Published in Proc Natl Acad Sci U S A on July 17, 2007
Role of Rab GTPases in membrane traffic and cell physiology. Physiol Rev (2011) 5.20
Golgi coiled-coil proteins contain multiple binding sites for Rab family G proteins. J Cell Biol (2008) 1.86
Structural insights into the dual nucleotide exchange and GDI displacement activity of SidM/DrrA. EMBO J (2009) 1.26
Splice variants of SmgGDS control small GTPase prenylation and membrane localization. J Biol Chem (2010) 1.25
Structural mechanisms for regulation of membrane traffic by rab GTPases. Traffic (2009) 1.25
Membrane targeting mechanism of Rab GTPases elucidated by semisynthetic protein probes. Nat Chem Biol (2010) 1.24
Rab GTPases implicated in inherited and acquired disorders. Semin Cell Dev Biol (2010) 1.15
Rab protein evolution and the history of the eukaryotic endomembrane system. Cell Mol Life Sci (2010) 1.15
Exploring protein lipidation with chemical biology. Chem Rev (2011) 1.15
Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation. EMBO J (2008) 0.97
The role of the hypervariable C-terminal domain in Rab GTPases membrane targeting. Proc Natl Acad Sci U S A (2014) 0.93
Rab GTPase localization and Rab cascades in Golgi transport. Biochem Soc Trans (2012) 0.92
Posttranslational modifications of Rab proteins cause effective displacement of GDP dissociation inhibitor. Proc Natl Acad Sci U S A (2012) 0.92
Structure of the disordered C terminus of Rab7 GTPase induced by binding to the Rab geranylgeranyl transferase catalytic complex reveals the mechanism of Rab prenylation. J Biol Chem (2009) 0.87
Quantitative analysis of prenylated RhoA interaction with its chaperone, RhoGDI. J Biol Chem (2012) 0.86
Regioselective covalent immobilization of catalytically active glutathione S-transferase on glass slides. Bioconjug Chem (2013) 0.80
Evolution of insect proteomes: insights into synapse organization and synaptic vesicle life cycle. Genome Biol (2008) 0.79
Proteomics on the rims: insights into the biology of the nuclear envelope and flagellar pocket of trypanosomes. Parasitology (2012) 0.79
Membrane extraction of Rab proteins by GDP dissociation inhibitor characterized using attenuated total reflection infrared spectroscopy. Proc Natl Acad Sci U S A (2013) 0.78
Hsp90 Co-localizes with Rab-GDI-1 and regulates agonist-induced amylase release in AR42J cells. Cell Physiol Biochem (2009) 0.78
Liposome reconstitution and modulation of recombinant prenylated human Rac1 by GEFs, GDI1 and Pak1. PLoS One (2014) 0.77
Molecular structure of the Brucella abortus metalloprotein RicA, a Rab2-binding virulence effector. Biochemistry (2013) 0.77
Rab GTPases: master regulators that establish the secretory and endocytic pathways. Mol Biol Cell (2017) 0.75
Molecular Dynamics of Rab7::REP1::GGTase-II Ternary Complex and Identification of Their Putative Drug Binding Sites. Indian J Pharm Sci (2013) 0.75
Locking GTPases covalently in their functional states. Nat Commun (2015) 0.75
Spatiotemporal imaging of small GTPases activity in live cells. Proc Natl Acad Sci U S A (2016) 0.75
All about that Amide Bond: The Sixth Chemical Protein Synthesis (CPS) Meeting. Chembiochem (2015) 0.75
Protein prenyltransferases. J Biol Chem (1996) 3.52
Semisynthesis of proteins by expressed protein ligation. Annu Rev Biochem (2003) 3.44
The Rab GTPase family. Genome Biol (2001) 3.37
Regulation of reversible binding of smg p25A, a ras p21-like GTP-binding protein, to synaptic plasma membranes and vesicles by its specific regulatory protein, GDP dissociation inhibitor. J Biol Chem (1990) 2.47
Yip3 catalyses the dissociation of endosomal Rab-GDI complexes. Nature (2003) 2.15
Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase. Science (2003) 1.80
Identification of a GDI displacement factor that releases endosomal Rab GTPases from Rab-GDI. EMBO J (1997) 1.71
The structural and mechanistic basis for recycling of Rab proteins between membrane compartments. Cell Mol Life Sci (2005) 1.63
Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease. Cell (2004) 1.62
Membrane targeting of Rab GTPases is influenced by the prenylation motif. Mol Biol Cell (2003) 1.57
Structure and mutational analysis of Rab GDP-dissociation inhibitor. Nature (1996) 1.56
Binding of prenylated and polybasic peptides to membranes: affinities and intervesicle exchange. Biochemistry (1995) 1.44
Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase. Mol Cell (2003) 1.37
Rab-GDI presents functional Rab9 to the intracellular transport machinery and contributes selectivity to Rab9 membrane recruitment. J Biol Chem (1994) 1.33
Photoaffinity analogues of farnesyl pyrophosphate transferable by protein farnesyl transferase. J Am Chem Soc (2002) 1.19
Identification and specificity profiling of protein prenyltransferase inhibitors using new fluorescent phosphoisoprenoids. J Am Chem Soc (2006) 1.15
Exploiting the substrate tolerance of farnesyltransferase for site-selective protein derivatization. Chembiochem (2007) 1.15
Quantitative analysis of the interactions between prenyl Rab9, GDP dissociation inhibitor-alpha, and guanine nucleotides. J Biol Chem (1995) 1.15
Structure of doubly prenylated Ypt1:GDI complex and the mechanism of GDI-mediated Rab recycling. EMBO J (2006) 1.14
Mechanism of digeranylgeranylation of Rab proteins. Formation of a complex between monogeranylgeranyl-Rab and Rab escort protein. J Biol Chem (1996) 1.13
The Hsp90 chaperone complex regulates GDI-dependent Rab recycling. Mol Biol Cell (2006) 1.09
Substrate binding is required for release of product from mammalian protein farnesyltransferase. J Biol Chem (1997) 1.07
Protein prenylation, et cetera: signal transduction in two dimensions. Science (1997) 1.03
Characterization of the ternary complex between Rab7, REP-1 and Rab geranylgeranyl transferase. Eur J Biochem (1999) 0.98
Expression of mammalian geranylgeranyltransferase type-II in Escherichia coli and its application for in vitro prenylation of Rab proteins. Protein Expr Purif (2001) 0.96
A protein fluorescence amplifier: continuous fluorometric assay for rab geranylgeranyltransferase. Chembiochem (2006) 0.93
Double prenylation by RabGGTase can proceed without dissociation of the mono-prenylated intermediate. J Biol Chem (2001) 0.92
Fluorescence methods for monitoring interactions of Rab proteins with nucleotides, Rab escort protein, and geranylgeranyltransferase. Methods Enzymol (2001) 0.89
Synthesis of fluorescently labeled mono- and diprenylated Rab7 GTPase. J Am Chem Soc (2004) 0.87
Allosteric regulation of substrate binding and product release in geranylgeranyltransferase type II. Biochemistry (2001) 0.86
Intein-mediated synthesis of geranylgeranylated Rab7 protein in vitro. J Am Chem Soc (2002) 0.85
Moderate discrimination of REP-1 between Rab7 x GDP and Rab7 x GTP arises from a difference of an order of magnitude in dissociation rates. FEBS Lett (1998) 0.84
A genetically encodable microtag for chemo-enzymatic derivatization and purification of recombinant proteins. Protein Expr Purif (2005) 0.83
Synthesis and application of fluorescent ras proteins for live-cell imaging. Chembiochem (2005) 0.81
An acylation cycle regulates localization and activity of palmitoylated Ras isoforms. Science (2005) 5.99
Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling. Nature (2013) 5.04
A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis. Nat Cell Biol (2009) 3.44
The Legionella effector protein DrrA AMPylates the membrane traffic regulator Rab1b. Science (2010) 2.73
The palmitoylation machinery is a spatially organizing system for peripheral membrane proteins. Cell (2010) 2.72
The original Michaelis constant: translation of the 1913 Michaelis-Menten paper. Biochemistry (2011) 2.44
Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation. Nat Chem Biol (2010) 2.39
Small-molecule inhibition of APT1 affects Ras localization and signaling. Nat Chem Biol (2010) 2.37
Charting biologically relevant chemical space: a structural classification of natural products (SCONP). Proc Natl Acad Sci U S A (2005) 2.35
A crowdsourcing evaluation of the NIH chemical probes. Nat Chem Biol (2009) 2.29
The scaffold tree--visualization of the scaffold universe by hierarchical scaffold classification. J Chem Inf Model (2007) 2.04
From protein domains to drug candidates-natural products as guiding principles in the design and synthesis of compound libraries. Angew Chem Int Ed Engl (2002) 2.03
Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo. Nat Chem Biol (2011) 2.00
Therapeutic intervention based on protein prenylation and associated modifications. Nat Chem Biol (2006) 1.96
Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis. Proc Natl Acad Sci U S A (2006) 1.96
Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase. Science (2003) 1.80
Inhibitors of protein tyrosine phosphatases: next-generation drugs? Angew Chem Int Ed Engl (2005) 1.73
Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease. Cell (2004) 1.62
A toolkit and benchmark study for FRET-restrained high-precision structural modeling. Nat Methods (2012) 1.56
Interactive exploration of chemical space with Scaffold Hunter. Nat Chem Biol (2009) 1.55
Chemical strategies for generating protein biochips. Angew Chem Int Ed Engl (2008) 1.55
Analysis of the eukaryotic prenylome by isoprenoid affinity tagging. Nat Chem Biol (2009) 1.50
Natural product-derived modulators of cell cycle progression and viral entry by enantioselective oxa Diels-Alder reactions on the solid phase. Chem Biol (2007) 1.43
Choline-releasing glycerophosphodiesterase EDI3 drives tumor cell migration and metastasis. Proc Natl Acad Sci U S A (2012) 1.41
Nucleotide exchange via local protein unfolding--structure of Rab8 in complex with MSS4. EMBO J (2006) 1.39
Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase. Mol Cell (2003) 1.37
Visualizing association of N-ras in lipid microdomains: influence of domain structure and interfacial adsorption. J Am Chem Soc (2006) 1.35
Non-pathogenic trypanosomatid protozoa as a platform for protein research and production. Protein Expr Purif (2002) 1.33
Beta-lactone probes identify a papain-like peptide ligase in Arabidopsis thaliana. Nat Chem Biol (2008) 1.30
HIV-1 Nef membrane association depends on charge, curvature, composition and sequence. Nat Chem Biol (2009) 1.29
Target identification for small bioactive molecules: finding the needle in the haystack. Angew Chem Int Ed Engl (2013) 1.28
Structural and thermodynamic analysis of the GFP:GFP-nanobody complex. Protein Sci (2010) 1.28
RabGEFs are a major determinant for specific Rab membrane targeting. J Cell Biol (2013) 1.26
Membrane targeting mechanism of Rab GTPases elucidated by semisynthetic protein probes. Nat Chem Biol (2010) 1.24
Synthesis of natural product inspired compound collections. Angew Chem Int Ed Engl (2009) 1.23
Species-independent translational leaders facilitate cell-free expression. Nat Biotechnol (2009) 1.22
A framework for identification of actionable cancer genome dependencies in small cell lung cancer. Proc Natl Acad Sci U S A (2012) 1.21
The Pictet-Spengler reaction in nature and in organic chemistry. Angew Chem Int Ed Engl (2011) 1.20
Highly enantioselective synthesis and cellular evaluation of spirooxindoles inspired by natural products. Nat Chem (2010) 1.19
Biology-oriented synthesis. Angew Chem Int Ed Engl (2011) 1.18
Sec2 is a highly efficient exchange factor for the Rab protein Sec4. J Mol Biol (2006) 1.18
Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor. Int J Cancer (2012) 1.18
Protein LidA from Legionella is a Rab GTPase supereffector. Proc Natl Acad Sci U S A (2011) 1.18
Natural-product-derived fragments for fragment-based ligand discovery. Nat Chem (2012) 1.17
Staudinger ligation: a new immobilization strategy for the preparation of small-molecule arrays. Angew Chem Int Ed Engl (2003) 1.17
Compound library development guided by protein structure similarity clustering and natural product structure. Proc Natl Acad Sci U S A (2004) 1.17
The therapeutic potential of phosphatase inhibitors. Curr Opin Chem Biol (2009) 1.16
Guanine nucleotide exchange factors operate by a simple allosteric competitive mechanism. Biochemistry (2005) 1.16
Identification and specificity profiling of protein prenyltransferase inhibitors using new fluorescent phosphoisoprenoids. J Am Chem Soc (2006) 1.15
Exploiting the substrate tolerance of farnesyltransferase for site-selective protein derivatization. Chembiochem (2007) 1.15
Noncompaction of the ventricular myocardium is associated with a de novo mutation in the beta-myosin heavy chain gene. PLoS One (2007) 1.15
High-affinity binding of phosphatidylinositol 4-phosphate by Legionella pneumophila DrrA. EMBO Rep (2010) 1.14
(-)-Englerin A is a potent and selective activator of TRPC4 and TRPC5 calcium channels. Angew Chem Int Ed Engl (2015) 1.14
A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1. EMBO J (2011) 1.14
Structure of doubly prenylated Ypt1:GDI complex and the mechanism of GDI-mediated Rab recycling. EMBO J (2006) 1.14
Reversible phosphocholination of Rab proteins by Legionella pneumophila effector proteins. EMBO J (2012) 1.14
Charting, navigating, and populating natural product chemical space for drug discovery. J Med Chem (2012) 1.14
Development of tau aggregation inhibitors for Alzheimer's disease. Angew Chem Int Ed Engl (2009) 1.13
N-Ras forms dimers at POPC membranes. Biophys J (2012) 1.13
GTPases involved in vesicular trafficking: structures and mechanisms. Semin Cell Dev Biol (2010) 1.12
Membrane insertion of a lipidated ras peptide studied by FTIR, solid-state NMR, and neutron diffraction spectroscopy. J Am Chem Soc (2003) 1.12
Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the Ras-signaling modulators palmostatin B and M. Angew Chem Int Ed Engl (2011) 1.11
Bioactivity-guided mapping and navigation of chemical space. Nat Chem Biol (2009) 1.11
Rhodanine-based tau aggregation inhibitors in cell models of tauopathy. Angew Chem Int Ed Engl (2007) 1.11
Diels-Alder ligation and surface immobilization of proteins. Angew Chem Int Ed Engl (2005) 1.10
Discovery of a new class of inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B by biology-oriented synthesis. Angew Chem Int Ed Engl (2008) 1.09
Influence of the lipidation motif on the partitioning and association of N-Ras in model membrane subdomains. J Am Chem Soc (2009) 1.09
Brunsvicamides A-C: sponge-related cyanobacterial peptides with Mycobacterium tuberculosis protein tyrosine phosphatase inhibitory activity. J Med Chem (2006) 1.09
Catalytic mechanism of a mammalian Rab·RabGAP complex in atomic detail. Proc Natl Acad Sci U S A (2012) 1.09
Small-molecule inhibitors of islet amyloid polypeptide fibril formation. Angew Chem Int Ed Engl (2008) 1.09
Adenylylation: renaissance of a forgotten post-translational modification. Trends Biochem Sci (2011) 1.09
Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras. Blood (2011) 1.08
Membrane-mediated induction and sorting of K-Ras microdomain signaling platforms. J Am Chem Soc (2010) 1.08
Bioactivity-guided navigation of chemical space. Acc Chem Res (2010) 1.07
Synthesis of the Rheb and K-Ras4B GTPases. Angew Chem Int Ed Engl (2010) 1.07
ATP competitive inhibitors of D-alanine-D-alanine ligase based on protein kinase inhibitor scaffolds. Bioorg Med Chem (2008) 1.07
A phosphoryl transfer intermediate in the GTPase reaction of Ras in complex with its GTPase-activating protein. Proc Natl Acad Sci U S A (2006) 1.06
Asymmetric solid-phase synthesis of 6,6-spiroketals. Angew Chem Int Ed Engl (2004) 1.06
The cholesterol membrane anchor of the Hedgehog protein confers stable membrane association to lipid-modified proteins. Proc Natl Acad Sci U S A (2004) 1.05
Biophysical analysis of the interaction of Rab6a GTPase with its effector domains. J Biol Chem (2008) 1.05
Environment-sensitive fluorescent turn-on probes targeting hydrophobic ligand-binding domains for selective protein detection. Angew Chem Int Ed Engl (2013) 1.03