Published in J Am Chem Soc on April 09, 2003
Lipid rafts: contentious only from simplistic standpoints. Nat Rev Mol Cell Biol (2006) 4.94
Individual palmitoyl residues serve distinct roles in H-ras trafficking, microlocalization, and signaling. Mol Cell Biol (2005) 2.24
Ras plasma membrane signalling platforms. Biochem J (2005) 2.15
Ras nanoclusters: molecular structure and assembly. Semin Cell Dev Biol (2007) 1.56
Palmitoylated Ras proteins traffic through recycling endosomes to the plasma membrane during exocytosis. J Cell Biol (2010) 1.30
H-ras protein in a bilayer: interaction and structure perturbation. J Am Chem Soc (2007) 1.16
Flexibility of ras lipid modifications studied by 2H solid-state NMR and molecular dynamics simulations. Biophys J (2007) 1.01
Water-membrane partition thermodynamics of an amphiphilic lipopeptide: an enthalpy-driven hydrophobic effect. Biophys J (2008) 0.95
Formation and domain partitioning of H-ras peptide nanoclusters: effects of peptide concentration and lipid composition. J Am Chem Soc (2012) 0.95
Molecular dynamics simulations reveal specific interactions of post-translational palmitoyl modifications with rhodopsin in membranes. J Am Chem Soc (2012) 0.95
Ras, an actor on many stages: posttranslational modifications, localization, and site-specified events. Genes Cancer (2011) 0.93
Segregation of negatively charged phospholipids by the polycationic and farnesylated membrane anchor of Kras. Biophys J (2010) 0.90
Insertion of lipidated Ras proteins into lipid monolayers studied by infrared reflection absorption spectroscopy (IRRAS). Biophys J (2006) 0.88
Aggregation of lipid-anchored full-length H-Ras in lipid bilayers: simulations with the MARTINI force field. PLoS One (2013) 0.87
Lessons from computer simulations of Ras proteins in solution and in membrane. Biochim Biophys Acta (2013) 0.87
Palmitoylation regulates vesicular trafficking of R-Ras to membrane ruffles and effects on ruffling and cell spreading. Small GTPases (2012) 0.85
H-ras distribution and signaling in plasma membrane microdomains are regulated by acylation and deacylation events. Mol Cell Biol (2015) 0.82
Solid-state NMR characterization of the putative membrane anchor of TWD1 from Arabidopsis thaliana. Eur Biophys J (2006) 0.80
The presence of membranes or micelles induces structural changes of the myristoylated guanylate-cyclase activating protein-2. Eur Biophys J (2011) 0.80
What drives the clustering of membrane-bound Ras? Small GTPases (2012) 0.78
Membrane binding of a lipidated N-Ras protein studied in lipid monolayers. Eur Biophys J (2006) 0.78
Palmitoylation pilots ras to recycling endosomes. Small GTPases (2011) 0.77
Integrating solid-state NMR and computational modeling to investigate the structure and dynamics of membrane-associated ghrelin. PLoS One (2015) 0.76
The Molecular Mechanism Underlying Recruitment and Insertion of Lipid-Anchored LC3 Protein into Membranes. Biophys J (2015) 0.75
Structural Thermodynamics of myr-Src(2-19) Binding to Phospholipid Membranes. Biophys J (2015) 0.75
An acylation cycle regulates localization and activity of palmitoylated Ras isoforms. Science (2005) 5.99
Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling. Nature (2013) 5.04
A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis. Nat Cell Biol (2009) 3.44
The palmitoylation machinery is a spatially organizing system for peripheral membrane proteins. Cell (2010) 2.72
Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation. Nat Chem Biol (2010) 2.39
Small-molecule inhibition of APT1 affects Ras localization and signaling. Nat Chem Biol (2010) 2.37
Charting biologically relevant chemical space: a structural classification of natural products (SCONP). Proc Natl Acad Sci U S A (2005) 2.35
A crowdsourcing evaluation of the NIH chemical probes. Nat Chem Biol (2009) 2.29
The scaffold tree--visualization of the scaffold universe by hierarchical scaffold classification. J Chem Inf Model (2007) 2.04
From protein domains to drug candidates-natural products as guiding principles in the design and synthesis of compound libraries. Angew Chem Int Ed Engl (2002) 2.03
Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo. Nat Chem Biol (2011) 2.00
Therapeutic intervention based on protein prenylation and associated modifications. Nat Chem Biol (2006) 1.96
Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis. Proc Natl Acad Sci U S A (2006) 1.96
Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase. Science (2003) 1.80
Inhibitors of protein tyrosine phosphatases: next-generation drugs? Angew Chem Int Ed Engl (2005) 1.73
Physico-chemical modelling of target depletion during hybridization on oligonulceotide microarrays. Phys Biol (2009) 1.65
Interactive exploration of chemical space with Scaffold Hunter. Nat Chem Biol (2009) 1.55
Chemical strategies for generating protein biochips. Angew Chem Int Ed Engl (2008) 1.55
The effect of metal cations on the phase behavior and hydration characteristics of phospholipid membranes. Chem Phys Lipids (2002) 1.53
Analysis of the eukaryotic prenylome by isoprenoid affinity tagging. Nat Chem Biol (2009) 1.50
Natural product-derived modulators of cell cycle progression and viral entry by enantioselective oxa Diels-Alder reactions on the solid phase. Chem Biol (2007) 1.43
Choline-releasing glycerophosphodiesterase EDI3 drives tumor cell migration and metastasis. Proc Natl Acad Sci U S A (2012) 1.41
Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase. Mol Cell (2003) 1.37
Visualizing association of N-ras in lipid microdomains: influence of domain structure and interfacial adsorption. J Am Chem Soc (2006) 1.35
Beta-lactone probes identify a papain-like peptide ligase in Arabidopsis thaliana. Nat Chem Biol (2008) 1.30
Target identification for small bioactive molecules: finding the needle in the haystack. Angew Chem Int Ed Engl (2013) 1.28
The phosphatidylcholine/lysophosphatidylcholine ratio in human plasma is an indicator of the severity of rheumatoid arthritis: investigations by 31P NMR and MALDI-TOF MS. Clin Biochem (2005) 1.27
Interaction analysis of prenylated Rab GTPase with Rab escort protein and GDP dissociation inhibitor explains the need for both regulators. Proc Natl Acad Sci U S A (2007) 1.26
Physico-chemical foundations underpinning microarray and next-generation sequencing experiments. Nucleic Acids Res (2013) 1.25
Membrane targeting mechanism of Rab GTPases elucidated by semisynthetic protein probes. Nat Chem Biol (2010) 1.24
Synthesis of natural product inspired compound collections. Angew Chem Int Ed Engl (2009) 1.23
A framework for identification of actionable cancer genome dependencies in small cell lung cancer. Proc Natl Acad Sci U S A (2012) 1.21
The Pictet-Spengler reaction in nature and in organic chemistry. Angew Chem Int Ed Engl (2011) 1.20
Combined proteomic and metabolomic profiling of serum reveals association of the complement system with obesity and identifies novel markers of body fat mass changes. J Proteome Res (2011) 1.20
Highly enantioselective synthesis and cellular evaluation of spirooxindoles inspired by natural products. Nat Chem (2010) 1.19
Biology-oriented synthesis. Angew Chem Int Ed Engl (2011) 1.18
Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor. Int J Cancer (2012) 1.18
Natural-product-derived fragments for fragment-based ligand discovery. Nat Chem (2012) 1.17
Staudinger ligation: a new immobilization strategy for the preparation of small-molecule arrays. Angew Chem Int Ed Engl (2003) 1.17
Compound library development guided by protein structure similarity clustering and natural product structure. Proc Natl Acad Sci U S A (2004) 1.17
DARIO: a ncRNA detection and analysis tool for next-generation sequencing experiments. Nucleic Acids Res (2011) 1.16
The therapeutic potential of phosphatase inhibitors. Curr Opin Chem Biol (2009) 1.16
Molecular classification of diffuse cerebral WHO grade II/III gliomas using genome- and transcriptome-wide profiling improves stratification of prognostically distinct patient groups. Acta Neuropathol (2015) 1.16
MALDI-TOF MS in lipidomics. Front Biosci (2007) 1.16
Identification and specificity profiling of protein prenyltransferase inhibitors using new fluorescent phosphoisoprenoids. J Am Chem Soc (2006) 1.15
Exploiting the substrate tolerance of farnesyltransferase for site-selective protein derivatization. Chembiochem (2007) 1.15
(-)-Englerin A is a potent and selective activator of TRPC4 and TRPC5 calcium channels. Angew Chem Int Ed Engl (2015) 1.14
The distribution of lipid attached spin probes in bilayers: application to membrane protein topology. Biophys J (2003) 1.14
Structure of doubly prenylated Ypt1:GDI complex and the mechanism of GDI-mediated Rab recycling. EMBO J (2006) 1.14
Charting, navigating, and populating natural product chemical space for drug discovery. J Med Chem (2012) 1.14
Development of tau aggregation inhibitors for Alzheimer's disease. Angew Chem Int Ed Engl (2009) 1.13
N-Ras forms dimers at POPC membranes. Biophys J (2012) 1.13
Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the Ras-signaling modulators palmostatin B and M. Angew Chem Int Ed Engl (2011) 1.11
Bioactivity-guided mapping and navigation of chemical space. Nat Chem Biol (2009) 1.11
Rhodanine-based tau aggregation inhibitors in cell models of tauopathy. Angew Chem Int Ed Engl (2007) 1.11
Diels-Alder ligation and surface immobilization of proteins. Angew Chem Int Ed Engl (2005) 1.10
Discovery of a new class of inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B by biology-oriented synthesis. Angew Chem Int Ed Engl (2008) 1.09
Effective dephosphorylation of Src substrates by SHP-1. J Biol Chem (2003) 1.09
Small-molecule inhibitors of islet amyloid polypeptide fibril formation. Angew Chem Int Ed Engl (2008) 1.09
Influence of the lipidation motif on the partitioning and association of N-Ras in model membrane subdomains. J Am Chem Soc (2009) 1.09
Brunsvicamides A-C: sponge-related cyanobacterial peptides with Mycobacterium tuberculosis protein tyrosine phosphatase inhibitory activity. J Med Chem (2006) 1.09
Delimitation of squamous cell cervical carcinoma using infrared microspectroscopic imaging. Anal Bioanal Chem (2005) 1.08
Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras. Blood (2011) 1.08
Membrane-mediated induction and sorting of K-Ras microdomain signaling platforms. J Am Chem Soc (2010) 1.08
Bioactivity-guided navigation of chemical space. Acc Chem Res (2010) 1.07
ATP competitive inhibitors of D-alanine-D-alanine ligase based on protein kinase inhibitor scaffolds. Bioorg Med Chem (2008) 1.07
Synthesis of the Rheb and K-Ras4B GTPases. Angew Chem Int Ed Engl (2010) 1.07
Asymmetric solid-phase synthesis of 6,6-spiroketals. Angew Chem Int Ed Engl (2004) 1.06
Are obese adolescents and young adults at higher risk for mental disorders? A community survey. Obes Res (2002) 1.05
The cholesterol membrane anchor of the Hedgehog protein confers stable membrane association to lipid-modified proteins. Proc Natl Acad Sci U S A (2004) 1.05
Annexin A2/P11 interaction: new insights into annexin A2 tetramer structure by chemical crosslinking, high-resolution mass spectrometry, and computational modeling. Proteins (2007) 1.04
Identification of harmless and pathogenic algae of the genus Prototheca by MALDI-MS. Proteomics Clin Appl (2009) 1.04
The lipidated membrane anchor of full length N-Ras protein shows an extensive dynamics as revealed by solid-state NMR spectroscopy. J Am Chem Soc (2006) 1.03
3-Substituted indolizine-1-carbonitrile derivatives as phosphatase inhibitors. Bioorg Med Chem Lett (2005) 1.02
Chemical biology of protein lipidation: semi-synthesis and structure elucidation of prenylated RabGTPases. Org Biomol Chem (2005) 1.02
Membrane binding of lipidated Ras peptides and proteins--the structural point of view. Biochim Biophys Acta (2008) 1.02
Revealing conformational substates of lipidated N-Ras protein by pressure modulation. Proc Natl Acad Sci U S A (2011) 1.02
Flexibility of ras lipid modifications studied by 2H solid-state NMR and molecular dynamics simulations. Biophys J (2007) 1.01
Identification of thiazolidinones spiro-fused to indolin-2-ones as potent and selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase B. Angew Chem Int Ed Engl (2010) 1.01
Synthesis and structure-activity correlation of natural-product inspired cyclodepsipeptides stabilizing F-actin. J Am Chem Soc (2010) 1.01
Localization of coenzyme Q10 in the center of a deuterated lipid membrane by neutron diffraction. Biochim Biophys Acta (2005) 1.00
A solid-state NMR study of the fast and slow dynamics of collagen fibrils at varying hydration levels. Magn Reson Chem (2004) 1.00
Lipid modifications of a Ras peptide exhibit altered packing and mobility versus host membrane as detected by 2H solid-state NMR. J Am Chem Soc (2005) 1.00
Site-selective protein immobilization by Staudinger ligation. Angew Chem Int Ed Engl (2006) 1.00
Oriented immobilization of farnesylated proteins by the thiol-ene reaction. Angew Chem Int Ed Engl (2010) 1.00
Structure of polydopamine: a never-ending story? Langmuir (2013) 1.00
Comparison of collagen dynamics in articular cartilage and isolated fibrils by solid-state NMR spectroscopy. Magn Reson Med (2002) 1.00
Natural product guided compound library development. Curr Med Chem (2002) 0.99
Lipidated ras and rab peptides and proteins--synthesis, structure, and function. Angew Chem Int Ed Engl (2006) 0.99
Raft protein clustering alters N-Ras membrane interactions and activation pattern. Mol Cell Biol (2011) 0.99
Applications of protein biochips in biomedical and biotechnological research. Angew Chem Int Ed Engl (2009) 0.98
Squalane is in the midplane of the lipid bilayer: implications for its function as a proton permeability barrier. Biochim Biophys Acta (2002) 0.97
Partitioning of dual-lipidated peptides into membrane microdomains: lipid sorting vs peptide aggregation. J Am Chem Soc (2004) 0.97
Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation. EMBO J (2008) 0.97
The core structures of roseophilin and the prodigiosin alkaloids define a new class of protein tyrosine phosphatase inhibitors. Chembiochem (2004) 0.97
Emergent functional properties of neuronal networks with controlled topology. PLoS One (2012) 0.97
G-stack modulated probe intensities on expression arrays - sequence corrections and signal calibration. BMC Bioinformatics (2010) 0.97