Published in Molecules on January 31, 2008
Activation of legumain involves proteolytic and conformational events, resulting in a context- and substrate-dependent activity profile. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.98
Trimethyl lock: A trigger for molecular release in chemistry, biology, and pharmacology. Chem Sci (2012) 0.95
Fluorogenic affinity label for the facile, rapid imaging of proteins in live cells. Org Biomol Chem (2009) 0.89
A highly sensitive fluorogenic probe for cytochrome P450 activity in live cells. Bioorg Med Chem Lett (2008) 0.86
Fluorogenic probe for constitutive cellular endocytosis. Chem Biol (2013) 0.86
Conversion of azides into diazo compounds in water. J Am Chem Soc (2013) 0.85
Sensitive fluorogenic substrate for alkaline phosphatase. Anal Biochem (2011) 0.83
Statistical Evaluation of HTS Assays for Enzymatic Hydrolysis of β-Keto Esters. PLoS One (2016) 0.75
The reaction of p-nitrophenyl esters with chymotrypsin and insulin. Biochem J (1954) 4.17
Bright ideas for chemical biology. ACS Chem Biol (2008) 3.84
De novo proteins from designed combinatorial libraries. Protein Sci (2004) 1.59
Fluorogenic label for biomolecular imaging. ACS Chem Biol (2006) 1.54
Enzyme-like proteins from an unselected library of designed amino acid sequences. Protein Eng Des Sel (2004) 1.31
Development of a high-throughput screen for soluble epoxide hydrolase inhibition. Anal Biochem (2006) 1.19
pH-dependence and structure-activity relationships in the papain-catalysed hydrolysis of anilides. Biochem J (1971) 1.19
The hydrolysis of p-nitrophenyl acetate catalyzed by 3-phosphoglyceraldehyde dehydrogenase. J Biol Chem (1961) 1.17
Latent fluorophore based on the trimethyl lock. J Am Chem Soc (2005) 1.16
Stereopopulation control. I. Rate enhancement in the lactonizations of 0-hydroxyhydrocinnamic acids. J Am Chem Soc (1972) 1.11
Latent blue and red fluorophores based on the trimethyl lock. Chembiochem (2006) 1.04
Stereopopulation control. II. Rate enhancement of intramolecular nucleophilic displacement. J Am Chem Soc (1972) 1.02
Amine prodrugs which utilize hydroxy amide lactonization. II. A potential esterase-sensitive amide prodrug. Pharm Res (1991) 1.01
High-throughput assays for lipases and esterases. Biomol Eng (2005) 0.94
A new chromogenic substrate for subtilisin. Anal Biochem (1974) 0.89
A low background high-throughput screening (HTS) fluorescence assay for lipases and esterases using acyloxymethylethers of umbelliferone. Bioorg Med Chem Lett (2003) 0.88
S-N transfer and dual acetylation in the S-acetylation and N-acetylation of 3-phosphoglyceraldehyde dehydrogenase by substrates. J Biol Chem (1966) 0.84
Directed evolution of lipases and esterases. Methods Enzymol (2004) 0.81
Fluorogenic substrates for lipases, esterases, and acylases using a TIM-mechanism for signal release. Biotechnol J (2007) 0.80
Collagen structure and stability. Annu Rev Biochem (2009) 4.62
Bright ideas for chemical biology. ACS Chem Biol (2008) 3.84
Hydrolytic stability of hydrazones and oximes. Angew Chem Int Ed Engl (2008) 2.45
Collagen stability: insights from NMR spectroscopic and hybrid density functional computational investigations of the effect of electronegative substituents on prolyl ring conformations. J Am Chem Soc (2002) 2.19
Pathway for polyarginine entry into mammalian cells. Biochemistry (2004) 2.14
An electronic effect on protein structure. Protein Sci (2003) 2.04
n-->pi* interactions in proteins. Nat Chem Biol (2010) 2.02
Prolyl 4-hydroxylase. Crit Rev Biochem Mol Biol (2010) 1.99
Nature of amide carbonyl--carbonyl interactions in proteins. J Am Chem Soc (2009) 1.89
Chemical synthesis of proteins. Annu Rev Biophys Biomol Struct (2005) 1.71
Insights on the conformational stability of collagen. Nat Prod Rep (2002) 1.71
Single-molecule tracking of the transcription cycle by sub-second RNA detection. Elife (2014) 1.67
Simple chemical transformation of lignocellulosic biomass into furans for fuels and chemicals. J Am Chem Soc (2009) 1.63
Self-assembly of synthetic collagen triple helices. Proc Natl Acad Sci U S A (2006) 1.61
Advances in Bioconjugation. Curr Org Chem (2010) 1.60
Fermentable sugars by chemical hydrolysis of biomass. Proc Natl Acad Sci U S A (2010) 1.57
Stereoelectronic effects on polyproline conformation. Protein Sci (2006) 1.57
Stereoelectronic and steric effects in the collagen triple helix: toward a code for strand association. J Am Chem Soc (2005) 1.56
Ribonuclease inhibitor: structure and function. Prog Nucleic Acid Res Mol Biol (2005) 1.55
Translocation of a beta-peptide across cell membranes. J Am Chem Soc (2002) 1.55
Fluorogenic label for biomolecular imaging. ACS Chem Biol (2006) 1.54
Stereoelectronic effects on collagen stability: the dichotomy of 4-fluoroproline diastereomers. J Am Chem Soc (2003) 1.53
Reaction mechanism and kinetics of the traceless Staudinger ligation. J Am Chem Soc (2006) 1.52
Energetics of an n --> pi interaction that impacts protein structure. Org Lett (2006) 1.50
Cytotoxicity of paclitaxel in breast cancer is due to chromosome missegregation on multipolar spindles. Sci Transl Med (2014) 1.50
Ribonuclease inhibitor as an intracellular sentry. Nucleic Acids Res (2003) 1.45
Bright building blocks for chemical biology. ACS Chem Biol (2014) 1.44
Inhibition of human pancreatic ribonuclease by the human ribonuclease inhibitor protein. J Mol Biol (2007) 1.41
n --> pi* Interaction and n)(pi Pauli repulsion are antagonistic for protein stability. J Am Chem Soc (2010) 1.37
Site-specific protein immobilization by Staudinger ligation. J Am Chem Soc (2003) 1.35
Inductive Effects on the Energetics of Prolyl Peptide Bond Isomerization: Implications for Collagen Folding and Stability. J Am Chem Soc (1996) 1.32
Ribonucleases as novel chemotherapeutics : the ranpirnase example. BioDrugs (2008) 1.31
Peptide bond isosteres: ester or (E)-alkene in the backbone of the collagen triple helix. Org Lett (2005) 1.29
Semisynthesis and characterization of mammalian thioredoxin reductase. Biochemistry (2006) 1.28
Bovine pancreatic ribonuclease: fifty years of the first enzymatic reaction mechanism. Biochemistry (2011) 1.27
Signature of n→π* interactions in α-helices. Protein Sci (2011) 1.25
Arginine grafting to endow cell permeability. ACS Chem Biol (2007) 1.24
Polyarginine as a multifunctional fusion tag. Protein Sci (2005) 1.24
Evasion of ribonuclease inhibitor as a determinant of ribonuclease cytotoxicity. Curr Pharm Biotechnol (2008) 1.23
Tuning the pK(a) of fluorescein to optimize binding assays. Anal Chem (2007) 1.22
An evaluation of peptide-bond isosteres. Chembiochem (2011) 1.22
Olefin metathesis for chemical biology. Curr Opin Chem Biol (2008) 1.21
Protein prosthesis: a semisynthetic enzyme with a beta-peptide reverse turn. J Am Chem Soc (2002) 1.20
Selective esterase-ester pair for targeting small molecules with cellular specificity. Proc Natl Acad Sci U S A (2012) 1.19
Excitation spectra and brightness optimization of two-photon excited probes. Biophys J (2012) 1.19
Effect of 3-hydroxyproline residues on collagen stability. J Am Chem Soc (2003) 1.19
Secretory ribonucleases are internalized by a dynamin-independent endocytic pathway. J Cell Sci (2003) 1.18
Reciprocity of steric and stereoelectronic effects in the collagen triple helix. J Am Chem Soc (2006) 1.17
Stereoelectronic and steric effects in side chains preorganize a protein main chain. Proc Natl Acad Sci U S A (2009) 1.17
Identifying latent enzyme activities: substrate ambiguity within modern bacterial sugar kinases. Biochemistry (2004) 1.17
Latent fluorophore based on the trimethyl lock. J Am Chem Soc (2005) 1.16
Protein assembly by orthogonal chemical ligation methods. J Am Chem Soc (2003) 1.14
Water-soluble phosphinothiols for traceless staudinger ligation and integration with expressed protein ligation. J Am Chem Soc (2007) 1.14
Staudinger ligation of alpha-azido acids retains stereochemistry. J Org Chem (2002) 1.13
4-chloroprolines: synthesis, conformational analysis, and effect on the collagen triple helix. Biopolymers (2008) 1.13
Solvent Effects on the Energetics of Prolyl Peptide Bond Isomerization. J Am Chem Soc (1992) 1.12
Structures of the noncanonical RNA ligase RtcB reveal the mechanism of histidine guanylylation. Biochemistry (2013) 1.12
Semisynthesis of proteins containing selenocysteine. Methods Enzymol (2002) 1.11
Disruption of shape-complementarity markers to create cytotoxic variants of ribonuclease A. J Mol Biol (2005) 1.10
Cytotoxic ribonucleases: the dichotomy of Coulombic forces. Biochemistry (2007) 1.09
Substituted 2-azabicyclo[2.1.1]hexanes as constrained proline analogues: implications for collagen stability. J Org Chem (2004) 1.08
n→π* interactions of amides and thioamides: implications for protein stability. J Am Chem Soc (2013) 1.08
Catalysis of imido group hydrolysis in a maleimide conjugate. Bioorg Med Chem Lett (2007) 1.06
Activation of the prolyl hydroxylase oxygen-sensor results in induction of GLUT1, heme oxygenase-1, and nitric-oxide synthase proteins and confers protection from metabolic inhibition to cardiomyocytes. J Biol Chem (2003) 1.06
Stabilization of the collagen triple helix by O-methylation of hydroxyproline residues. J Am Chem Soc (2008) 1.06
A stereoelectronic effect in prebiotic nucleotide synthesis. ACS Chem Biol (2010) 1.06
Potent inhibition of ribonuclease A by oligo(vinylsulfonic acid). J Biol Chem (2003) 1.05
Conformational preferences of substrates for human prolyl 4-hydroxylase. Biochemistry (2008) 1.05
Reactivity of intein thioesters: appending a functional group to a protein. Chembiochem (2006) 1.05
The chemistry of small-molecule fluorogenic probes. Prog Mol Biol Transl Sci (2013) 1.05
Creation of a zymogen. Nat Struct Biol (2003) 1.05
Synthesis and utility of fluorogenic acetoxymethyl ethers. Chem Sci (2011) 1.04
Protein prosthesis: 1,5-disubstituted[1,2,3]triazoles as cis-peptide bond surrogates. J Am Chem Soc (2007) 1.04
Latent blue and red fluorophores based on the trimethyl lock. Chembiochem (2006) 1.04
Reconstitution of a defunct glycolytic pathway via recruitment of ambiguous sugar kinases. Biochemistry (2005) 1.03
Rational design and evaluation of mammalian ribonuclease cytotoxins. Methods Enzymol (2012) 1.03
The CXC motif: a functional mimic of protein disulfide isomerase. Biochemistry (2003) 1.02
Boronate-mediated biologic delivery. J Am Chem Soc (2012) 1.02
Comprehensive comparison of the cytotoxic activities of onconase and bovine seminal ribonuclease. Comp Biochem Physiol C Toxicol Pharmacol (2003) 1.01
Facile and general synthesis of photoactivatable xanthene dyes. Angew Chem Int Ed Engl (2011) 1.00
A potent, versatile disulfide-reducing agent from aspartic acid. J Am Chem Soc (2012) 1.00
Imaging the binding ability of proteins immobilized on surfaces with different orientations by using liquid crystals. J Am Chem Soc (2004) 1.00
Onconase cytotoxicity relies on the distribution of its positive charge. FEBS J (2009) 0.99
Genetic selection for critical residues in ribonucleases. J Mol Biol (2006) 0.99
Tunable, post-translational hydroxylation of collagen Domains in Escherichia coli. ACS Chem Biol (2011) 0.99
Quantum mechanical origin of the conformational preferences of 4-thiaproline and its S-oxides. Amino Acids (2010) 0.99
A tRNA splicing operon: Archease endows RtcB with dual GTP/ATP cofactor specificity and accelerates RNA ligation. Nucleic Acids Res (2014) 0.98
Thermodynamic Origin of Prolyl Peptide Bond Isomers. Tetrahedron Lett (1993) 0.98
Cellular uptake of ribonuclease A relies on anionic glycans. Biochemistry (2010) 0.98
Production of human prolyl 4-hydroxylase in Escherichia coli. Protein Expr Purif (2004) 0.98
Interplay of hydrogen bonds and n→π* interactions in proteins. J Am Chem Soc (2013) 0.98
An n→π* interaction in aspirin: implications for structure and reactivity. J Org Chem (2011) 0.97
Structure and function of Bacillus subtilis YphP, a prokaryotic disulfide isomerase with a CXC catalytic motif . Biochemistry (2009) 0.97
Synthesis of furfural from xylose and xylan. ChemSusChem (2010) 0.96
Contribution of active-site residues to the function of onconase, a ribonuclease with antitumoral activity. Biochemistry (2003) 0.96
Limits to Catalysis by Ribonuclease A. Bioorg Chem (1995) 0.96
Fluorescence assay for the binding of ribonuclease A to the ribonuclease inhibitor protein. Anal Biochem (2002) 0.96