Nucleic Acids Res (2005) 7.24
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Nat Genet (2009) 6.42
Multiplex peptide stable isotope dimethyl labeling for quantitative proteomics. Nat Protoc (2009) 4.61
Cyclo-oxygenase 2 function is essential for bone fracture healing. J Bone Miner Res (2002) 3.63
Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21. Nat Genet (2009) 3.59
A role for small RNAs in DNA double-strand break repair. Cell (2012) 3.15
Dengue virus type 2 infections of Aedes aegypti are modulated by the mosquito's RNA interference pathway. PLoS Pathog (2009) 3.09
Bioinformatic identification of candidate cis-regulatory elements involved in human mRNA polyadenylation. RNA (2005) 3.08
Bringing the role of mRNA decay in the control of gene expression into focus. Trends Genet (2004) 2.98
Type 5 adenylyl cyclase disruption increases longevity and protects against stress. Cell (2007) 2.96
The RNA-binding protein CUGBP1 regulates stability of tumor necrosis factor mRNA in muscle cells: implications for myotonic dystrophy. J Biol Chem (2008) 2.60
Polymorphisms in interleukin-15 gene on chromosome 4q31.2 are associated with psoriasis vulgaris in Chinese population. J Invest Dermatol (2007) 2.59
Identification of hepatitis C virus NS5A inhibitors. J Virol (2010) 2.58
Resistance analysis of the hepatitis C virus NS5A inhibitor BMS-790052 in an in vitro replicon system. Antimicrob Agents Chemother (2010) 2.50
Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change. Proc Natl Acad Sci U S A (2006) 2.49
Aedes aegypti uses RNA interference in defense against Sindbis virus infection. BMC Microbiol (2008) 2.33
C6/36 Aedes albopictus cells have a dysfunctional antiviral RNA interference response. PLoS Negl Trop Dis (2010) 2.29
Impact of a baseline polymorphism on the emergence of resistance to the hepatitis C virus nonstructural protein 5A replication complex inhibitor, BMS-790052. Hepatology (2012) 2.29
True versus reported waiting times for valvular aortic stenosis surgery. Can J Cardiol (2006) 2.21
Significant improvement in short-term mortality in women undergoing coronary artery bypass surgery (1991 to 2004). J Am Coll Cardiol (2007) 2.11
Genotypic and phenotypic analysis of variants resistant to hepatitis C virus nonstructural protein 5A replication complex inhibitor BMS-790052 in humans: in vitro and in vivo correlations. Hepatology (2011) 2.10
Downstream sequence elements with different affinities for the hnRNP H/H' protein influence the processing efficiency of mammalian polyadenylation signals. Nucleic Acids Res (2002) 2.00
Adenosine augments IL-10 production by macrophages through an A2B receptor-mediated posttranscriptional mechanism. J Immunol (2005) 1.98
Development of a cell-based high-throughput specificity screen using a hepatitis C virus-bovine viral diarrhea virus dual replicon assay. Antimicrob Agents Chemother (2005) 1.94
Multiple ascending dose study of BMS-790052, a nonstructural protein 5A replication complex inhibitor, in patients infected with hepatitis C virus genotype 1. Hepatology (2011) 1.83
The effects of local platelet rich plasma delivery on diabetic fracture healing. Bone (2005) 1.79
CUG-BP binds to RNA substrates and recruits PARN deadenylase. RNA (2006) 1.78
A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure. EMBO J (2003) 1.72
Alternative polyadenylation of cyclooxygenase-2. Nucleic Acids Res (2005) 1.61
Dose and time-dependent effects of cyclooxygenase-2 inhibition on fracture-healing. J Bone Joint Surg Am (2007) 1.61
Eukaryotic Lsm proteins: lessons from bacteria. Nat Struct Mol Biol (2005) 1.60
Upstream elements present in the 3'-untranslated region of collagen genes influence the processing efficiency of overlapping polyadenylation signals. J Biol Chem (2002) 1.58
Dis3-like 1: a novel exoribonuclease associated with the human exosome. EMBO J (2010) 1.57
Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production. Nat Immunol (2006) 1.52
Systematic analysis of cis-elements in unstable mRNAs demonstrates that CUGBP1 is a key regulator of mRNA decay in muscle cells. PLoS One (2010) 1.49
Quantitative analysis of human heart valves: does anorexigen exposure produce a distinctive morphological lesion? Cardiovasc Pathol (2002) 1.47
Genome-wide association study identifies two new susceptibility loci for atopic dermatitis in the Chinese Han population. Nat Genet (2011) 1.46
Small intestinal hemolymphangioma with bleeding: a case report. World J Gastroenterol (2012) 1.45
Identifying priorities in methodological research using ICD-9-CM and ICD-10 administrative data: report from an international consortium. BMC Health Serv Res (2006) 1.45
Distinct functions of NS5A in hepatitis C virus RNA replication uncovered by studies with the NS5A inhibitor BMS-790052. J Virol (2011) 1.44
Efficient in vitro amplification of chronic wasting disease PrPRES. J Virol (2007) 1.42
Angina with "normal" coronary arteries: sex differences in outcomes. Am Heart J (2007) 1.41
Increased citrullination of histone H3 in multiple sclerosis brain and animal models of demyelination: a role for tumor necrosis factor-induced peptidylarginine deiminase 4 translocation. J Neurosci (2006) 1.41
The mortality rate from anorexia nervosa. Int J Eat Disord (2005) 1.40
Trends in wait times for cardiac revascularization. Can J Cardiol (2011) 1.39
Percutaneous coronary intervention and 30-day mortality: the British Columbia PCI risk score. Catheter Cardiovasc Interv (2009) 1.37
Acanthamoeba keratitis: clinical characteristics and management. Ophthalmology (2006) 1.36
A noncoding RNA produced by arthropod-borne flaviviruses inhibits the cellular exoribonuclease XRN1 and alters host mRNA stability. RNA (2012) 1.32
Specific inhibition of bovine viral diarrhea virus replicase. J Virol (2003) 1.28
Profiling of N-acetylated protein termini provides in-depth insights into the N-terminal nature of the proteome. Mol Cell Proteomics (2010) 1.28
RNA recognition by 3'-to-5' exonucleases: the substrate perspective. Biochim Biophys Acta (2007) 1.27
Fine mapping of the psoriasis susceptibility locus PSORS1 supports HLA-C as the susceptibility gene in the Han Chinese population. PLoS Genet (2008) 1.26
RNA structures that resist degradation by Xrn1 produce a pathogenic Dengue virus RNA. Elife (2014) 1.25
Characterization of a closed femur fracture model in mice. J Orthop Trauma (2004) 1.25
An intronic polyadenylation site in human and mouse CstF-77 genes suggests an evolutionarily conserved regulatory mechanism. Gene (2005) 1.24
MPP6 is an exosome-associated RNA-binding protein involved in 5.8S rRNA maturation. Nucleic Acids Res (2005) 1.24
Confirmation by exome sequencing of the pathogenic role of NCSTN mutations in acne inversa (hidradenitis suppurativa). J Invest Dermatol (2011) 1.23
The effects of local insulin delivery on diabetic fracture healing. Bone (2005) 1.23
Sindbis virus usurps the cellular HuR protein to stabilize its transcripts and promote productive infections in mammalian and mosquito cells. Cell Host Microbe (2010) 1.22
Functional analysis of in-frame indel ARID1A mutations reveals new regulatory mechanisms of its tumor suppressor functions. Neoplasia (2012) 1.22
Specific trans-acting proteins interact with auxiliary RNA polyadenylation elements in the COX-2 3'-UTR. RNA (2007) 1.22
Convergence of Itch-induced ubiquitination with MEKK1-JNK signaling in Th2 tolerance and airway inflammation. J Clin Invest (2006) 1.21
New ways to meet your (3') end oligouridylation as a step on the path to destruction. Genes Dev (2008) 1.19
Role of NF-kappaB signaling in hepatocyte growth factor/scatter factor-mediated cell protection. Oncogene (2005) 1.19
Outcome of mitral valve repair or replacement: a comparison by propensity score analysis. Circulation (2003) 1.19
The 3' untranslated region of sindbis virus represses deadenylation of viral transcripts in mosquito and Mammalian cells. J Virol (2007) 1.18
In vitro activity of daclatasvir on hepatitis C virus genotype 3 NS5A. Antimicrob Agents Chemother (2012) 1.17
Myelin localization of peptidylarginine deiminases 2 and 4: comparison of PAD2 and PAD4 activities. Lab Invest (2008) 1.15
Phosphorylation of PPARgamma via active ERK1/2 leads to its physical association with p65 and inhibition of NF-kappabeta. J Cell Biochem (2003) 1.15
The structural basis of pathogenic subgenomic flavivirus RNA (sfRNA) production. Science (2014) 1.14
Exome sequencing identifies MVK mutations in disseminated superficial actinic porokeratosis. Nat Genet (2012) 1.12
Human RIF1 encodes an anti-apoptotic factor required for DNA repair. Carcinogenesis (2009) 1.12
Comparative multiplexed mass spectrometric analyses of endogenously expressed yeast nuclear and cytoplasmic exosomes. J Mol Biol (2008) 1.11
Evolution and expression analysis of the grape (Vitis vinifera L.) WRKY gene family. J Exp Bot (2014) 1.11
Persistence of resistant variants in hepatitis C virus-infected patients treated with the NS5A replication complex inhibitor daclatasvir. Antimicrob Agents Chemother (2013) 1.11
Do younger women fare worse? Sex differences in acute myocardial infarction hospitalization and early mortality rates over ten years. J Womens Health (Larchmt) (2013) 1.11
Replication-competent chimeric hepatitis C virus subgenomic replicons. Intervirology (2005) 1.10
p54nrb is a component of the snRNP-free U1A (SF-A) complex that promotes pre-mRNA cleavage during polyadenylation. RNA (2006) 1.09
Hepatitis C virus RNA elimination and development of resistance in replicon cells treated with BMS-790052. Antimicrob Agents Chemother (2012) 1.09
The effects of NS5A inhibitors on NS5A phosphorylation, polyprotein processing and localization. J Gen Virol (2011) 1.08
Genetic variation of promoter sequence modulates XBP1 expression and genetic risk for vitiligo. PLoS Genet (2009) 1.07
Downregulation of human farnesoid X receptor by miR-421 promotes proliferation and migration of hepatocellular carcinoma cells. Mol Cancer Res (2012) 1.07
Sequence-specific RNA binding mediated by the RNase PH domain of components of the exosome. RNA (2006) 1.06
Effect on hepatitis C virus replication of combinations of direct-acting antivirals, including NS5A inhibitor daclatasvir. Antimicrob Agents Chemother (2012) 1.06
Lsm proteins and Hfq: Life at the 3' end. RNA Biol (2013) 1.05
In vitro activity of BMS-790052 on hepatitis C virus genotype 4 NS5A. Antimicrob Agents Chemother (2011) 1.05
Selective translation of eukaryotic mRNAs: functional molecular analysis of GRSF-1, a positive regulator of influenza virus protein synthesis. J Virol (2002) 1.04
A comparison between the effects of acetaminophen and celecoxib on bone fracture healing in rats. J Orthop Trauma (2005) 1.04
Novel aspects of autoantibodies to the PM/Scl complex: clinical, genetic and diagnostic insights. Autoimmun Rev (2007) 1.03
Pharmacological inhibition of 5-lipoxygenase accelerates and enhances fracture-healing. J Bone Joint Surg Am (2009) 1.03
Effects of nonsteroidal anti-inflammatory drugs on flexor tendon adhesion. J Hand Surg Am (2010) 1.03
Selective functional inhibition of JAK-3 is sufficient for efficacy in collagen-induced arthritis in mice. Arthritis Rheum (2010) 1.03
Autoantibodies directed to novel components of the PM/Scl complex, the human exosome. Arthritis Res (2001) 1.02
Lsm proteins bind and stabilize RNAs containing 5' poly(A) tracts. Nat Struct Mol Biol (2007) 1.02
Sex differences in clinical outcomes in patients with stable angina and no obstructive coronary artery disease. Am Heart J (2013) 1.02
Functional consequences of mitochondrial tRNA Trp and tRNA Arg mutations causing combined OXPHOS defects. Eur J Hum Genet (2009) 1.01