Published in J Immunol on June 15, 1991
Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors. J Clin Invest (1998) 3.96
Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development. Proc Natl Acad Sci U S A (1994) 2.41
Regulation of inherently autoreactive VH4-34 B cells in the maintenance of human B cell tolerance. J Clin Invest (2001) 2.26
Human immunoglobulin selection associated with class switch and possible tolerogenic origins for C delta class-switched B cells. J Clin Invest (2004) 2.21
Human memory B cells originate from three distinct germinal center-dependent and -independent maturation pathways. Blood (2011) 2.15
Bruton's tyrosine kinase is essential for human B cell tolerance. J Exp Med (2004) 1.94
Clonal evolution of a follicular lymphoma: evidence for antigen selection. Proc Natl Acad Sci U S A (1992) 1.82
A somatically mutated human antiganglioside IgM antibody that induces experimental neuropathy in mice is encoded by the variable region heavy chain gene, V1-18. J Clin Invest (1996) 1.74
Naive antibody gene-segment frequencies are heritable and unaltered by chronic lymphocyte ablation. Proc Natl Acad Sci U S A (2011) 1.74
Activation-induced cytidine deaminase (AID) is required for B-cell tolerance in humans. Proc Natl Acad Sci U S A (2011) 1.44
Primary cold agglutinin-associated lymphoproliferative disease: a B-cell lymphoma of the bone marrow distinct from lymphoplasmacytic lymphoma. Haematologica (2013) 1.11
Antibody repertoires in humanized NOD-scid-IL2Rγ(null) mice and human B cells reveals human-like diversification and tolerance checkpoints in the mouse. PLoS One (2012) 1.09
Molecular characterization of a cross-reactive idiotope on human immunoglobulins utilizing the VH4-21 gene segment. J Exp Med (1993) 1.07
Characterization of the cDNA of a broadly reactive neutralizing human anti-gp120 monoclonal antibody. J Clin Invest (1992) 1.05
Revenge of the microbes. Superantigens of the T and B cell lineage. Am J Pathol (1994) 1.04
9G4 autoreactivity is increased in HIV-infected patients and correlates with HIV broadly neutralizing serum activity. PLoS One (2012) 1.02
Natural IgM: beneficial autoantibodies for the control of inflammatory and autoimmune disease. J Clin Immunol (2014) 1.01
Large-scale analysis of human heavy chain V(D)J recombination patterns. Immunome Res (2008) 1.00
Human innate B cells: a link between host defense and autoimmunity? Springer Semin Immunopathol (2005) 0.98
Two acquired immunodeficiency syndrome-associated Burkitt's lymphomas produce specific anti-i IgM cold agglutinins using somatically mutated VH4-21 segments. Blood (1994) 0.96
Function of B cells expressing a human immunoglobulin M rheumatoid factor autoantibody in transgenic mice. J Exp Med (1993) 0.93
Next generation sequencing reveals skewing of the T and B cell receptor repertoires in patients with wiskott-Aldrich syndrome. Front Immunol (2014) 0.92
Early Antibody Lineage Diversification and Independent Limb Maturation Lead to Broad HIV-1 Neutralization Targeting the Env High-Mannose Patch. Immunity (2016) 0.90
Fundamental roles of the innate-like repertoire of natural antibodies in immune homeostasis. Front Immunol (2013) 0.89
Lentiviral-mediated gene therapy restores B cell tolerance in Wiskott-Aldrich syndrome patients. J Clin Invest (2015) 0.88
Naturally occurring anti-i/I cold agglutinins may be encoded by different VH3 genes as well as the VH4.21 gene segment. J Clin Invest (1993) 0.88
Restricted use of fetal VH3 immunoglobulin genes by unselected B cells in the adult. Predominance of 56p1-like VH genes in common variable immunodeficiency. J Clin Invest (1992) 0.88
Biased use of the IGHV4 family and evidence for antigen selection in Chlamydophila psittaci-negative ocular adnexal extranodal marginal zone lymphomas. PLoS One (2011) 0.87
Clonal redemption of autoantibodies by somatic hypermutation away from self-reactivity during human immunization. J Exp Med (2016) 0.86
Exploiting human memory B cell heterogeneity for improved vaccine efficacy. Front Immunol (2011) 0.85
Autoantibody selection and production in early human life. J Clin Invest (2007) 0.84
Altered B cell signalling in autoimmunity. Nat Rev Immunol (2017) 0.80
Strategies for B-cell receptor repertoire analysis in primary immunodeficiencies: from severe combined immunodeficiency to common variable immunodeficiency. Front Immunol (2015) 0.79
Human monoclonal antibodies encoded by the V4-34 gene segment show cold agglutinin activity and variable multireactivity which correlates with the predicted charge of the heavy-chain variable region. Immunology (1998) 0.79
Human monoclonal rheumatoid factors: incidence of cross-reactions with tissue components and correlation with VH gene usage. Immunology (1994) 0.78
Monoclonal IgM from patients with peripheral demyelinating neuropathies cross-react with bacterial polypeptides. Clin Exp Immunol (1994) 0.78
Human B-1 and B-2 B Cells Develop from Lin-CD34+CD38lo Stem Cells. J Immunol (2016) 0.75
Germline-encoded neutralization of a Staphylococcus aureus virulence factor by the human antibody repertoire. Nat Commun (2016) 0.75
Ro52 autoantibodies arise from self-reactive progenitors in a mother of a child with neonatal lupus. J Autoimmun (2017) 0.75
Analysis of human antitopoisomerase-I idiotypes. J Clin Invest (1993) 0.75
Virginia Pascual, MD: a conversation with the editor. Proc (Bayl Univ Med Cent) (2008) 0.75
Self-reactive VH4-34-expressing IgG B cells recognize commensal bacteria. J Exp Med (2017) 0.75
Synergistic cooperation and crosstalk between MYD88(L265P) and mutations that dysregulate CD79B and surface IgM. J Exp Med (2017) 0.75
Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood (1999) 11.50
Cross-idiotypic specificity among monoclonal IgM proteins with anti- -globulin activity. J Exp Med (1973) 4.93
Analysis of somatic mutation in five B cell subsets of human tonsil. J Exp Med (1994) 4.52
Antigenic specificities related to the cold agglutinin activity of gamma M globulins. Science (1968) 4.32
Interaction of cell-type-specific nuclear proteins with immunoglobulin VH promoter region sequences. Nature (1986) 4.21
Automated amino acid sequence of small peptides utilizing Polybrene. Anal Biochem (1978) 3.48
Anti-keratin antibodies in rheumatoid arthritis. Br Med J (1979) 3.33
Neisseria gonorrhoeae and neisseria meningitidis: extracellular enzyme cleaves human immunoglobulin A. Science (1975) 3.27
HLA-DQ and T-cell receptor genes in insulin-dependent diabetes mellitus. Cold Spring Harb Symp Quant Biol (1986) 3.15
Human CD14 mediates recognition and phagocytosis of apoptotic cells. Nature (1998) 3.11
Initial characterization of monoclonal antibodies against human monocytes. Proc Natl Acad Sci U S A (1980) 2.61
B-cell chronic lymphocytic leukemia: a bird of a different feather. J Clin Oncol (1999) 2.60
Similarities in the light chains of anti-gamma-globulins showing cross-idiotypic specificities. J Exp Med (1974) 2.60
Chronic lymphocytic leukaemia. Lancet (2008) 2.59
Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes. J Exp Med (1998) 2.39
Small RNA regulators and the bacterial response to stress. Cold Spring Harb Symp Quant Biol (2006) 2.31
Aggregation of gamma-G3 proteins: relevance to the hyperviscosity syndrome. J Clin Invest (1970) 2.19
Organization of the immune response genes. Science (1979) 2.18
The smaller human VH gene families display remarkably little polymorphism. EMBO J (1989) 2.15
Subunit structure and N-terminal amino acid sequence of the three chains of cholera enterotoxin. Immunochemistry (1976) 2.14
The cost-effectiveness of air bags by seating position. JAMA (1997) 2.09
Fake. Br Med J (Clin Res Ed) (1982) 2.08
Euthanasia. BMJ (1992) 2.06
Hypervariable regions, idiotypy, and the antibody-combining site. Adv Immunol (1975) 1.99
A comparison of the haemagglutination-inhibition test and the neutralisation test for the detection of rubella antibody. Lancet (1967) 1.98
Glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase are differentially regulated in rats by dietary selenium. J Nutr (1995) 1.94
Establishing the incidence of myelodysplastic syndrome. Br J Haematol (1994) 1.92
Differential susceptibility of human IgA immunoglobulins to streptococcal IgA protease. J Clin Invest (1974) 1.91
Nucleotide sequences of eight human natural autoantibody VH regions reveals apparent restricted use of VH families. J Immunol (1989) 1.88
The amino acid sequence of ragweed pollen allergen Ra5. Biochemistry (1975) 1.85
Structure of antibodies with shared idiotypy: the complete sequence of the heavy chain variable regions of two immunoglobulin M anti-gamma globulins. Proc Natl Acad Sci U S A (1974) 1.84
Reliability of reports of violent victimization and posttraumatic stress disorder among men and women with serious mental illness. J Trauma Stress (1999) 1.84
DNA vaccines with single-chain Fv fused to fragment C of tetanus toxin induce protective immunity against lymphoma and myeloma. Nat Med (1998) 1.83
The protein products of the murine 17th chromosome: genetics and structure. Adv Immunol (1978) 1.76
Alpha and beta chains of SB and DR antigens are structurally distinct. J Exp Med (1982) 1.76
Analysis of HLA-DQ genotypes and susceptibility in insulin-dependent diabetes mellitus. N Engl J Med (1990) 1.74
Immunological reason for chronic ill health after infectious mononucleosis. Br Med J (Clin Res Ed) (1983) 1.74
Myeloma VL and VH gene sequences reveal a complementary imprint of antigen selection in tumor cells. Blood (1997) 1.73
Amino acid sequence of ragweed allergen Ra3. Biochemistry (1980) 1.71
Structure-function relationships among anti-gamma globulin antibodies. Ann N Y Acad Sci (1971) 1.71
Studies on the clonal origin of multiple myeloma. Use of individually specific (idiotype) antibodies to trace the oncogenic event to its earliest point of expression in B-cell differentiation. J Exp Med (1979) 1.70
Human immunoglobulin heavy-chain variable region genes: organization, polymorphism, and expression. Adv Immunol (1991) 1.68
The immunodeficiency of chronic lymphocytic leukaemia. Br Med Bull (2008) 1.66
Light chain sequences of human IgM cold agglutinins (variable-region subgroups amino-acid sequence-kappa light chain-N-terminal). Proc Natl Acad Sci U S A (1972) 1.64
Antibody to a molecularly-defined antigen confined to a tumour cell surface. Nature (1975) 1.61
Complete amino acid sequence of variable domains from two monoclonal human anti-gamma globulins of the Wa cross-idiotypic group: suggestion that the J segments are involved in the structural correlate of the idiotype. Proc Natl Acad Sci U S A (1981) 1.60
Receptor revision of immunoglobulin heavy chain variable region genes in normal human B lymphocytes. J Exp Med (2000) 1.59
Myelodysplastic syndromes: a scoring system with prognostic significance. Br J Haematol (1985) 1.57
Extracellular idiotypic immunoglobulin arising from human leukemic B lymphocytes. J Exp Med (1980) 1.57
Vaccination of women with the Cendehill strain of rubella virus. Practitioner (1971) 1.57
NonO, a non-POU-domain-containing, octamer-binding protein, is the mammalian homolog of Drosophila nonAdiss. Mol Cell Biol (1993) 1.57
Clonally related IgM rheumatoid factors undergo affinity maturation in the rheumatoid synovial tissue. J Immunol (1992) 1.55
A new human immunoglobulin VH family preferentially rearranged in immature B-cell tumours. Nature (1988) 1.55
V kappa and J kappa gene segments of A/J Ars-A antibodies: somatic recombination generates the essential arginine at the junction of the variable and joining regions. Proc Natl Acad Sci U S A (1987) 1.53
Variable region sequences of five human immunoglobulin heavy chains of the VH3 subgroup: definitive identification of four heavy chain hypervariable regions. Proc Natl Acad Sci U S A (1974) 1.52
VH restriction among human cold agglutinins. The VH4-21 gene segment is required to encode anti-I and anti-i specificities. J Immunol (1992) 1.52
Heterogeneity of an intrastrain cross-reactive idiotype associated with anti-p-azophenylarsonate antibodies of A/J mice. J Immunol (1980) 1.51
Isolation of rubella virus from abortion material. Br Med J (1970) 1.48
Immunological abnormalities in myelodysplastic syndromes. II. Coexistent lymphoid or plasma cell neoplasms: a report of 20 cases unrelated to chemotherapy. Br J Haematol (1986) 1.42
Structural studies on the murine Ia alloantigens--III. Tryptic peptide comparisons of allelic products of the I-E/C sub-region. Mol Immunol (1979) 1.42
Driver distance from the steering wheel: perception and objective measurement. Am J Public Health (1999) 1.41
Anti-idiotype sera raised against surface immunoglobulin of human neoplastic lymphocytes. J Exp Med (1976) 1.41
A human monoclonal antiphospholipid antibody that is representative of serum antibodies and is germline encoded. Arthritis Rheum (1995) 1.40
Structure, function, and genetics of human class II molecules. Adv Immunol (1985) 1.39
Autoantibodies revealed: the role of B cells in autoimmune disease. Immunol Today (1999) 1.39
Serous effusions in monocytic leukaemias. Br J Haematol (1984) 1.38
Primary structural variation among serologically indistinguishable DS antigens: the MB3-bearing molecule in DR4 cells differs from the MB3-bearing molecule in DR5 cells. J Immunol (1984) 1.38
Continuous rabbit kidney cell cultures in the diagnosis of rebella infections. Mon Bull Minist Health Public Health Lab Serv (1965) 1.37
Surface immunoglobulin of guinea-pig leukaemic lymphocytes. Immunology (1975) 1.36
Cold-reactive rheumatoid factors in infectious mononucleosis and other diseases. Arthritis Rheum (1969) 1.35
Structural studies on the murine Ia alloantigens. V. Evidence that the structural gene for the I-E/C beta polypeptide is encoded within the I-A subregion. J Exp Med (1979) 1.34
Molecular characterization of human Ro/SS-A antigen. Amino terminal sequence of the protein moiety of human Ro/SS-A antigen and immunological activity of a corresponding synthetic peptide. J Clin Invest (1988) 1.32
Anti-keratin antibodies in rheumatoid arthritis: frequency and correlation with other features of the disease. Clin Exp Immunol (1983) 1.32
Hypergammaglobulinemic purpura. Studies on the unusual anti- -globulins characteristic of the sera of these patients. Medicine (Baltimore) (1971) 1.32
Production and characterization of recombinant human Ku antigen. Nucleic Acids Res (1994) 1.32
Discovery and development of therapeutic aptamers. Annu Rev Pharmacol Toxicol (2010) 1.32
Phylogenetically associated residues within the VH3 subgroup of several mammalian species. Evidence for a "pauci-gene" basis for antibody diversity. J Exp Med (1973) 1.31
Immunoglobulin V genes and CD38 expression in CLL. Blood (2000) 1.30
Violence in G-rated animated films. JAMA (2000) 1.30
VH sequence of a human anti-Sm autoantibody. Evidence that autoantibodies can be unmutated copies of germline genes. J Immunol (1989) 1.30
Staphylococcal protein A simultaneously interacts with framework region 1, complementarity-determining region 2, and framework region 3 on human VH3-encoded Igs. J Immunol (1996) 1.29