Published in Nat Genet on October 28, 2012
Biological insights from 108 schizophrenia-associated genetic loci. Nature (2014) 16.13
A global reference for human genetic variation. Nature (2015) 12.85
Genetic studies of body mass index yield new insights for obesity biology. Nature (2015) 8.27
Genetic and epigenetic fine mapping of causal autoimmune disease variants. Nature (2014) 5.22
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet (2013) 4.62
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13
New genetic loci link adipose and insulin biology to body fat distribution. Nature (2015) 3.38
Genetic insights into common pathways and complex relationships among immune-mediated diseases. Nat Rev Genet (2013) 2.85
Joint analysis of functional genomic data and genome-wide association studies of 18 human traits. Am J Hum Genet (2014) 2.55
Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases. Am J Hum Genet (2014) 2.53
Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers. Nat Genet (2015) 2.04
Integrating functional data to prioritize causal variants in statistical fine-mapping studies. PLoS Genet (2014) 1.91
Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis. Nat Commun (2015) 1.70
Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration. Nat Genet (2015) 1.66
Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus. Nat Genet (2016) 1.56
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. Nat Genet (2015) 1.55
Quantifying missing heritability at known GWAS loci. PLoS Genet (2013) 1.55
The genetic architecture of type 2 diabetes. Nature (2016) 1.43
Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus. Nat Genet (2015) 1.42
Improved imputation quality of low-frequency and rare variants in European samples using the 'Genome of The Netherlands'. Eur J Hum Genet (2014) 1.41
Identifying causal variants at loci with multiple signals of association. Genetics (2014) 1.41
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Nat Genet (2015) 1.39
Association between a common immunoglobulin heavy chain allele and rheumatic heart disease risk in Oceania. Nat Commun (2017) 1.38
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation. Nat Genet (2015) 1.28
Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters. Cell (2016) 1.20
Whole-genome analyses of whole-brain data: working within an expanded search space. Nat Neurosci (2014) 1.13
Disentangling the Effects of Colocalizing Genomic Annotations to Functionally Prioritize Non-coding Variants within Complex-Trait Loci. Am J Hum Genet (2015) 1.13
High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry. Nat Genet (2016) 1.09
Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nat Genet (2016) 1.08
Fine Mapping Causal Variants with an Approximate Bayesian Method Using Marginal Test Statistics. Genetics (2015) 1.07
Genetic susceptibility to type 2 diabetes and obesity: follow-up of findings from genome-wide association studies. Int J Endocrinol (2014) 1.04
Leveraging Functional-Annotation Data in Trans-ethnic Fine-Mapping Studies. Am J Hum Genet (2015) 1.03
A novel locus of resistance to severe malaria in a region of ancient balancing selection. Nature (2015) 1.03
Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. Nat Genet (2015) 1.02
FINEMAP: efficient variable selection using summary data from genome-wide association studies. Bioinformatics (2016) 0.97
Genetic basis of autoimmunity. J Clin Invest (2015) 0.96
GWAS in autoimmune thyroid disease: redefining our understanding of pathogenesis. Nat Rev Endocrinol (2013) 0.96
Revisiting the thrifty gene hypothesis via 65 loci associated with susceptibility to type 2 diabetes. Am J Hum Genet (2014) 0.96
Identification of causal genes for complex traits. Bioinformatics (2015) 0.94
Applying compressed sensing to genome-wide association studies. Gigascience (2014) 0.94
Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture. Am J Hum Genet (2015) 0.91
Trans-ethnic study design approaches for fine-mapping. Eur J Hum Genet (2016) 0.89
A refined study of FCRL genes from a genome-wide association study for Graves' disease. PLoS One (2013) 0.89
The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share. Hum Mol Genet (2014) 0.88
Strategies for fine-mapping complex traits. Hum Mol Genet (2015) 0.88
Genome-wide associations for birth weight and correlations with adult disease. Nature (2016) 0.87
Joint Bayesian inference of risk variants and tissue-specific epigenomic enrichments across multiple complex human diseases. Nucleic Acids Res (2016) 0.86
Integration of multiethnic fine-mapping and genomic annotation to prioritize candidate functional SNPs at prostate cancer susceptibility regions. Hum Mol Genet (2015) 0.85
Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping. PLoS Genet (2015) 0.85
The type 2 diabetes presumed causal variant within TCF7L2 resides in an element that controls the expression of ACSL5. Diabetologia (2016) 0.85
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease. Nat Genet (2017) 0.85
Fine mapping of genetic susceptibility loci for melanoma reveals a mixture of single variant and multiple variant regions. Int J Cancer (2014) 0.84
Genetics of obesity and type 2 diabetes in African Americans. J Obes (2013) 0.83
Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps. Nat Genet (2016) 0.82
Lupus Risk Variant Increases pSTAT1 Binding and Decreases ETS1 Expression. Am J Hum Genet (2015) 0.82
Rare variants at 16p11.2 are associated with common variable immunodeficiency. J Allergy Clin Immunol (2015) 0.82
Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation. PLoS Genet (2015) 0.82
Genetic variation in MHC proteins is associated with T cell receptor expression biases. Nat Genet (2016) 0.82
Type 2 diabetes: genetic data sharing to advance complex disease research. Nat Rev Genet (2016) 0.82
Colocalization of GWAS and eQTL Signals Detects Target Genes. Am J Hum Genet (2016) 0.81
Imputation of Orofacial Clefting Data Identifies Novel Risk Loci and Sheds Light on the Genetic Background of Cleft Lip ± Cleft Palate and Cleft Palate Only. Hum Mol Genet (2017) 0.81
Fine mapping of type 2 diabetes susceptibility loci. Curr Diab Rep (2014) 0.81
Evaluating the Performance of Fine-Mapping Strategies at Common Variant GWAS Loci. PLoS Genet (2015) 0.81
Generation of primary human intestinal T cell transcriptomes reveals differential expression at genetic risk loci for immune-mediated disease. Gut (2014) 0.81
Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms. Hum Mol Genet (2016) 0.81
Characterization of the transcriptional machinery bound across the widely presumed type 2 diabetes causal variant, rs7903146, within TCF7L2. Eur J Hum Genet (2014) 0.80
Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms. Proc Natl Acad Sci U S A (2016) 0.80
Bayesian Polynomial Regression Models to Fit Multiple Genetic Models for Quantitative Traits. Bayesian Anal (2015) 0.80
Association of BTG2, CYR61, ZFP36, and SCD gene polymorphisms with Graves' disease and ophthalmopathy. Thyroid (2014) 0.80
Lupus risk variants in the PXK locus alter B-cell receptor internalization. Front Genet (2015) 0.80
Dissecting the genetics of complex traits using summary association statistics. Nat Rev Genet (2016) 0.80
Fine-mapping inflammatory bowel disease loci to single-variant resolution. Nature (2017) 0.79
Progress in genetic association studies of plasma lipids. Curr Opin Lipidol (2013) 0.79
Efficient Integrative Multi-SNP Association Analysis via Deterministic Approximation of Posteriors. Am J Hum Genet (2016) 0.78
Polymorphism in a lincRNA Associates with a Doubled Risk of Pneumococcal Bacteremia in Kenyan Children. Am J Hum Genet (2016) 0.78
Incorporating Functional Genomic Information in Genetic Association Studies Using an Empirical Bayes Approach. Genet Epidemiol (2016) 0.78
Common and rare forms of diabetes mellitus: towards a continuum of diabetes subtypes. Nat Rev Endocrinol (2016) 0.78
Redundant enhancers and causal variants in the TCF7L2 gene. Eur J Hum Genet (2014) 0.78
An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans. Diabetes (2017) 0.78
JAM: A Scalable Bayesian Framework for Joint Analysis of Marginal SNP Effects. Genet Epidemiol (2016) 0.77
Novel bayes factors that capture expert uncertainty in prior density specification in genetic association studies. Genet Epidemiol (2015) 0.77
From GWAS to function: lessons from blood cells. ISBT Sci Ser (2015) 0.77
Mechanisms of Type 2 Diabetes Risk Loci. Curr Diab Rep (2017) 0.76
Genetics of coronary artery disease: discovery, biology and clinical translation. Nat Rev Genet (2017) 0.76
A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci. Nat Genet (2017) 0.75
Improved methods for multi-trait fine mapping of pleiotropic risk loci. Bioinformatics (2016) 0.75
Using GWAS to identify novel therapeutic targets for osteoporosis. Transl Res (2016) 0.75
Trans-ethnic Fine Mapping Highlights Kidney-Function Genes Linked to Salt Sensitivity. Am J Hum Genet (2016) 0.75
Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin. Am J Hum Genet (2016) 0.75
Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis. Am J Hum Genet (2016) 0.75
Reflections on the Field of Human Genetics: A Call for Increased Disease Genetics Theory. Front Genet (2016) 0.75
Deep targeted sequencing of 12 breast cancer susceptibility regions in 4611 women across four different ethnicities. Breast Cancer Res (2016) 0.75
Sexual Dimorphisms in Genetic Loci Linked to Body Fat Distribution. Biosci Rep (2017) 0.75
The Decay of Disease Association with Declining Linkage Disequilibrium: A Fine Mapping Theorem. Front Genet (2016) 0.75
Integrated Post-GWAS Analysis Sheds New Light on the Disease Mechanisms of Schizophrenia. Genetics (2016) 0.75
Multiethnic genome-wide association study identifies ethnic-specific associations with body mass index in Hispanics and African Americans. BMC Genet (2016) 0.75
Fine-mapping, novel loci identification, and SNP association transferability in a genome-wide association study of QRS duration in African Americans. Hum Mol Genet (2016) 0.75
Recombinant Haplotypes Narrow the ARMS2/HTRA1 Association Signal for Age-Related Macular Degeneration. Genetics (2016) 0.75
A novel TCF7L2 type 2 diabetes SNP identified from fine mapping in African American women. PLoS One (2017) 0.75
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet (2007) 12.62
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09
A genotype calling algorithm for the Illumina BeadArray platform. Bioinformatics (2007) 8.03
Patterns of cis regulatory variation in diverse human populations. PLoS Genet (2012) 5.28
Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource. Nat Genet (2009) 3.59
Thirty-five common variants for coronary artery disease: the fruits of much collaborative labour. Hum Mol Genet (2011) 2.21
Mixed results with modulation of TH-17 cells in human autoimmune diseases. Nat Immunol (2009) 1.73
A map of human genome variation from population-scale sequencing. Nature (2010) 121.13
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Finding the missing heritability of complex diseases. Nature (2009) 67.95
Mutations of the BRAF gene in human cancer. Nature (2002) 65.42
An integrated map of genetic variation from 1,092 human genomes. Nature (2012) 59.82
A new multipoint method for genome-wide association studies by imputation of genotypes. Nat Genet (2007) 52.68
Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing. Nat Genet (2008) 43.63
Patterns of somatic mutation in human cancer genomes. Nature (2007) 38.41
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
A census of human cancer genes. Nat Rev Cancer (2004) 36.20
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science (2007) 32.97
Integrating common and rare genetic variation in diverse human populations. Nature (2010) 32.30
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genet (2009) 30.09
Genome-wide association study identifies novel breast cancer susceptibility loci. Nature (2007) 29.23
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
A fine-scale map of recombination rates and hotspots across the human genome. Science (2005) 26.82
A comparison of bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet (2003) 26.59
The variant call format and VCFtools. Bioinformatics (2011) 25.88
COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer. Nucleic Acids Res (2010) 25.55
Population structure, differential bias and genomic control in a large-scale, case-control association study. Nat Genet (2005) 25.34
Genomewide association analysis of coronary artery disease. N Engl J Med (2007) 24.38
A comprehensive catalogue of somatic mutations from a human cancer genome. Nature (2009) 24.27
Relative impact of nucleotide and copy number variation on gene expression phenotypes. Science (2007) 23.38
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
A genome-wide association study of global gene expression. Nat Genet (2007) 22.98
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Signatures of mutational processes in human cancer. Nature (2013) 21.63
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
International network of cancer genome projects. Nature (2010) 20.35
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Integrated detection and population-genetic analysis of SNPs and copy number variation. Nat Genet (2008) 19.55
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet (2007) 19.04
A small-cell lung cancer genome with complex signatures of tobacco exposure. Nature (2009) 18.39
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet (2010) 17.38
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
Genome-wide associations of gene expression variation in humans. PLoS Genet (2005) 17.27
Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med (2007) 17.06
The fine-scale structure of recombination rate variation in the human genome. Science (2004) 17.05
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Genome-wide association analysis identifies 20 loci that influence adult height. Nat Genet (2008) 16.92
Massive genomic rearrangement acquired in a single catastrophic event during cancer development. Cell (2011) 16.72
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet (2009) 16.53
Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science (2009) 16.35
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature (2012) 16.13
Replicating genotype-phenotype associations. Nature (2007) 16.11
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94