Published in Proc Natl Acad Sci U S A on March 01, 1974
The three-dimensional structure of a phosphorylcholine-binding mouse immunoglobulin Fab and the nature of the antigen binding site. Proc Natl Acad Sci U S A (1974) 3.92
The promise and challenge of high-throughput sequencing of the antibody repertoire. Nat Biotechnol (2014) 2.54
Diversity and structure of human T-cell receptor beta-chain variable region genes. Proc Natl Acad Sci U S A (1986) 2.19
Structure of antibodies with shared idiotypy: the complete sequence of the heavy chain variable regions of two immunoglobulin M anti-gamma globulins. Proc Natl Acad Sci U S A (1974) 1.84
Resolution of hypervariable regions in T-cell receptor beta chains by a modified Wu-Kabat index of amino acid diversity. Proc Natl Acad Sci U S A (1990) 1.36
Natural occurrence and origin of somatically mutated memory B cells in mice. J Exp Med (1992) 1.31
The structural basis of germline-encoded VH3 immunoglobulin binding to staphylococcal protein A. J Exp Med (1993) 1.26
Amino acid sequence diversity within the family of antibodies bearing the major antiarsonate cross-reactive idiotype of the A strain mouse. J Exp Med (1983) 1.22
Mouse immunoglobulin heavy chains are coded by multiple germ line variable region genes. Proc Natl Acad Sci U S A (1974) 1.22
The structural basis of antibody-antigen recognition. Front Immunol (2013) 1.14
Similarities among hypervariable segments of immunoglobulin chains. Proc Natl Acad Sci U S A (1975) 1.10
Antibody differentiation: apparent sequence identity between variable regions shared by IgA and IgG immunoglobulins. Proc Natl Acad Sci U S A (1976) 1.09
Variability of three-dimensional structure in immunoglobulins. Proc Natl Acad Sci U S A (1975) 1.09
Attempts to locate residues in complementarity-determining regions of antibody combining sites that make contact with antigen. Proc Natl Acad Sci U S A (1976) 1.02
Structural implications of sequence variability in immunoglobulins. Proc Natl Acad Sci U S A (1977) 0.93
Human and murine phosphorycholine-binding immunoglobulins: conserved subgroup and first hypervariable region of heavy chains. Proc Natl Acad Sci U S A (1976) 0.93
Diversity of light chain variable region sequences among rabbit antibodies elicited by the same antigens. Proc Natl Acad Sci U S A (1975) 0.85
An immunoglobulin heavy chain variable region (VH) marker associated with cross-reactive idiotypes in man. Clin Exp Immunol (1977) 0.84
Serological detection of variable region (Vh) subgroups of Ig heavy chains. J Exp Med (1976) 0.84
Analysis and modeling of the variable region of camelid single-domain antibodies. J Immunol (2011) 0.78
Immunoglobulin isotype isolated from human placental extract does not interfere in complement-mediated bacterial opsonization within the wound milieu. FEBS Open Bio (2015) 0.75
Fragments produced by digestion of human immunoglobulin G subclasses with pepsin in urea. Biochem J (1977) 0.75
A protein sequenator. Eur J Biochem (1967) 17.03
Zone electrophoresis. Methods Biochem Anal (1954) 10.49
An analysis of the sequences of the variable regions of Bence Jones proteins and myeloma light chains and their implications for antibody complementarity. J Exp Med (1970) 9.83
THE ARRANGEMENT OF THE PEPTIDE CHAINS IN GAMMA-GLOBULIN. Biochem J (1963) 7.40
The covalent structure of an entire gammaG immunoglobulin molecule. Proc Natl Acad Sci U S A (1969) 5.90
Nonenzymatic cleavage of peptide bonds: the methionine residues in bovine pancreatic ribonuclease. J Biol Chem (1962) 5.10
Cross-idiotypic specificity among monoclonal IgM proteins with anti- -globulin activity. J Exp Med (1973) 4.93
Antigenic specificities related to the cold agglutinin activity of gamma M globulins. Science (1968) 4.32
Affinity labeling of a phosphorylcholine binding mouse myeloma protein. Biochemistry (1972) 4.26
Linked groups of residues in immunoglobulin k chains. Nature (1967) 3.12
Affinity labeling of a mouse myeloma protein which binds nitrophenyl ligands. Kinetics of labeling and isolation of a labeled peptide. Biochemistry (1970) 2.88
Aggregation of gamma-G3 proteins: relevance to the hyperviscosity syndrome. J Clin Invest (1970) 2.19
Allotypically related sequences in the Fd fragment of rabbit immunoglobulin heavy chains. Biochem J (1971) 1.90
Structure-function relationships among anti-gamma globulin antibodies. Ann N Y Acad Sci (1971) 1.71
Common peptides from the N-terminal half of heavy chain of immunoglobulin G from normal rabbit serum and a specific antibody. Biochem J (1968) 1.69
Subgroups of amino acid sequences in the variable regions of immunoglobulin heavy chains. Proc Natl Acad Sci U S A (1969) 1.67
Macroglobulin structure: homology of mu and gamma heavy chains of human immunoglobulins. Science (1969) 1.64
Phylogenetically associated residues within the VH3 subgroup of several mammalian species. Evidence for a "pauci-gene" basis for antibody diversity. J Exp Med (1973) 1.31
Localization of two additional hypervariable regions in immunoglobulin heavy chains. Proc Natl Acad Sci U S A (1971) 1.27
The amino acid sequences of the Fd fragments of two human gamma-1 heavy chains. Biochem J (1970) 1.21
Localization of affinity-labeled residues on the heavy and light chain of two myeloma proteins with anti-hapten activity. Biochemistry (1972) 1.17
Localization of affinity-labeled residues in the primary structure of anti-dinitrophenyl antibody raised in strain 13 guinea pigs. Biochemistry (1972) 1.07
Hypervariable region of human immunoglobulin heavy chains. Nat New Biol (1971) 1.06
Amino acid sequence similarities in two human anti gamma globulin antibodies. Proc Natl Acad Sci U S A (1970) 1.05
Construction of a three-dimensional model of the polypeptide backbone of the variable region of kappa immunoglobulin light chains. Proc Natl Acad Sci U S A (1972) 1.04
[Primary structure of a monoclonal gamma-1-immunoglobulin (myeloma protein NIE). I. Amino acid sequence of the variable part of the H-chain, subgroups of variable regions]. Hoppe Seylers Z Physiol Chem (1970) 1.02
Sequence of amino acids of the NH 2 -terminal region of a mouse-clonal immunoglobulin heavy chain. Eur J Biochem (1972) 0.98
Sequence relationships among the variable regions of immunoglobulin heavy chains from various mammalian species. Proc Natl Acad Sci U S A (1972) 0.91
Affinity labeling by m-nitrobenzenediazonium fluoroborate of porcine ANTI-dinitrophenyl antibodies. Position of labeled tyrosine in the lambda-chains. Eur J Biochem (1971) 0.90
Amino acid sequences in the Fd of a rabbit antibody heavy chain. Immunochemistry (1973) 0.90
Evolutionary relationship between carboxyterminal region of a human alpha chain and other immunoglobulin heavy chain constant regions. Nature (1973) 0.85
Demonstration of a simple method for reducing losses of tryptic peptides during automated sequencing. Biochem Biophys Res Commun (1972) 0.83
Cross-idiotypic specificity among monoclonal IgM proteins with anti- -globulin activity. J Exp Med (1973) 4.93
Analysis of somatic mutation in five B cell subsets of human tonsil. J Exp Med (1994) 4.52
Antigenic specificities related to the cold agglutinin activity of gamma M globulins. Science (1968) 4.32
Interaction of cell-type-specific nuclear proteins with immunoglobulin VH promoter region sequences. Nature (1986) 4.21
Automated amino acid sequence of small peptides utilizing Polybrene. Anal Biochem (1978) 3.48
Neisseria gonorrhoeae and neisseria meningitidis: extracellular enzyme cleaves human immunoglobulin A. Science (1975) 3.27
HLA-DQ and T-cell receptor genes in insulin-dependent diabetes mellitus. Cold Spring Harb Symp Quant Biol (1986) 3.15
Human CD14 mediates recognition and phagocytosis of apoptotic cells. Nature (1998) 3.11
Initial characterization of monoclonal antibodies against human monocytes. Proc Natl Acad Sci U S A (1980) 2.61
Similarities in the light chains of anti-gamma-globulins showing cross-idiotypic specificities. J Exp Med (1974) 2.60
Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes. J Exp Med (1998) 2.39
Aggregation of gamma-G3 proteins: relevance to the hyperviscosity syndrome. J Clin Invest (1970) 2.19
Organization of the immune response genes. Science (1979) 2.18
The smaller human VH gene families display remarkably little polymorphism. EMBO J (1989) 2.15
Subunit structure and N-terminal amino acid sequence of the three chains of cholera enterotoxin. Immunochemistry (1976) 2.14
Hypervariable regions, idiotypy, and the antibody-combining site. Adv Immunol (1975) 1.99
Differential susceptibility of human IgA immunoglobulins to streptococcal IgA protease. J Clin Invest (1974) 1.91
Nucleotide sequences of eight human natural autoantibody VH regions reveals apparent restricted use of VH families. J Immunol (1989) 1.88
The amino acid sequence of ragweed pollen allergen Ra5. Biochemistry (1975) 1.85
Structure of antibodies with shared idiotypy: the complete sequence of the heavy chain variable regions of two immunoglobulin M anti-gamma globulins. Proc Natl Acad Sci U S A (1974) 1.84
Alpha and beta chains of SB and DR antigens are structurally distinct. J Exp Med (1982) 1.76
The protein products of the murine 17th chromosome: genetics and structure. Adv Immunol (1978) 1.76
Analysis of HLA-DQ genotypes and susceptibility in insulin-dependent diabetes mellitus. N Engl J Med (1990) 1.74
Amino acid sequence of ragweed allergen Ra3. Biochemistry (1980) 1.71
Structure-function relationships among anti-gamma globulin antibodies. Ann N Y Acad Sci (1971) 1.71
Studies on the clonal origin of multiple myeloma. Use of individually specific (idiotype) antibodies to trace the oncogenic event to its earliest point of expression in B-cell differentiation. J Exp Med (1979) 1.70
Human immunoglobulin heavy-chain variable region genes: organization, polymorphism, and expression. Adv Immunol (1991) 1.68
Light chain sequences of human IgM cold agglutinins (variable-region subgroups amino-acid sequence-kappa light chain-N-terminal). Proc Natl Acad Sci U S A (1972) 1.64
Complete amino acid sequence of variable domains from two monoclonal human anti-gamma globulins of the Wa cross-idiotypic group: suggestion that the J segments are involved in the structural correlate of the idiotype. Proc Natl Acad Sci U S A (1981) 1.60
Receptor revision of immunoglobulin heavy chain variable region genes in normal human B lymphocytes. J Exp Med (2000) 1.59
NonO, a non-POU-domain-containing, octamer-binding protein, is the mammalian homolog of Drosophila nonAdiss. Mol Cell Biol (1993) 1.57
Nucleotide sequence analysis of the V regions of two IgM cold agglutinins. Evidence that the VH4-21 gene segment is responsible for the major cross-reactive idiotype. J Immunol (1991) 1.56
Clonally related IgM rheumatoid factors undergo affinity maturation in the rheumatoid synovial tissue. J Immunol (1992) 1.55
A new human immunoglobulin VH family preferentially rearranged in immature B-cell tumours. Nature (1988) 1.55
Immunoglobulin peptide with complement fixing activity. Nature (1969) 1.54
V kappa and J kappa gene segments of A/J Ars-A antibodies: somatic recombination generates the essential arginine at the junction of the variable and joining regions. Proc Natl Acad Sci U S A (1987) 1.53
VH restriction among human cold agglutinins. The VH4-21 gene segment is required to encode anti-I and anti-i specificities. J Immunol (1992) 1.52
Heterogeneity of an intrastrain cross-reactive idiotype associated with anti-p-azophenylarsonate antibodies of A/J mice. J Immunol (1980) 1.51
Structural studies on the murine Ia alloantigens--III. Tryptic peptide comparisons of allelic products of the I-E/C sub-region. Mol Immunol (1979) 1.42
Structure, function, and genetics of human class II molecules. Adv Immunol (1985) 1.39
Primary structural variation among serologically indistinguishable DS antigens: the MB3-bearing molecule in DR4 cells differs from the MB3-bearing molecule in DR5 cells. J Immunol (1984) 1.38
Cold-reactive rheumatoid factors in infectious mononucleosis and other diseases. Arthritis Rheum (1969) 1.35
Structural studies on the murine Ia alloantigens. V. Evidence that the structural gene for the I-E/C beta polypeptide is encoded within the I-A subregion. J Exp Med (1979) 1.34
Chromatographic isolation of the hemagglutinin polypeptides from influenza virus vaccine and determination of their amino-terminal sequences. Proc Natl Acad Sci U S A (1976) 1.33
Molecular characterization of human Ro/SS-A antigen. Amino terminal sequence of the protein moiety of human Ro/SS-A antigen and immunological activity of a corresponding synthetic peptide. J Clin Invest (1988) 1.32
Production and characterization of recombinant human Ku antigen. Nucleic Acids Res (1994) 1.32
Hypergammaglobulinemic purpura. Studies on the unusual anti- -globulins characteristic of the sera of these patients. Medicine (Baltimore) (1971) 1.32
Phylogenetically associated residues within the VH3 subgroup of several mammalian species. Evidence for a "pauci-gene" basis for antibody diversity. J Exp Med (1973) 1.31
VH sequence of a human anti-Sm autoantibody. Evidence that autoantibodies can be unmutated copies of germline genes. J Immunol (1989) 1.30
Staphylococcal protein A simultaneously interacts with framework region 1, complementarity-determining region 2, and framework region 3 on human VH3-encoded Igs. J Immunol (1996) 1.29
Protein-nucleotide contacts in the immunoglobulin heavy-chain promoter region. Proc Natl Acad Sci U S A (1987) 1.29
Structural studies on the murine Ia alloantigens. IV. NH2-terminal sequence analysis of allelic products of the I-A and I-E/C subregions. J Immunol (1979) 1.28
Localization of two additional hypervariable regions in immunoglobulin heavy chains. Proc Natl Acad Sci U S A (1971) 1.27
Novel rearrangements at the immunoglobulin D locus. Inversions and fusions add to IgH somatic diversity. J Exp Med (1989) 1.25
Use of antipeptide antibodies to demonstrate external orientation of the NH2-terminus of the low density lipoprotein receptor in the plasma membrane of fibroblasts. J Cell Biol (1983) 1.25
Complete amino acid sequence of light chain variable regions derived from five monoclonal anti-p-azophenylarsonate antibodies differing with respect to a crossreactive idiotype. Proc Natl Acad Sci U S A (1981) 1.24
VH4-21, a human VH gene segment overrepresented in the autoimmune repertoire. Arthritis Rheum (1992) 1.23
Amino acid sequence diversity within the family of antibodies bearing the major antiarsonate cross-reactive idiotype of the A strain mouse. J Exp Med (1983) 1.22
Organization of the murine immunoglobulin VH complex in the inbred strains. EMBO J (1987) 1.22
Structural analysis of a human I-A homologue using a monoclonal antibody that recognizes an MB3-like specificity. J Exp Med (1983) 1.21
An incomplete cold-reactive gamma G antibody with i specificity in infectious mononucleosis. Vox Sang (1969) 1.20
The amino acid sequence of the variable regions of the light chains from two idiotypically cross reactive IgM anti-gamma globulins. Ann Immunol (Paris) (1976) 1.20
Junctional diversity is essential to antibody activity. J Immunol (1984) 1.20
The human HLA-DR antigens are encoded by multiple beta-chain loci. J Immunol (1982) 1.19
Induction of somatic mutation in a human B cell line in vitro. Immunity (1997) 1.19
Primary structure of the porin protein of Haemophilus influenzae type b determined by nucleotide sequence analysis. Infect Immun (1989) 1.19
Use of JH4 joining segment gene by an anti-arsonate antibody that bears the major A-strain cross-reactive idiotype but displays diminished antigen binding. J Immunol (1984) 1.18
Peptide recognition, T cell receptor usage and HLA restriction elements of human heat-shock protein (hsp) 60 and mycobacterial 65-kDa hsp-reactive T cell clones from rheumatoid synovial fluid. Eur J Immunol (1992) 1.17
VH families in the antibody response to p-azophenylarsonate: correlation between serology and amino acid sequence. J Immunol (1982) 1.17
A human Ro/SS-A autoantigen is the homologue of calreticulin and is highly homologous with onchocercal RAL-1 antigen and an aplysia "memory molecule". J Clin Invest (1990) 1.17
Construction of recombinant DNA by exonuclease recession. Nucleic Acids Res (1993) 1.16
Diversity of the Ig repertoire is maintained with age in spite of reduced germinal centre cells in human tonsil lymphoid tissue. Scand J Immunol (2006) 1.15
The partial amino-acid sequence of an H-2K molecule. Proc Natl Acad Sci U S A (1976) 1.14
The ubiquitous octamer-binding protein(s) is sufficient for transcription of immunoglobulin genes. Mol Cell Biol (1990) 1.13
Rheumatoid factors isolated from patients with autoimmune disorders are derived from germline genes distinct from those encoding the Wa, Po, and Bla cross-reactive idiotypes. J Clin Invest (1991) 1.12
Monoclonal antibodies to immunoglobulin G4 induce histamine release from human basophils in vitro. J Allergy Clin Immunol (1982) 1.12
Somatic mutation in genes for the variable portion of the immunoglobulin heavy chain. Science (1982) 1.11
Germ-line sequence of the DH segment employed in Ars-A antibodies: implications for the generation of junctional diversity. J Immunol (1986) 1.11
NonO enhances the association of many DNA-binding proteins to their targets. Nucleic Acids Res (1997) 1.11
Structural studies on induced antibodies with defined idiotypic specificities. I. The heavy chains of anti-p-azophenylarsonate antibodies from A/J mice bearing a cross-reactive idiotype. J Immunol (1975) 1.10
The I binding specificity of human VH 4-34 (VH 4-21) encoded antibodies is determined by both VH framework region 1 and complementarity determining region 3. J Mol Biol (1996) 1.08
Molecular characterization of five human anti-human immunodeficiency virus type 1 antibody heavy chains reveals extensive somatic mutation typical of an antigen-driven immune response. Proc Natl Acad Sci U S A (1991) 1.07
The 5'-flanking region of the human calreticulin gene shares homology with the human GRP78, GRP94, and protein disulfide isomerase promoters. J Biol Chem (1992) 1.07
Molecular characterization of a cross-reactive idiotope on human immunoglobulins utilizing the VH4-21 gene segment. J Exp Med (1993) 1.07
Expression of HLA-DR, MB, MT and SB antigens on human mononuclear cells: identification of two phenotypically distinct monocyte populations. J Immunol (1984) 1.06
Hypervariable region of human immunoglobulin heavy chains. Nat New Biol (1971) 1.06
Amino acid insertions and deletions contribute to diversify the human Ig repertoire. Immunol Rev (1998) 1.06