Published in Int J Cancer on February 01, 2007
Clusterin, a haploinsufficient tumor suppressor gene in neuroblastomas. J Natl Cancer Inst (2009) 1.19
Intracellular clusterin inhibits mitochondrial apoptosis by suppressing p53-activating stress signals and stabilizing the cytosolic Ku70-Bax protein complex. Clin Cancer Res (2009) 1.16
Inhibition of ABCB1 (MDR1) expression by an siRNA nanoparticulate delivery system to overcome drug resistance in osteosarcoma. PLoS One (2010) 1.16
Clusterin and chemoresistance. Adv Cancer Res (2009) 1.14
Doxorubicin loaded Polymeric Nanoparticulate Delivery System to overcome drug resistance in osteosarcoma. BMC Cancer (2009) 1.05
Insulin-like growth factor-I receptor tyrosine kinase inhibitor cyclolignan picropodophyllin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines. Mol Cancer Ther (2009) 1.04
The kinase Mirk is a potential therapeutic target in osteosarcoma. Carcinogenesis (2009) 1.01
Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway. BMC Cancer (2010) 1.00
Induction of clusterin by AKT--role in cytoprotection against docetaxel in prostate tumor cells. Mol Cancer Ther (2010) 1.00
NSC23925, identified in a high-throughput cell-based screen, reverses multidrug resistance. PLoS One (2009) 0.93
Clusterin is a potential molecular predictor for ovarian cancer patient's survival: targeting clusterin improves response to paclitaxel. J Exp Clin Cancer Res (2011) 0.91
Histone deacetylase inhibitor PCI-24781 enhances chemotherapy-induced apoptosis in multidrug-resistant sarcoma cell lines. Anticancer Res (2011) 0.88
Clusterin confers gemcitabine resistance in pancreatic cancer. World J Surg Oncol (2011) 0.88
Farnesyl diphosphate synthase is involved in the resistance to zoledronic acid of osteosarcoma cells. J Cell Mol Med (2008) 0.86
Identification of host-immune response protein candidates in the sera of human oral squamous cell carcinoma patients. PLoS One (2014) 0.84
Secreted clusterin (sCLU) regulates cell proliferation and chemosensitivity to cisplatin by modulating ERK1/2 signals in human osteosarcoma cells. World J Surg Oncol (2014) 0.80
Therapeutic targeting of myeloid-derived suppressor cells involves a novel mechanism mediated by clusterin. Sci Rep (2016) 0.80
Development of reverse phase protein microarrays for the validation of clusterin, a mid-abundant blood biomarker. Proteome Sci (2009) 0.79
HMGB1 induction of clusterin creates a chemoresistant niche in human prostate tumor cells. Sci Rep (2015) 0.78
A-770041 reverses paclitaxel and doxorubicin resistance in osteosarcoma cells. BMC Cancer (2014) 0.78
p53 overexpression increases chemosensitivity in multidrug-resistant osteosarcoma cell lines. Cancer Chemother Pharmacol (2015) 0.78
Clusterin inhibition using OGX-011 synergistically enhances zoledronic acid activity in osteosarcoma. Oncotarget (2014) 0.77
NVP-TAE684 reverses multidrug resistance (MDR) in human osteosarcoma by inhibiting P-glycoprotein (PGP1) function. Br J Pharmacol (2016) 0.77
Combining GRP78 suppression and MK2206-induced Akt inhibition decreases doxorubicin-induced P-glycoprotein expression and mitigates chemoresistance in human osteosarcoma. Oncotarget (2016) 0.76
miR-15b modulates multidrug resistance in human osteosarcoma in vitro and in vivo. Mol Oncol (2016) 0.75
Lentivirus-mediated shRNA interference of clusterin blocks proliferation, motility, invasion and cell cycle in the ovarian cancer cells. J Ovarian Res (2015) 0.75
Clusterin/Akt Up-Regulation Is Critical for GATA-4 Mediated Cytoprotection of Mesenchymal Stem Cells against Ischemia Injury. PLoS One (2016) 0.75
Transcription factor NF‑YA promotes a malignant phenotype by upregulating fatty acid synthase expression. Mol Med Rep (2016) 0.75
Clusterin/apolipoprotein J in human aging and cancer. Int J Biochem Cell Biol (2002) 1.70
The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific. Aging Cell (2013) 1.56
Central role of the proteasome in senescence and survival of human fibroblasts: induction of a senescence-like phenotype upon its inhibition and resistance to stress upon its activation. J Biol Chem (2003) 1.51
Overexpression of proteasome beta5 assembled subunit increases the amount of proteasome and confers ameliorated response to oxidative stress and higher survival rates. J Biol Chem (2005) 1.43
Regulation of clusterin/apolipoprotein J, a functional homologue to the small heat shock proteins, by oxidative stress in ageing and age-related diseases. Free Radic Res (2006) 1.40
Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response. Aging Cell (2012) 1.35
Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study. Aging Cell (2013) 1.33
The genetics of human longevity. Ann N Y Acad Sci (2006) 1.30
Proteasome dysfunction in mammalian aging: steps and factors involved. Exp Gerontol (2005) 1.27
Advances and challenges in basic and translational research on clusterin. Cancer Res (2009) 1.20
Intracellular clusterin inhibits mitochondrial apoptosis by suppressing p53-activating stress signals and stabilizing the cytosolic Ku70-Bax protein complex. Clin Cancer Res (2009) 1.16
Nuclear erythroid factor 2-mediated proteasome activation delays senescence in human fibroblasts. J Biol Chem (2010) 1.16
Serum levels of the senescence biomarker clusterin/apolipoprotein J increase significantly in diabetes type II and during development of coronary heart disease or at myocardial infarction. Exp Gerontol (2002) 1.09
Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins. J Cell Biol (2011) 1.04
What evidence is there for the existence of individual genes with antagonistic pleiotropic effects? Mech Ageing Dev (2005) 1.03
Differential effects of clusterin/apolipoprotein J on cellular growth and survival. Free Radic Biol Med (2005) 1.01
The olive constituent oleuropein exhibits proteasome stimulatory properties in vitro and confers life span extension of human embryonic fibroblasts. Rejuvenation Res (2007) 1.01
Glucocorticoid receptor isoforms in human hepatocarcinoma HepG2 and SaOS-2 osteosarcoma cells: presence of glucocorticoid receptor alpha in mitochondria and of glucocorticoid receptor beta in nucleoli. Int J Biochem Cell Biol (2005) 0.99
What studies on human longevity tell us about the risk for cancer in the oldest old: data and hypotheses on the genetics and immunology of centenarians. Exp Gerontol (2002) 0.97
Overexpression of apolipoprotein J in human fibroblasts protects against cytotoxicity and premature senescence induced by ethanol and tert-butylhydroperoxide. Cell Stress Chaperones (2002) 0.96
Identification of a candidate tumor-suppressor gene specifically activated during Ras-induced senescence. Exp Cell Res (2002) 0.95
Identification of differentially expressed proteins in senescent human embryonic fibroblasts. Mech Ageing Dev (2005) 0.95
Proteasome dysfunction in Drosophila signals to an Nrf2-dependent regulatory circuit aiming to restore proteostasis and prevent premature aging. Aging Cell (2013) 0.93
Proteasome inhibition induces a senescence-like phenotype in primary human fibroblasts cultures. Biogerontology (2004) 0.92
Natural compounds with anti-ageing activity. Nat Prod Rep (2013) 0.91
Anti-ageing and rejuvenating effects of quercetin. Exp Gerontol (2010) 0.91
Oxidative stress-mediated biomolecular damage and inflammation in tumorigenesis. In Vivo (2012) 0.90
Chapter 9: Oxidative stress in malignant progression: The role of Clusterin, a sensitive cellular biosensor of free radicals. Adv Cancer Res (2009) 0.89
Overexpression of hUMP1/POMP proteasome accessory protein enhances proteasome-mediated antioxidant defence. Exp Gerontol (2007) 0.89
Differential regulation of proteasome functionality in reproductive vs. somatic tissues of Drosophila during aging or oxidative stress. FASEB J (2013) 0.88
The proteasome is an integral part of solar ultraviolet a radiation-induced gene expression. J Biol Chem (2009) 0.87
Cloning of differentially expressed genes in skin fibroblasts from centenarians. Biogerontology (2004) 0.87
Protein degradation during aging: the lysosome-, the calpain- and the proteasome-dependent cellular proteolytic systems. Biogerontology (2002) 0.87
CHIP-dependent p53 regulation occurs specifically during cellular senescence. Free Radic Biol Med (2010) 0.87
Proteasome response to interferon-gamma is altered in senescent human fibroblasts. FEBS Lett (2006) 0.87
Comparative effects of hypoxia on normal and immortalized human diploid fibroblasts. Anticancer Res (2006) 0.86
Proteasome activation as a novel antiaging strategy. IUBMB Life (2008) 0.86
Functional analysis of clusterin/apolipoprotein J in cellular death induced by severe genotoxic stress. Ann N Y Acad Sci (2004) 0.85
Vanadium-induced apoptosis of HaCaT cells is mediated by c-fos and involves nuclear accumulation of clusterin. FEBS J (2009) 0.84
Proteasome function determines cellular homeostasis and the rate of aging. Adv Exp Med Biol (2010) 0.84
Increased expression levels of apolipoprotein J/clusterin during primary osteoarthritis. In Vivo (2011) 0.84
Apolipoprotein J/Clusterin is a novel structural component of human erythrocytes and a biomarker of cellular stress and senescence. PLoS One (2011) 0.83
Partial proteasome inhibition in human fibroblasts triggers accelerated M1 senescence or M2 crisis depending on p53 and Rb status. Aging Cell (2008) 0.83
CHIP E3 ligase regulates mammalian senescence by modulating the levels of oxidized proteins. Mech Ageing Dev (2011) 0.82
Exposure of human diploid fibroblasts to hypoxia extends proliferative life span. Ann N Y Acad Sci (2007) 0.82
Clusterin/Apolipoprotein J up-regulation after zinc exposure, replicative senescence or differentiation of human haematopoietic cells. Biogerontology (2006) 0.82
A novel mitochondrial DNA-like sequence insertion polymorphism in Intron I of the FOXO1A gene. Gene (2004) 0.82
Reduced expression levels of the senescence biomarker clusterin/apolipoprotein j in lymphocytes from healthy centenarians. Ann N Y Acad Sci (2006) 0.81
CRM1 protein-mediated regulation of nuclear clusterin (nCLU), an ionizing radiation-stimulated, Bax-dependent pro-death factor. J Biol Chem (2011) 0.81
Structure and function of the ubiquitin-proteasome system: modulation of components. Prog Mol Biol Transl Sci (2012) 0.80
Bcl-2 but not clusterin/apolipoprotein J protected human diploid fibroblasts and immortalized keratinocytes from ceramide-induced apoptosis: role of p53 in the ceramide response. Arch Biochem Biophys (2005) 0.80
Transcriptional and posttranslational regulation of clusterin by the two main cellular proteolytic pathways. Free Radic Biol Med (2009) 0.79
Biological monitoring of hexavalent chromium and serum levels of the senescence biomarker apolipoprotein J/Clusterin in welders. Bioinorg Chem Appl (2008) 0.79
Diet-derived advanced glycation end products or lipofuscin disrupts proteostasis and reduces life span in Drosophila melanogaster. Free Radic Biol Med (2013) 0.79
Crystalline yolk spheroids in Drosophila melanogaster oocyte: freeze fracture and two-dimensional reconstruction analysis. J Insect Physiol (2007) 0.79
Alterations of senescence biomarkers in human cells by exposure to CrVI in vivo and in vitro. Exp Gerontol (2004) 0.79
High-resolution quantitative metabolome analysis of urine by automated flow injection NMR. Anal Chem (2013) 0.78
Apolipoprotein J/clusterin in human erythrocytes is involved in the molecular process of defected material disposal during vesiculation. PLoS One (2011) 0.78
The 19S proteasome subunit Rpn7 stabilizes DNA damage foci upon genotoxic insult. IUBMB Life (2012) 0.78
Prothymosin α and a prothymosin α-derived peptide enhance T(H)1-type immune responses against defined HER-2/neu epitopes. BMC Immunol (2013) 0.78
Ectopic expression of clusterin/apolipoprotein J or Bcl-2 decreases the sensitivity of HaCaT cells to toxic effects of ropivacaine. Cell Res (2004) 0.78
Genome-wide transcriptome profile of the human osteosarcoma Sa OS and U-2 OS cell lines. Cancer Genet Cytogenet (2010) 0.77
Zinc, metallothioneins, and longevity--effect of zinc supplementation: zincage study. Ann N Y Acad Sci (2007) 0.77
Mediterranean diet and inflammaging in the elderly: the European project NU-AGE. Preface. Mech Ageing Dev (2014) 0.76
Design, synthesis and antiproliferative activity of novel aminosubstituted benzothiopyranoisoindoles. Bioorg Med Chem Lett (2011) 0.75
Structural and biochemical analysis of the Leptinotarsa decemlineata (Coleoptera; Chrysomeloidea) crystalline chorionic layer. J Insect Physiol (2003) 0.75
Cloning approaches for identifying aging and longevity-related genes in mammals. ScientificWorldJournal (2002) 0.75