Published in Chem Commun (Camb) on September 27, 2006
A novel small molecule that alters shelterin integrity and triggers a DNA-damage response at telomeres. J Am Chem Soc (2008) 1.91
Ligand-driven G-quadruplex conformational switching by using an unusual mode of interaction. Angew Chem Int Ed Engl (2007) 1.15
Interaction of human telomeric DNA with N-methyl mesoporphyrin IX. Nucleic Acids Res (2012) 1.11
A platinum-quinacridine hybrid as a G-quadruplex ligand. J Biol Inorg Chem (2007) 0.95
"One ring to bind them all"-part I: the efficiency of the macrocyclic scaffold for g-quadruplex DNA recognition. J Nucleic Acids (2010) 0.83
Recognition and discrimination of DNA quadruplexes by acridine-peptide conjugates. Org Biomol Chem (2008) 0.81
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V-shaped dinuclear Pt(II) complexes: selective interaction with human telomeric G-quadruplex and significant inhibition towards telomerase. Sci Rep (2013) 0.76
Cationic porphyrin induced a telomeric DNA to g-quadruplex form in water. Bioinorg Chem Appl (2008) 0.75
Specific association of human telomerase activity with immortal cells and cancer. Science (1994) 28.20
Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription. Proc Natl Acad Sci U S A (2002) 9.60
Prevalence of quadruplexes in the human genome. Nucleic Acids Res (2005) 7.79
In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronuclei. Proc Natl Acad Sci U S A (2001) 3.97
Structure and stability of human telomeric sequence. J Biol Chem (1994) 2.86
Studies on the structure and dynamics of the human telomeric G quadruplex by single-molecule fluorescence resonance energy transfer. Proc Natl Acad Sci U S A (2003) 2.82
Not so crystal clear: the structure of the human telomere G-quadruplex in solution differs from that present in a crystal. Nucleic Acids Res (2005) 2.57
A highly selective telomerase inhibitor limiting human cancer cell proliferation. EMBO J (2001) 1.79
Effects of cationic porphyrins as G-quadruplex interactive agents in human tumor cells. Cancer Res (1999) 1.63
Accelerated assembly of G-quadruplex structures by a small molecule. Biochemistry (1999) 1.36
Interactions of porphyrins with nucleic acids. Biochemistry (1983) 1.28
G-quadruplex-specific peptide-hemicyanine ligands by partial combinatorial selection. J Am Chem Soc (2003) 1.16
Selective recognition of G-qQuadruplex telomeric DNA by a bis(quinacridine) macrocycle. J Am Chem Soc (2003) 1.15
Synthesis and evaluation of quindoline derivatives as G-quadruplex inducing and stabilizing ligands and potential inhibitors of telomerase. J Med Chem (2005) 0.97
Synthesis and G-quadruplex binding studies of new 4-N-methylpyridinium porphyrins. Org Biomol Chem (2006) 0.87
Photophysical properties of neutral and cationic tetrapyridinoporphyrazines. Photochem Photobiol (2000) 0.79
Accurate whole human genome sequencing using reversible terminator chemistry. Nature (2008) 90.20
Prevalence of quadruplexes in the human genome. Nucleic Acids Res (2005) 7.79
G-quadruplexes in promoters throughout the human genome. Nucleic Acids Res (2006) 5.84
Quantitative sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution. Science (2012) 5.17
Quantitative visualization of DNA G-quadruplex structures in human cells. Nat Chem (2013) 4.61
An RNA G-quadruplex in the 5' UTR of the NRAS proto-oncogene modulates translation. Nat Chem Biol (2007) 4.11
Putative DNA quadruplex formation within the human c-kit oncogene. J Am Chem Soc (2005) 3.28
Loop-length-dependent folding of G-quadruplexes. J Am Chem Soc (2004) 3.16
Studies on the structure and dynamics of the human telomeric G quadruplex by single-molecule fluorescence resonance energy transfer. Proc Natl Acad Sci U S A (2003) 2.82
LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans. Nat Struct Mol Biol (2009) 2.79
A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene. Biochemistry (2006) 2.62
Dynamic covalent chemistry. Angew Chem Int Ed Engl (2002) 2.49
Small-molecule-induced DNA damage identifies alternative DNA structures in human genes. Nat Chem Biol (2012) 2.41
Dynamic combinatorial chemistry. Chem Rev (2006) 2.40
5'-UTR RNA G-quadruplexes: translation regulation and targeting. Nucleic Acids Res (2012) 2.36
G-quadruplexes: the beginning and end of UTRs. Nucleic Acids Res (2008) 2.18
Genome-wide distribution of 5-formylcytosine in embryonic stem cells is associated with transcription and depends on thymine DNA glycosylase. Genome Biol (2012) 1.94
FANCJ is a structure-specific DNA helicase associated with the maintenance of genomic G/C tracts. J Biol Chem (2008) 1.93
A novel small molecule that alters shelterin integrity and triggers a DNA-damage response at telomeres. J Am Chem Soc (2008) 1.91
Template-assisted fabrication of salt-independent catalytic tubular microengines. ACS Nano (2010) 1.90
Trisubstituted isoalloxazines as a new class of G-quadruplex binding ligands: small molecule regulation of c-kit oncogene expression. J Am Chem Soc (2007) 1.87
The transcription factor FOXM1 is a cellular target of the natural product thiostrepton. Nat Chem (2011) 1.82
Discovery of an organic trefoil knot. Science (2012) 1.75
A sequence-independent study of the influence of short loop lengths on the stability and topology of intramolecular DNA G-quadruplexes. Biochemistry (2007) 1.75
G-quadruplex structures are stable and detectable in human genomic DNA. Nat Commun (2013) 1.72
Ultrasensitive coincidence fluorescence detection of single DNA molecules. Anal Chem (2003) 1.60
Oxidative bisulfite sequencing of 5-methylcytosine and 5-hydroxymethylcytosine. Nat Protoc (2013) 1.54
Kinetics of unfolding the human telomeric DNA quadruplex using a PNA trap. J Am Chem Soc (2003) 1.51
A screen for hydroxymethylcytosine and formylcytosine binding proteins suggests functions in transcription and chromatin regulation. Genome Biol (2013) 1.50
FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA. Nucleic Acids Res (2011) 1.45
A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands. Nat Chem (2011) 1.43
A proton-fuelled DNA nanomachine. Angew Chem Int Ed Engl (2003) 1.42
Filling helical nanotubes with C60. Angew Chem Int Ed Engl (2007) 1.41
A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics. J Am Chem Soc (2009) 1.40
Formation of an interlocked quadruplex dimer by d(GGGT). J Am Chem Soc (2004) 1.37
Genome-wide mapping of FOXM1 binding reveals co-binding with estrogen receptor alpha in breast cancer cells. Genome Biol (2013) 1.31
Small-molecule-mediated G-quadruplex isolation from human cells. Nat Chem (2010) 1.26
Single-molecule conformational analysis of G-quadruplex formation in the promoter DNA duplex of the proto-oncogene c-kit. J Am Chem Soc (2007) 1.25
Oxazole-based peptide macrocycles: a new class of G-quadruplex binding ligands. J Am Chem Soc (2006) 1.20
Identification of a new RNA.RNA interaction site for human telomerase RNA (hTR): structural implications for hTR accumulation and a dyskeratosis congenita point mutation. Nucleic Acids Res (2003) 1.19
Determination of the fraction and stoichiometry of femtomolar levels of biomolecular complexes in an excess of monomer using single-molecule, two-color coincidence detection. Anal Chem (2006) 1.17
G-quadruplex-specific peptide-hemicyanine ligands by partial combinatorial selection. J Am Chem Soc (2003) 1.16
Single-molecule analysis of human telomerase monomer. Nat Chem Biol (2008) 1.16
Genome-wide analysis of a G-quadruplex-specific single-chain antibody that regulates gene expression. Nucleic Acids Res (2009) 1.15
Motion-based DNA detection using catalytic nanomotors. Nat Commun (2010) 1.15
Ligand-driven G-quadruplex conformational switching by using an unusual mode of interaction. Angew Chem Int Ed Engl (2007) 1.15
Rudimentary G-quadruplex-based telomere capping in Saccharomyces cerevisiae. Nat Struct Mol Biol (2011) 1.14
Chemical inhibition of NAT10 corrects defects of laminopathic cells. Science (2014) 1.13
A non-canonical DNA structure is a binding motif for the transcription factor SP1 in vitro. Nucleic Acids Res (2011) 1.12
Small molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex. Org Biomol Chem (2010) 1.11
An intramolecular G-quadruplex structure is required for binding of telomeric repeat-containing RNA to the telomeric protein TRF2. J Am Chem Soc (2012) 1.11
The BCL-2 5' untranslated region contains an RNA G-quadruplex-forming motif that modulates protein expression. Biochemistry (2010) 1.11
Templated amplification of a naphthalenediimide-based receptor from a donor-acceptor dynamic combinatorial library in water. Chem Commun (Camb) (2008) 1.10
Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands. J Am Chem Soc (2007) 1.10
Molecule by molecule direct and quantitative counting of antibody-protein complexes in solution. Anal Chem (2004) 1.10
Rapid delivery of drug carriers propelled and navigated by catalytic nanoshuttles. Small (2010) 1.10
Binding interactions between long noncoding RNA HOTAIR and PRC2 proteins. Biochemistry (2013) 1.09
Structural analysis of the catalytic core of human telomerase RNA by FRET and molecular modeling. Biochemistry (2006) 1.08
A LIN28-dependent structural change in pre-let-7g directly inhibits dicer processing. Biochemistry (2011) 1.08
DNA molecular motor driven micromechanical cantilever arrays. J Am Chem Soc (2005) 1.07
Selective RNA versus DNA G-quadruplex targeting by in situ click chemistry. Angew Chem Int Ed Engl (2012) 1.07
A reversible pH-driven DNA nanoswitch array. J Am Chem Soc (2006) 1.07
Inclusion of C60 into an adjustable porphyrin dimer generated by dynamic disulfide chemistry. Chem Commun (Camb) (2005) 1.06
Distinct functions of maternal and somatic Pat1 protein paralogs. RNA (2010) 1.06
Minimum length requirement of the alignment domain of human telomerase RNA to sustain catalytic activity in vitro. Nucleic Acids Res (2002) 1.05
Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells. Org Biomol Chem (2012) 1.05
G-quadruplex-binding benzo[a]phenoxazines down-regulate c-KIT expression in human gastric carcinoma cells. J Am Chem Soc (2011) 1.05
Measuring single-molecule nucleic acid dynamics in solution by two-color filtered ratiometric fluorescence correlation spectroscopy. Proc Natl Acad Sci U S A (2004) 1.04
A sequence-independent analysis of the loop length dependence of intramolecular RNA G-quadruplex stability and topology. Biochemistry (2011) 1.04
Exploring the differential recognition of DNA G-quadruplex targets by small molecules using dynamic combinatorial chemistry. Angew Chem Int Ed Engl (2008) 1.03
The kinetics and folding pathways of intramolecular G-quadruplex nucleic acids. J Am Chem Soc (2012) 1.03
Selective recognition of a DNA G-quadruplex by an engineered antibody. Biochemistry (2008) 1.02
Selection and amplification of hosts from dynamic combinatorial libraries of macrocyclic disulfides. Science (2002) 1.02
Exploring the recognition of quadruplex DNA by an engineered Cys2-His2 zinc finger protein. Biochemistry (2006) 1.02
A PNA4 quadruplex. J Am Chem Soc (2004) 1.00
An RNA hairpin to G-quadruplex conformational transition. J Am Chem Soc (2012) 1.00
G-quadruplex DNA as a molecular target for induced synthetic lethality in cancer cells. J Am Chem Soc (2013) 0.98
Inhibition of human telomerase activity by an engineered zinc finger protein that binds G-quadruplexes. Biochemistry (2004) 0.98
Position and stability are determining factors for translation repression by an RNA G-quadruplex-forming sequence within the 5' UTR of the NRAS proto-oncogene. Biochemistry (2008) 0.98
Disulfide exchange: exposing supramolecular reactivity through dynamic covalent chemistry. Chem Soc Rev (2014) 0.97
Triarylpyridines: a versatile small molecule scaffold for G-quadruplex recognition. Chem Commun (Camb) (2008) 0.97
Discovery of linear receptors for multiple dihydrogen phosphate ions using dynamic combinatorial chemistry. J Am Chem Soc (2011) 0.96
Functionalized micromachines for selective and rapid isolation of nucleic acid targets from complex samples. Nano Lett (2011) 0.95
G-quadruplex DNA bound by a synthetic ligand is highly dynamic. J Am Chem Soc (2009) 0.95
Solid-phase methods for the synthesis of cyanine dyes. J Org Chem (2005) 0.95
Diarylethynyl amides that recognize the parallel conformation of genomic promoter DNA G-quadruplexes. J Am Chem Soc (2008) 0.94