Published in Proc Natl Acad Sci U S A on December 01, 2006
Physiology and pathophysiology of canonical transient receptor potential channels. FASEB J (2008) 2.31
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Alterations in the ankyrin domain of TRPV4 cause congenital distal SMA, scapuloperoneal SMA and HMSN2C. Nat Genet (2009) 2.22
Pressure-induced and store-operated cation influx in vascular smooth muscle cells is independent of TRPC1. Pflugers Arch (2007) 2.17
Hypoxia triggers subcellular compartmental redox signaling in vascular smooth muscle cells. Circ Res (2009) 1.92
Tumor suppressors TSC1 and TSC2 differentially modulate actin cytoskeleton and motility of mouse embryonic fibroblasts. PLoS One (2014) 1.45
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Deletion of TRPC4 and TRPC6 in mice impairs smooth muscle contraction and intestinal motility in vivo. Gastroenterology (2009) 1.31
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Hypoxic pulmonary vasoconstriction requires connexin 40-mediated endothelial signal conduction. J Clin Invest (2012) 1.24
New mechanisms of pulmonary arterial hypertension: role of Ca²⁺ signaling. Am J Physiol Heart Circ Physiol (2012) 1.24
TRPC6 channels and their binding partners in podocytes: role in glomerular filtration and pathophysiology. Am J Physiol Renal Physiol (2010) 1.14
Transient receptor potential channels in the vasculature. Physiol Rev (2015) 1.14
Superoxide generated at mitochondrial complex III triggers acute responses to hypoxia in the pulmonary circulation. Am J Respir Crit Care Med (2013) 1.14
Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells. J Vasc Res (2008) 1.08
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ROS-dependent signaling mechanisms for hypoxic Ca(2+) responses in pulmonary artery myocytes. Antioxid Redox Signal (2010) 1.04
Activation of neutral sphingomyelinase is involved in acute hypoxic pulmonary vasoconstriction. Cardiovasc Res (2008) 1.03
TRPC channel lipid specificity and mechanisms of lipid regulation. Cell Calcium (2009) 1.03
Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2. Nucleic Acids Res (2013) 1.01
Ion channel regulation of intracellular calcium and airway smooth muscle function. Pulm Pharmacol Ther (2008) 1.01
Inhibition of SOC/Ca2+/NFAT pathway is involved in the anti-proliferative effect of sildenafil on pulmonary artery smooth muscle cells. Respir Res (2009) 1.00
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The role of inflammation in hypoxic pulmonary hypertension: from cellular mechanisms to clinical phenotypes. Am J Physiol Lung Cell Mol Physiol (2014) 0.94
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Integration of transient receptor potential canonical channels with lipids. Acta Physiol (Oxf) (2011) 0.86
TRP channel Ca(2+) sparklets: fundamental signals underlying endothelium-dependent hyperpolarization. Am J Physiol Cell Physiol (2013) 0.86
Hypoxic pulmonary vasoconstriction in the absence of pretone: essential role for intracellular Ca2+ release. J Physiol (2013) 0.86
Mechanisms of oxygen sensing: a key to therapy of pulmonary hypertension and patent ductus arteriosus. Br J Pharmacol (2008) 0.85
CFTR and sphingolipids mediate hypoxic pulmonary vasoconstriction. Proc Natl Acad Sci U S A (2015) 0.82
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Characterization of a murine model of monocrotaline pyrrole-induced acute lung injury. BMC Pulm Med (2008) 0.81
Molecular and clinical analysis of TRPC6 and AGTR1 genes in patients with pulmonary arterial hypertension. Orphanet J Rare Dis (2015) 0.81
Bone morphogenetic protein 2 decreases TRPC expression, store-operated Ca(2+) entry, and basal [Ca(2+)]i in rat distal pulmonary arterial smooth muscle cells. Am J Physiol Cell Physiol (2013) 0.81
Inhibition of lipid signaling enzyme diacylglycerol kinase epsilon attenuates mutant huntingtin toxicity. J Biol Chem (2012) 0.81
Unraveling smooth muscle contraction: the TRP link. Gastroenterology (2009) 0.80
Cigarette Smoke-Induced Emphysema and Pulmonary Hypertension Can Be Prevented by Phosphodiesterase 4 and 5 Inhibition in Mice. PLoS One (2015) 0.80
TRP channels and STIM/ORAI proteins: sensors and effectors of cancer and stroma cell migration. Br J Pharmacol (2014) 0.80
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Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol-sensitive TRPC cation channels. Br J Pharmacol (2015) 0.77
SNF8, a member of the ESCRT-II complex, interacts with TRPC6 and enhances its channel activity. BMC Cell Biol (2012) 0.77
TRPC6 is required for hypoxia‑induced basal intracellular calcium concentration elevation, and for the proliferation and migration of rat distal pulmonary venous smooth muscle cells. Mol Med Rep (2015) 0.76
Effects of dimethylarginine dimethylaminohydrolase-1 overexpression on the response of the pulmonary vasculature to hypoxia. Am J Respir Cell Mol Biol (2013) 0.76
Attenuation of canonical transient receptor potential-like channel 6 expression specifically reduces the diacylglycerol-mediated increase in intracellular calcium in human myometrial cells. Endocrinology (2009) 0.76
Expression of trpC1 and trpC6 orthologs in zebrafish. Gene Expr Patterns (2008) 0.76
Transient receptor potential canonical type 3 channels control the vascular contractility of mouse mesenteric arteries. PLoS One (2014) 0.76
Regulation of rat intrapulmonary arterial tone by arachidonic acid and prostaglandin E2 during hypoxia. PLoS One (2013) 0.76
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Oxygen physiology: sensors and ion channels. Pflugers Arch (2015) 0.75
TRP channels as sensors of oxygen availability. Pflugers Arch (2013) 0.75
NADPH oxidases-do they play a role in TRPC regulation under hypoxia? Pflugers Arch (2015) 0.75
Redox-sensitive transient receptor potential channels in oxygen sensing and adaptation. Pflugers Arch (2015) 0.75
Deletion of TRPC6 Attenuates NMDA Receptor-Mediated Ca(2+) Entry and Ca(2+)-Induced Neurotoxicity Following Cerebral Ischemia and Oxygen-Glucose Deprivation. Front Neurosci (2017) 0.75
The Role of Transient Receptor Potential Channel 6 Channels in the Pulmonary Vasculature. Front Immunol (2017) 0.75
TRPC6 channels modulate the response of pancreatic stellate cells to hypoxia. Pflugers Arch (2017) 0.75
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Increased vascular smooth muscle contractility in TRPC6-/- mice. Mol Cell Biol (2005) 3.28
Model for hypoxic pulmonary vasoconstriction involving mitochondrial oxygen sensing. Circ Res (2001) 3.07
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TRPM3 is a nociceptor channel involved in the detection of noxious heat. Neuron (2011) 2.31
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