Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability.

The power to reduce: pyridine nucleotides--small molecules with a multitude of functions. Biochem J (2007) 3.11

Ku acts in a unique way at the mammalian telomere to prevent end joining. Genes Dev (2000) 2.38

Ku is associated with the telomere in mammals. Proc Natl Acad Sci U S A (1999) 2.36

Natural and pharmacological regulation of telomerase. Nucleic Acids Res (2002) 1.92

Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination. Nucleic Acids Res (2003) 1.86

Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions. EMBO J (2012) 1.71

DNA-PKcs is critical for telomere capping. Proc Natl Acad Sci U S A (2001) 1.64

PARP Inhibitors for BRCA1/2 mutation-associated and BRCA-like malignancies. Ann Oncol (2013) 1.55

Tankyrase 2 poly(ADP-ribose) polymerase domain-deleted mice exhibit growth defects but have normal telomere length and capping. Mol Cell Biol (2006) 1.45

Involvement of poly(ADP-Ribose) polymerase 1 and poly(ADP-Ribosyl)ation in regulation of centrosome function. Mol Cell Biol (2003) 1.43

Functional interaction between poly(ADP-Ribose) polymerase 2 (PARP-2) and TRF2: PARP activity negatively regulates TRF2. Mol Cell Biol (2004) 1.27

DNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression. Mol Cell Biol (2001) 1.20

Misregulation of gene expression in primary fibroblasts lacking poly(ADP-ribose) polymerase. Proc Natl Acad Sci U S A (2000) 1.20

Normal telomere length and chromosomal end capping in poly(ADP-ribose) polymerase-deficient mice and primary cells despite increased chromosomal instability. J Cell Biol (2001) 1.19

Genetic cooperation between the Werner syndrome protein and poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice. Am J Pathol (2003) 1.17

Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs. J Cell Biol (2004) 1.11

Regulation of poly(ADP-ribose) polymerase-1 (PARP-1) gene expression through the post-translational modification of Sp1: a nuclear target protein of PARP-1. BMC Mol Biol (2007) 1.10

Rapid regulation of telomere length is mediated by poly(ADP-ribose) polymerase-1. Nucleic Acids Res (2008) 1.06

PARP1 suppresses homologous recombination events in mice in vivo. Nucleic Acids Res (2010) 1.02

Poly(ADP-ribosyl)ation basally activated by DNA strand breaks reflects glutamate-nitric oxide neurotransmission. Proc Natl Acad Sci U S A (2000) 1.01

Accelerated telomere shortening in the human inactive X chromosome. Am J Hum Genet (1999) 0.99

Thymoquinone induces telomere shortening, DNA damage and apoptosis in human glioblastoma cells. PLoS One (2010) 0.98

Vault poly(ADP-ribose) polymerase is associated with mammalian telomerase and is dispensable for telomerase function and vault structure in vivo. Mol Cell Biol (2004) 0.97

Regulation of Epstein-Barr virus OriP replication by poly(ADP-ribose) polymerase 1. J Virol (2010) 0.96

Role of nicotinamide in DNA damage, mutagenesis, and DNA repair. J Nucleic Acids (2010) 0.96

Selective small molecule inhibition of poly(ADP-ribose) glycohydrolase (PARG). ACS Chem Biol (2012) 0.95

Telomere biology: integrating chromosomal end protection with DNA damage response. Chromosoma (2005) 0.92

Potential biological role of poly (ADP-ribose) polymerase (PARP) in male gametes. Reprod Biol Endocrinol (2009) 0.92

Pleiotropic cellular functions of PARP1 in longevity and aging: genome maintenance meets inflammation. Oxid Med Cell Longev (2012) 0.90

QTL mapping of leukocyte telomere length in American Indians: the Strong Heart Family Study. Aging (Albany NY) (2013) 0.89

Synthesis, [¹⁸F] radiolabeling, and evaluation of poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors for in vivo imaging of PARP-1 using positron emission tomography. Bioorg Med Chem (2014) 0.87

Poly(ADP-ribose) polymerase (PARP-1) and p53 independently function in regulating double-strand break repair in primate cells. Nucleic Acids Res (2004) 0.86

Quantification of cellular poly(ADP-ribosyl)ation by stable isotope dilution mass spectrometry reveals tissue- and drug-dependent stress response dynamics. ACS Chem Biol (2013) 0.85

Telomere-mediated chromosomal instability triggers TLR4 induced inflammation and death in mice. PLoS One (2010) 0.85

Association between PARP-1 V762A polymorphism and cancer susceptibility: a meta-analysis. Genet Epidemiol (2011) 0.85

Inhibition of poly (ADP-Ribose) polymerase-1 in telomerase deficient mouse embryonic fibroblasts increases arsenite-induced genome instability. Genome Integr (2010) 0.84

Need telomere maintenance? Call 911. Cell Div (2007) 0.81

Analysis of poly(ADP-Ribose) polymerases in Arabidopsis telomere biology. PLoS One (2014) 0.81

PARP1 and DNA-PKcs synergize to suppress p53 mutation and telomere fusions during T-lineage lymphomagenesis. Oncogene (2012) 0.81

Inhibition of poly(ADP-ribose) polymerase activity is insufficient to induce tetraploidy. Nucleic Acids Res (2001) 0.80

Affinity-based assays for the identification and quantitative evaluation of noncovalent poly(ADP-ribose)-binding proteins. Methods Mol Biol (2011) 0.80

PARP1 gene expression is downregulated by knockdown of PARG gene. Oncol Rep (2013) 0.80

Involvement of PARP-1 Val762Ala polymorphism in the onset of cervical cancer in caucasian women. Mol Diagn Ther (2013) 0.79

Tankyrase1-mediated poly(ADP-ribosyl)ation of TRF1 maintains cell survival after telomeric DNA damage. Nucleic Acids Res (2017) 0.75

Characterization of the 5'-flanking region of the human DNA helicase B (HELB) gene and its response to trans-Resveratrol. Sci Rep (2016) 0.75

Telomere length modulation in human astroglial brain tumors. PLoS One (2013) 0.75

Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell (1997) 13.34

DNA double-strand breaks: signaling, repair and the cancer connection. Nat Genet (2001) 10.77

Production of hybridoma growth factor by human monocytes. Eur J Immunol (1987) 7.99

The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell (1993) 7.17

c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling. Science (1994) 5.97

The DNA-dependent protein kinase. Genes Dev (1999) 5.80

Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing. EMBO J (1998) 5.79

Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell (1995) 5.58

A role for Saccharomyces cerevisiae histone H2A in DNA repair. Nature (2001) 5.28

Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination. Science (1994) 4.99

DNA end-joining: from yeast to man. Trends Biochem Sci (1998) 4.94

Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats. Proc Natl Acad Sci U S A (1997) 4.88

Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry. Nat Biotechnol (1998) 4.68

DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell (1995) 4.64

Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways. EMBO J (1996) 4.58

Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age. Proc Natl Acad Sci U S A (1994) 4.57

Pathophysiology of premature skin aging induced by ultraviolet light. N Engl J Med (1997) 4.57

Synergistic activation by the glutamine-rich domains of human transcription factor Sp1. Cell (1989) 4.49

Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance. Nucleic Acids Res (1996) 4.37

Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood. J Exp Med (1999) 4.27

Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia. Nat Med (1997) 4.12

Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization. Proc Natl Acad Sci U S A (1998) 4.11

Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP. Cell (1994) 3.91

Molecular basis of sun-induced premature skin ageing and retinoid antagonism. Nature (1996) 3.83

Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo. Genes Dev (1995) 3.81

Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV. Curr Biol (1997) 3.67

The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms. Mol Cell (2000) 3.64

Direct interaction between Sp1 and the BPV enhancer E2 protein mediates synergistic activation of transcription. Cell (1991) 3.46

Identification of a yeast snRNP protein and detection of snRNP-snRNP interactions. Cell (1987) 3.46

Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy. Proc Natl Acad Sci U S A (1990) 3.43

Identification of Saccharomyces cerevisiae DNA ligase IV: involvement in DNA double-strand break repair. EMBO J (1997) 3.29

Regulation of p53 in response to DNA damage. Oncogene (1999) 3.23

The FHA domain is a modular phosphopeptide recognition motif. Mol Cell (1999) 3.16

Sequential generations of hematopoietic colonies derived from single nonlineage-committed CD34+CD38- progenitor cells. Blood (1991) 3.12

Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells. Proc Natl Acad Sci U S A (1994) 3.08

The TATA-binding protein: a general transcription factor in eukaryotes and archaebacteria. Science (1994) 3.06

Repression of RNA polymerase III transcription by the retinoblastoma protein. Nature (1996) 3.04

Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient. Curr Biol (1999) 2.98

DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme? Curr Opin Cell Biol (2001) 2.93

DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair. Proc Natl Acad Sci U S A (1995) 2.87

Menage à trois: double strand break repair, V(D)J recombination and DNA-PK. Bioessays (1995) 2.86

Short telomeres on human chromosome 17p. Nat Genet (1998) 2.81

Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse. Proc Natl Acad Sci U S A (1996) 2.77

The yeast Xrs2 complex functions in S phase checkpoint regulation. Genes Dev (2001) 2.75

Developmental expression of Sp1 in the mouse. Mol Cell Biol (1991) 2.73

A nonpeptidyl mimic of superoxide dismutase with therapeutic activity in rats. Science (1999) 2.68

Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia. Mol Cell Biol (1997) 2.61

Functional characterization of individual human hematopoietic stem cells cultured at limiting dilution on supportive marrow stromal layers. Proc Natl Acad Sci U S A (1990) 2.59

Nitric oxide: a key mediator in the early and late phase of carrageenan-induced rat paw inflammation. Br J Pharmacol (1996) 2.55

DNA looping and Sp1 multimer links: a mechanism for transcriptional synergism and enhancement. Proc Natl Acad Sci U S A (1991) 2.51

Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro. Blood (1989) 2.44

Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity. Immunity (1998) 2.43

Ku acts in a unique way at the mammalian telomere to prevent end joining. Genes Dev (2000) 2.38

Lack of expression of Thy-1 (CD90) on acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo. Blood (1997) 2.33

Ischemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase. J Cereb Blood Flow Metab (1997) 2.31

Human cell senescence as a DNA damage response. Mech Ageing Dev (2005) 2.26

Mechanism and regulation of transcription in archaea. Curr Opin Microbiol (2001) 2.25

Extension of cell life-span and telomere length in animals cloned from senescent somatic cells. Science (2000) 2.25

LCD1: an essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae. EMBO J (2000) 2.22

Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells. Curr Biol (2001) 2.21

Ku, a DNA repair protein with multiple cellular functions? Mutat Res (1999) 2.16

Expression of Thy-1 on human hematopoietic progenitor cells. J Exp Med (1993) 2.09

Transcription and translation in Archaea: a mosaic of eukaryal and bacterial features. Trends Microbiol (1998) 2.08

Crystal structure of an Xrcc4-DNA ligase IV complex. Nat Struct Biol (2001) 2.07

The absence of c-fos prevents light-induced apoptotic cell death of photoreceptors in retinal degeneration in vivo. Nat Med (1997) 2.07

Telomere length measurements using digital fluorescence microscopy. Cytometry (1999) 2.03

Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin. Nat Med (1999) 1.98

Differential expression of telomerase activity in hematopoietic progenitors from adult human bone marrow. Stem Cells (1996) 1.97

DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis. EMBO J (1996) 1.97

The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo. Curr Biol (2000) 1.97

Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin. J Invest Dermatol (2000) 1.97

Polar overdominance at the ovine callipyge locus. Science (1996) 1.96

Conserved functional domains of the RNA polymerase III general transcription factor BRF. Genes Dev (1994) 1.90

Telomere length in leukocyte subpopulations of patients with aplastic anemia. Blood (2001) 1.89

Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism. Proc Natl Acad Sci U S A (1999) 1.88

Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death. Mutat Res (2001) 1.85

A role for the TATA-box-binding protein component of the transcription factor IID complex as a general RNA polymerase III transcription factor. Proc Natl Acad Sci U S A (1992) 1.85

Cancer incidence and risk estimation among medical x-ray workers in China, 1950-1995. Health Phys (2002) 1.85

Orientation of the transcription preinitiation complex in archaea. Proc Natl Acad Sci U S A (1999) 1.84

Isolation in a single step of a highly enriched murine hematopoietic stem cell population with competitive long-term repopulating ability. Blood (1989) 1.84

Atm deficiency results in severe meiotic disruption as early as leptonema of prophase I. Development (1998) 1.81

Poly(ADP-ribose) polymerase null mouse cells synthesize ADP-ribose polymers. J Biol Chem (1998) 1.79

A growth-factor dependent B-cell hybridoma. Curr Top Microbiol Immunol (1986) 1.79

Factor requirements for transcription in the Archaeon Sulfolobus shibatae. EMBO J (1997) 1.78

Telomere length regulation in mice is linked to a novel chromosome locus. Proc Natl Acad Sci U S A (1998) 1.78

Telomerase activity in candidate stem cells from fetal liver and adult bone marrow. Blood (1998) 1.77

Expression of the subtype 2 angiotensin (AT2) receptor protein in rat kidney. Hypertension (1997) 1.77

Mechanism of TATA-binding protein recruitment to a TATA-less class III promoter. Cell (1992) 1.76

New approaches to understanding p53 gene tumor mutation spectra. Mutat Res (1999) 1.75

Competitive and noncompetitive inhibition of the DNA-dependent protein kinase. Cancer Res (1999) 1.74

Mapping of protein-protein interactions within the DNA-dependent protein kinase complex. Nucleic Acids Res (1999) 1.72

Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes. Proc Natl Acad Sci U S A (1999) 1.71

Transfer of the human telomerase reverse transcriptase (TERT) gene into T lymphocytes results in extension of replicative potential. Blood (2001) 1.71

Sequence-specific DNA binding by the S. shibatae TFIIB homolog, TFB, and its effect on promoter strength. Mol Cell (1998) 1.71