Published in Cell on June 11, 2004
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Structural basis of family-wide Rab GTPase recognition by rabenosyn-5. Nature (2005) 2.23
Refinement and prediction of protein prenylation motifs. Genome Biol (2005) 1.84
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Structural mechanisms for regulation of membrane traffic by rab GTPases. Traffic (2009) 1.25
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Exploring protein lipidation with chemical biology. Chem Rev (2011) 1.15
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C3 exoenzymes, novel insights into structure and action of Rho-ADP-ribosylating toxins. Naunyn Schmiedebergs Arch Pharmacol (2006) 1.11
Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation. EMBO J (2008) 0.97
Guanine nucleotide exchange factors (GEFs) have a critical but not exclusive role in organelle localization of Rab GTPases. J Biol Chem (2013) 0.96
Structures of PI4KIIIβ complexes show simultaneous recruitment of Rab11 and its effectors. Science (2014) 0.94
The role of the hypervariable C-terminal domain in Rab GTPases membrane targeting. Proc Natl Acad Sci U S A (2014) 0.93
Systems-wide analysis of BCR signalosomes and downstream phosphorylation and ubiquitylation. Mol Syst Biol (2015) 0.92
Crystal structure of the C3bot-RalA complex reveals a novel type of action of a bacterial exoenzyme. EMBO J (2005) 0.90
Molecular genetic diagnostic techniques in choroideremia. Mol Vis (2014) 0.88
Structure of the disordered C terminus of Rab7 GTPase induced by binding to the Rab geranylgeranyl transferase catalytic complex reveals the mechanism of Rab prenylation. J Biol Chem (2009) 0.87
Clinical characteristics of a large choroideremia pedigree carrying a novel CHM mutation. Arch Ophthalmol (2012) 0.86
Phylogeny and evolution of Rab7 and Rab9 proteins. BMC Evol Biol (2009) 0.85
Rab GTPase prenylation hierarchy and its potential role in choroideremia disease. PLoS One (2013) 0.83
PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7. Nat Commun (2016) 0.83
The C. elegans rab family: identification, classification and toolkit construction. PLoS One (2012) 0.82
Rapid analysis of protein farnesyltransferase substrate specificity using peptide libraries and isoprenoid diphosphate analogues. ACS Chem Biol (2014) 0.82
Genetic and phenotypic characteristics of three Mainland Chinese families with choroideremia. Mol Vis (2012) 0.81
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Pathogenic mechanisms and the prospect of gene therapy for choroideremia. Expert Opin Orphan Drugs (2015) 0.79
Interaction between shrimp and white spot syndrome virus through PmRab7-VP28 complex: an insight using simulation and docking studies. J Mol Model (2012) 0.78
REP1 inhibits FOXO3-mediated apoptosis to promote cancer cell survival. Cell Death Dis (2017) 0.78
Rab geranylgeranyl transferase β subunit is essential for male fertility and tip growth in Arabidopsis. J Exp Bot (2014) 0.77
Purification, crystallization and preliminary X-ray crystallographic analysis of mammalian MSS4-Rab8 GTPase protein complex. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.76
Multimodal assessment of choroideremia patients defines pre-treatment characteristics. Graefes Arch Clin Exp Ophthalmol (2015) 0.76
A modification switch on a molecular switch: Phosphoregulation of Rab7 during endosome maturation. Small GTPases (2016) 0.76
Are There Rab GTPases in Archaea? Mol Biol Evol (2016) 0.76
Locking GTPases covalently in their functional states. Nat Commun (2015) 0.75
On the accuracy of unit-cell parameters in protein crystallography. Acta Crystallogr D Biol Crystallogr (2015) 0.75
Synthetic isoprenoid analogues for the study of prenylated proteins: Fluorescent imaging and proteomic applications. Bioorg Chem (2015) 0.75
Molecular Dynamics of Rab7::REP1::GGTase-II Ternary Complex and Identification of Their Putative Drug Binding Sites. Indian J Pharm Sci (2013) 0.75
REP1 Modulates Autophagy and Macropinocytosis to Enhance Cancer Cell Survival. Int J Mol Sci (2017) 0.75
Purification, crystallization and X-ray crystallographic analysis of human RAB11(S20V), a constitutively active GTP-binding form. Acta Crystallogr F Struct Biol Commun (2015) 0.75
The Legionella effector protein DrrA AMPylates the membrane traffic regulator Rab1b. Science (2010) 2.73
Rab GTPases at a glance. J Cell Sci (2007) 2.68
The original Michaelis constant: translation of the 1913 Michaelis-Menten paper. Biochemistry (2011) 2.44
KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron. Nat Genet (2012) 1.93
The human formin FHOD1 contains a bipartite structure of FH3 and GTPase-binding domains required for activation. Structure (2008) 1.85
Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase. Science (2003) 1.80
A toolkit and benchmark study for FRET-restrained high-precision structural modeling. Nat Methods (2012) 1.56
Analysis of the eukaryotic prenylome by isoprenoid affinity tagging. Nat Chem Biol (2009) 1.50
Nucleotide exchange via local protein unfolding--structure of Rab8 in complex with MSS4. EMBO J (2006) 1.39
Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase. Mol Cell (2003) 1.37
Non-pathogenic trypanosomatid protozoa as a platform for protein research and production. Protein Expr Purif (2002) 1.33
HIV-1 Nef membrane association depends on charge, curvature, composition and sequence. Nat Chem Biol (2009) 1.29
Structural and thermodynamic analysis of the GFP:GFP-nanobody complex. Protein Sci (2010) 1.28
RabGEFs are a major determinant for specific Rab membrane targeting. J Cell Biol (2013) 1.26
Interaction analysis of prenylated Rab GTPase with Rab escort protein and GDP dissociation inhibitor explains the need for both regulators. Proc Natl Acad Sci U S A (2007) 1.26
Membrane targeting mechanism of Rab GTPases elucidated by semisynthetic protein probes. Nat Chem Biol (2010) 1.24
Species-independent translational leaders facilitate cell-free expression. Nat Biotechnol (2009) 1.22
Sec2 is a highly efficient exchange factor for the Rab protein Sec4. J Mol Biol (2006) 1.18
Protein LidA from Legionella is a Rab GTPase supereffector. Proc Natl Acad Sci U S A (2011) 1.18
Crystal structure of OxyB, a cytochrome P450 implicated in an oxidative phenol coupling reaction during vancomycin biosynthesis. J Biol Chem (2002) 1.16
Guanine nucleotide exchange factors operate by a simple allosteric competitive mechanism. Biochemistry (2005) 1.16
Identification and specificity profiling of protein prenyltransferase inhibitors using new fluorescent phosphoisoprenoids. J Am Chem Soc (2006) 1.15
Exploiting the substrate tolerance of farnesyltransferase for site-selective protein derivatization. Chembiochem (2007) 1.15
Noncompaction of the ventricular myocardium is associated with a de novo mutation in the beta-myosin heavy chain gene. PLoS One (2007) 1.15
High-affinity binding of phosphatidylinositol 4-phosphate by Legionella pneumophila DrrA. EMBO Rep (2010) 1.14
A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1. EMBO J (2011) 1.14
Structure of doubly prenylated Ypt1:GDI complex and the mechanism of GDI-mediated Rab recycling. EMBO J (2006) 1.14
Reversible phosphocholination of Rab proteins by Legionella pneumophila effector proteins. EMBO J (2012) 1.14
GTPases involved in vesicular trafficking: structures and mechanisms. Semin Cell Dev Biol (2010) 1.12
Diels-Alder ligation and surface immobilization of proteins. Angew Chem Int Ed Engl (2005) 1.10
Adenylylation: renaissance of a forgotten post-translational modification. Trends Biochem Sci (2011) 1.09
Catalytic mechanism of a mammalian Rab·RabGAP complex in atomic detail. Proc Natl Acad Sci U S A (2012) 1.09
A phosphoryl transfer intermediate in the GTPase reaction of Ras in complex with its GTPase-activating protein. Proc Natl Acad Sci U S A (2006) 1.06
Biophysical analysis of the interaction of Rab6a GTPase with its effector domains. J Biol Chem (2008) 1.05
Chemical biology of protein lipidation: semi-synthesis and structure elucidation of prenylated RabGTPases. Org Biomol Chem (2005) 1.02
Single-molecule analysis reveals self assembly and nanoscale segregation of two distinct cavin subcomplexes on caveolae. Elife (2013) 1.01
Oriented immobilization of farnesylated proteins by the thiol-ene reaction. Angew Chem Int Ed Engl (2010) 1.00
Site-selective protein immobilization by Staudinger ligation. Angew Chem Int Ed Engl (2006) 1.00
Lipidated ras and rab peptides and proteins--synthesis, structure, and function. Angew Chem Int Ed Engl (2006) 0.99
A structural model of the GDP dissociation inhibitor rab membrane extraction mechanism. J Biol Chem (2008) 0.99
Understanding and exploiting protein prenyltransferases. Chembiochem (2010) 0.99
Development of an inducible protein expression system based on the protozoan host Leishmania tarentolae. Protein Expr Purif (2005) 0.98
Cortactin scaffolds Arp2/3 and WAVE2 at the epithelial zonula adherens. J Biol Chem (2014) 0.97
A newly designed microspectrofluorometer for kinetic studies on protein crystals in combination with x-ray diffraction. Biophys J (2006) 0.97
Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation. EMBO J (2008) 0.97
Flow cytometry for real-time measurement of guanine nucleotide binding and exchange by Ras-like GTPases. Anal Biochem (2008) 0.96
Mechanism of Rab1b deactivation by the Legionella pneumophila GAP LepB. EMBO Rep (2013) 0.95
Extreme temperature tolerance of a hyperthermophilic protein coupled to residual structure in the unfolded state. J Mol Biol (2008) 0.95
Structure of the extremely slow GTPase Rab6A in the GTP bound form at 1.8A resolution. J Struct Biol (2005) 0.95
InCa-SiteFinder: a method for structure-based prediction of inositol and carbohydrate binding sites on proteins. J Mol Graph Model (2009) 0.94
A highly efficient strategy for modification of proteins at the C terminus. Angew Chem Int Ed Engl (2010) 0.94
A protein fluorescence amplifier: continuous fluorometric assay for rab geranylgeranyltransferase. Chembiochem (2006) 0.93
The role of the hypervariable C-terminal domain in Rab GTPases membrane targeting. Proc Natl Acad Sci U S A (2014) 0.93
Posttranslational modifications of Rab proteins cause effective displacement of GDP dissociation inhibitor. Proc Natl Acad Sci U S A (2012) 0.92
Interaction of yeast Rab geranylgeranyl transferase with its protein and lipid substrates. Biochemistry (2002) 0.91
Farnesylation of the SNARE protein Ykt6 increases its stability and helical folding. J Mol Biol (2008) 0.91
Farnesylation of pex19p is required for its structural integrity and function in peroxisome biogenesis. J Biol Chem (2009) 0.90
Direct readout of protein-protein interactions by mass spectrometry from protein-DNA microarrays. Angew Chem Int Ed Engl (2005) 0.90
Rab-subfamily-specific regions of Ypt7p are structurally different from other RabGTPases. Structure (2002) 0.90
Leishmania cell-free protein expression system. Methods (2011) 0.90
Psoromic acid is a selective and covalent Rab-prenylation inhibitor targeting autoinhibited RabGGTase. J Am Chem Soc (2012) 0.90
A generic building block for C- and N-terminal protein-labeling and protein-immobilization. Bioorg Med Chem (2006) 0.88
Design and application of in vivo FRET biosensors to identify protein prenylation and nanoclustering inhibitors. Chem Biol (2012) 0.87
Structure of the disordered C terminus of Rab7 GTPase induced by binding to the Rab geranylgeranyl transferase catalytic complex reveals the mechanism of Rab prenylation. J Biol Chem (2009) 0.87
Chaperone-assisted production of active human Rab8A GTPase in Escherichia coli. Protein Expr Purif (2008) 0.87
Synthesis of fluorescently labeled mono- and diprenylated Rab7 GTPase. J Am Chem Soc (2004) 0.87
Direct targeting of Rab-GTPase-effector interactions. Angew Chem Int Ed Engl (2014) 0.87
Monitoring the real-time kinetics of the hydrolysis reaction of guanine nucleotide-binding proteins. Biol Chem (2005) 0.87
Construction and analysis of Leishmania tarentolae transgenic strains free of selection markers. Mol Biochem Parasitol (2007) 0.86
Quantitative analysis of prenylated RhoA interaction with its chaperone, RhoGDI. J Biol Chem (2012) 0.86
Flexible and general synthesis of functionalized phosphoisoprenoids for the study of prenylation in vivo and in vitro. Chembiochem (2012) 0.86