Published in Chembiochem on December 01, 2006
Interaction analysis of prenylated Rab GTPase with Rab escort protein and GDP dissociation inhibitor explains the need for both regulators. Proc Natl Acad Sci U S A (2007) 1.26
Membrane targeting mechanism of Rab GTPases elucidated by semisynthetic protein probes. Nat Chem Biol (2010) 1.24
Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation. EMBO J (2008) 0.97
Phosphonocarboxylates inhibit the second geranylgeranyl addition by Rab geranylgeranyl transferase. J Biol Chem (2008) 0.96
The role of the hypervariable C-terminal domain in Rab GTPases membrane targeting. Proc Natl Acad Sci U S A (2014) 0.93
Structure of the disordered C terminus of Rab7 GTPase induced by binding to the Rab geranylgeranyl transferase catalytic complex reveals the mechanism of Rab prenylation. J Biol Chem (2009) 0.87
Locking GTPases covalently in their functional states. Nat Commun (2015) 0.75
An acylation cycle regulates localization and activity of palmitoylated Ras isoforms. Science (2005) 5.99
Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling. Nature (2013) 5.04
A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis. Nat Cell Biol (2009) 3.44
The Legionella effector protein DrrA AMPylates the membrane traffic regulator Rab1b. Science (2010) 2.73
The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs. Proc Natl Acad Sci U S A (2006) 2.73
The palmitoylation machinery is a spatially organizing system for peripheral membrane proteins. Cell (2010) 2.72
The original Michaelis constant: translation of the 1913 Michaelis-Menten paper. Biochemistry (2011) 2.44
Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation. Nat Chem Biol (2010) 2.39
Small-molecule inhibition of APT1 affects Ras localization and signaling. Nat Chem Biol (2010) 2.37
Charting biologically relevant chemical space: a structural classification of natural products (SCONP). Proc Natl Acad Sci U S A (2005) 2.35
A crowdsourcing evaluation of the NIH chemical probes. Nat Chem Biol (2009) 2.29
Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy. Ann N Y Acad Sci (2007) 2.15
The scaffold tree--visualization of the scaffold universe by hierarchical scaffold classification. J Chem Inf Model (2007) 2.04
From protein domains to drug candidates-natural products as guiding principles in the design and synthesis of compound libraries. Angew Chem Int Ed Engl (2002) 2.03
Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo. Nat Chem Biol (2011) 2.00
Therapeutic intervention based on protein prenylation and associated modifications. Nat Chem Biol (2006) 1.96
Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis. Proc Natl Acad Sci U S A (2006) 1.96
Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase. Science (2003) 1.80
A common reference population from four European Holstein populations increases reliability of genomic predictions. Genet Sel Evol (2011) 1.74
Inhibitors of protein tyrosine phosphatases: next-generation drugs? Angew Chem Int Ed Engl (2005) 1.73
Influence of bone affinity on the skeletal distribution of fluorescently labeled bisphosphonates in vivo. J Bone Miner Res (2012) 1.66
Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease. Cell (2004) 1.62
A toolkit and benchmark study for FRET-restrained high-precision structural modeling. Nat Methods (2012) 1.56
Interactive exploration of chemical space with Scaffold Hunter. Nat Chem Biol (2009) 1.55
Chemical strategies for generating protein biochips. Angew Chem Int Ed Engl (2008) 1.55
Analysis of the eukaryotic prenylome by isoprenoid affinity tagging. Nat Chem Biol (2009) 1.50
Natural product-derived modulators of cell cycle progression and viral entry by enantioselective oxa Diels-Alder reactions on the solid phase. Chem Biol (2007) 1.43
Choline-releasing glycerophosphodiesterase EDI3 drives tumor cell migration and metastasis. Proc Natl Acad Sci U S A (2012) 1.41
Fluorescent risedronate analogues reveal bisphosphonate uptake by bone marrow monocytes and localization around osteocytes in vivo. J Bone Miner Res (2010) 1.39
Nucleotide exchange via local protein unfolding--structure of Rab8 in complex with MSS4. EMBO J (2006) 1.39
Bisphosphonates and cancer-induced bone disease: beyond their antiresorptive activity. Cancer Res (2005) 1.38
Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase. J Med Chem (2008) 1.37
Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase. Mol Cell (2003) 1.37
Visualizing association of N-ras in lipid microdomains: influence of domain structure and interfacial adsorption. J Am Chem Soc (2006) 1.35
Non-pathogenic trypanosomatid protozoa as a platform for protein research and production. Protein Expr Purif (2002) 1.33
Beta-lactone probes identify a papain-like peptide ligase in Arabidopsis thaliana. Nat Chem Biol (2008) 1.30
HIV-1 Nef membrane association depends on charge, curvature, composition and sequence. Nat Chem Biol (2009) 1.29
Target identification for small bioactive molecules: finding the needle in the haystack. Angew Chem Int Ed Engl (2013) 1.28
Structural and thermodynamic analysis of the GFP:GFP-nanobody complex. Protein Sci (2010) 1.28
RabGEFs are a major determinant for specific Rab membrane targeting. J Cell Biol (2013) 1.26
Interaction analysis of prenylated Rab GTPase with Rab escort protein and GDP dissociation inhibitor explains the need for both regulators. Proc Natl Acad Sci U S A (2007) 1.26
Membrane targeting mechanism of Rab GTPases elucidated by semisynthetic protein probes. Nat Chem Biol (2010) 1.24
Synthesis of natural product inspired compound collections. Angew Chem Int Ed Engl (2009) 1.23
Species-independent translational leaders facilitate cell-free expression. Nat Biotechnol (2009) 1.22
A framework for identification of actionable cancer genome dependencies in small cell lung cancer. Proc Natl Acad Sci U S A (2012) 1.21
The Pictet-Spengler reaction in nature and in organic chemistry. Angew Chem Int Ed Engl (2011) 1.20
Impacts of both reference population size and inclusion of a residual polygenic effect on the accuracy of genomic prediction. Genet Sel Evol (2011) 1.19
Highly enantioselective synthesis and cellular evaluation of spirooxindoles inspired by natural products. Nat Chem (2010) 1.19
Biology-oriented synthesis. Angew Chem Int Ed Engl (2011) 1.18
Sec2 is a highly efficient exchange factor for the Rab protein Sec4. J Mol Biol (2006) 1.18
Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor. Int J Cancer (2012) 1.18
Protein LidA from Legionella is a Rab GTPase supereffector. Proc Natl Acad Sci U S A (2011) 1.18
Natural-product-derived fragments for fragment-based ligand discovery. Nat Chem (2012) 1.17
Staudinger ligation: a new immobilization strategy for the preparation of small-molecule arrays. Angew Chem Int Ed Engl (2003) 1.17
Compound library development guided by protein structure similarity clustering and natural product structure. Proc Natl Acad Sci U S A (2004) 1.17
The therapeutic potential of phosphatase inhibitors. Curr Opin Chem Biol (2009) 1.16
Guanine nucleotide exchange factors operate by a simple allosteric competitive mechanism. Biochemistry (2005) 1.16
Identification and specificity profiling of protein prenyltransferase inhibitors using new fluorescent phosphoisoprenoids. J Am Chem Soc (2006) 1.15
Exploiting the substrate tolerance of farnesyltransferase for site-selective protein derivatization. Chembiochem (2007) 1.15
Noncompaction of the ventricular myocardium is associated with a de novo mutation in the beta-myosin heavy chain gene. PLoS One (2007) 1.15
High-affinity binding of phosphatidylinositol 4-phosphate by Legionella pneumophila DrrA. EMBO Rep (2010) 1.14
(-)-Englerin A is a potent and selective activator of TRPC4 and TRPC5 calcium channels. Angew Chem Int Ed Engl (2015) 1.14
A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1. EMBO J (2011) 1.14
Structure of doubly prenylated Ypt1:GDI complex and the mechanism of GDI-mediated Rab recycling. EMBO J (2006) 1.14
Inhibition of protein prenylation by bisphosphonates causes sustained activation of Rac, Cdc42, and Rho GTPases. J Bone Miner Res (2006) 1.14
Reversible phosphocholination of Rab proteins by Legionella pneumophila effector proteins. EMBO J (2012) 1.14
Charting, navigating, and populating natural product chemical space for drug discovery. J Med Chem (2012) 1.14
Development of tau aggregation inhibitors for Alzheimer's disease. Angew Chem Int Ed Engl (2009) 1.13
N-Ras forms dimers at POPC membranes. Biophys J (2012) 1.13
GTPases involved in vesicular trafficking: structures and mechanisms. Semin Cell Dev Biol (2010) 1.12
Membrane insertion of a lipidated ras peptide studied by FTIR, solid-state NMR, and neutron diffraction spectroscopy. J Am Chem Soc (2003) 1.12
Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the Ras-signaling modulators palmostatin B and M. Angew Chem Int Ed Engl (2011) 1.11
Bioactivity-guided mapping and navigation of chemical space. Nat Chem Biol (2009) 1.11
Rhodanine-based tau aggregation inhibitors in cell models of tauopathy. Angew Chem Int Ed Engl (2007) 1.11
Diels-Alder ligation and surface immobilization of proteins. Angew Chem Int Ed Engl (2005) 1.10
Discovery of a new class of inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B by biology-oriented synthesis. Angew Chem Int Ed Engl (2008) 1.09
Adenylylation: renaissance of a forgotten post-translational modification. Trends Biochem Sci (2011) 1.09