Published in Proc Natl Acad Sci U S A on June 01, 1981
A conserved human germline V kappa gene directly encodes rheumatoid factor light chains. J Exp Med (1986) 1.92
Autoantibody-associated kappa light chain variable region gene expressed in chronic lymphocytic leukemia with little or no somatic mutation. Implications for etiology and immunotherapy. J Exp Med (1988) 1.73
Anti-hypervariable region antibody induced by a defined peptide: an approach for studying the structural correlates of idiotypes. Proc Natl Acad Sci U S A (1984) 1.50
Complete sequence of the genes encoding the VH and VL regions of low- and high-affinity monoclonal IgM and IgA1 rheumatoid factors produced by CD5+ B cells from a rheumatoid arthritis patient. Int Immunol (1991) 1.50
Shared idiotypes and restricted immunoglobulin variable region heavy chain genes characterize murine autoantibodies of various specificities. J Clin Invest (1986) 1.48
Delineation of a cross-reactive idiotype on human autoantibodies with antibody against a synthetic peptide. J Exp Med (1984) 1.40
Idiotypic and subgroup analysis of human monoclonal rheumatoid factors. Implications for structural and genetic basis of autoantibodies in humans. J Clin Invest (1988) 1.38
Expression of the immunoglobulin VH gene 51p1 is proportional to its germline gene copy number. J Clin Invest (1996) 1.35
High-frequency expression of a conserved kappa light-chain variable-region gene in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A (1987) 1.35
A natural autoantibody is encoded by germline heavy and lambda light chain variable region genes without somatic mutation. J Clin Invest (1989) 1.33
Characterization of an epibody. An antiidiotype that reacts with both the idiotype of rheumatoid factors (RF) and the antigen recognized by RF. J Exp Med (1985) 1.32
Among B cell non-Hodgkin's lymphomas, MALT lymphomas express a unique antibody repertoire with frequent rheumatoid factor reactivity. J Exp Med (2005) 1.32
Genetic basis for the cross-reactive idiotypes on the light chains of human IgM anti-IgG autoantibodies. Proc Natl Acad Sci U S A (1986) 1.24
Idiotypic markers of polyclonal B cell activation. Public idiotypes shared by monoclonal antibodies derived from patients with systemic lupus erythematosus or leprosy. J Clin Invest (1987) 1.14
Characterization of human rheumatoid factors with seven antiidiotypes induced by synthetic hypervariable region peptides. J Exp Med (1985) 1.14
Complete protein sequences of the variable regions of the cloned heavy and light chains of a human anti-cytomegalovirus antibody reveal a striking similarity to human monoclonal rheumatoid factors of the Wa idiotypic family. J Clin Invest (1988) 1.06
The antigen-binding domain of a human IgG-anti-F(ab')2 autoantibody. Proc Natl Acad Sci U S A (1997) 1.04
High frequency of autoantibodies bearing cross-reactive idiotopes among hybridomas using VH7183 genes prepared from normal and autoimmune murine strains. J Clin Invest (1987) 0.95
Chemical synthesis of idiotopes. Evidence that antisera to the same JH1 peptide detect multiple binding site-associated idiotopes. J Exp Med (1984) 0.85
Rheumatoid factors from the peripheral blood of two patients with rheumatoid arthritis are genetically heterogeneous and somatically mutated. J Clin Invest (1994) 0.84
Synthetic peptides corresponding to third hypervariable region of human monoclonal IgM rheumatoid factor heavy chains define an immunodominant idiotype. J Exp Med (1985) 0.82
Rheumatoid factor isotype switch and somatic mutation variants within rheumatoid arthritis synovium. Immunology (1999) 0.82
Towards a network theory of the immune system. Ann Immunol (Paris) (1974) 16.43
Individual Antigenic Specificity of Isolated Antibodies. Science (1963) 7.27
Quantitative procedures for use with the Edman-Begg sequenator. Partial sequences of two unusual immunoglobulin light chains, Rzf and Sac. Biochemistry (1971) 6.10
Immunological relationships among the myeloma proteins. J Exp Med (1955) 5.11
Cross-idiotypic specificity among monoclonal IgM proteins with anti- -globulin activity. J Exp Med (1973) 4.93
Antigenic specificities related to the cold agglutinin activity of gamma M globulins. Science (1968) 4.32
Automated amino acid sequence of small peptides utilizing Polybrene. Anal Biochem (1978) 3.48
Three-dimensional structure of the Fab' fragment of a human immunoglobulin at 2,8-A resolution. Proc Natl Acad Sci U S A (1973) 3.14
[A new allotype form of rabbit serum gamma-globulins, apparently associated with antibody function and specificity]. C R Hebd Seances Acad Sci (1963) 2.64
Similarities in the light chains of anti-gamma-globulins showing cross-idiotypic specificities. J Exp Med (1974) 2.60
A technique for the removal of pyroglutamic acid from the amino terminus of proteins using calf liver pyroglutamate amino peptidase. Biochem Biophys Res Commun (1978) 2.30
Evidence for a subset of rheumatoid factors that cross-react with DNA-histone and have a distinct cross-idiotype. J Exp Med (1980) 2.10
Structure of antibodies with shared idiotypy: the complete sequence of the heavy chain variable regions of two immunoglobulin M anti-gamma globulins. Proc Natl Acad Sci U S A (1974) 1.84
Light chain sequences of human IgM cold agglutinins (variable-region subgroups amino-acid sequence-kappa light chain-N-terminal). Proc Natl Acad Sci U S A (1972) 1.64
Bence-Jones proteins and light chains of immunoglobulins. VII. Localization of antigenic sites responsible for immunochemical heterogeneity of kappa chains. J Biol Chem (1972) 1.32
The amino acid sequence of the variable regions of the light chains from two idiotypically cross reactive IgM anti-gamma globulins. Ann Immunol (Paris) (1976) 1.20
Structural studies on induced antibodies with defined idiotypic specificities. I. The heavy chains of anti-p-azophenylarsonate antibodies from A/J mice bearing a cross-reactive idiotype. J Immunol (1975) 1.10
Cross-idiotypic specificity among monoclonal IgM proteins with anti- -globulin activity. J Exp Med (1973) 4.93
A cytosolic herpes simplex virus protein inhibits antigen presentation to CD8+ T lymphocytes. Cell (1994) 4.70
Analysis of somatic mutation in five B cell subsets of human tonsil. J Exp Med (1994) 4.52
Antigenic specificities related to the cold agglutinin activity of gamma M globulins. Science (1968) 4.32
Interaction of cell-type-specific nuclear proteins with immunoglobulin VH promoter region sequences. Nature (1986) 4.21
Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types. EMBO J (1996) 3.68
Interstitial cells of Cajal generate a rhythmic pacemaker current. Nat Med (1998) 3.62
Automated amino acid sequence of small peptides utilizing Polybrene. Anal Biochem (1978) 3.48
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ (2009) 3.44
Neisseria gonorrhoeae and neisseria meningitidis: extracellular enzyme cleaves human immunoglobulin A. Science (1975) 3.27
HLA-DQ and T-cell receptor genes in insulin-dependent diabetes mellitus. Cold Spring Harb Symp Quant Biol (1986) 3.15
Human CD14 mediates recognition and phagocytosis of apoptotic cells. Nature (1998) 3.11
Antisocial boys and their friends in early adolescence: relationship characteristics, quality, and interactional process. Child Dev (1995) 2.99
Preventing escalation in problem behaviors with high-risk young adolescents: immediate and 1-year outcomes. J Consult Clin Psychol (1995) 2.81
Initial characterization of monoclonal antibodies against human monocytes. Proc Natl Acad Sci U S A (1980) 2.61
Similarities in the light chains of anti-gamma-globulins showing cross-idiotypic specificities. J Exp Med (1974) 2.60
Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes. J Exp Med (1998) 2.39
Stable binding of the herpes simplex virus ICP47 protein to the peptide binding site of TAP. EMBO J (1996) 2.26
Saccharomyces cerevisiae peroxisomal thiolase is imported as a dimer. Proc Natl Acad Sci U S A (1994) 2.26
Aggregation of gamma-G3 proteins: relevance to the hyperviscosity syndrome. J Clin Invest (1970) 2.19
Organization of the immune response genes. Science (1979) 2.18
The smaller human VH gene families display remarkably little polymorphism. EMBO J (1989) 2.15
Subunit structure and N-terminal amino acid sequence of the three chains of cholera enterotoxin. Immunochemistry (1976) 2.14
Hypervariable regions, idiotypy, and the antibody-combining site. Adv Immunol (1975) 1.99
Differential susceptibility of human IgA immunoglobulins to streptococcal IgA protease. J Clin Invest (1974) 1.91
Nucleotide sequences of eight human natural autoantibody VH regions reveals apparent restricted use of VH families. J Immunol (1989) 1.88
The cotranslational integration of membrane proteins into the phospholipid bilayer is a multistep process. Cell (1996) 1.88
The amino acid sequence of ragweed pollen allergen Ra5. Biochemistry (1975) 1.85
Structure of antibodies with shared idiotypy: the complete sequence of the heavy chain variable regions of two immunoglobulin M anti-gamma globulins. Proc Natl Acad Sci U S A (1974) 1.84
Alpha and beta chains of SB and DR antigens are structurally distinct. J Exp Med (1982) 1.76
The protein products of the murine 17th chromosome: genetics and structure. Adv Immunol (1978) 1.76
Analysis of HLA-DQ genotypes and susceptibility in insulin-dependent diabetes mellitus. N Engl J Med (1990) 1.74
Still embedded together binding to membranes regulates Bcl-2 protein interactions. Oncogene (2010) 1.72
Amino acid sequence of ragweed allergen Ra3. Biochemistry (1980) 1.71
Structure-function relationships among anti-gamma globulin antibodies. Ann N Y Acad Sci (1971) 1.71
Studies on the clonal origin of multiple myeloma. Use of individually specific (idiotype) antibodies to trace the oncogenic event to its earliest point of expression in B-cell differentiation. J Exp Med (1979) 1.70
Human immunoglobulin heavy-chain variable region genes: organization, polymorphism, and expression. Adv Immunol (1991) 1.68
Light chain sequences of human IgM cold agglutinins (variable-region subgroups amino-acid sequence-kappa light chain-N-terminal). Proc Natl Acad Sci U S A (1972) 1.64
Myc potentiates apoptosis by stimulating Bax activity at the mitochondria. Mol Cell Biol (2001) 1.61
Receptor revision of immunoglobulin heavy chain variable region genes in normal human B lymphocytes. J Exp Med (2000) 1.59
Mutagenesis of the amino targeting signal of Saccharomyces cerevisiae 3-ketoacyl-CoA thiolase reveals conserved amino acids required for import into peroxisomes in vivo. J Biol Chem (1994) 1.58
NonO, a non-POU-domain-containing, octamer-binding protein, is the mammalian homolog of Drosophila nonAdiss. Mol Cell Biol (1993) 1.57
Nucleotide sequence analysis of the V regions of two IgM cold agglutinins. Evidence that the VH4-21 gene segment is responsible for the major cross-reactive idiotype. J Immunol (1991) 1.56
Clonally related IgM rheumatoid factors undergo affinity maturation in the rheumatoid synovial tissue. J Immunol (1992) 1.55
A new human immunoglobulin VH family preferentially rearranged in immature B-cell tumours. Nature (1988) 1.55
Assembly of Bcl-2 into microsomal and outer mitochondrial membranes. J Biol Chem (1994) 1.54
V kappa and J kappa gene segments of A/J Ars-A antibodies: somatic recombination generates the essential arginine at the junction of the variable and joining regions. Proc Natl Acad Sci U S A (1987) 1.53
Variable region sequences of five human immunoglobulin heavy chains of the VH3 subgroup: definitive identification of four heavy chain hypervariable regions. Proc Natl Acad Sci U S A (1974) 1.52
VH restriction among human cold agglutinins. The VH4-21 gene segment is required to encode anti-I and anti-i specificities. J Immunol (1992) 1.52
Heterogeneity of an intrastrain cross-reactive idiotype associated with anti-p-azophenylarsonate antibodies of A/J mice. J Immunol (1980) 1.51
Both the 5' untranslated region and the sequences surrounding the start site contribute to efficient initiation of translation in vitro. Mol Cell Biol (1991) 1.42
Structural studies on the murine Ia alloantigens--III. Tryptic peptide comparisons of allelic products of the I-E/C sub-region. Mol Immunol (1979) 1.42
Structure, function, and genetics of human class II molecules. Adv Immunol (1985) 1.39
Bid: a Bax-like BH3 protein. Oncogene (2008) 1.38
Primary structural variation among serologically indistinguishable DS antigens: the MB3-bearing molecule in DR4 cells differs from the MB3-bearing molecule in DR5 cells. J Immunol (1984) 1.38
Cold-reactive rheumatoid factors in infectious mononucleosis and other diseases. Arthritis Rheum (1969) 1.35
Evidence for multiple mechanisms for membrane binding and integration via carboxyl-terminal insertion sequences. Biochemistry (1997) 1.34
Processing and activation of pro-interleukin-16 by caspase-3. J Biol Chem (1998) 1.34
Structural studies on the murine Ia alloantigens. V. Evidence that the structural gene for the I-E/C beta polypeptide is encoded within the I-A subregion. J Exp Med (1979) 1.34
Molecular characterization of human Ro/SS-A antigen. Amino terminal sequence of the protein moiety of human Ro/SS-A antigen and immunological activity of a corresponding synthetic peptide. J Clin Invest (1988) 1.32
Hypergammaglobulinemic purpura. Studies on the unusual anti- -globulins characteristic of the sera of these patients. Medicine (Baltimore) (1971) 1.32
Endoplasmic reticulum localized Bcl-2 prevents apoptosis when redistribution of cytochrome c is a late event. Oncogene (2001) 1.32
Production and characterization of recombinant human Ku antigen. Nucleic Acids Res (1994) 1.32
Phylogenetically associated residues within the VH3 subgroup of several mammalian species. Evidence for a "pauci-gene" basis for antibody diversity. J Exp Med (1973) 1.31
VH sequence of a human anti-Sm autoantibody. Evidence that autoantibodies can be unmutated copies of germline genes. J Immunol (1989) 1.30
A stop transfer sequence recognizes receptors for nascent chain translocation across the endoplasmic reticulum membrane. Cell (1986) 1.30
Staphylococcal protein A simultaneously interacts with framework region 1, complementarity-determining region 2, and framework region 3 on human VH3-encoded Igs. J Immunol (1996) 1.29
Protein-nucleotide contacts in the immunoglobulin heavy-chain promoter region. Proc Natl Acad Sci U S A (1987) 1.29
Structural studies on the murine Ia alloantigens. IV. NH2-terminal sequence analysis of allelic products of the I-A and I-E/C subregions. J Immunol (1979) 1.28
Localization of two additional hypervariable regions in immunoglobulin heavy chains. Proc Natl Acad Sci U S A (1971) 1.27
Novel rearrangements at the immunoglobulin D locus. Inversions and fusions add to IgH somatic diversity. J Exp Med (1989) 1.25
Use of antipeptide antibodies to demonstrate external orientation of the NH2-terminus of the low density lipoprotein receptor in the plasma membrane of fibroblasts. J Cell Biol (1983) 1.25
Complete amino acid sequence of light chain variable regions derived from five monoclonal anti-p-azophenylarsonate antibodies differing with respect to a crossreactive idiotype. Proc Natl Acad Sci U S A (1981) 1.24
VH4-21, a human VH gene segment overrepresented in the autoimmune repertoire. Arthritis Rheum (1992) 1.23
Amino acid sequence diversity within the family of antibodies bearing the major antiarsonate cross-reactive idiotype of the A strain mouse. J Exp Med (1983) 1.22
Organization of the murine immunoglobulin VH complex in the inbred strains. EMBO J (1987) 1.22
Structural analysis of a human I-A homologue using a monoclonal antibody that recognizes an MB3-like specificity. J Exp Med (1983) 1.21
The amino acid sequence of the variable regions of the light chains from two idiotypically cross reactive IgM anti-gamma globulins. Ann Immunol (Paris) (1976) 1.20
Junctional diversity is essential to antibody activity. J Immunol (1984) 1.20
An incomplete cold-reactive gamma G antibody with i specificity in infectious mononucleosis. Vox Sang (1969) 1.20
Primary structure of the porin protein of Haemophilus influenzae type b determined by nucleotide sequence analysis. Infect Immun (1989) 1.19
The human HLA-DR antigens are encoded by multiple beta-chain loci. J Immunol (1982) 1.19
Induction of somatic mutation in a human B cell line in vitro. Immunity (1997) 1.19
Use of JH4 joining segment gene by an anti-arsonate antibody that bears the major A-strain cross-reactive idiotype but displays diminished antigen binding. J Immunol (1984) 1.18
Peptide recognition, T cell receptor usage and HLA restriction elements of human heat-shock protein (hsp) 60 and mycobacterial 65-kDa hsp-reactive T cell clones from rheumatoid synovial fluid. Eur J Immunol (1992) 1.17
VH families in the antibody response to p-azophenylarsonate: correlation between serology and amino acid sequence. J Immunol (1982) 1.17
Identification of the endoplasmic reticulum targeting signal in vesicle-associated membrane proteins. J Biol Chem (1999) 1.17
A human Ro/SS-A autoantigen is the homologue of calreticulin and is highly homologous with onchocercal RAL-1 antigen and an aplysia "memory molecule". J Clin Invest (1990) 1.17
Construction of recombinant DNA by exonuclease recession. Nucleic Acids Res (1993) 1.16
Diversity of the Ig repertoire is maintained with age in spite of reduced germinal centre cells in human tonsil lymphoid tissue. Scand J Immunol (2006) 1.15
The partial amino-acid sequence of an H-2K molecule. Proc Natl Acad Sci U S A (1976) 1.14
Cytoplasmic O-glycosylation prevents cell surface transport of E-cadherin during apoptosis. EMBO J (2001) 1.14
The ubiquitous octamer-binding protein(s) is sufficient for transcription of immunoglobulin genes. Mol Cell Biol (1990) 1.13
Structure of the signal recognition particle by electron microscopy. Proc Natl Acad Sci U S A (1985) 1.13
FtsY binds to the Escherichia coli inner membrane via interactions with phosphatidylethanolamine and membrane proteins. J Biol Chem (2001) 1.13
An amino-terminal domain containing hydrophobic and hydrophilic sequences binds the signal recognition particle receptor alpha subunit to the beta subunit on the endoplasmic reticulum membrane. J Biol Chem (1995) 1.12