Published in ACS Chem Biol on May 23, 2006
Bright ideas for chemical biology. ACS Chem Biol (2008) 3.84
Advances in Bioconjugation. Curr Org Chem (2010) 1.60
Bright building blocks for chemical biology. ACS Chem Biol (2014) 1.44
Inhibition of human pancreatic ribonuclease by the human ribonuclease inhibitor protein. J Mol Biol (2007) 1.41
Cell-trappable fluorescent probes for endogenous hydrogen sulfide signaling and imaging H2O2-dependent H2S production. Proc Natl Acad Sci U S A (2013) 1.13
Cytotoxic ribonucleases: the dichotomy of Coulombic forces. Biochemistry (2007) 1.09
Catalysis of imido group hydrolysis in a maleimide conjugate. Bioorg Med Chem Lett (2007) 1.06
Synthesis of fluorogenic polymers for visualizing cellular internalization. Org Lett (2008) 1.03
Rational design and evaluation of mammalian ribonuclease cytotoxins. Methods Enzymol (2012) 1.03
Onconase cytotoxicity relies on the distribution of its positive charge. FEBS J (2009) 0.99
Cellular uptake of ribonuclease A relies on anionic glycans. Biochemistry (2010) 0.98
Trimethyl lock: A trigger for molecular release in chemistry, biology, and pharmacology. Chem Sci (2012) 0.95
Carbofluoresceins and carborhodamines as scaffolds for high-contrast fluorogenic probes. ACS Chem Biol (2013) 0.94
Mechanism of ribonuclease A endocytosis: analogies to cell-penetrating peptides. Biochemistry (2011) 0.94
Synthesis of rhodamines from fluoresceins using Pd-catalyzed C-N cross-coupling. Org Lett (2011) 0.92
Trimethyl lock: a stable chromogenic substrate for esterases. Molecules (2008) 0.92
Fluorogenic affinity label for the facile, rapid imaging of proteins in live cells. Org Biomol Chem (2009) 0.89
Protease probes built from DNA: multispectral fluorescent DNA-peptide conjugates as caspase chemosensors. Angew Chem Int Ed Engl (2011) 0.88
64Cu-labeled phosphonium cations as PET radiotracers for tumor imaging. Bioconjug Chem (2011) 0.87
Membrane permeable esterase-activated fluorescent imaging probe. Bioorg Med Chem Lett (2007) 0.87
Fluorogenic probe for constitutive cellular endocytosis. Chem Biol (2013) 0.86
A highly sensitive fluorogenic probe for cytochrome P450 activity in live cells. Bioorg Med Chem Lett (2008) 0.86
Mapping of heavy metal ion sorption to cell-extracellular polymeric substance-mineral aggregates by using metal-selective fluorescent probes and confocal laser scanning microscopy. Appl Environ Microbiol (2013) 0.85
Arginine residues are more effective than lysine residues in eliciting the cellular uptake of onconase. Biochemistry (2011) 0.84
Synthesis, characterization, and in vitro transfection activity of charge-reversal amphiphiles for DNA delivery. Bioconjug Chem (2011) 0.84
Activatable Optical Probes for the Detection of Enzymes. Curr Org Synth (2011) 0.84
Sensitive fluorogenic substrate for alkaline phosphatase. Anal Biochem (2011) 0.83
Contribution of electrostatics to the binding of pancreatic-type ribonucleases to membranes. Biochemistry (2013) 0.82
64Cu-labeled lissamine rhodamine B: a promising PET radiotracer targeting tumor mitochondria. Mol Pharm (2011) 0.82
Lanthanide(III) complexes of rhodamine-DO3A conjugates as agents for dual-modal imaging. Inorg Chem (2013) 0.82
Intraspecies regulation of ribonucleolytic activity. Biochemistry (2007) 0.81
Rotational and vibrational dynamics in the excited electronic state of deprotonated and protonated fluorescein studied by time-resolved photofragmentation in an ion trap. Struct Dyn (2016) 0.80
Optical imaging of tumors with copper-labeled rhodamine derivatives by targeting mitochondria. Theranostics (2012) 0.79
Potentiation of ribonuclease cytotoxicity by a poly(amidoamine) dendrimer. Bioorg Med Chem Lett (2010) 0.79
Fluorogenic label to quantify the cytosolic delivery of macromolecules. Mol Biosyst (2013) 0.79
Boronic Acid for the Traceless Delivery of Proteins into Cells. ACS Chem Biol (2015) 0.77
Far-red fluorogenic probes for esterase and lipase detection. Chembiochem (2014) 0.76
Ultrasensitivity by molecular titration in spatially propagating enzymatic reactions. Biophys J (2013) 0.76
Electronic and Steric Optimization of Fluorogenic Probes for Biomolecular Imaging. J Org Chem (2017) 0.75
In vivo histone H1 migration from necrotic to viable tissue. Oncotarget (2017) 0.75
A general method to fine-tune fluorophores for live-cell and in vivo imaging. Nat Methods (2017) 0.75
General Synthetic Method for Si-Fluoresceins and Si-Rhodamines. ACS Cent Sci (2017) 0.75
Membrane properties of living mammalian cells as studied by enzymatic hydrolysis of fluorogenic esters. Proc Natl Acad Sci U S A (1966) 8.92
Global survey of organ and organelle protein expression in mouse: combined proteomic and transcriptomic profiling. Cell (2006) 5.72
Ribonuclease A. Chem Rev (1998) 4.72
A mammalian organelle map by protein correlation profiling. Cell (2006) 4.54
Organic azides: an exploding diversity of a unique class of compounds. Angew Chem Int Ed Engl (2005) 3.62
Evolution of fluorescein as a platform for finely tunable fluorescence probes. J Am Chem Soc (2005) 2.35
Improved FACS-Gal: flow cytometric analysis and sorting of viable eukaryotic cells expressing reporter gene constructs. Cytometry (1991) 1.99
Conjugation of glucose oxidase from Aspergillus niger and rabbit antibodies using N-hydroxysuccinimide ester of N-(4-carboxycyclohexylmethyl)-maleimide. Eur J Biochem (1979) 1.63
A homobifunctional rhodamine for labeling proteins with defined orientations of a fluorophore. Bioconjug Chem (1998) 1.47
Ribonuclease inhibitor as an intracellular sentry. Nucleic Acids Res (2003) 1.45
Intracellular trafficking pathways and drug delivery: fluorescence imaging of living and fixed cells. Adv Drug Deliv Rev (2005) 1.44
Rhodamine-based compounds as fluorogenic substrates for serine proteinases. Biochem J (1983) 1.42
Bifunctional reagents. Methods Enzymol (1983) 1.24
Reactivity and pH dependence of thiol conjugation to N-ethylmaleimide: detection of a conformational change in chalcone isomerase. Biochemistry (1990) 1.23
Secretory ribonucleases are internalized by a dynamin-independent endocytic pathway. J Cell Sci (2003) 1.18
Latent fluorophore based on the trimethyl lock. J Am Chem Soc (2005) 1.16
Stereopopulation control. I. Rate enhancement in the lactonizations of 0-hydroxyhydrocinnamic acids. J Am Chem Soc (1972) 1.11
Effects of the state of the succinimido-ring on the fluorescence and structural properties of pyrene maleimide-labeled alpha alpha-tropomyosin. Biophys J (1986) 1.05
Acid hydrolases in early and late endosome fractions from rat liver. J Biol Chem (1991) 1.04
Latent blue and red fluorophores based on the trimethyl lock. Chembiochem (2006) 1.04
Design and synthesis of rhodamine 110 derivative and caspase-3 substrate for enzyme and cell-based fluorescent assay. Bioorg Med Chem Lett (2001) 1.03
Stereopopulation control. II. Rate enhancement of intramolecular nucleophilic displacement. J Am Chem Soc (1972) 1.02
Amine prodrugs which utilize hydroxy amide lactonization. II. A potential esterase-sensitive amide prodrug. Pharm Res (1991) 1.01
Kinetic mechanism of a partial folding reaction. 1. Properties Of the reaction and effects of denaturants. Biochemistry (1998) 1.00
Carboxy-fluorescein diacetate, succinimidyl ester labeled papillomavirus virus-like particles fluoresce after internalization and interact with heparan sulfate for binding and entry. Virology (2003) 0.99
Fluorescent molecular probes V: a sensitive caspase-3 substrate for fluorometric assays. Bioorg Med Chem Lett (1999) 0.95
New class of sensitive and selective fluorogenic substrates for serine proteinases. Amino acid and dipeptide derivatives of rhodamine. Biochem J (1983) 0.95
Possible physiological roles of carboxylic ester hydrolases. Drug Metab Rev (1987) 0.91
Highly efficient transport of carboxyfluorescein diacetate succinimidyl ester into COS7 cells using human papillomavirus-like particles. FEBS Lett (2003) 0.89
N-Ac-DEVD-N'-(Polyfluorobenzoyl)-R110: novel cell-permeable fluorogenic caspase substrates for the detection of caspase activity and apoptosis. Bioconjug Chem (2003) 0.88
N-DEVD-N'-morpholinecarbonyl-rhodamine 110: novel caspase-3 fluorogenic substrates for cell-based apoptosis assay. Bioorg Med Chem Lett (2005) 0.88
Esterase-triggered fluorescence of fluorogenic oligonucleotides. Bioconjug Chem (1998) 0.87
Nonperturbing fluorescent labeling of polysaccharides. Biomacromolecules (2002) 0.86
Syntheses of regioisomerically pure 5- or 6-halogenated fluoresceins. J Org Chem (2003) 0.86
Prodrug strategies based on intramolecular cyclization reactions. J Pharm Sci (1997) 0.84
Rational design of a chromo- and fluorogenic hybrid chemosensor material for the detection of long-chain carboxylates. J Am Chem Soc (2005) 0.84
Triacylglycerol hydrolysis in isolated hepatic endosomes. J Biol Chem (1992) 0.84
Carboxylesterases (EC 3.1.1). The molecular weight and equivalent weight of pig liver carboxylesterase. Biochemistry (1969) 0.84
Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-benzimidazole conjugates with remarkable DNA-binding affinity. Bioorg Med Chem Lett (2004) 0.83
Transcellular proteolysis demonstrated by novel cell surface-associated substrates of dipeptidyl peptidase IV (CD26). J Biol Chem (2002) 0.79
Collagen structure and stability. Annu Rev Biochem (2009) 4.62
Bright ideas for chemical biology. ACS Chem Biol (2008) 3.84
Hydrolytic stability of hydrazones and oximes. Angew Chem Int Ed Engl (2008) 2.45
Collagen stability: insights from NMR spectroscopic and hybrid density functional computational investigations of the effect of electronegative substituents on prolyl ring conformations. J Am Chem Soc (2002) 2.19
Pathway for polyarginine entry into mammalian cells. Biochemistry (2004) 2.14
An electronic effect on protein structure. Protein Sci (2003) 2.04
n-->pi* interactions in proteins. Nat Chem Biol (2010) 2.02
Prolyl 4-hydroxylase. Crit Rev Biochem Mol Biol (2010) 1.99
Nature of amide carbonyl--carbonyl interactions in proteins. J Am Chem Soc (2009) 1.89
Chemical synthesis of proteins. Annu Rev Biophys Biomol Struct (2005) 1.71
Insights on the conformational stability of collagen. Nat Prod Rep (2002) 1.71
Simple chemical transformation of lignocellulosic biomass into furans for fuels and chemicals. J Am Chem Soc (2009) 1.63
Self-assembly of synthetic collagen triple helices. Proc Natl Acad Sci U S A (2006) 1.61
Advances in Bioconjugation. Curr Org Chem (2010) 1.60
Fermentable sugars by chemical hydrolysis of biomass. Proc Natl Acad Sci U S A (2010) 1.57
Stereoelectronic effects on polyproline conformation. Protein Sci (2006) 1.57
Stereoelectronic and steric effects in the collagen triple helix: toward a code for strand association. J Am Chem Soc (2005) 1.56
Ribonuclease inhibitor: structure and function. Prog Nucleic Acid Res Mol Biol (2005) 1.55
Translocation of a beta-peptide across cell membranes. J Am Chem Soc (2002) 1.55
Stereoelectronic effects on collagen stability: the dichotomy of 4-fluoroproline diastereomers. J Am Chem Soc (2003) 1.53
Reaction mechanism and kinetics of the traceless Staudinger ligation. J Am Chem Soc (2006) 1.52
Energetics of an n --> pi interaction that impacts protein structure. Org Lett (2006) 1.50
Cytotoxicity of paclitaxel in breast cancer is due to chromosome missegregation on multipolar spindles. Sci Transl Med (2014) 1.50
Ribonuclease inhibitor as an intracellular sentry. Nucleic Acids Res (2003) 1.45
Bright building blocks for chemical biology. ACS Chem Biol (2014) 1.44
Inhibition of human pancreatic ribonuclease by the human ribonuclease inhibitor protein. J Mol Biol (2007) 1.41
n --> pi* Interaction and n)(pi Pauli repulsion are antagonistic for protein stability. J Am Chem Soc (2010) 1.37
Site-specific protein immobilization by Staudinger ligation. J Am Chem Soc (2003) 1.35
Inductive Effects on the Energetics of Prolyl Peptide Bond Isomerization: Implications for Collagen Folding and Stability. J Am Chem Soc (1996) 1.32
Ribonucleases as novel chemotherapeutics : the ranpirnase example. BioDrugs (2008) 1.31
Peptide bond isosteres: ester or (E)-alkene in the backbone of the collagen triple helix. Org Lett (2005) 1.29
Semisynthesis and characterization of mammalian thioredoxin reductase. Biochemistry (2006) 1.28
Bovine pancreatic ribonuclease: fifty years of the first enzymatic reaction mechanism. Biochemistry (2011) 1.27
Signature of n→π* interactions in α-helices. Protein Sci (2011) 1.25
Arginine grafting to endow cell permeability. ACS Chem Biol (2007) 1.24
Polyarginine as a multifunctional fusion tag. Protein Sci (2005) 1.24
Evasion of ribonuclease inhibitor as a determinant of ribonuclease cytotoxicity. Curr Pharm Biotechnol (2008) 1.23
Tuning the pK(a) of fluorescein to optimize binding assays. Anal Chem (2007) 1.22
An evaluation of peptide-bond isosteres. Chembiochem (2011) 1.22
Olefin metathesis for chemical biology. Curr Opin Chem Biol (2008) 1.21
Protein prosthesis: a semisynthetic enzyme with a beta-peptide reverse turn. J Am Chem Soc (2002) 1.20
Effect of 3-hydroxyproline residues on collagen stability. J Am Chem Soc (2003) 1.19
Secretory ribonucleases are internalized by a dynamin-independent endocytic pathway. J Cell Sci (2003) 1.18
Reciprocity of steric and stereoelectronic effects in the collagen triple helix. J Am Chem Soc (2006) 1.17
Stereoelectronic and steric effects in side chains preorganize a protein main chain. Proc Natl Acad Sci U S A (2009) 1.17
Identifying latent enzyme activities: substrate ambiguity within modern bacterial sugar kinases. Biochemistry (2004) 1.17
Latent fluorophore based on the trimethyl lock. J Am Chem Soc (2005) 1.16
Protein assembly by orthogonal chemical ligation methods. J Am Chem Soc (2003) 1.14
Water-soluble phosphinothiols for traceless staudinger ligation and integration with expressed protein ligation. J Am Chem Soc (2007) 1.14
Staudinger ligation of alpha-azido acids retains stereochemistry. J Org Chem (2002) 1.13
4-chloroprolines: synthesis, conformational analysis, and effect on the collagen triple helix. Biopolymers (2008) 1.13
Solvent Effects on the Energetics of Prolyl Peptide Bond Isomerization. J Am Chem Soc (1992) 1.12
Structures of the noncanonical RNA ligase RtcB reveal the mechanism of histidine guanylylation. Biochemistry (2013) 1.12
Semisynthesis of proteins containing selenocysteine. Methods Enzymol (2002) 1.11
Disruption of shape-complementarity markers to create cytotoxic variants of ribonuclease A. J Mol Biol (2005) 1.10
Cytotoxic ribonucleases: the dichotomy of Coulombic forces. Biochemistry (2007) 1.09
Substituted 2-azabicyclo[2.1.1]hexanes as constrained proline analogues: implications for collagen stability. J Org Chem (2004) 1.08
n→π* interactions of amides and thioamides: implications for protein stability. J Am Chem Soc (2013) 1.08
Activation of the prolyl hydroxylase oxygen-sensor results in induction of GLUT1, heme oxygenase-1, and nitric-oxide synthase proteins and confers protection from metabolic inhibition to cardiomyocytes. J Biol Chem (2003) 1.06
Stabilization of the collagen triple helix by O-methylation of hydroxyproline residues. J Am Chem Soc (2008) 1.06
Catalysis of imido group hydrolysis in a maleimide conjugate. Bioorg Med Chem Lett (2007) 1.06
A stereoelectronic effect in prebiotic nucleotide synthesis. ACS Chem Biol (2010) 1.06
Potent inhibition of ribonuclease A by oligo(vinylsulfonic acid). J Biol Chem (2003) 1.05
Conformational preferences of substrates for human prolyl 4-hydroxylase. Biochemistry (2008) 1.05
Reactivity of intein thioesters: appending a functional group to a protein. Chembiochem (2006) 1.05
Creation of a zymogen. Nat Struct Biol (2003) 1.05
Synthesis and utility of fluorogenic acetoxymethyl ethers. Chem Sci (2011) 1.04
Protein prosthesis: 1,5-disubstituted[1,2,3]triazoles as cis-peptide bond surrogates. J Am Chem Soc (2007) 1.04
Latent blue and red fluorophores based on the trimethyl lock. Chembiochem (2006) 1.04
Reconstitution of a defunct glycolytic pathway via recruitment of ambiguous sugar kinases. Biochemistry (2005) 1.03
Rational design and evaluation of mammalian ribonuclease cytotoxins. Methods Enzymol (2012) 1.03
The CXC motif: a functional mimic of protein disulfide isomerase. Biochemistry (2003) 1.02
Boronate-mediated biologic delivery. J Am Chem Soc (2012) 1.02
Comprehensive comparison of the cytotoxic activities of onconase and bovine seminal ribonuclease. Comp Biochem Physiol C Toxicol Pharmacol (2003) 1.01
A potent, versatile disulfide-reducing agent from aspartic acid. J Am Chem Soc (2012) 1.00
Imaging the binding ability of proteins immobilized on surfaces with different orientations by using liquid crystals. J Am Chem Soc (2004) 1.00
Onconase cytotoxicity relies on the distribution of its positive charge. FEBS J (2009) 0.99
Genetic selection for critical residues in ribonucleases. J Mol Biol (2006) 0.99
Quantum mechanical origin of the conformational preferences of 4-thiaproline and its S-oxides. Amino Acids (2010) 0.99
Tunable, post-translational hydroxylation of collagen Domains in Escherichia coli. ACS Chem Biol (2011) 0.99
Domains within the GARP subunit Vps54 confer separate functions in complex assembly and early endosome recognition. Mol Biol Cell (2006) 0.99
A tRNA splicing operon: Archease endows RtcB with dual GTP/ATP cofactor specificity and accelerates RNA ligation. Nucleic Acids Res (2014) 0.98
Thermodynamic Origin of Prolyl Peptide Bond Isomers. Tetrahedron Lett (1993) 0.98
Production of human prolyl 4-hydroxylase in Escherichia coli. Protein Expr Purif (2004) 0.98
Cellular uptake of ribonuclease A relies on anionic glycans. Biochemistry (2010) 0.98
Interplay of hydrogen bonds and n→π* interactions in proteins. J Am Chem Soc (2013) 0.98
An n→π* interaction in aspirin: implications for structure and reactivity. J Org Chem (2011) 0.97
Structure and function of Bacillus subtilis YphP, a prokaryotic disulfide isomerase with a CXC catalytic motif . Biochemistry (2009) 0.97
Synthesis of furfural from xylose and xylan. ChemSusChem (2010) 0.96
Fluorescence assay for the binding of ribonuclease A to the ribonuclease inhibitor protein. Anal Biochem (2002) 0.96
Contribution of active-site residues to the function of onconase, a ribonuclease with antitumoral activity. Biochemistry (2003) 0.96
Fluorescence polarization assay to quantify protein-protein interactions. Methods Mol Biol (2004) 0.96
Limits to Catalysis by Ribonuclease A. Bioorg Chem (1995) 0.96
General method for site-specific protein immobilization by Staudinger ligation. Bioconjug Chem (2007) 0.95
Increasing the potency of a cytotoxin with an arginine graft. Protein Eng Des Sel (2007) 0.95
Trimethyl lock: A trigger for molecular release in chemistry, biology, and pharmacology. Chem Sci (2012) 0.95
X-ray structure of two crystalline forms of a streptomycete ribonuclease with cytotoxic activity. J Biol Chem (2002) 0.95