Published in Blood on August 01, 1991
Expansion of human SCID-repopulating cells under hypoxic conditions. J Clin Invest (2003) 2.37
RUNX1a enhances hematopoietic lineage commitment from human embryonic stem cells and inducible pluripotent stem cells. Blood (2013) 2.00
Self-renewal of primitive human hematopoietic cells (long-term-culture-initiating cells) in vitro and their expansion in defined medium. Proc Natl Acad Sci U S A (1996) 1.55
Differential cytokine effects on primitive (CD34+CD38-) human hematopoietic cells: novel responses to Flt3-ligand and thrombopoietin. J Exp Med (1996) 1.53
Temporal mapping of gene expression levels during the differentiation of individual primary hematopoietic cells. Proc Natl Acad Sci U S A (1996) 1.51
Long-term repopulating ability of xenogeneic transplanted human fetal liver hematopoietic stem cells in sheep. J Clin Invest (1994) 1.29
C1qRp defines a new human stem cell population with hematopoietic and hepatic potential. Proc Natl Acad Sci U S A (2002) 1.26
Direct adhesion to bone marrow stroma via fibronectin receptors inhibits hematopoietic progenitor proliferation. J Clin Invest (1995) 1.13
Proliferation of totipotent hematopoietic stem cells in vitro with retention of long-term competitive in vivo reconstituting ability. Proc Natl Acad Sci U S A (1992) 1.10
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Retroviral gene transfer to primitive normal and leukemic hematopoietic cells using clinically applicable procedures. J Clin Invest (1992) 0.96
Long-term culture system for selective growth of human B-cell progenitors. Proc Natl Acad Sci U S A (1995) 0.94
Neuronal nitric oxide synthase contributes to the regulation of hematopoiesis. Mol Med (2008) 0.92
Macrophage inflammatory protein 1 alpha, interleukin 3 and diffusible marrow stromal factors maintain human hematopoietic stem cells for at least eight weeks in vitro. J Exp Med (1994) 0.89
Rapid decline of chronic myeloid leukemic cells in long-term culture due to a defect at the leukemic stem cell level. Proc Natl Acad Sci U S A (1992) 0.89
Spatial development of the cultivation of a bone marrow stromal cell line in porous carriers. Cytotechnology (1999) 0.86
Long-term in vitro correction of alpha-L-iduronidase deficiency (Hurler syndrome) in human bone marrow. Proc Natl Acad Sci U S A (1996) 0.81
Cobblestone-area forming cells derived from patients with mantle cell lymphoma are enriched for CD133+ tumor-initiating cells. PLoS One (2014) 0.81
Identification of genes potentially involved in supporting hematopoietic stem cell activity of stromal cell line MC3T3-G2/PA6. Int J Hematol (2008) 0.79
Adipocytic cells augment the support of primitive hematopoietic cells in vitro but have no effect in the bone marrow niche under homeostatic conditions. Stem Cells Dev (2013) 0.78
Novel Wnt Regulator NEL-Like Molecule-1 Antagonizes Adipogenesis and Augments Osteogenesis Induced by Bone Morphogenetic Protein 2. Am J Pathol (2016) 0.77
Functional assessment of hematopoietic niche cells derived from human embryonic stem cells. Stem Cells Dev (2014) 0.75
The regulation of hematopoietic stem cell populations. F1000Res (2016) 0.75
Hypercholesterolemia Tunes Hematopoietic Stem/Progenitor Cells for Inflammation and Atherosclerosis. Int J Mol Sci (2016) 0.75
DNA damage induced by Strontium-90 exposure at low concentrations in mesenchymal stromal cells: the functional consequences. Sci Rep (2017) 0.75
Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell (1997) 13.34
Production of hybridoma growth factor by human monocytes. Eur J Immunol (1987) 7.99
Phenotypic and functional characterization in vitro of a multipotent epithelial cell present in the normal adult human breast. Differentiation (1998) 5.43
Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats. Proc Natl Acad Sci U S A (1997) 4.88
Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry. Nat Biotechnol (1998) 4.68
Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age. Proc Natl Acad Sci U S A (1994) 4.57
Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood. J Exp Med (1999) 4.27
Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization. Proc Natl Acad Sci U S A (1998) 4.11
Characterization of bipotent mammary epithelial progenitor cells in normal adult human breast tissue. Breast Cancer Res Treat (2001) 3.96
Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo. Genes Dev (1995) 3.81
Demonstration of permanent factor-dependent multipotential (erythroid/neutrophil/basophil) hematopoietic progenitor cell lines. Proc Natl Acad Sci U S A (1983) 3.76
Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy. Proc Natl Acad Sci U S A (1990) 3.43
Correction of sickle cell disease in transgenic mouse models by gene therapy. Science (2001) 3.25
Sequential generations of hematopoietic colonies derived from single nonlineage-committed CD34+CD38- progenitor cells. Blood (1991) 3.12
Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells. Proc Natl Acad Sci U S A (1994) 3.08
Short telomeres on human chromosome 17p. Nat Genet (1998) 2.81
Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia. Mol Cell Biol (1997) 2.61
Functional characterization of individual human hematopoietic stem cells cultured at limiting dilution on supportive marrow stromal layers. Proc Natl Acad Sci U S A (1990) 2.59
Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro. Blood (1989) 2.44
Lack of expression of Thy-1 (CD90) on acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo. Blood (1997) 2.33
Extension of cell life-span and telomere length in animals cloned from senescent somatic cells. Science (2000) 2.25
Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells. Curr Biol (2001) 2.21
Expression of Thy-1 on human hematopoietic progenitor cells. J Exp Med (1993) 2.09
Human hematopoietic stem cells stimulated to proliferate in vitro lose engraftment potential during their S/G(2)/M transit and do not reenter G(0). Blood (2000) 2.05
Telomere length measurements using digital fluorescence microscopy. Cytometry (1999) 2.03
Differential expression of telomerase activity in hematopoietic progenitors from adult human bone marrow. Stem Cells (1996) 1.97
The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo. Curr Biol (2000) 1.97
Self-renewal of hemopoietic stem cells during mixed colony formation in vitro. Proc Natl Acad Sci U S A (1981) 1.96
Telomere length in leukocyte subpopulations of patients with aplastic anemia. Blood (2001) 1.89
Clonal hematopoiesis demonstrated by X-linked DNA polymorphisms after allogeneic bone marrow transplantation. N Engl J Med (1989) 1.89
Improved engraftment of human acute myeloid leukemia progenitor cells in beta 2-microglobulin-deficient NOD/SCID mice and in NOD/SCID mice transgenic for human growth factors. Leukemia (2003) 1.85
Isolation in a single step of a highly enriched murine hematopoietic stem cell population with competitive long-term repopulating ability. Blood (1989) 1.84
Expansion in vitro of adult murine hematopoietic stem cells with transplantable lympho-myeloid reconstituting ability. Proc Natl Acad Sci U S A (1997) 1.84
Expression of HOX genes, HOX cofactors, and MLL in phenotypically and functionally defined subpopulations of leukemic and normal human hematopoietic cells. Leukemia (1999) 1.80
Properties of the earliest clonogenic hemopoietic precursors to appear in the developing murine yolk sac. Proc Natl Acad Sci U S A (1986) 1.80
A growth-factor dependent B-cell hybridoma. Curr Top Microbiol Immunol (1986) 1.79
Telomere length regulation in mice is linked to a novel chromosome locus. Proc Natl Acad Sci U S A (1998) 1.78
Telomerase activity in candidate stem cells from fetal liver and adult bone marrow. Blood (1998) 1.77
Leukocyte count as a predictor of death during remission induction in acute myeloid leukemia. Leuk Lymphoma (2006) 1.74
Shifting to outpatient management of acute myeloid leukemia: a prospective experience. Ann Oncol (2006) 1.73
High level engraftment of NOD/SCID mice by primitive normal and leukemic hematopoietic cells from patients with chronic myeloid leukemia in chronic phase. Blood (1998) 1.72
Transfer of the human telomerase reverse transcriptase (TERT) gene into T lymphocytes results in extension of replicative potential. Blood (2001) 1.71
Direct evidence for multiple self-renewal divisions of human in vivo repopulating hematopoietic cells in short-term culture. Blood (1999) 1.70
The human hematopoietic stem cell in vitro and in vivo. Blood Cells (1992) 1.58
2-Tridecanone: A Naturally Occurring Insecticide from the Wild Tomato Lycopersicon hirsutum f.glabratum. Science (1980) 1.57
Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability. Nat Genet (1999) 1.56
Self-renewal of primitive human hematopoietic cells (long-term-culture-initiating cells) in vitro and their expansion in defined medium. Proc Natl Acad Sci U S A (1996) 1.55
Erythropoietin (Ep) dose-response curves for three classes of erythroid progenitors in normal human marrow and in patients with polycythemia vera. Blood (1978) 1.55
Differential cytokine effects on primitive (CD34+CD38-) human hematopoietic cells: novel responses to Flt3-ligand and thrombopoietin. J Exp Med (1996) 1.53
Lineage commitment in human hemopoiesis involves asymmetric cell division of multipotent progenitors and does not appear to be influenced by cytokines. J Cell Physiol (1993) 1.53
Growth characteristics of acute myelogenous leukemia progenitors that initiate malignant hematopoiesis in nonobese diabetic/severe combined immunodeficient mice. Blood (1999) 1.52
High-efficiency gene transfer to human hematopoietic cells maintained in long-term marrow culture. Blood (1989) 1.52
Autografting with cultured marrow in chronic myeloid leukemia: results of a pilot study. Blood (1994) 1.51
Insights into the stem cells of chronic myeloid leukemia. Leukemia (2010) 1.51
Functional differences between transplantable human hematopoietic stem cells from fetal liver, cord blood, and adult marrow. Exp Hematol (1999) 1.47
The repopulation potential of fetal liver hematopoietic stem cells in mice exceeds that of their liver adult bone marrow counterparts. Blood (1996) 1.45
Most acute myeloid leukemia progenitor cells with long-term proliferative ability in vitro and in vivo have the phenotype CD34(+)/CD71(-)/HLA-DR-. Blood (1998) 1.44
Previously undetected human hematopoietic cell populations with short-term repopulating activity selectively engraft NOD/SCID-beta2 microglobulin-null mice. J Clin Invest (2001) 1.43
A comparison of long-term repopulating hematopoietic stem cells in fetal liver and adult bone marrow from the mouse. Exp Hematol (1996) 1.42
Telomere maintenance in telomerase-deficient mouse embryonic stem cells: characterization of an amplified telomeric DNA. Mol Cell Biol (2000) 1.42
Elucidating critical mechanisms of deregulated stem cell turnover in the chronic phase of chronic myeloid leukemia. Leukemia (2002) 1.35
Enzymatic treatment of long-term human marrow cultures reveals the preferential location of primitive hemopoietic progenitors in the adherent layer. Blood (1983) 1.35
Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo. Blood (2001) 1.34
Immunological study of in vitro maturation of human megakaryocytes. Br J Haematol (1984) 1.32
Selective expression of CD45 isoforms on functional subpopulations of CD34+ hemopoietic cells from human bone marrow. J Exp Med (1990) 1.31
Accumulation of short telomeres in human fibroblasts prior to replicative senescence. Exp Cell Res (2000) 1.30
Cytokine manipulation of primitive human hematopoietic cell self-renewal. Proc Natl Acad Sci U S A (1997) 1.29
Retrovirus-mediated gene transfer to purified hemopoietic stem cells with long-term lympho-myelopoietic repopulating ability. Proc Natl Acad Sci U S A (1989) 1.29
Regulated proliferation of primitive hematopoietic progenitor cells in long-term human marrow cultures. Blood (1985) 1.28
Kinetic evidence of the regeneration of multilineage hematopoiesis from primitive cells in normal human bone marrow transplanted into immunodeficient mice. Blood (1997) 1.28
Asymmetric cell divisions sustain long-term hematopoiesis from single-sorted human fetal liver cells. J Exp Med (1998) 1.27
Expansion in vitro of retrovirally marked totipotent hematopoietic stem cells. Blood (1990) 1.27
Accelerated telomere shortening in hematological lineages is limited to the first year following stem cell transplantation. Blood (2001) 1.26
Biology of human umbilical cord blood-derived hematopoietic stem/progenitor cells. Stem Cells (1998) 1.26
Monoclonal antibodies against human platelet glycoprotein IIIa. Br J Haematol (1983) 1.25
Impaired steel factor responsiveness differentially affects the detection and long-term maintenance of fetal liver hematopoietic stem cells in vivo. Blood (1997) 1.24