Published in J Neurosci on November 02, 2011
Cellular metabolic and autophagic pathways: traffic control by redox signaling. Free Radic Biol Med (2013) 1.46
Role of mitochondrial dysfunction and altered autophagy in cardiovascular aging and disease: from mechanisms to therapeutics. Am J Physiol Heart Circ Physiol (2013) 1.12
Mitochondria-targeted antioxidants for treatment of Parkinson's disease: preclinical and clinical outcomes. Biochim Biophys Acta (2013) 1.04
Mitochondrial-targeted peptide rapidly improves mitochondrial energetics and skeletal muscle performance in aged mice. Aging Cell (2013) 1.02
Deconstructing mitochondrial dysfunction in Alzheimer disease. Oxid Med Cell Longev (2013) 0.99
Mitochondrial- and endoplasmic reticulum-associated oxidative stress in Alzheimer's disease: from pathogenesis to biomarkers. Int J Cell Biol (2012) 0.96
The role of mitochondrial DNA mutation on neurodegenerative diseases. Exp Mol Med (2015) 0.96
Recent advances in the treatment of neurodegenerative diseases based on GSH delivery systems. Oxid Med Cell Longev (2012) 0.96
APP/PS1 mice overexpressing SREBP-2 exhibit combined Aβ accumulation and tau pathology underlying Alzheimer's disease. Hum Mol Genet (2013) 0.95
MitoQ, a mitochondria-targeted antioxidant, delays disease progression and alleviates pathogenesis in an experimental autoimmune encephalomyelitis mouse model of multiple sclerosis. Biochim Biophys Acta (2013) 0.94
Calcium regulation of neural rhythms, memory and Alzheimer's disease. J Physiol (2013) 0.91
The endocannabinoid system in normal and pathological brain ageing. Philos Trans R Soc Lond B Biol Sci (2012) 0.90
Mitochondrial abnormalities in Alzheimer's disease: possible targets for therapeutic intervention. Adv Pharmacol (2012) 0.89
P-glycoprotein (Mdr1a/1b) and breast cancer resistance protein (Bcrp) decrease the uptake of hydrophobic alkyl triphenylphosphonium cations by the brain. Biochim Biophys Acta (2013) 0.89
Senescence-accelerated OXYS rats: a model of age-related cognitive decline with relevance to abnormalities in Alzheimer disease. Cell Cycle (2014) 0.85
Centella asiatica Attenuates Amyloid-β-Induced Oxidative Stress and Mitochondrial Dysfunction. J Alzheimers Dis (2015) 0.85
Epoxyeicosatrienoic acids pretreatment improves amyloid β-induced mitochondrial dysfunction in cultured rat hippocampal astrocytes. Am J Physiol Heart Circ Physiol (2013) 0.84
Mitochondria, diabetes, and Alzheimer's disease. Diabetes (2012) 0.84
Mitochondria-derived reactive oxygen species mediate caspase-dependent and -independent neuronal deaths. Mol Cell Neurosci (2014) 0.84
Mitochondrial DNA damage in a mouse model of Alzheimer's disease decreases amyloid beta plaque formation. Neurobiol Aging (2013) 0.81
Cytoplasmic superoxide radical: a possible contributing factor to intracellular Aβ oligomerization in Alzheimer disease. Commun Integr Biol (2012) 0.80
Mitochondria-Targeted Protective Compounds in Parkinson's and Alzheimer's Diseases. Oxid Med Cell Longev (2015) 0.80
The rise of mitochondria in medicine. Mitochondrion (2016) 0.80
Early onset Alzheimer's disease and oxidative stress. Oxid Med Cell Longev (2014) 0.79
Altered Kv2.1 functioning promotes increased excitability in hippocampal neurons of an Alzheimer's disease mouse model. Cell Death Dis (2016) 0.79
Glutathione administration reduces mitochondrial damage and shifts cell death from necrosis to apoptosis in ageing diabetic mice hearts during exercise. Br J Pharmacol (2014) 0.77
Mitochondrial Superoxide Contributes to Hippocampal Synaptic Dysfunction and Memory Deficits in Angelman Syndrome Model Mice. J Neurosci (2015) 0.77
Posterior Cingulate Lactate as a Metabolic Biomarker in Amnestic Mild Cognitive Impairment. Biomed Res Int (2015) 0.77
Mitoquinone restores platelet production in irradiation-induced thrombocytopenia. Platelets (2014) 0.77
A new chiral pyrrolyl α-nitronyl nitroxide radical attenuates β-amyloid deposition and rescues memory deficits in a mouse model of Alzheimer disease. Neurotherapeutics (2013) 0.77
A mitochondrial redox oxygen sensor in the pulmonary vasculature and ductus arteriosus. Pflugers Arch (2015) 0.76
An overview on therapeutics attenuating amyloid β level in Alzheimer's disease: targeting neurotransmission, inflammation, oxidative stress and enhanced cholesterol levels. Am J Transl Res (2016) 0.76
Indomethacin-induced translocation of bacteria across enteric epithelia is reactive oxygen species-dependent and reduced by vitamin C. Am J Physiol Gastrointest Liver Physiol (2012) 0.76
Oxidation of KCNB1 Potassium Channels Causes Neurotoxicity and Cognitive Impairment in a Mouse Model of Traumatic Brain Injury. J Neurosci (2016) 0.76
Tau accumulation impairs mitophagy via increasing mitochondrial membrane potential and reducing mitochondrial Parkin. Oncotarget (2016) 0.76
Selective Mitochondrial Targeting Exerts Anxiolytic Effects In Vivo. Neuropsychopharmacology (2015) 0.75
Oxidation of KCNB1 potassium channels triggers apoptotic integrin signaling in the brain. Cell Death Dis (2017) 0.75
Metabolic effects of a mitochondrial-targeted coenzyme Q analog in high fat fed obese mice. Pharmacol Res Perspect (2017) 0.75
STX, a Novel Membrane Estrogen Receptor Ligand, Protects Against Amyloid-β Toxicity. J Alzheimers Dis (2016) 0.75
Targeting the prodromal stage of Alzheimer's disease: bioenergetic and mitochondrial opportunities. Neurotherapeutics (2015) 0.75
Potential Protection of Coeloglossum viride var. Bracteatum Extract against Oxidative Stress in Rat Cortical Neurons. J Anal Methods Chem (2013) 0.75
AUTOPHAGY, MITOCHONDRIAL DYNAMICS AND RETINAL DISEASES. Asia Pac J Ophthalmol (Phila) (2015) 0.75
Energy crisis precedes global metabolic failure in a novel Caenorhabditis elegans Alzheimer Disease model. Sci Rep (2016) 0.75
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science (2002) 49.51
Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods (1984) 16.43
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature (2006) 15.69
Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron (2003) 14.03
Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am J Physiol (1996) 13.14
Vitamin E and donepezil for the treatment of mild cognitive impairment. N Engl J Med (2005) 12.04
Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial. Lancet (2008) 8.51
Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nat Protoc (2006) 7.64
A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study. N Engl J Med (1997) 7.56
Oxidative damage and mitochondrial decay in aging. Proc Natl Acad Sci U S A (1994) 6.84
Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice. Neuron (2005) 6.20
Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides. Science (1990) 6.03
Ginkgo biloba for prevention of dementia: a randomized controlled trial. JAMA (2008) 6.00
ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease. Science (2004) 4.81
Mild cognitive impairment can be distinguished from Alzheimer disease and normal aging for clinical trials. Arch Neurol (2004) 4.66
Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state. J Neurosci (1993) 4.60
Development of novel fluorescence probes that can reliably detect reactive oxygen species and distinguish specific species. J Biol Chem (2002) 4.54
Mitochondrial abnormalities in Alzheimer's disease. J Neurosci (2001) 4.39
S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury. Science (2009) 4.25
Targeting antioxidants to mitochondria by conjugation to lipophilic cations. Annu Rev Pharmacol Toxicol (2007) 4.16
Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression. Hum Mol Genet (2006) 3.94
The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci (2001) 3.92
Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease. Neurobiol Aging (2003) 3.83
Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins. Proc Natl Acad Sci U S A (2008) 3.68
Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease. Neurology (2003) 3.62
Mitochondria and neuronal survival. Physiol Rev (2000) 3.56
Evaluation of 2',7'-dichlorofluorescin and dihydrorhodamine 123 as fluorescent probes for intracellular H2O2 in cultured endothelial cells. Arch Biochem Biophys (1993) 3.48
Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A (2009) 3.31
Caspase activation precedes and leads to tangles. Nature (2010) 3.24
Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties. J Biol Chem (2000) 3.12
Contributions of mitochondria to animal physiology: from homeostatic sensor to calcium signalling and cell death. J Physiol (1999) 3.07
Superoxide production by the mitochondrial respiratory chain. Biosci Rep (1997) 2.92
Mitochondrial Abeta: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease. FASEB J (2005) 2.91
Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. J Clin Invest (2004) 2.80
A hundred years of Alzheimer's disease research. Neuron (2006) 2.76
Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction. J Neurosci (1998) 2.65
Combining MR imaging, positron-emission tomography, and CSF biomarkers in the diagnosis and prognosis of Alzheimer disease. AJNR Am J Neuroradiol (2010) 2.61
A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease. Proc Natl Acad Sci U S A (1994) 2.39
Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury. FASEB J (2005) 2.33
Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells. J Cell Biol (2003) 2.32
The amyloid beta-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae. Proc Natl Acad Sci U S A (2008) 2.30
Mitochondria-targeted antioxidant MitoQ10 improves endothelial function and attenuates cardiac hypertrophy. Hypertension (2009) 2.28
Structure-activity analyses of beta-amyloid peptides: contributions of the beta 25-35 region to aggregation and neurotoxicity. J Neurochem (1995) 2.24
Mitochondrial membrane potential and neuronal glutamate excitotoxicity: mortality and millivolts. Trends Neurosci (2000) 2.23
Delivery of bioactive molecules to mitochondria in vivo. Proc Natl Acad Sci U S A (2003) 2.12
Roles of amyloid beta-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment. Free Radic Biol Med (2007) 2.08
Regional analysis of FDG and PIB-PET images in normal aging, mild cognitive impairment, and Alzheimer's disease. Eur J Nucl Med Mol Imaging (2008) 2.04
Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice. J Neurochem (2004) 1.92
Hippocampal hypometabolism predicts cognitive decline from normal aging. Neurobiol Aging (2007) 1.90
ABAD enhances Abeta-induced cell stress via mitochondrial dysfunction. FASEB J (2005) 1.89
Oxidative stress increases expression and activity of BACE in NT2 neurons. Neurobiol Dis (2002) 1.85
Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer's disease neurons. J Alzheimers Dis (2010) 1.84
Energy inhibition elevates beta-secretase levels and activity and is potentially amyloidogenic in APP transgenic mice: possible early events in Alzheimer's disease pathogenesis. J Neurosci (2005) 1.76
Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer's disease. Neurobiol Aging (2003) 1.75
Grape-derived polyphenolics prevent Abeta oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer's disease. J Neurosci (2008) 1.75
RAGE-mediated signaling contributes to intraneuronal transport of amyloid-beta and neuronal dysfunction. Proc Natl Acad Sci U S A (2009) 1.74
Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities. J Neurochem (2002) 1.74
Complete rescue of cerebrovascular function in aged Alzheimer's disease transgenic mice by antioxidants and pioglitazone, a peroxisome proliferator-activated receptor gamma agonist. J Neurosci (2008) 1.73
A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease. Mov Disord (2010) 1.72
Mitochondria-targeted antioxidants protect Friedreich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants. FASEB J (2003) 1.70
Reduction in mitochondrial superoxide dismutase modulates Alzheimer's disease-like pathology and accelerates the onset of behavioral changes in human amyloid precursor protein transgenic mice. J Neurosci (2006) 1.69
Animal and human studies with the mitochondria-targeted antioxidant MitoQ. Ann N Y Acad Sci (2010) 1.67
Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's disease. Ann N Y Acad Sci (2008) 1.64
Identification of nitrated proteins in Alzheimer's disease brain using a redox proteomics approach. Neurobiol Dis (2005) 1.58
Oxidative stress in Alzheimer's disease brain: new insights from redox proteomics. Eur J Pharmacol (2006) 1.57
The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharide-peptidoglycan model of sepsis. Free Radic Biol Med (2008) 1.55
Caffeine protects Alzheimer's mice against cognitive impairment and reduces brain beta-amyloid production. Neuroscience (2006) 1.53
Beta-site APP cleaving enzyme up-regulation induced by 4-hydroxynonenal is mediated by stress-activated protein kinases pathways. J Neurochem (2005) 1.53
Redox proteomics identification of oxidized proteins in Alzheimer's disease hippocampus and cerebellum: an approach to understand pathological and biochemical alterations in AD. Neurobiol Aging (2005) 1.52
Nuclear import of proinflammatory transcription factors is required for massive liver apoptosis induced by bacterial lipopolysaccharide. J Biol Chem (2004) 1.49
Oxidative stress potentiates BACE1 gene expression and Abeta generation. J Neural Transm (Vienna) (2004) 1.48
Reduction of oxidative stress, amyloid deposition, and memory deficit by manganese superoxide dismutase overexpression in a transgenic mouse model of Alzheimer's disease. FASEB J (2009) 1.47
The role of caspase cleavage of tau in Alzheimer disease neuropathology. J Neuropathol Exp Neurol (2005) 1.44
Prevention of diabetic nephropathy in Ins2(+/)⁻(AkitaJ) mice by the mitochondria-targeted therapy MitoQ. Biochem J (2010) 1.40
Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria. J Biol Chem (2004) 1.39
Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease. Free Radic Biol Med (2008) 1.38
Fine-tuning the hydrophobicity of a mitochondria-targeted antioxidant. FEBS Lett (2004) 1.38
The Alzheimer's disease mitochondrial cascade hypothesis: an update. Exp Neurol (2009) 1.36
Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice. Neurobiol Dis (2007) 1.30
Prevention of age-related spatial memory deficits in a transgenic mouse model of Alzheimer's disease by chronic Ginkgo biloba treatment. Exp Neurol (2003) 1.30
Functional mitochondria are required for amyloid beta-mediated neurotoxicity. FASEB J (2001) 1.29
Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis. J Biol Chem (2004) 1.28
Beta-amyloid mediated nitration of manganese superoxide dismutase: implication for oxidative stress in a APPNLH/NLH X PS-1P264L/P264L double knock-in mouse model of Alzheimer's disease. Am J Pathol (2006) 1.28
Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice. Free Radic Biol Med (2009) 1.26
Amyloid beta peptide and NMDA induce ROS from NADPH oxidase and AA release from cytosolic phospholipase A2 in cortical neurons. J Neurochem (2008) 1.25
Mitochondria: a therapeutic target in neurodegeneration. Biochim Biophys Acta (2009) 1.25
Protective effect of resveratrol on beta-amyloid-induced oxidative PC12 cell death. Free Radic Biol Med (2003) 1.25
Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model. Neurobiol Aging (2008) 1.24
Alterations in intracellular thiol homeostasis during the metabolism of menadione by isolated rat hepatocytes. Arch Biochem Biophys (1984) 1.23
A Bax-induced pro-oxidant state is critical for cytochrome c release during programmed neuronal death. J Neurosci (2002) 1.23
Mitochondrial medicine for aging and neurodegenerative diseases. Neuromolecular Med (2008) 1.22
Oxidative stress induces intracellular accumulation of amyloid beta-protein (Abeta) in human neuroblastoma cells. Biochemistry (2000) 1.20
Overexpression of SOD-2 reduces hippocampal superoxide and prevents memory deficits in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A (2009) 1.20
Lack of pathology in a triple transgenic mouse model of Alzheimer's disease after overexpression of the anti-apoptotic protein Bcl-2. J Neurosci (2008) 1.18
MitoQ administration prevents endotoxin-induced cardiac dysfunction. Am J Physiol Regul Integr Comp Physiol (2009) 1.17
Evidence for redox regulation of cytochrome C release during programmed neuronal death: antioxidant effects of protein synthesis and caspase inhibition. J Neurosci (2001) 1.17
Interaction of the mitochondria-targeted antioxidant MitoQ with phospholipid bilayers and ubiquinone oxidoreductases. J Biol Chem (2007) 1.16
Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage. J Biol Chem (2006) 1.16
Amyloid-beta leads to impaired cellular respiration, energy production and mitochondrial electron chain complex activities in human neuroblastoma cells. Cell Mol Neurobiol (2009) 1.12
Selective fluorescent imaging of superoxide in vivo using ethidium-based probes. Proc Natl Acad Sci U S A (2006) 4.64
The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production. J Cell Biol (2007) 3.47
Complex I is the major site of mitochondrial superoxide production by paraquat. J Biol Chem (2007) 3.31
Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I. Nat Med (2013) 3.10
Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing. Nature (2016) 2.98
Mitochondrial DNA damage can promote atherosclerosis independently of reactive oxygen species through effects on smooth muscle cells and monocytes and correlates with higher-risk plaques in humans. Circulation (2013) 2.94
DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88. Cell (2012) 2.81
KSR2 mutations are associated with obesity, insulin resistance, and impaired cellular fuel oxidation. Cell (2013) 2.56
Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury. FASEB J (2005) 2.33
Mitochondria-targeted antioxidant MitoQ10 improves endothelial function and attenuates cardiac hypertrophy. Hypertension (2009) 2.28
Reversible glutathionylation of complex I increases mitochondrial superoxide formation. J Biol Chem (2003) 2.28
Delivery of bioactive molecules to mitochondria in vivo. Proc Natl Acad Sci U S A (2003) 2.12
Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes. Diabetes (2004) 2.08
Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants. J Biol Chem (2002) 2.04
Glutaredoxin 2 catalyzes the reversible oxidation and glutathionylation of mitochondrial membrane thiol proteins: implications for mitochondrial redox regulation and antioxidant DEFENSE. J Biol Chem (2004) 1.99
Anti-Abeta42- and anti-Abeta40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model. J Clin Invest (2005) 1.96
Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix. Cell Metab (2011) 1.87
Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer's disease neurons. J Alzheimers Dis (2010) 1.84
Mitochondrial superoxide and aging: uncoupling-protein activity and superoxide production. Biochem Soc Symp (2004) 1.82
Inhibition of complex I of the electron transport chain causes O2-. -mediated mitochondrial outgrowth. Am J Physiol Cell Physiol (2005) 1.82
Glutathionylation of mitochondrial proteins. Antioxid Redox Signal (2005) 1.79
A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury. Proc Natl Acad Sci U S A (2009) 1.78
A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease. Mov Disord (2010) 1.72
Mitochondria-targeted antioxidants protect Friedreich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants. FASEB J (2003) 1.70
Neurological deficits caused by tissue hypoxia in neuroinflammatory disease. Ann Neurol (2013) 1.70
Animal and human studies with the mitochondria-targeted antioxidant MitoQ. Ann N Y Acad Sci (2010) 1.67
Mitochondria-targeted small molecule therapeutics and probes. Antioxid Redox Signal (2011) 1.66
Persistent S-nitrosation of complex I and other mitochondrial membrane proteins by S-nitrosothiols but not nitric oxide or peroxynitrite: implications for the interaction of nitric oxide with mitochondria. J Biol Chem (2006) 1.65
Non-expanded adipose stromal vascular fraction cell therapy for multiple sclerosis. J Transl Med (2009) 1.62
A mitochondria-targeted macrocyclic Mn(II) superoxide dismutase mimetic. Chem Biol (2012) 1.55
The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharide-peptidoglycan model of sepsis. Free Radic Biol Med (2008) 1.55
The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients. Liver Int (2010) 1.54
PTEN and p53 are required for hypoxia induced expression of maspin in glioblastoma cells. Cell Cycle (2009) 1.54
Adhesion of biologically inspired vertical and angled polymer microfiber arrays. Langmuir (2007) 1.54
A complication from neurocranial restructuring: nasal septum fracture. Arch Otolaryngol Head Neck Surg (2003) 1.53
Mitochondrial pharmacology. Trends Pharmacol Sci (2012) 1.51
Mitochondria-derived reactive oxygen species mediate blue light-induced death of retinal pigment epithelial cells. Photochem Photobiol (2004) 1.50
A redox switch in angiotensinogen modulates angiotensin release. Nature (2010) 1.50
Development of a single-chain, quasi-dimeric zinc-finger nuclease for the selective degradation of mutated human mitochondrial DNA. Nucleic Acids Res (2008) 1.48
Estimating the risk of solid organ malignancy in patients undergoing routine computed tomography scans after endovascular aneurysm repair. J Vasc Surg (2012) 1.46
Safety, tolerability, pharmacokinetics, and Abeta levels after short-term administration of R-flurbiprofen in healthy elderly individuals. Alzheimer Dis Assoc Disord (2007) 1.44
Femoral arterial access management for endovascular aortic aneurysm repair: evolution and outcome. Perspect Vasc Surg Endovasc Ther (2009) 1.42
Use of animals by NATO countries in military medical training exercises: an international survey. Mil Med (2012) 1.42
Prevention of diabetic nephropathy in Ins2(+/)⁻(AkitaJ) mice by the mitochondria-targeted therapy MitoQ. Biochem J (2010) 1.40
Dialysis access steal syndromes. Perspect Vasc Surg Endovasc Ther (2009) 1.38
Detection of reactive oxygen species-sensitive thiol proteins by redox difference gel electrophoresis: implications for mitochondrial redox signaling. J Biol Chem (2007) 1.38
Fine-tuning the hydrophobicity of a mitochondria-targeted antioxidant. FEBS Lett (2004) 1.38
A targeted antioxidant reveals the importance of mitochondrial reactive oxygen species in the hypoxic signaling of HIF-1alpha. FEBS Lett (2005) 1.36
DNA damage links mitochondrial dysfunction to atherosclerosis and the metabolic syndrome. Circ Res (2010) 1.36
Complex I within oxidatively stressed bovine heart mitochondria is glutathionylated on Cys-531 and Cys-704 of the 75-kDa subunit: potential role of CYS residues in decreasing oxidative damage. J Biol Chem (2008) 1.36
How mitochondrial damage affects cell function. J Biomed Sci (2002) 1.34
Mitochondrially targeted compounds and their impact on cellular bioenergetics. Redox Biol (2013) 1.34
Activation of mitogen-activated protein kinases by lysophosphatidylcholine-induced mitochondrial reactive oxygen species generation in endothelial cells. Am J Pathol (2006) 1.33
Antioxidant properties of MitoTEMPOL and its hydroxylamine. Free Radic Res (2009) 1.31
Gene expression analysis of spontaneously hypertensive rat cerebral cortex following transient focal cerebral ischemia. J Neurochem (2002) 1.30
Rapid and extensive uptake and activation of hydrophobic triphenylphosphonium cations within cells. Biochem J (2008) 1.28
Cysteine residues exposed on protein surfaces are the dominant intramitochondrial thiol and may protect against oxidative damage. FEBS J (2010) 1.28
Beta-amyloid mediated nitration of manganese superoxide dismutase: implication for oxidative stress in a APPNLH/NLH X PS-1P264L/P264L double knock-in mouse model of Alzheimer's disease. Am J Pathol (2006) 1.28
Mitochondria-targeted ubiquinone (MitoQ) decreases ethanol-dependent micro and macro hepatosteatosis. Hepatology (2011) 1.27
Mitochondrial redox signalling at a glance. J Cell Sci (2012) 1.26
Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice. Free Radic Biol Med (2009) 1.26
A mitochondria-targeted nitroxide is reduced to its hydroxylamine by ubiquinol in mitochondria. Free Radic Biol Med (2008) 1.24
A Bax-induced pro-oxidant state is critical for cytochrome c release during programmed neuronal death. J Neurosci (2002) 1.23
Sequence-specific modification of mitochondrial DNA using a chimeric zinc finger methylase. Proc Natl Acad Sci U S A (2006) 1.22
Application of polychromatic flow cytometry to identify novel subsets of circulating cells with angiogenic potential. Cytometry A (2010) 1.22
Ubiad1 is an antioxidant enzyme that regulates eNOS activity by CoQ10 synthesis. Cell (2013) 1.21
Protection through postconditioning or a mitochondria-targeted S-nitrosothiol is unaffected by cardiomyocyte-selective ablation of protein kinase G. Basic Res Cardiol (2013) 1.21
Antioxidant and prooxidant properties of mitochondrial Coenzyme Q. Arch Biochem Biophys (2004) 1.21
Release of proinflammatory mediators and expression of proinflammatory adhesion molecules by endothelial progenitor cells. Am J Physiol Heart Circ Physiol (2009) 1.20
Mesenchymal stem cells as anti-inflammatories: implications for treatment of Duchenne muscular dystrophy. Cell Immunol (2010) 1.19
Mitochondrial function is required for hydrogen peroxide-induced growth factor receptor transactivation and downstream signaling. J Biol Chem (2004) 1.19
Marvels, mysteries, and misconceptions of vascular compensation to peripheral artery occlusion. Microcirculation (2010) 1.18
Specific modification of mitochondrial protein thiols in response to oxidative stress: a proteomics approach. J Biol Chem (2002) 1.18
Emergency physician-verified out-of-hospital intubation: miss rates by paramedics. Acad Emerg Med (2004) 1.18
Mitochondrial uncouplers with an extraordinary dynamic range. Biochem J (2007) 1.16
Oxidative modification of hepatic mitochondria protein thiols: effect of chronic alcohol consumption. Am J Physiol Gastrointest Liver Physiol (2003) 1.16
Interaction of the mitochondria-targeted antioxidant MitoQ with phospholipid bilayers and ubiquinone oxidoreductases. J Biol Chem (2007) 1.16
Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease. Hum Mol Genet (2010) 1.15
Defects in mitochondrial clearance predispose human monocytes to interleukin-1β hypersecretion. J Biol Chem (2013) 1.15
Amyloid β-induced impairments in hippocampal synaptic plasticity are rescued by decreasing mitochondrial superoxide. J Neurosci (2011) 1.14
Slow calcium waves and redox changes precede mitochondrial permeability transition pore opening in the intact heart during hypoxia and reoxygenation. Cardiovasc Res (2011) 1.13
Proteomic approaches to the characterization of protein thiol modification. Curr Opin Chem Biol (2010) 1.13
Rapid uptake of lipophilic triphenylphosphonium cations by mitochondria in vivo following intravenous injection: implications for mitochondria-specific therapies and probes. Biochim Biophys Acta (2010) 1.13
MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress. Aging Cell (2003) 1.11
The mitochondria-targeted antioxidant MitoQ decreases features of the metabolic syndrome in ATM+/-/ApoE-/- mice. Free Radic Biol Med (2011) 1.10
Feasibility investigation of allogeneic endometrial regenerative cells. J Transl Med (2009) 1.10
Antioxidant and pro-oxidant properties of pyrroloquinoline quinone (PQQ): implications for its function in biological systems. Biochem Pharmacol (2003) 1.10
Mitochondrial 'flashes': a radical concept repHined. Trends Cell Biol (2012) 1.10
Glucose metabolism impacts the spatiotemporal onset and magnitude of HSC induction in vivo. Blood (2013) 1.10
Feasibility of combination allogeneic stem cell therapy for spinal cord injury: a case report. Int Arch Med (2010) 1.09
The effects of exogenous antioxidants on lifespan and oxidative stress resistance in Drosophila melanogaster. Mech Ageing Dev (2006) 1.08
Cystic masses of the knee: magnetic resonance imaging findings. Curr Probl Diagn Radiol (2005) 1.07
A new hypertrophic mechanism of serotonin in cardiac myocytes: receptor-independent ROS generation. FASEB J (2005) 1.06
Mitochondrial targeting of quinones: therapeutic implications. Mitochondrion (2007) 1.06
Rapid activation of antioxidant defenses by nerve growth factor suppresses reactive oxygen species during neuronal apoptosis: evidence for a role in cytochrome c redistribution. J Neurosci (2007) 1.05
The mitochondria-targeted antioxidant mitoquinone protects against cold storage injury of renal tubular cells and rat kidneys. J Pharmacol Exp Ther (2010) 1.05
Interactions of mitochondrial thiols with nitric oxide. Antioxid Redox Signal (2003) 1.05