Published in J Biol Chem on January 20, 2005
Enhancement of proteasome activity by a small-molecule inhibitor of USP14. Nature (2010) 5.08
Retracted Expression of concern: Heightened endoplasmic reticulum stress in the lungs of patients with chronic obstructive pulmonary disease: the role of Nrf2-regulated proteasomal activity. Am J Respir Crit Care Med (2009) 2.28
Ubiquitin/proteasome pathway impairment in neurodegeneration: therapeutic implications. Apoptosis (2010) 1.31
Dissecting beta-ring assembly pathway of the mammalian 20S proteasome. EMBO J (2008) 1.28
Aging and regulated protein degradation: who has the UPPer hand? Aging Cell (2007) 1.27
Changes in select redox proteins of the retinal pigment epithelium in age-related macular degeneration. Am J Ophthalmol (2007) 1.26
Protein aggregation and proteasome dysfunction after brain ischemia. Stroke (2007) 1.22
Aging and immune function: molecular mechanisms to interventions. Antioxid Redox Signal (2011) 1.18
Nuclear erythroid factor 2-mediated proteasome activation delays senescence in human fibroblasts. J Biol Chem (2010) 1.16
The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution. Front Mol Neurosci (2014) 1.10
Yeast toxicogenomics: genome-wide responses to chemical stresses with impact in environmental health, pharmacology, and biotechnology. Front Genet (2012) 1.02
Evidence for the Existence in Arabidopsis thaliana of the Proteasome Proteolytic Pathway: ACTIVATION IN RESPONSE TO CADMIUM. J Biol Chem (2009) 0.94
20S proteasome activation promotes life span extension and resistance to proteotoxicity in Caenorhabditis elegans. FASEB J (2014) 0.93
Regulation of acetylation restores proteolytic function of diseased myocardium in mouse and human. Mol Cell Proteomics (2013) 0.91
Oxidative stress adaptation with acute, chronic, and repeated stress. Free Radic Biol Med (2012) 0.91
The proteasome is an integral part of solar ultraviolet a radiation-induced gene expression. J Biol Chem (2009) 0.87
Redox regulation of the proteasome in T lymphocytes during aging. Free Radic Biol Med (2006) 0.87
Comparison of rat liver and brain proteasomes for oxidative stress-induced inactivation: Influence of ageing and dietary restriction. Free Radic Res (2009) 0.86
The casein kinase 2-nrf1 axis controls the clearance of ubiquitinated proteins by regulating proteasome gene expression. Mol Cell Biol (2013) 0.86
Lifespan of mice and primates correlates with immunoproteasome expression. J Clin Invest (2015) 0.86
Happily (n)ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence. Redox Biol (2016) 0.86
Cytoprotective effects of proteasome beta5 subunit overexpression in lens epithelial cells. Mol Vis (2007) 0.85
Proteasome modulates mitochondrial function during cellular senescence. Free Radic Biol Med (2007) 0.85
Proteasome nuclear import mediated by Arc3 can influence efficient DNA damage repair and mitosis in Schizosaccharomyces pombe. Mol Biol Cell (2010) 0.84
PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasis. Mol Cell Biol (2010) 0.82
A simple fluorescence labeling method for studies of protein oxidation, protein modification, and proteolysis. Free Radic Biol Med (2011) 0.81
Gene expression profiling of a Zn-tolerant and a Zn-sensitive Suillus luteus isolate exposed to increased external zinc concentrations. Mycorrhiza (2007) 0.80
The life cycle of the 26S proteasome: from birth, through regulation and function, and onto its death. Cell Res (2016) 0.80
Drug resistance in lung cancer. Lung Cancer (Auckl) (2010) 0.80
A novel role of proteasomal β1 subunit in tumorigenesis. Biosci Rep (2013) 0.79
18α-Glycyrrhetinic Acid Proteasome Activator Decelerates Aging and Alzheimer's Disease Progression in Caenorhabditis elegans and Neuronal Cultures. Antioxid Redox Signal (2016) 0.79
Proteasome inhibition modulates kinase activation in neural cells: relevance to ubiquitination, ribosomes, and survival. J Neurosci Res (2009) 0.78
Biomarkers of oxidative stress, antioxidant defence and inflammation are altered in the senescence-accelerated mouse prone 8. Age (Dordr) (2012) 0.78
Activation of PERK kinase in neural cells by proteasome inhibitor treatment. J Neurochem (2009) 0.78
Induction of autophagy in rats upon overexpression of wild-type and mutant optineurin gene. BMC Cell Biol (2015) 0.78
The over-expression of the β2 catalytic subunit of the proteasome decreases homologous recombination and impairs DNA double-strand break repair in human cells. J Biomed Biotechnol (2011) 0.76
Ischaemia-induced protein ubiquitinylation is differentially accompanied with heat-shock protein 70 expression after naïve and preconditioned ischaemia. Cell Mol Neurobiol (2011) 0.76
Assembly mechanisms of specialized core particles of the proteasome. Biomolecules (2014) 0.76
The proteasome activity reporter GFP-Cl1 is degraded by autophagy in the aging model Podospora anserina. F1000Res (2014) 0.75
Reversion of the Arabidopsis rpn12a-1 exon-trap mutation by an intragenic suppressor that weakens the chimeric 5' splice site. F1000Res (2013) 0.75
Higher expression of somatic repair genes in long-lived ant queens than workers. Aging (Albany NY) (2016) 0.75
Establishment of a suite of assays that support the discovery of proteasome stimulators. Biochim Biophys Acta (2017) 0.75
Inhibition of cytoskeletal protein carbonylation may protect against oxidative damage in traumatic brain injury. Exp Ther Med (2016) 0.75
Agouti Related Peptide Secreted Via Human Mesenchymal Stem Cells Upregulates Proteasome Activity in an Alzheimer's Disease Model. Sci Rep (2017) 0.75
Proteostasis, oxidative stress and aging. Redox Biol (2017) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
ESCRTs and Fab1 regulate distinct steps of autophagy. Curr Biol (2007) 2.46
PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody. Nat Cell Biol (2010) 2.33
Changes in the proteolytic activities of proteasomes and lysosomes in human fibroblasts produced by serum withdrawal, amino-acid deprivation and confluent conditions. Biochem J (2003) 1.89
Clusterin/apolipoprotein J in human aging and cancer. Int J Biochem Cell Biol (2002) 1.70
The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific. Aging Cell (2013) 1.56
Central role of the proteasome in senescence and survival of human fibroblasts: induction of a senescence-like phenotype upon its inhibition and resistance to stress upon its activation. J Biol Chem (2003) 1.51
Comparative analysis of ESCRT-I, ESCRT-II and ESCRT-III function in Drosophila by efficient isolation of ESCRT mutants. J Cell Sci (2009) 1.42
Regulation of clusterin/apolipoprotein J, a functional homologue to the small heat shock proteins, by oxidative stress in ageing and age-related diseases. Free Radic Res (2006) 1.40
p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects. Autophagy (2011) 1.39
Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response. Aging Cell (2012) 1.35
Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study. Aging Cell (2013) 1.33
The genetics of human longevity. Ann N Y Acad Sci (2006) 1.30
Phosphorylation of 20S proteasome alpha subunit C8 (alpha7) stabilizes the 26S proteasome and plays a role in the regulation of proteasome complexes by gamma-interferon. Biochem J (2004) 1.30
Development of resistance to chemotherapeutic drugs in human osteosarcoma cell lines largely depends on up-regulation of Clusterin/Apolipoprotein J. Int J Cancer (2007) 1.27
Proteasome dysfunction in mammalian aging: steps and factors involved. Exp Gerontol (2005) 1.27
Advances and challenges in basic and translational research on clusterin. Cancer Res (2009) 1.20
Intracellular clusterin inhibits mitochondrial apoptosis by suppressing p53-activating stress signals and stabilizing the cytosolic Ku70-Bax protein complex. Clin Cancer Res (2009) 1.16
Nuclear erythroid factor 2-mediated proteasome activation delays senescence in human fibroblasts. J Biol Chem (2010) 1.16
Interaction of U-box E3 ligase SNEV with PSMB4, the beta7 subunit of the 20 S proteasome. Biochem J (2005) 1.14
Serum levels of the senescence biomarker clusterin/apolipoprotein J increase significantly in diabetes type II and during development of coronary heart disease or at myocardial infarction. Exp Gerontol (2002) 1.09
Structure and functions of stable intercellular bridges formed by incomplete cytokinesis during development. Commun Integr Biol (2011) 1.03
What evidence is there for the existence of individual genes with antagonistic pleiotropic effects? Mech Ageing Dev (2005) 1.03
Cindr interacts with anillin to control cytokinesis in Drosophila melanogaster. Curr Biol (2010) 1.02
The olive constituent oleuropein exhibits proteasome stimulatory properties in vitro and confers life span extension of human embryonic fibroblasts. Rejuvenation Res (2007) 1.01
Differential effects of clusterin/apolipoprotein J on cellular growth and survival. Free Radic Biol Med (2005) 1.01
What studies on human longevity tell us about the risk for cancer in the oldest old: data and hypotheses on the genetics and immunology of centenarians. Exp Gerontol (2002) 0.97
Overexpression of apolipoprotein J in human fibroblasts protects against cytotoxicity and premature senescence induced by ethanol and tert-butylhydroperoxide. Cell Stress Chaperones (2002) 0.96
Identification of a candidate tumor-suppressor gene specifically activated during Ras-induced senescence. Exp Cell Res (2002) 0.95
Identification of differentially expressed proteins in senescent human embryonic fibroblasts. Mech Ageing Dev (2005) 0.95
Mechanisms of programmed cell death during oogenesis in Drosophila virilis. Cell Tissue Res (2006) 0.94
Proteasome inhibition induces a senescence-like phenotype in primary human fibroblasts cultures. Biogerontology (2004) 0.92
Anti-ageing and rejuvenating effects of quercetin. Exp Gerontol (2010) 0.91
A structural model of 20S immunoproteasomes: effect of LMP2 codon 60 polymorphism on expression, activity, intracellular localisation and insight into the regulatory mechanisms. Biol Chem (2006) 0.91
Trypanocidal effect of alpha',beta'-epoxyketones indicates that trypanosomes are particularly sensitive to inhibitors of proteasome trypsin-like activity. Int J Antimicrob Agents (2004) 0.91
Autophagy and its physiological relevance in arthropods: current knowledge and perspectives. Autophagy (2010) 0.90
Apoptosis and autophagy function cooperatively for the efficacious execution of programmed nurse cell death during Drosophila virilis oogenesis. Autophagy (2007) 0.90
Chapter 9: Oxidative stress in malignant progression: The role of Clusterin, a sensitive cellular biosensor of free radicals. Adv Cancer Res (2009) 0.89
Mutant Escherichia coli heat-labile toxin B subunit that separates toxoid-mediated signaling and immunomodulatory action from trafficking and delivery functions. Infect Immun (2003) 0.89
The transcriptional repressor protein PRH interacts with the proteasome. Biochem J (2003) 0.89
Overexpression of hUMP1/POMP proteasome accessory protein enhances proteasome-mediated antioxidant defence. Exp Gerontol (2007) 0.89
Cell death induced by GSM 900-MHz and DCS 1800-MHz mobile telephony radiation. Mutat Res (2006) 0.89
Visualisation of liposomes prepared from skin and stratum corneum lipids by transmission electron microscopy. Micron (2007) 0.88
The proteasome is an integral part of solar ultraviolet a radiation-induced gene expression. J Biol Chem (2009) 0.87
Proteasome response to interferon-gamma is altered in senescent human fibroblasts. FEBS Lett (2006) 0.87
CHIP-dependent p53 regulation occurs specifically during cellular senescence. Free Radic Biol Med (2010) 0.87
Cloning of differentially expressed genes in skin fibroblasts from centenarians. Biogerontology (2004) 0.87
Protein degradation during aging: the lysosome-, the calpain- and the proteasome-dependent cellular proteolytic systems. Biogerontology (2002) 0.87
Comparative effects of hypoxia on normal and immortalized human diploid fibroblasts. Anticancer Res (2006) 0.86
Proteasome activation as a novel antiaging strategy. IUBMB Life (2008) 0.86
Assays of proteasome activity in relation to aging. Exp Gerontol (2002) 0.86
Enhanced delivery of exogenous peptides into the class I antigen processing and presentation pathway. Infect Immun (2002) 0.86
Functional analysis of clusterin/apolipoprotein J in cellular death induced by severe genotoxic stress. Ann N Y Acad Sci (2004) 0.85
Proteasome function determines cellular homeostasis and the rate of aging. Adv Exp Med Biol (2010) 0.84
Vanadium-induced apoptosis of HaCaT cells is mediated by c-fos and involves nuclear accumulation of clusterin. FEBS J (2009) 0.84
Partial proteasome inhibition in human fibroblasts triggers accelerated M1 senescence or M2 crisis depending on p53 and Rb status. Aging Cell (2008) 0.83
Treatment of COS-7 cells with proteasome inhibitors or gamma-interferon reduces the increase in caspase 3 activity associated with staurosporine-induced apoptosis. Arch Biochem Biophys (2002) 0.83
Programmed cell death of the ovarian nurse cells during oogenesis of the silkmoth Bombyx mori. Dev Growth Differ (2006) 0.83
A novel mitochondrial DNA-like sequence insertion polymorphism in Intron I of the FOXO1A gene. Gene (2004) 0.82
Exposure of human diploid fibroblasts to hypoxia extends proliferative life span. Ann N Y Acad Sci (2007) 0.82
CHIP E3 ligase regulates mammalian senescence by modulating the levels of oxidized proteins. Mech Ageing Dev (2011) 0.82
Clusterin/Apolipoprotein J up-regulation after zinc exposure, replicative senescence or differentiation of human haematopoietic cells. Biogerontology (2006) 0.82
A tumor-associated mutation of FYVE-CENT prevents its interaction with Beclin 1 and interferes with cytokinesis. PLoS One (2011) 0.82
CRM1 protein-mediated regulation of nuclear clusterin (nCLU), an ionizing radiation-stimulated, Bax-dependent pro-death factor. J Biol Chem (2011) 0.81
Reduced expression levels of the senescence biomarker clusterin/apolipoprotein j in lymphocytes from healthy centenarians. Ann N Y Acad Sci (2006) 0.81
Different modes of programmed cell death during oogenesis of the silkmoth Bombyx mori. Autophagy (2007) 0.81
Effective CD8(+) T cell priming and tumor protection by enterotoxin B subunit-conjugated peptides targeted to dendritic cells. Vaccine (2009) 0.80
Trafficking of exogenous peptides into proteasome-dependent major histocompatibility complex class I pathway following enterotoxin B subunit-mediated delivery. J Biol Chem (2004) 0.80
Structure and function of the ubiquitin-proteasome system: modulation of components. Prog Mol Biol Transl Sci (2012) 0.80
Bcl-2 but not clusterin/apolipoprotein J protected human diploid fibroblasts and immortalized keratinocytes from ceramide-induced apoptosis: role of p53 in the ceramide response. Arch Biochem Biophys (2005) 0.80
Transcriptional and posttranslational regulation of clusterin by the two main cellular proteolytic pathways. Free Radic Biol Med (2009) 0.79
Biological monitoring of hexavalent chromium and serum levels of the senescence biomarker apolipoprotein J/Clusterin in welders. Bioinorg Chem Appl (2008) 0.79
Alterations of senescence biomarkers in human cells by exposure to CrVI in vivo and in vitro. Exp Gerontol (2004) 0.79
Evaluation of the anti-trypanosomal activity of tyropeptin A. Planta Med (2006) 0.78
High-resolution quantitative metabolome analysis of urine by automated flow injection NMR. Anal Chem (2013) 0.78
The 19S proteasome subunit Rpn7 stabilizes DNA damage foci upon genotoxic insult. IUBMB Life (2012) 0.78
Ectopic expression of clusterin/apolipoprotein J or Bcl-2 decreases the sensitivity of HaCaT cells to toxic effects of ropivacaine. Cell Res (2004) 0.78
Stage-specific regulation of programmed cell death during oogenesis of the medfly Ceratitis capitata (Diptera, Tephritidae). Int J Dev Biol (2007) 0.78
Genome-wide transcriptome profile of the human osteosarcoma Sa OS and U-2 OS cell lines. Cancer Genet Cytogenet (2010) 0.77
Zinc, metallothioneins, and longevity--effect of zinc supplementation: zincage study. Ann N Y Acad Sci (2007) 0.77
Mediterranean diet and inflammaging in the elderly: the European project NU-AGE. Preface. Mech Ageing Dev (2014) 0.76
Cloning approaches for identifying aging and longevity-related genes in mammals. ScientificWorldJournal (2002) 0.75