Published in Pain on December 06, 2006
Contribution of afferent pathways to nerve injury-induced spontaneous pain and evoked hypersensitivity. Pain (2011) 1.12
Noradrenergic neurons in the locus coeruleus contribute to neuropathic pain. Neuroscience (2009) 1.01
Neuropathy-induced spinal GAP-43 expression is not a main player in the onset of mechanical pain hypersensitivity. J Neurotrauma (2011) 0.88
Effects of general anesthetics on substance P release and c-Fos expression in the spinal dorsal horn. Anesthesiology (2013) 0.84
Descending facilitation maintains long-term spontaneous neuropathic pain. J Pain (2013) 0.83
Central Sensitization and Neuropathic Features of Ongoing Pain in a Rat Model of Advanced Osteoarthritis. J Pain (2015) 0.79
Pregnancy suppresses neuropathic pain induced by chronic constriction injury in rats through the inhibition of TNF-α. J Pain Res (2017) 0.75
An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain (1992) 9.17
Induction of c-fos-like protein in spinal cord neurons following sensory stimulation. Nature (1987) 4.59
Chronic pain and medullary descending facilitation. Trends Neurosci (2002) 3.54
Transmission of chronic nociception by spinal neurons expressing the substance P receptor. Science (1999) 2.43
Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways. Nat Neurosci (2002) 2.24
Multiple actions of systemic artemin in experimental neuropathy. Nat Med (2003) 2.12
Time-dependent descending facilitation from the rostral ventromedial medulla maintains, but does not initiate, neuropathic pain. J Neurosci (2002) 2.00
Myelinated afferents signal the hyperalgesia associated with nerve injury. Pain (1988) 1.92
Bad news from the brain: descending 5-HT pathways that control spinal pain processing. Trends Pharmacol Sci (2004) 1.91
Expression of c-fos-like protein as a marker for neuronal activity following noxious stimulation in the rat. J Comp Neurol (1990) 1.88
Using c-fos as a neural marker of pain. Brain Res Bull (1998) 1.88
Systemic morphine suppresses noxious stimulus-evoked Fos protein-like immunoreactivity in the rat spinal cord. J Neurosci (1990) 1.77
Neurokinin 1 receptor expression by neurons in laminae I, III and IV of the rat spinal dorsal horn that project to the brainstem. Eur J Neurosci (2000) 1.75
Inhibition of neuropathic pain by selective ablation of brainstem medullary cells expressing the mu-opioid receptor. J Neurosci (2001) 1.72
Dynamic and static components of mechanical hyperalgesia in human hairy skin. Pain (1992) 1.59
Nociceptor modulated central sensitization causes mechanical hyperalgesia in acute chemogenic and chronic neuropathic pain. Brain (1994) 1.48
Lack of involvement of capsaicin-sensitive primary afferents in nerve-ligation injury induced tactile allodynia in rats. Pain (1999) 1.43
Descending facilitation from the rostral ventromedial medulla maintains nerve injury-induced central sensitization. Neuroscience (2006) 1.39
Expression of c-fos protein in interneurons and projection neurons of the rat spinal cord in response to noxious somatic, articular, and visceral stimulation. J Comp Neurol (1989) 1.38
Windup leads to characteristics of central sensitization. Pain (1999) 1.29
Pelvic visceral input into the nucleus gracilis is largely mediated by the postsynaptic dorsal column pathway. J Neurophysiol (1996) 1.20
Effects of spinal nerve ligation on immunohistochemically identified neurons in the L4 and L5 dorsal root ganglia of the rat. J Comp Neurol (2004) 1.18
Selective mediation of nerve injury-induced tactile hypersensitivity by neuropeptide Y. J Neurosci (2002) 1.18
A visceral pain pathway in the dorsal column of the spinal cord. Proc Natl Acad Sci U S A (1999) 1.17
Visceral nociceptive input into the ventral posterolateral nucleus of the thalamus: a new function for the dorsal column pathway. J Neurophysiol (1996) 1.15
Down-regulation of mu-opioid receptors in rat and monkey dorsal root ganglion neurons and spinal cord after peripheral axotomy. Neuroscience (1998) 1.13
Anatomy of primary afferents and projection neurones in the rat spinal dorsal horn with particular emphasis on substance P and the neurokinin 1 receptor. Exp Physiol (2002) 1.09
Nerve injury-induced tactile allodynia is mediated via ascending spinal dorsal column projections. Pain (2001) 1.08
The roles of pathways in the spinal cord lateral and dorsal funiculi in signaling nociceptive somatic and visceral stimuli in rats. Pain (2002) 1.05
Characterization of the antiallodynic efficacy of morphine in a model of neuropathic pain in rats. Neuroreport (1995) 1.05
MOR-1-immunoreactive neurons in the dorsal horn of the rat spinal cord: evidence for nonsynaptic innervation by substance P-containing primary afferents and for selective activation by noxious thermal stimuli. Eur J Neurosci (2002) 1.02
Is there a pathway in the posterior funiculus that signals visceral pain? Pain (1996) 1.01
Basal and touch-evoked fos-like immunoreactivity during experimental inflammation in the rat. Pain (1996) 1.00
Fos-like proteins in the lumbosacral spinal cord following noxious and non-noxious colorectal distention in the rat. Pain (1992) 0.99
Systemic and supraspinal, but not spinal, opiates suppress allodynia in a rat neuropathic pain model. Neurosci Lett (1995) 0.98
Setting the tone: superficial dorsal horn projection neurons regulate pain sensitivity. Trends Neurosci (2004) 0.98
Postsynaptic dorsal column pathway of the rat. I. Anatomical studies. J Neurophysiol (1984) 0.97
Dorsal column lesions reverse the reduction of homecage activity in rats with pancreatitis. Neuroreport (1997) 0.97
Surgical interruption of a midline dorsal column visceral pain pathway. Case report and review of the literature. J Neurosurg (1997) 0.95
Extra- and intracellular recordings from dorsal column postsynaptic spinomedullary neurons in the cat. Exp Neurol (1983) 0.94
Intravenous morphine does not modify dorsal horn touch-evoked allodynia in the mononeuropathic rat: a Fos study. Pain (2001) 0.94
Are there long-term changes in the basal or evoked Fos expression in the dorsal horn of the spinal cord of the mononeuropathic rat? Pain (1999) 0.93
Ascending projections from the area around the spinal cord central canal: A Phaseolus vulgaris leucoagglutinin study in rats. J Comp Neurol (1999) 0.92
Postsynaptic dorsal column pathway of the rat. II. Evidence against an important role in nociception. Brain Res (1985) 0.92
The role of dorsal columns pathway in visceral pain. Physiol Res (2004) 0.92
The morphology of dorsal column postsynaptic spinomedullary neurons in the cat. J Comp Neurol (1984) 0.92
Do nociceptive signals from the pancreas travel in the dorsal column? Pain (2001) 0.91
The cells of origin of the dorsal column postsynaptic projection in the lumbosacral enlargements of cats and monkeys. Somatosens Res (1983) 0.87
Change in the expression of c-fos in the rat brain following sciatic nerve ligation. Neurosci Lett (2003) 0.86
Comparative study of viscerosomatic input onto postsynaptic dorsal column and spinothalamic tract neurons in the primate. J Neurophysiol (1999) 0.86
Fos expression in spinothalamic and postsynaptic dorsal column neurons following noxious visceral and cutaneous stimuli. Pain (2003) 0.85
Increase of preprotachykinin mRNA and substance P immunoreactivity in spared dorsal root ganglion neurons following partial sciatic nerve injury. Eur J Neurosci (1998) 0.84
Determination of changes in mRNA expression in a rat model of neuropathic pain by Taqman quantitative RT-PCR. Brain Res Mol Brain Res (2001) 0.84
Partial sciatic nerve ligation induced more dramatic increase of neuropeptide Y immunoreactive axonal fibers in the gracile nucleus of middle-aged rats than in young adult rats. J Neurosci Res (2000) 0.83
Upregulation of brain-derived neurotrophic factor and neuropeptide Y in the dorsal ascending sensory pathway following sciatic nerve injury in rat. Neurosci Lett (1999) 0.82
The time-course of abeta-evoked c-fos expression in neurons of the dorsal horn and gracile nucleus after peripheral nerve injury. Brain Res (1998) 0.82
Dorsal column postsynaptic neurons in the cat are excited by myelinated nociceptors. Brain Res (1986) 0.80
Excitability of spinal cord and gracile nucleus neurons in rats with chronically injured sciatic nerve examined by c-fos expression. Brain Res (1999) 0.80
The neuropeptide Y Y1 receptor is a somatic receptor on dorsal root ganglion neurons and a postsynaptic receptor on somatostatin dorsal horn neurons. Eur J Neurosci (1999) 0.79
Morphological evidence for selective modulation by serotonin of a subpopulation of dorsal horn cells which possess the neurokinin-1 receptor. Eur J Neurosci (2000) 0.78
The differential synaptic organization of the spinal and lemniscal projections to the ventrobasal complex of the rat thalamus. Evidence for convergence of the two systems upon single thalamic neurons. Neuroscience (1987) 0.77
Somatotopic redistribution of c-fos expressing neurons in the superficial dorsal horn after peripheral nerve injury. Neuroscience (1998) 0.76
Peripheral component in the enhanced antinociceptive effect of systemic U-69,593, a kappa-opioid receptor agonist in mononeuropathic rats. Eur J Pharmacol (1998) 0.76
Somatic noxious mechanical stimulation induces Fos expression in the postsynaptic dorsal column neurons in laminae III and IV of the rat spinal dorsal horn. Neurosci Res (2001) 0.76
Sites of renal pain processing in the rat spinal cord. A c-fos study using a percutaneous method to perform ureteral obstruction. J Auton Nerv Syst (1997) 0.76
Chronic pain and medullary descending facilitation. Trends Neurosci (2002) 3.54
Unmasking the tonic-aversive state in neuropathic pain. Nat Neurosci (2009) 2.77
CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids. Proc Natl Acad Sci U S A (2005) 2.36
Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS. Proc Natl Acad Sci U S A (2003) 2.29
Inhibition of neuropathic pain by decreased expression of the tetrodotoxin-resistant sodium channel, NaV1.8. Pain (2002) 2.24
Dynorphin A activates bradykinin receptors to maintain neuropathic pain. Nat Neurosci (2006) 2.23
A newly identified role for superoxide in inflammatory pain. J Pharmacol Exp Ther (2004) 2.21
Molecular determinants of vanilloid sensitivity in TRPV1. J Biol Chem (2004) 2.17
Central modulation of pain. J Clin Invest (2010) 2.12
Multiple actions of systemic artemin in experimental neuropathy. Nat Med (2003) 2.12
AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties. J Pharmacol Exp Ther (2004) 2.08
Time-dependent descending facilitation from the rostral ventromedial medulla maintains, but does not initiate, neuropathic pain. J Neurosci (2002) 2.00
Opioid self-administration in the nerve-injured rat: relevance of antiallodynic effects to drug consumption and effects of intrathecal analgesics. Anesthesiology (2007) 1.96
Antinociceptive and nociceptive actions of opioids. J Neurobiol (2004) 1.93
Voltage-gated sodium channels and hyperalgesia. Annu Rev Pharmacol Toxicol (2004) 1.93
Redistribution of Na(V)1.8 in uninjured axons enables neuropathic pain. J Neurosci (2003) 1.89
Morphine treatment accelerates sarcoma-induced bone pain, bone loss, and spontaneous fracture in a murine model of bone cancer. Pain (2007) 1.88
Underlying mechanisms of pronociceptive consequences of prolonged morphine exposure. Biopolymers (2005) 1.83
Engagement of descending inhibition from the rostral ventromedial medulla protects against chronic neuropathic pain. Pain (2011) 1.82
Is paradoxical pain induced by sustained opioid exposure an underlying mechanism of opioid antinociceptive tolerance? Neurosignals (2005) 1.80
The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system. Brain (2011) 1.70
Spinal GABA(A) and GABA(B) receptor pharmacology in a rat model of neuropathic pain. Anesthesiology (2002) 1.63
Inhibition of inflammatory hyperalgesia by activation of peripheral CB2 cannabinoid receptors. Anesthesiology (2003) 1.60
The role of sodium channels in chronic inflammatory and neuropathic pain. J Pain (2006) 1.59
Reversal of pancreatitis-induced pain by an orally available, small molecule interleukin-6 receptor antagonist. Pain (2010) 1.58
Sustained morphine exposure induces a spinal dynorphin-dependent enhancement of excitatory transmitter release from primary afferent fibers. J Neurosci (2002) 1.58
Parallel synthesis and biological evaluation of different sizes of bicyclo[2,3]-Leu-enkephalin analogues. Biopolymers (2005) 1.54
Spinal L-type calcium channel blockade abolishes opioid-induced sensory hypersensitivity and antinociceptive tolerance. Anesth Analg (2005) 1.53
An efficient intrathecal delivery of small interfering RNA to the spinal cord and peripheral neurons. Mol Pain (2005) 1.49
Role of NK-1 neurotransmission in opioid-induced hyperalgesia. Pain (2005) 1.49
Medullary pain facilitating neurons mediate allodynia in headache-related pain. Ann Neurol (2009) 1.48
CB2 cannabinoid receptor mediation of antinociception. Pain (2006) 1.47
Persistent restoration of sensory function by immediate or delayed systemic artemin after dorsal root injury. Nat Neurosci (2008) 1.47
Reversal of experimental neuropathic pain by T-type calcium channel blockers. Pain (2003) 1.46
Pain relief produces negative reinforcement through activation of mesolimbic reward-valuation circuitry. Proc Natl Acad Sci U S A (2012) 1.44
Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists. J Med Chem (2006) 1.40
CB2 cannabinoid receptor agonists: pain relief without psychoactive effects? Curr Opin Pharmacol (2003) 1.39
Impaired nociception and inflammatory pain sensation in mice lacking the prokineticin receptor PKR1: focus on interaction between PKR1 and the capsaicin receptor TRPV1 in pain behavior. J Neurosci (2006) 1.37
Therapeutic manipulation of peroxynitrite attenuates the development of opiate-induced antinociceptive tolerance in mice. J Clin Invest (2007) 1.37
Lesion of the rostral anterior cingulate cortex eliminates the aversiveness of spontaneous neuropathic pain following partial or complete axotomy. Pain (2011) 1.37
Regular exercise reverses sensory hypersensitivity in a rat neuropathic pain model: role of endogenous opioids. Anesthesiology (2011) 1.35
Descending facilitation from the rostral ventromedial medulla maintains visceral pain in rats with experimental pancreatitis. Gastroenterology (2006) 1.34
The role of alpha 6 integrin in prostate cancer migration and bone pain in a novel xenograft model. PLoS One (2008) 1.31
Descending pain modulation and chronification of pain. Curr Opin Support Palliat Care (2014) 1.30
Spinal protein kinase M ζ underlies the maintenance mechanism of persistent nociceptive sensitization. J Neurosci (2011) 1.30
Cholecystokinin in the rostral ventromedial medulla mediates opioid-induced hyperalgesia and antinociceptive tolerance. J Neurosci (2005) 1.29
Nausea and vomiting side effects with opioid analgesics during treatment of chronic pain: mechanisms, implications, and management options. Pain Med (2009) 1.29
Synthesis and investigations of double-pharmacophore ligands for treatment of chronic and neuropathic pain. Bioorg Med Chem (2009) 1.28
Synthesis and evaluation of 3-aminopropionyl substituted fentanyl analogues for opioid activity. Bioorg Med Chem Lett (2006) 1.23
Differential mediation of descending pain facilitation and inhibition by spinal 5HT-3 and 5HT-7 receptors. Brain Res (2009) 1.22
Development of novel enkephalin analogues that have enhanced opioid activities at both mu and delta opioid receptors. J Med Chem (2007) 1.21
Design, synthesis, and biological evaluation of novel bifunctional C-terminal-modified peptides for delta/mu opioid receptor agonists and neurokinin-1 receptor antagonists. J Med Chem (2007) 1.21
Pregabalin suppresses spinal neuronal hyperexcitability and visceral hypersensitivity in the absence of peripheral pathophysiology. Anesthesiology (2011) 1.21
Cannabilactones: a novel class of CB2 selective agonists with peripheral analgesic activity. J Med Chem (2007) 1.19
Selective mediation of nerve injury-induced tactile hypersensitivity by neuropeptide Y. J Neurosci (2002) 1.18