Published in Biol Chem on December 01, 2006
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Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70. Cell (2003) 4.46
Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions. Cell (2011) 3.98
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Molecular chaperone functions in protein folding and proteostasis. Annu Rev Biochem (2013) 3.56
Structural features of the GroEL-GroES nano-cage required for rapid folding of encapsulated protein. Cell (2006) 3.45
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Structural basis for the cooperation of Hsp70 and Hsp110 chaperones in protein folding. Cell (2008) 2.80
Molecular chaperones of the Hsp110 family act as nucleotide exchange factors of Hsp70s. EMBO J (2006) 2.58
Structural probing of a protein phosphatase 2A network by chemical cross-linking and mass spectrometry. Science (2012) 2.34
Protein synthesis upon acute nutrient restriction relies on proteasome function. Science (2005) 2.32
Chaperones increase association of tau protein with microtubules. Proc Natl Acad Sci U S A (2003) 2.32
Real-time observation of trigger factor function on translating ribosomes. Nature (2006) 2.23
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Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation. Mol Cell (2004) 2.19
Chaperonin TRiC promotes the assembly of polyQ expansion proteins into nontoxic oligomers. Mol Cell (2006) 2.16
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The molecular architecture of the eukaryotic chaperonin TRiC/CCT. Structure (2012) 1.80
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Protein folding in the cytoplasm and the heat shock response. Cold Spring Harb Perspect Biol (2010) 1.71
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Coupled chaperone action in folding and assembly of hexadecameric Rubisco. Nature (2010) 1.63
Mitigation of chlorine-induced lung injury by low-molecular-weight antioxidants. Am J Physiol Lung Cell Mol Physiol (2008) 1.58
The proteasomal subunit Rpn6 is a molecular clamp holding the core and regulatory subcomplexes together. Proc Natl Acad Sci U S A (2011) 1.57
Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11. Proc Natl Acad Sci U S A (2014) 1.57
DnaK functions as a central hub in the E. coli chaperone network. Cell Rep (2012) 1.52
Retracted L25 functions as a conserved ribosomal docking site shared by nascent chain-associated complex and signal-recognition particle. EMBO Rep (2006) 1.51
Monitoring protein conformation along the pathway of chaperonin-assisted folding. Cell (2008) 1.45
An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis. EMBO J (2006) 1.45
In vivo analysis of the overlapping functions of DnaK and trigger factor. EMBO Rep (2004) 1.42
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Chaperonin-catalyzed rescue of kinetically trapped states in protein folding. Cell (2010) 1.36
Firefly luciferase mutants as sensors of proteome stress. Nat Methods (2011) 1.35
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The three-dimensional organization of polyribosomes in intact human cells. Mol Cell (2010) 1.26
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Structure and function of the AAA+ protein CbbX, a red-type Rubisco activase. Nature (2011) 1.20
Essential role of the unusual DNA-binding motif of BAG-1 for inhibition of the glucocorticoid receptor. J Biol Chem (2002) 1.19
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Proteolytic cleavage of polyglutamine-expanded ataxin-3 is critical for aggregation and sequestration of non-expanded ataxin-3. Hum Mol Genet (2006) 1.18
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Identification of nascent chain interaction sites on trigger factor. J Biol Chem (2007) 1.11
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Crystal structures of ethanolamine ammonia-lyase complexed with coenzyme B12 analogs and substrates. J Biol Chem (2010) 1.09
Calpain inhibition is sufficient to suppress aggregation of polyglutamine-expanded ataxin-3. J Biol Chem (2007) 1.07
Biosynthesis of pteridines. Reaction mechanism of GTP cyclohydrolase I. J Mol Biol (2003) 1.06
ATP binding is critical for the conformational change from an open to closed state in archaeal group II chaperonin. J Biol Chem (2003) 1.06
Pathogenic mutations located in the hydrophobic core of the prion protein interfere with folding and attachment of the glycosylphosphatidylinositol anchor. J Biol Chem (2004) 1.05
Post-exposure antioxidant treatment in rats decreases airway hyperplasia and hyperreactivity due to chlorine inhalation. Am J Respir Cell Mol Biol (2011) 1.05
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Structure of green-type Rubisco activase from tobacco. Nat Struct Mol Biol (2011) 1.05
Identification of anti-prion compounds as efficient inhibitors of polyglutamine protein aggregation in a zebrafish model. J Biol Chem (2006) 1.03
Exploring the capacity of trigger factor to function as a shield for ribosome bound polypeptide chains. FEBS Lett (2005) 1.03
Mutations in p97/VCP induce unfolding activity. FEBS Lett (2007) 1.02
Structure of a halophilic nucleoside diphosphate kinase from Halobacterium salinarum. FEBS Lett (2005) 1.02
Crystal structure of an archaeal actin homolog. J Mol Biol (2006) 1.00
The heat shock protein 90-targeting drug cisplatin selectively inhibits steroid receptor activation. Mol Endocrinol (2003) 1.00
Physicochemical determinants of chaperone requirements. J Mol Biol (2010) 0.99
Crystal structure of the GABA(A)-receptor-associated protein, GABARAP. EMBO Rep (2002) 0.98
Large FK506-binding proteins shape the pharmacology of rapamycin. Mol Cell Biol (2013) 0.98
Inhibition of GR-mediated transcription by p23 requires interaction with Hsp90. FEBS Lett (2004) 0.97
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Folding of large multidomain proteins by partial encapsulation in the chaperonin TRiC/CCT. Proc Natl Acad Sci U S A (2012) 0.95
Crystal structure of a chaperone-bound assembly intermediate of form I Rubisco. Nat Struct Mol Biol (2011) 0.95
Interaction of the Hsp110 molecular chaperones from S. cerevisiae with substrate protein. J Mol Biol (2010) 0.94
Differential substrate specificity of group I and group II chaperonins in the archaeon Methanosarcina mazei. Mol Microbiol (2009) 0.93