Published in J Cell Sci on December 12, 2006
Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes. Blood (2011) 5.82
Regulation of immune responses by extracellular vesicles. Nat Rev Immunol (2014) 3.24
Exosome release of β-catenin: a novel mechanism that antagonizes Wnt signaling. J Cell Biol (2010) 2.85
IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome. J Cell Biol (2009) 2.16
Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau. J Neurosci (2008) 1.88
Age-dependent changes in FasL (CD95L) modulate macrophage function in a model of age-related macular degeneration. Invest Ophthalmol Vis Sci (2013) 1.48
Cytotoxic immunological synapses. Immunol Rev (2010) 1.45
Resveratrol sensitizes melanomas to TRAIL through modulation of antiapoptotic gene expression. Exp Cell Res (2007) 1.14
Human NK cell lytic granules and regulation of their exocytosis. Front Immunol (2012) 1.10
TRIM9, a novel brain-specific E3 ubiquitin ligase, is repressed in the brain of Parkinson's disease and dementia with Lewy bodies. Neurobiol Dis (2010) 1.08
The biogenesis of lysosomes and lysosome-related organelles. Cold Spring Harb Perspect Biol (2014) 1.03
Diacylglycerol kinase α regulates the formation and polarisation of mature multivesicular bodies involved in the secretion of Fas ligand-containing exosomes in T lymphocytes. Cell Death Differ (2011) 0.97
Inactivation of macrophage Rab7 by Burkholderia cenocepacia. J Innate Immun (2010) 0.94
Targeting immune privilege to prevent pathogenic neovascularization. Invest Ophthalmol Vis Sci (2010) 0.92
Nedd4-2-mediated ubiquitination facilitates processing of surfactant protein-C. Am J Respir Cell Mol Biol (2009) 0.91
Posttranslational regulation of Fas ligand function. Cell Commun Signal (2008) 0.90
Diacylglycerol kinases: regulated controllers of T cell activation, function, and development. Int J Mol Sci (2013) 0.90
Interleukin-5 supports the expansion of fas ligand-expressing killer B cells that induce antigen-specific apoptosis of CD4(+) T cells and secrete interleukin-10. PLoS One (2013) 0.89
Membrane trafficking of death receptors: implications on signalling. Int J Mol Sci (2013) 0.89
Many checkpoints on the road to cell death: regulation of Fas-FasL interactions and Fas signaling in peripheral immune responses. Results Probl Cell Differ (2009) 0.89
Post-translational modifications of exosomal proteins. Front Immunol (2014) 0.89
The traffic of the NKG2D/Dap10 receptor complex during natural killer (NK) cell activation. J Biol Chem (2009) 0.86
Prolactin promotes the secretion of active cathepsin D at the basal side of rat mammary acini. Endocrinology (2008) 0.83
Regulation of chronic inflammatory and immune processes by extracellular vesicles. J Clin Invest (2016) 0.82
An active form of sphingosine kinase-1 is released in the extracellular medium as component of membrane vesicles shed by two human tumor cell lines. J Oncol (2010) 0.82
Protein kinase D1/2 is involved in the maturation of multivesicular bodies and secretion of exosomes in T and B lymphocytes. Cell Death Differ (2015) 0.80
Stem Cell-Derived Extracellular Vesicles and Immune-Modulation. Front Cell Dev Biol (2016) 0.80
HIV-1 Intersection with CD4 T Cell Vesicle Exocytosis: Intercellular Communication Goes Viral. Front Immunol (2014) 0.80
Identification of SH3 domain proteins interacting with the cytoplasmic tail of the a disintegrin and metalloprotease 10 (ADAM10). PLoS One (2014) 0.78
Intestinal epithelial apoptosis initiates gut mucosal injury during extracorporeal membrane oxygenation in the newborn piglet. Lab Invest (2013) 0.78
Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. BMC Immunol (2009) 0.76
Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans. Science (2009) 25.61
Clinical aspects of pandemic 2009 influenza A (H1N1) virus infection. N Engl J Med (2010) 9.90
A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins. Nature (2002) 6.22
Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation. Nat Cell Biol (2003) 5.43
Surveillance of resistance to adamantanes among influenza A(H3N2) and A(H1N1) viruses isolated worldwide. J Infect Dis (2007) 5.21
Spread of HTLV-I between lymphocytes by virus-induced polarization of the cytoskeleton. Science (2003) 5.19
Centrosome polarization delivers secretory granules to the immunological synapse. Nature (2006) 4.28
Secretory lysosomes. Nat Rev Mol Cell Biol (2002) 3.70
Secretory mechanisms in cell-mediated cytotoxicity. Annu Rev Cell Dev Biol (2007) 2.63
Screening for Barrett's esophagus in colonoscopy patients with and without heartburn. Gastroenterology (2003) 2.59
Design of treatment trials for functional gastrointestinal disorders. Gastroenterology (2006) 2.58
Adaptor protein 3-dependent microtubule-mediated movement of lytic granules to the immunological synapse. Nat Immunol (2003) 2.56
Isolation and characterization of avian influenza viruses, including highly pathogenic H5N1, from poultry in live bird markets in Hanoi, Vietnam, in 2001. J Virol (2005) 2.51
Outbreak of variant influenza A(H3N2) virus in the United States. Clin Infect Dis (2013) 2.38
The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation. J Exp Med (2007) 2.37
Localisation of DivIVA by targeting to negatively curved membranes. EMBO J (2009) 2.35
Structural and kinetic basis for heightened immunogenicity of T cell vaccines. J Exp Med (2005) 2.22
The strength of T cell receptor signal controls the polarization of cytotoxic machinery to the immunological synapse. Immunity (2009) 2.16
Linking albinism and immunity: the secrets of secretory lysosomes. Science (2004) 2.07
Identification of a Titin-derived HLA-A1-presented peptide as a cross-reactive target for engineered MAGE A3-directed T cells. Sci Transl Med (2013) 2.07
Ubiquitin in trafficking: the network at work. Exp Cell Res (2008) 1.94
Hedgehog signaling controls T cell killing at the immunological synapse. Science (2013) 1.84
Hedgehog signaling regulates nociceptive sensitization. Curr Biol (2011) 1.81
Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability in vivo. Nat Commun (2012) 1.78
A general role for Rab27a in secretory cells. Mol Biol Cell (2003) 1.76
Delivering the kiss of death. Nat Immunol (2003) 1.72
Nod1/RICK and TLR signaling regulate chemokine and antimicrobial innate immune responses in mesothelial cells. J Immunol (2007) 1.60
The leaden gene product is required with Rab27a to recruit myosin Va to melanosomes in melanocytes. Traffic (2002) 1.59
Clinical effectiveness of laparoscopic fundoplication in a U.S. community. Am J Med (2003) 1.57
Monoclonal TCR-redirected tumor cell killing. Nat Med (2012) 1.57
Syntaxin 11 is required for NK and CD8⁺ T-cell cytotoxicity and neutrophil degranulation. Eur J Immunol (2012) 1.57
Homogeneous monocytes and macrophages from human embryonic stem cells following coculture-free differentiation in M-CSF and IL-3. Exp Hematol (2008) 1.52
Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse. Traffic (2008) 1.38
CTL secretory lysosomes: biogenesis and secretion of a harmful organelle. Semin Immunol (2005) 1.35
Regulating secretory lysosomes. J Biochem (2006) 1.26
R292K substitution and drug susceptibility of influenza A(H7N9) viruses. Emerg Infect Dis (2013) 1.25
The ubiquitination code: a signalling problem. Cell Div (2007) 1.25
Molecular basis of familial hemophagocytic lymphohistiocytosis. Haematologica (2010) 1.25
Positive and negative signaling through SLAM receptors regulate synapse organization and thresholds of cytolysis. Immunity (2012) 1.20
Innate immunity defects in Hermansky-Pudlak type 2 syndrome. Blood (2006) 1.19
Lytic granules, secretory lysosomes and disease. Curr Opin Immunol (2003) 1.14
Cell polarisation and the immunological synapse. Curr Opin Cell Biol (2012) 1.13
Centrosome docking at the immunological synapse is controlled by Lck signaling. J Cell Biol (2011) 1.13
A single amino acid change, A91V, leads to conformational changes that can impair processing to the active form of perforin. Blood (2005) 1.12
Ligand-induced EGF receptor oligomerization is kinase-dependent and enhances internalization. J Biol Chem (2010) 1.11
STXBP2 mutations in children with familial haemophagocytic lymphohistiocytosis type 5. J Med Genet (2010) 1.11
A novel role for BRCA1 in regulating breast cancer cell spreading and motility. J Cell Biol (2011) 1.08
The synapse and cytolytic machinery of cytotoxic T cells. Curr Opin Immunol (2010) 1.08
The secretory synapse: the secrets of a serial killer. Immunol Rev (2002) 1.08
Centriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systems. BMC Biol (2011) 1.06
Genotype-phenotype study of familial haemophagocytic lymphohistiocytosis type 3. J Med Genet (2011) 1.05
Combined zebrafish-yeast chemical-genetic screens reveal gene-copper-nutrition interactions that modulate melanocyte pigmentation. Dis Model Mech (2010) 1.04
Two patients with Hermansky Pudlak syndrome type 2 and novel mutations in AP3B1. Haematologica (2009) 1.03
Microtubule-dependent transport of secretory vesicles in RBL-2H3 cells. Traffic (2003) 1.03
Differences in influenza seasonality by latitude, northern India. Emerg Infect Dis (2014) 1.02
Syntaxin binding mechanism and disease-causing mutations in Munc18-2. Proc Natl Acad Sci U S A (2013) 1.01
The HLA A*0201-restricted hTERT(540-548) peptide is not detected on tumor cells by a CTL clone or a high-affinity T-cell receptor. Mol Cancer Ther (2007) 1.01
The role of the secretory immunological synapse in killing by CD8+ CTL. Semin Immunol (2003) 1.00
Genomic events underlying the changes in adamantane resistance among influenza A(H3N2) viruses during 2006-2008. Influenza Other Respir Viruses (2009) 0.99
A role for Rab7 in the movement of secretory granules in cytotoxic T lymphocytes. Traffic (2011) 0.98
Genetic analysis of avian influenza A viruses isolated from domestic waterfowl in live-bird markets of Hanoi, Vietnam, preceding fatal H5N1 human infections in 2004. Arch Virol (2009) 0.97
The GTPase-activating protein RN-tre controls focal adhesion turnover and cell migration. Curr Biol (2013) 0.97
The role of the cytoskeleton at the immunological synapse. Immunol Rev (2013) 0.95
A vitellogenic-like carboxypeptidase expressed by human macrophages is localized in endoplasmic reticulum and membrane ruffles. Int J Exp Pathol (2006) 0.94
Competing discrete interfacial effects are critical for amyloidogenesis. FASEB J (2009) 0.93
Analysis of influenza viruses from patients clinically suspected of infection with an oseltamivir resistant virus during the 2009 pandemic in the United States. Antiviral Res (2012) 0.93
Isolation and characterization of TgVP1, a type I vacuolar H+-translocating pyrophosphatase from Toxoplasma gondii. The dynamics of its subcellular localization and the cellular effects of a diphosphonate inhibitor. J Biol Chem (2002) 0.91
The presence of valine at residue 129 in human prion protein accelerates amyloid formation. FEBS Lett (2005) 0.91
Identification of common and distinctive mechanisms of resistance to different anti-IGF-IR agents in Ewing's sarcoma. Mol Endocrinol (2012) 0.90
Mutations affecting mRNA splicing are the most common molecular defect in patients with familial hemophagocytic lymphohistiocytosis type 3. Haematologica (2008) 0.89
Both exogenous commensal and endogenous self antigens stimulate T cell proliferation under lymphopenic conditions. Cell Immunol (2011) 0.87
Heterologous amyloid seeding: revisiting the role of acetylcholinesterase in Alzheimer's disease. PLoS One (2007) 0.87
Polarization effects on contrast in structured illumination microscopy. Opt Lett (2012) 0.86
Normal lytic granule secretion by cytotoxic T lymphocytes deficient in BLOC-1, -2 and -3 and myosins Va, VIIa and XV. Traffic (2005) 0.85
Prevalence of hyperprolactinaemia in a naturalistic cohort of schizophrenia and bipolar outpatients during treatment with typical and atypical antipsychotics. J Psychopharmacol (2007) 0.85
Combined effects of agitation, macromolecular crowding, and interfaces on amyloidogenesis. J Biol Chem (2012) 0.85
Transcriptional and cellular responses to defective mitochondrial proteolysis in fission yeast. J Mol Biol (2011) 0.84
Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL. Elife (2014) 0.84
Cytotoxic T lymphocyte effector function is independent of nucleus-centrosome dissociation. Eur J Immunol (2012) 0.84
Identifying patients with gastroesophageal reflux disease: validation of a practical screening tool. Dig Dis Sci (2002) 0.83
Arbitrary self-assembly of peptide extracellular microscopic matrices. Angew Chem Int Ed Engl (2011) 0.82
Reduced type I interferon production by dendritic cells and weakened antiviral immunity in patients with Wiskott-Aldrich syndrome protein deficiency. J Allergy Clin Immunol (2012) 0.82
A review of the association between antipsychotic use and hyperprolactinaemia. J Psychopharmacol (2008) 0.82
Prevalence of Barrett's Esophagus. Gastroenterology (2006) 0.81
Structural elements regulating amyloidogenesis: a cholinesterase model system. PLoS One (2008) 0.80
Targeting cardiovascular protection: the concept of dual renin-angiotensin system control. Medscape J Med (2008) 0.80
Self-selection and use patterns of over-the-counter omeprazole for frequent heartburn. Clin Gastroenterol Hepatol (2004) 0.80
Preparing for the availability of a partially effective HIV vaccine: some lessons from other licensed vaccines. Vaccine (2011) 0.80
No HOPE without proof: do ARBs meet the standard for cardiovascular protection? Medscape J Med (2008) 0.79
Prospects for renovascular protection by more aggressive renin-angiotensin system control. Medscape J Med (2008) 0.78