Published in Endocrinology on November 09, 2006
Development of subtype-selective oestrogen receptor-based therapeutics. Nat Rev Drug Discov (2011) 1.39
Liquiritigenin is a plant-derived highly selective estrogen receptor beta agonist. Mol Cell Endocrinol (2007) 1.30
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Aqueous cinnamon extract (ACE-c) from the bark of Cinnamomum cassia causes apoptosis in human cervical cancer cell line (SiHa) through loss of mitochondrial membrane potential. BMC Cancer (2010) 1.16
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A ginseng-derived oestrogen receptor beta (ERbeta) agonist, Rb1 ginsenoside, attenuates capillary morphogenesis. Br J Pharmacol (2007) 0.86
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Serum oestrogen receptor alpha and beta bioactivity are independently associated with breast cancer: a proof of principle study. Br J Cancer (2009) 0.84
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Estrogen receptor beta-selective agonists stimulate calcium oscillations in human and mouse embryonic stem cell-derived neurons. PLoS One (2010) 0.82
In vitro chronic administration of ERbeta selective ligands and prostate cancer cell growth: hypotheses on the selective role of 3beta-adiol in AR-positive RV1 cells. Biomed Res Int (2014) 0.80
Estrogenic plant extracts reverse weight gain and fat accumulation without causing mammary gland or uterine proliferation. PLoS One (2011) 0.80
Possible antiosteoporotic mechanism of Cicer arietinum extract in ovariectomized rats. Int J Clin Exp Pathol (2015) 0.77
Cyclopia extracts act as ERα antagonists and ERβ agonists, in vitro and in vivo. PLoS One (2013) 0.76
Estrogen Receptor β in Melanoma: From Molecular Insights to Potential Clinical Utility. Front Endocrinol (Lausanne) (2016) 0.75
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Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science (2009) 13.87
Propagation of tau misfolding from the outside to the inside of a cell. J Biol Chem (2009) 5.76
Prion-like mechanisms in neurodegenerative diseases. Nat Rev Neurosci (2009) 3.68
Anti-androgens and androgen-depleting therapies in prostate cancer: new agents for an established target. Lancet Oncol (2009) 3.13
Rapid signaling of estrogen in hypothalamic neurons involves a novel G-protein-coupled estrogen receptor that activates protein kinase C. J Neurosci (2003) 2.73
Estrogen receptor beta inhibits human breast cancer cell proliferation and tumor formation by causing a G2 cell cycle arrest. Cancer Res (2004) 2.67
Trans-cellular propagation of Tau aggregation by fibrillar species. J Biol Chem (2012) 2.42
A G-protein-coupled estrogen receptor is involved in hypothalamic control of energy homeostasis. J Neurosci (2006) 2.40
Conformational diversity of wild-type Tau fibrils specified by templated conformation change. J Biol Chem (2008) 2.34
Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion. J Clin Invest (2007) 2.20
Alternate surfaces of transcriptional coregulator GRIP1 function in different glucocorticoid receptor activation and repression contexts. Proc Natl Acad Sci U S A (2002) 2.12
In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice. J Neurosci (2011) 2.00
Role of p63 and basal cells in the prostate. Development (2004) 2.00
Polyglutamine diseases: emerging concepts in pathogenesis and therapy. Hum Mol Genet (2007) 1.95
Thyronamines inhibit plasma membrane and vesicular monoamine transport. ACS Chem Biol (2007) 1.91
The structural basis of androgen receptor activation: intramolecular and intermolecular amino-carboxy interactions. Proc Natl Acad Sci U S A (2005) 1.89
Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds. Proc Natl Acad Sci U S A (2013) 1.88
Rapid nongenomic actions of thyroid hormone. Proc Natl Acad Sci U S A (2006) 1.79
Polybrominated diphenyl ethers induce developmental neurotoxicity in a human in vitro model: evidence for endocrine disruption. Environ Health Perspect (2010) 1.75
Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta. Mol Biol Cell (2003) 1.70
MF101, a selective estrogen receptor beta modulator for the treatment of menopausal hot flushes: a phase II clinical trial. Menopause (2009) 1.63
Distinct roles of unliganded and liganded estrogen receptors in transcriptional repression. Mol Cell (2006) 1.63
Phosphorylation of C/EBPalpha inhibits granulopoiesis. Mol Cell Biol (2004) 1.61
Differential expression of p63 isoforms in female reproductive organs. Mech Dev (2005) 1.55
Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice. Proc Natl Acad Sci U S A (2005) 1.52
Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues. J Med Chem (2006) 1.52
Amphioxus postembryonic development reveals the homology of chordate metamorphosis. Curr Biol (2008) 1.51
Mechanisms of protein seeding in neurodegenerative diseases. JAMA Neurol (2013) 1.51
In vivo activity of the thyroid hormone receptor beta- and α-selective agonists GC-24 and CO23 on rat liver, heart, and brain. Endocrinology (2011) 1.50
Interaction with polyglutamine aggregates reveals a Q/N-rich domain in TDP-43. J Biol Chem (2010) 1.47
A rapid cellular FRET assay of polyglutamine aggregation identifies a novel inhibitor. Neuron (2003) 1.45
Effects of the thyroid hormone receptor agonist GC-1 on metabolic rate and cholesterol in rats and primates: selective actions relative to 3,5,3'-triiodo-L-thyronine. Endocrinology (2003) 1.42
Soluble androgen receptor oligomers underlie pathology in a mouse model of spinobulbar muscular atrophy. J Biol Chem (2006) 1.41
Stimulating the GPR30 estrogen receptor with a novel tamoxifen analogue activates SF-1 and promotes endometrial cell proliferation. Cancer Res (2009) 1.39
Non-competitive androgen receptor inhibition in vitro and in vivo. Proc Natl Acad Sci U S A (2009) 1.37
Phosphorylation of profilin by ROCK1 regulates polyglutamine aggregation. Mol Cell Biol (2008) 1.35
Novel arylpyrazole compounds selectively modulate glucocorticoid receptor regulatory activity. Genes Dev (2006) 1.34
Cardiac effects of 3-iodothyronamine: a new aminergic system modulating cardiac function. FASEB J (2007) 1.34
In vitro anticancer activity of twelve Chinese medicinal herbs. Phytother Res (2005) 1.32
Targeted expression of a dominant-negative fibroblast growth factor (FGF) receptor in gonadotropin-releasing hormone (GnRH) neurons reduces FGF responsiveness and the size of GnRH neuronal population. Mol Endocrinol (2004) 1.30
Liquiritigenin is a plant-derived highly selective estrogen receptor beta agonist. Mol Cell Endocrinol (2007) 1.30
Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment. J Med Chem (2002) 1.28
Selective estrogen receptor-beta agonists repress transcription of proinflammatory genes. J Immunol (2008) 1.26
Rationalizing the development of live attenuated virus vaccines. Nat Biotechnol (2010) 1.26
Frequency and severity of hot flashes and sleep disturbance in postmenopausal women with hot flashes. Menopause (2009) 1.23
Novel thyroxine derivatives, thyronamine and 3-iodothyronamine, induce transient hypothermia and marked neuroprotection against stroke injury. Stroke (2007) 1.23
Imaging molecular interactions in living cells. Mol Endocrinol (2005) 1.23
Tissue distribution and cardiac metabolism of 3-iodothyronamine. Endocrinology (2010) 1.22
Estrogen receptor beta binds to and regulates three distinct classes of target genes. J Biol Chem (2010) 1.21
Functional sequestration of transcription factor activity by repetitive DNA. J Biol Chem (2007) 1.19
Traditional Chinese medicine in the treatment of breast cancer. Semin Oncol (2002) 1.19
Ligand selectivity by seeking hydrophobicity in thyroid hormone receptor. Proc Natl Acad Sci U S A (2003) 1.17
Y-27632 improves rotarod performance and reduces huntingtin levels in R6/2 mice. Neurobiol Dis (2009) 1.16
Toward deciphering the code to aminergic G protein-coupled receptor drug design. Chem Biol (2008) 1.16
Biologically active molecules that reduce polyglutamine aggregation and toxicity. Hum Mol Genet (2006) 1.14
Regulation of specific target genes and biological responses by estrogen receptor subtype agonists. Curr Opin Pharmacol (2010) 1.12
Fibronectin- and protein kinase C-mediated activation of ERK/MAPK are essential for proplateletlike formation. Blood (2002) 1.11
Thyroid hormone receptor beta-specific agonist GC-1 increases energy expenditure and prevents fat-mass accumulation in rats. J Endocrinol (2007) 1.08
Quantitative proteomics of the thyroid hormone receptor-coregulator interactions. J Biol Chem (2004) 1.06
A PIT-1 homeodomain mutant blocks the intranuclear recruitment of the CCAAT/enhancer binding protein alpha required for prolactin gene transcription. Mol Endocrinol (2003) 1.06
A thyroid hormone antagonist that inhibits thyroid hormone action in vivo. J Biol Chem (2002) 1.05
Thyroid hormone receptor subtype specificity for hormone-dependent neurogenesis in Xenopus laevis. Dev Biol (2008) 1.05
Development of a validated liquid chromatography/tandem mass spectrometry method for the distinction of thyronine and thyronamine constitutional isomers and for the identification of new deiodinase substrates. Rapid Commun Mass Spectrom (2008) 1.05
Estrogens activate bone morphogenetic protein-2 gene transcription in mouse mesenchymal stem cells. Mol Endocrinol (2003) 1.04
Cardiac effects of trace amines: pharmacological characterization of trace amine-associated receptors. Eur J Pharmacol (2008) 1.04
Contribution of a membrane estrogen receptor to the estrogenic regulation of body temperature and energy homeostasis. Endocrinology (2010) 1.04
Differential effects of triiodothyronine and the thyroid hormone receptor beta-specific agonist GC-1 on thyroid hormone target genes in the b ain. Endocrinology (2003) 1.04
Polychlorinated biphenyls disturb differentiation of normal human neural progenitor cells: clue for involvement of thyroid hormone receptors. Environ Health Perspect (2005) 1.04
Exploring the structure-activity relationship of the ethylamine portion of 3-iodothyronamine for rat and mouse trace amine-associated receptor 1. J Med Chem (2007) 1.03
Synthesis and biological evaluation of SERMs with potent nongenomic estrogenic activity. ChemMedChem (2006) 1.03
A cellular conformation-based screen for androgen receptor inhibitors. ACS Chem Biol (2008) 1.03
A phase 1B dose escalation trial of Scutellaria barbata (BZL101) for patients with metastatic breast cancer. Breast Cancer Res Treat (2010) 1.03
Normal thermoregulatory responses to 3-iodothyronamine, trace amines and amphetamine-like psychostimulants in trace amine associated receptor 1 knockout mice. J Neurosci Res (2010) 1.03
Estrogen receptor β causes a G2 cell cycle arrest by inhibiting CDK1 activity through the regulation of cyclin B1, GADD45A, and BTG2. Breast Cancer Res Treat (2010) 1.02
A palmitoylation cycle dynamically regulates partitioning of the GABA-synthesizing enzyme GAD65 between ER-Golgi and post-Golgi membranes. J Cell Sci (2008) 1.02
Phase I trial and antitumor effects of BZL101 for patients with advanced breast cancer. Breast Cancer Res Treat (2006) 1.02
Reduction of MTT by aqueous herbal extracts in the absence of cells. J Ethnopharmacol (2004) 1.01
Cellular mechanisms of protein aggregate propagation. Curr Opin Neurol (2012) 1.01
Design and characterization of a thyroid hormone receptor alpha (TRalpha)-specific agonist. ACS Chem Biol (2006) 1.01
Timosaponin AIII is preferentially cytotoxic to tumor cells through inhibition of mTOR and induction of ER stress. PLoS One (2009) 1.01
Littoral cell angioma of the spleen: appearance on sonography and CT. J Clin Ultrasound (2002) 1.01
Tumor necrosis factor-alpha down-regulates human Cu/Zn superoxide dismutase 1 promoter via JNK/AP-1 signaling pathway. Free Radic Biol Med (2006) 1.00
Fluorescent protein tools for studying protein dynamics in living cells: a review. J Biomed Opt (2008) 1.00
Effects of parabens on adipocyte differentiation. Toxicol Sci (2012) 0.99