Published in Curr Biol on November 21, 2006
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Tollip, an early regulator of the acute inflammatory response in the substantia nigra. J Neuroinflammation (2016) 0.75
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Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat Immunol (2009) 9.24
Intracellular pattern recognition receptors in the host response. Nature (2006) 8.04
The inflammasome: a danger sensing complex triggering innate immunity. Curr Opin Immunol (2007) 6.81
Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors. Nat Med (2009) 6.73
Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell (2004) 6.06
RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation. Nat Immunol (2004) 5.74
Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence. Nature (2009) 5.00
Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome. Curr Biol (2004) 4.89
Poxviruses and immune evasion. Annu Rev Immunol (2001) 4.80
A pilot study of IL-1 inhibition by anakinra in acute gout. Arthritis Res Ther (2007) 4.65
Role of LBPA and Alix in multivesicular liposome formation and endosome organization. Science (2004) 4.35
The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress. Science (2004) 4.17
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Type I interferon inhibits interleukin-1 production and inflammasome activation. Immunity (2011) 3.97
Cutting edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome. J Immunol (2008) 3.66
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Toll-like receptors and RNA helicases: two parallel ways to trigger antiviral responses. Mol Cell (2006) 3.23
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CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation. Nat Immunol (2002) 3.16
Transforming growth factor-beta1 to the bone. Endocr Rev (2005) 3.13
BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha. Mol Cell (2009) 3.07
Caspase-14 protects against epidermal UVB photodamage and water loss. Nat Cell Biol (2007) 2.82
The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex. J Biol Chem (2002) 2.75
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Activation of the IL-1beta-processing inflammasome is involved in contact hypersensitivity. J Invest Dermatol (2007) 2.73
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A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses. Nat Immunol (2007) 2.68
T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes. Nature (2009) 2.59
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The RIP kinases: crucial integrators of cellular stress. Trends Biochem Sci (2005) 2.56
cFLIP regulation of lymphocyte activation and development. Nat Rev Immunol (2006) 2.53
Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complex. Mol Cell Biol (2003) 2.50
The unfolded protein response: integrating stress signals through the stress sensor IRE1α. Physiol Rev (2011) 2.50
Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis. Am J Respir Crit Care Med (2009) 2.45
Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation. Immunity (2003) 2.41
Stimulation of Toll-like receptor 3 and 4 induces interleukin-1beta maturation by caspase-8. J Exp Med (2008) 2.40
TRADD protein is an essential component of the RIG-like helicase antiviral pathway. Immunity (2008) 2.37
Life and death decisions: secondary complexes and lipid rafts in TNF receptor family signal transduction. Immunity (2004) 2.36
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Innate immunity: cytoplasmic DNA sensing by the AIM2 inflammasome. Curr Biol (2009) 2.34
Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide. Mol Cell Biol (2006) 2.33
Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses. Nat Immunol (2008) 2.32
Innate immune sensing of modified vaccinia virus Ankara (MVA) is mediated by TLR2-TLR6, MDA-5 and the NALP3 inflammasome. PLoS Pathog (2009) 2.24
NMR structure of the apoptosis- and inflammation-related NALP1 pyrin domain. Structure (2003) 2.15
Single-cell analysis of population context advances RNAi screening at multiple levels. Mol Syst Biol (2012) 2.13
N-terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-kappaB signaling pathway. Mol Cell Biol (2004) 2.11
Crystal structure of NLRC4 reveals its autoinhibition mechanism. Science (2013) 2.10
Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β. Proc Natl Acad Sci U S A (2010) 2.09
Modulation of Rab5 and Rab7 recruitment to phagosomes by phosphatidylinositol 3-kinase. Mol Cell Biol (2003) 2.03
Identification of proteoglycans as the APRIL-specific binding partners. J Exp Med (2005) 2.03
Plasticity of astrocytic coverage and glutamate transporter expression in adult mouse cortex. PLoS Biol (2006) 2.00
Caspase-independent cell death in T lymphocytes. Nat Immunol (2003) 1.99
Caspase-14 is required for filaggrin degradation to natural moisturizing factors in the skin. J Invest Dermatol (2011) 1.93
NALP inflammasomes: a central role in innate immunity. Semin Immunopathol (2007) 1.91
Intra-endosomal membrane traffic. Trends Cell Biol (2006) 1.87
Sonic hedgehog induces the segregation of patched and smoothened in endosomes. Curr Biol (2002) 1.86
Type I IFN controls chikungunya virus via its action on nonhematopoietic cells. J Exp Med (2010) 1.86
Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex. J Biol Chem (2007) 1.85
Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies. PLoS Biol (2008) 1.85
TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts. Blood (2007) 1.85
Annexin II regulates multivesicular endosome biogenesis in the degradation pathway of animal cells. EMBO J (2003) 1.85
Caspase-2 activation in the absence of PIDDosome formation. J Cell Biol (2009) 1.74
Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-kappaB pathway. EMBO J (2006) 1.74
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