Published in Cell on January 23, 2009
Converging concepts of protein folding in vitro and in vivo. Nat Struct Mol Biol (2009) 5.47
Diffusion, crowding & protein stability in a dynamic molecular model of the bacterial cytoplasm. PLoS Comput Biol (2010) 3.65
The ribosome as a platform for co-translational processing, folding and targeting of newly synthesized proteins. Nat Struct Mol Biol (2009) 3.21
Structures of the bacterial ribosome in classical and hybrid states of tRNA binding. Science (2011) 3.14
Superresolution imaging of ribosomes and RNA polymerase in live Escherichia coli cells. Mol Microbiol (2012) 2.80
Post-reductionist protein science, or putting Humpty Dumpty back together again. Nat Chem Biol (2009) 2.52
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A structural view on the mechanism of the ribosome-catalyzed peptide bond formation. Biochim Biophys Acta (2009) 1.08
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Two promoters and two translation start sites control the expression of the Shigella flexneri outer membrane protease IcsP. Arch Microbiol (2011) 0.81
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Archaeal aminoacyl-tRNA synthetases interact with the ribosome to recycle tRNAs. Nucleic Acids Res (2014) 0.80
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A cylindrical specimen holder for electron cryo-tomography. Ultramicroscopy (2013) 0.79
Polyribosomes are molecular 3D nanoprinters that orchestrate the assembly of vault particles. ACS Nano (2014) 0.78
Ribosomes in a stacked array: elucidation of the step in translation elongation at which they are stalled during S-adenosyl-L-methionine-induced translation arrest of CGS1 mRNA. J Biol Chem (2014) 0.78
Structural characterization of the interaction of α-synuclein nascent chains with the ribosomal surface and trigger factor. Proc Natl Acad Sci U S A (2016) 0.78
Spatially segregated transcription and translation in cells of the endomembrane-containing bacterium Gemmata obscuriglobus. Proc Natl Acad Sci U S A (2014) 0.78
Chaperoning roles of macromolecules interacting with proteins in vivo. Int J Mol Sci (2011) 0.77
Mechanisms of activation of voltage-gated potassium channels. Acta Naturae (2014) 0.77
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Three distinct ribosome assemblies modulated by translation are the building blocks of polysomes. J Cell Biol (2015) 0.76
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Atomic force microscopy captures folded ribosome bound nascent chains. Chem Commun (Camb) (2012) 0.75
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Ribosomes are optimized for autocatalytic production. Nature (2017) 0.75
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Macromolecular architecture in eukaryotic cells visualized by cryoelectron tomography. Science (2002) 5.28
Proteome-wide analysis of chaperonin-dependent protein folding in Escherichia coli. Cell (2005) 4.78
A stress sensor for the bacterial periplasm. Cell (2003) 4.52
Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70. Cell (2003) 4.46
Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions. Cell (2011) 3.98
Three-dimensional structure of herpes simplex virus from cryo-electron tomography. Science (2003) 3.82
Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics (2008) 3.78
Diffusion, crowding & protein stability in a dynamic molecular model of the bacterial cytoplasm. PLoS Comput Biol (2010) 3.65
Nuclear pore complex structure and dynamics revealed by cryoelectron tomography. Science (2004) 3.61
Molecular chaperone functions in protein folding and proteostasis. Annu Rev Biochem (2013) 3.56
Structural features of the GroEL-GroES nano-cage required for rapid folding of encapsulated protein. Cell (2006) 3.45
Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach. Proc Natl Acad Sci U S A (2012) 3.42
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Retrovirus envelope protein complex structure in situ studied by cryo-electron tomography. Proc Natl Acad Sci U S A (2005) 3.17
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ATP hydrolysis by the proteasome regulatory complex PAN serves multiple functions in protein degradation. Mol Cell (2003) 3.14
Snapshots of nuclear pore complexes in action captured by cryo-electron tomography. Nature (2007) 2.99
Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3. EMBO J (2009) 2.83
Structural basis for the cooperation of Hsp70 and Hsp110 chaperones in protein folding. Cell (2008) 2.80
From words to literature in structural proteomics. Nature (2003) 2.80
Molecular chaperones of the Hsp110 family act as nucleotide exchange factors of Hsp70s. EMBO J (2006) 2.58
Protein synthesis upon acute nutrient restriction relies on proteasome function. Science (2005) 2.32
Chaperones increase association of tau protein with microtubules. Proc Natl Acad Sci U S A (2003) 2.32
Correlative microscopy: bridging the gap between fluorescence light microscopy and cryo-electron tomography. J Struct Biol (2007) 2.29
Real-time observation of trigger factor function on translating ribosomes. Nature (2006) 2.23
A balance of protein synthesis and proteasome-dependent degradation determines the maintenance of LTP. Neuron (2006) 2.23
Role of the myosin assembly protein UNC-45 as a molecular chaperone for myosin. Science (2002) 2.22
Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation. Mol Cell (2004) 2.19
Chaperonin TRiC promotes the assembly of polyQ expansion proteins into nontoxic oligomers. Mol Cell (2006) 2.16
Roles of molecular chaperones in protein misfolding diseases. Semin Cell Dev Biol (2004) 2.14
Structure and function of RbcX, an assembly chaperone for hexadecameric Rubisco. Cell (2007) 2.11
Structure of the 26S proteasome from Schizosaccharomyces pombe at subnanometer resolution. Proc Natl Acad Sci U S A (2010) 2.05
Near-atomic resolution structural model of the yeast 26S proteasome. Proc Natl Acad Sci U S A (2012) 2.04
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Identification of macromolecular complexes in cryoelectron tomograms of phantom cells. Proc Natl Acad Sci U S A (2002) 1.98
Regulation of Hsp70 function by HspBP1: structural analysis reveals an alternate mechanism for Hsp70 nucleotide exchange. Mol Cell (2005) 1.94
Three-dimensional architecture of murine rod outer segments determined by cryoelectron tomography. J Cell Biol (2007) 1.92
Visualizing cells at the nanoscale. Trends Biochem Sci (2008) 1.91
Focused ion beam micromachining of eukaryotic cells for cryoelectron tomography. Proc Natl Acad Sci U S A (2012) 1.89
Function of trigger factor and DnaK in multidomain protein folding: increase in yield at the expense of folding speed. Cell (2004) 1.85
3D structure of eukaryotic flagella in a quiescent state revealed by cryo-electron tomography. Proc Natl Acad Sci U S A (2005) 1.83
Insights into the molecular architecture of the 26S proteasome. Proc Natl Acad Sci U S A (2009) 1.81
The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication. EMBO J (2011) 1.80
The molecular architecture of the eukaryotic chaperonin TRiC/CCT. Structure (2012) 1.80
A visual approach to proteomics. Nat Rev Mol Cell Biol (2006) 1.79
PolyQ proteins interfere with nuclear degradation of cytosolic proteins by sequestering the Sis1p chaperone. Cell (2013) 1.76
Cryo-electron tomography reveals the cytoskeletal structure of Spiroplasma melliferum. Science (2005) 1.72
Protein folding in the cytoplasm and the heat shock response. Cold Spring Harb Perspect Biol (2010) 1.71
Cryo-electron tomography: the challenge of doing structural biology in situ. J Cell Biol (2013) 1.68
The role of molecular chaperones in human misfolding diseases. FEBS Lett (2009) 1.68
Formation of cristae and crista junctions in mitochondria depends on antagonism between Fcj1 and Su e/g. J Cell Biol (2009) 1.66
Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity. Proc Natl Acad Sci U S A (2002) 1.65
Coupled chaperone action in folding and assembly of hexadecameric Rubisco. Nature (2010) 1.63
Organization of actin networks in intact filopodia. Curr Biol (2007) 1.59
The proteasomal subunit Rpn6 is a molecular clamp holding the core and regulatory subcomplexes together. Proc Natl Acad Sci U S A (2011) 1.57
Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11. Proc Natl Acad Sci U S A (2014) 1.57
DnaK functions as a central hub in the E. coli chaperone network. Cell Rep (2012) 1.52
Retracted L25 functions as a conserved ribosomal docking site shared by nascent chain-associated complex and signal-recognition particle. EMBO Rep (2006) 1.51
Structure of the 26S proteasome with ATP-γS bound provides insights into the mechanism of nucleotide-dependent substrate translocation. Proc Natl Acad Sci U S A (2013) 1.50
Micromachining tools and correlative approaches for cellular cryo-electron tomography. J Struct Biol (2010) 1.49
Quantitative analysis of the native presynaptic cytomatrix by cryoelectron tomography. J Cell Biol (2010) 1.48
Cryo-electron tomography of vaccinia virus. Proc Natl Acad Sci U S A (2005) 1.48
The structure of human tripeptidyl peptidase II as determined by a hybrid approach. Structure (2012) 1.47
Monitoring protein conformation along the pathway of chaperonin-assisted folding. Cell (2008) 1.45
Noise contributions in an inducible genetic switch: a whole-cell simulation study. PLoS Comput Biol (2011) 1.44
Evidence of direct cell-cell fusion in Borrelia by cryogenic electron tomography. Cell Microbiol (2011) 1.43
Localization of the proteasomal ubiquitin receptors Rpn10 and Rpn13 by electron cryomicroscopy. Proc Natl Acad Sci U S A (2012) 1.42
Atomically detailed simulations of concentrated protein solutions: the effects of salt, pH, point mutations, and protein concentration in simulations of 1000-molecule systems. J Am Chem Soc (2006) 1.42
In vivo analysis of the overlapping functions of DnaK and trigger factor. EMBO Rep (2004) 1.42
Automated segmentation of electron tomograms for a quantitative description of actin filament networks. J Struct Biol (2011) 1.39
Retracted TRiC/CCT cooperates with different upstream chaperones in the folding of distinct protein classes. EMBO J (2003) 1.38
Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S proteasome. Proc Natl Acad Sci U S A (2014) 1.37
Chaperonin-catalyzed rescue of kinetically trapped states in protein folding. Cell (2010) 1.36
Firefly luciferase mutants as sensors of proteome stress. Nat Methods (2011) 1.35
Multiscale imaging of neurons grown in culture: from light microscopy to cryo-electron tomography. J Struct Biol (2007) 1.32
Prospects of electron cryotomography to visualize macromolecular complexes inside cellular compartments: implications of crowding. Biophys Chem (2003) 1.30
Essential role of the chaperonin folding compartment in vivo. EMBO J (2008) 1.29
Absolute protein-protein association rate constants from flexible, coarse-grained Brownian dynamics simulations: the role of intermolecular hydrodynamic interactions in barnase-barstar association. Biophys J (2010) 1.29
Mapping 70S ribosomes in intact cells by cryoelectron tomography and pattern recognition. J Struct Biol (2006) 1.28
An atomic model AAA-ATPase/20S core particle sub-complex of the 26S proteasome. Biochem Biophys Res Commun (2009) 1.28
The three-dimensional organization of polyribosomes in intact human cells. Mol Cell (2010) 1.26
Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system. EMBO J (2003) 1.25
20S proteasomes have the potential to keep substrates in store for continual degradation. J Biol Chem (2006) 1.20
Structure and function of the AAA+ protein CbbX, a red-type Rubisco activase. Nature (2011) 1.20
Computational sampling of a cryptic drug binding site in a protein receptor: explicit solvent molecular dynamics and inhibitor docking to p38 MAP kinase. J Mol Biol (2006) 1.19
Toward an integrated structural model of the 26S proteasome. Mol Cell Proteomics (2010) 1.19
Essential role of the unusual DNA-binding motif of BAG-1 for inhibition of the glucocorticoid receptor. J Biol Chem (2002) 1.19
Structure of hibernating ribosomes studied by cryoelectron tomography in vitro and in situ. J Cell Biol (2010) 1.19
Proteolytic cleavage of polyglutamine-expanded ataxin-3 is critical for aggregation and sequestration of non-expanded ataxin-3. Hum Mol Genet (2006) 1.18
Molecular dynamics simulations of hydrophobic associations in aqueous salt solutions indicate a connection between water hydrogen bonding and the Hofmeister effect. J Am Chem Soc (2007) 1.17
The catalytic activity of Ubp6 enhances maturation of the proteasomal regulatory particle. Mol Cell (2011) 1.17
Automated cryoelectron microscopy of "single particles" applied to the 26S proteasome. FEBS Lett (2007) 1.17
Mitochondrial stress signaling: a pathway unfolds. Trends Cell Biol (2007) 1.16
De novo folding of GFP fusion proteins: high efficiency in eukaryotes but not in bacteria. J Mol Biol (2005) 1.15