Published in J Biol Chem on December 19, 2006
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Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes. J Biol Chem (2015) 0.99
Prolyl hydroxylation- and glycosylation-dependent functions of Skp1 in O2-regulated development of Dictyostelium. Dev Biol (2010) 0.98
Three autocrine feedback loops determine HIF1 alpha expression in chronic hypoxia. Biochim Biophys Acta (2007) 0.97
Alpha-ketoglutarate dehydrogenase and glutamate dehydrogenase work in tandem to modulate the antioxidant alpha-ketoglutarate during oxidative stress in Pseudomonas fluorescens. J Bacteriol (2009) 0.97
Metabolic regulation of stem cell function. J Intern Med (2014) 0.97
Excess glucose induces hypoxia-inducible factor-1α in pancreatic cancer cells and stimulates glucose metabolism and cell migration. Cancer Biol Ther (2013) 0.97
Metabolomics of AS-5 RBC supernatants following routine storage. Vox Sang (2014) 0.96
Insulin/IGF-1 and hypoxia signaling act in concert to regulate iron homeostasis in Caenorhabditis elegans. PLoS Genet (2012) 0.96
D-beta-hydroxybutyrate extends lifespan in C. elegans. Aging (Albany NY) (2014) 0.96
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The role of inflammation in hypoxic pulmonary hypertension: from cellular mechanisms to clinical phenotypes. Am J Physiol Lung Cell Mol Physiol (2014) 0.94
Requirements for Skp1 processing by cytosolic prolyl 4(trans)-hydroxylase and α-N-acetylglucosaminyltransferase enzymes involved in O₂ signaling in dictyostelium. Biochemistry (2011) 0.92
The Skp1 protein from Toxoplasma is modified by a cytoplasmic prolyl 4-hydroxylase associated with oxygen sensing in the social amoeba Dictyostelium. J Biol Chem (2012) 0.92
Metabolic mechanisms of epigenetic regulation. ACS Chem Biol (2013) 0.92
Immunometabolism: Cellular Metabolism Turns Immune Regulator. J Biol Chem (2015) 0.91
Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors. J Med Chem (2013) 0.89
Mitochondria-controlled signaling mechanisms of brain protection in hypoxia. Front Neurosci (2015) 0.88
Screening chelating inhibitors of HIF-prolyl hydroxylase domain 2 (PHD2) and factor inhibiting HIF (FIH). J Inorg Biochem (2012) 0.87
Identification of hypoxia-inducible factor HIF-1A as transcriptional regulator of the A2B adenosine receptor during acute lung injury. J Immunol (2014) 0.86
Extended ischemia prevents HIF1alpha degradation at reoxygenation by impairing prolyl-hydroxylation: role of Krebs cycle metabolites. J Biol Chem (2010) 0.86
Glutamate metabolism in HIV-1 infected macrophages: Role of HIV-1 Vpr. Cell Cycle (2016) 0.86
Mitochondrial respiration and redox coupling in articular chondrocytes. Arthritis Res Ther (2015) 0.86
Hypoxia-inducible factor (HIF) network: insights from mathematical models. Cell Commun Signal (2013) 0.85
Stable differences in intrinsic mitochondrial membrane potential of tumor cell subpopulations reflect phenotypic heterogeneity. Int J Cell Biol (2011) 0.85
The oncometabolite fumarate promotes pseudohypoxia through noncanonical activation of NF-κB signaling. J Biol Chem (2014) 0.84
Deregulation of E2-EPF ubiquitin carrier protein in papillary renal cell carcinoma. Am J Pathol (2011) 0.84
Hypoxia-inducible factors and the prevention of acute organ injury. Crit Care (2011) 0.83
Metabolic control of renin secretion. Pflugers Arch (2012) 0.83
The real face of HIF1α in the tumor process. Cell Cycle (2012) 0.83
Immunosuppressive activity enhances central carbon metabolism and bioenergetics in myeloid-derived suppressor cells in vitro models. BMC Cell Biol (2012) 0.83
Oxygen availability and metabolic adaptations. Nat Rev Cancer (2016) 0.83
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Altered dynamics of intestinal cell maturation in Apc1638N/+ mice. Cancer Res (2010) 0.82
Fumaric acid esters stimulate astrocytic VEGF expression through HIF-1α and Nrf2. PLoS One (2013) 0.82
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Structural basis for malfunction in complex II. J Biol Chem (2012) 0.82
Neuronal apoptosis by prolyl hydroxylation: implication in nervous system tumours and the Warburg conundrum. J Cell Mol Med (2009) 0.82
Succinate dehydrogenase upregulation destabilize complex I and limits the lifespan of gas-1 mutant. PLoS One (2013) 0.82
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Ascorbate as a co-factor for fe- and 2-oxoglutarate dependent dioxygenases: physiological activity in tumor growth and progression. Front Oncol (2014) 0.81
Perception of self: distinguishing autoimmunity from autoinflammation. Nat Rev Rheumatol (2015) 0.81
Altered metabolite levels in cancer: implications for tumour biology and cancer therapy. Nat Rev Cancer (2016) 0.80
Oxygen concentration controls epigenetic effects in models of familial paraganglioma. PLoS One (2015) 0.80
New cancer targets emerging from studies of the Von Hippel-Lindau tumor suppressor protein. Ann N Y Acad Sci (2010) 0.80
Mitochondria, cholesterol and cancer cell metabolism. Clin Transl Med (2016) 0.80
The role of PHD2 mutations in the pathogenesis of erythrocytosis. Hypoxia (Auckl) (2014) 0.80
Genetically modeled mice with mutations in mitochondrial metabolic enzymes for the study of cancer. Front Oncol (2014) 0.78
Prolyl hydroxylase 2 deficiency limits proliferation of vascular smooth muscle cells by hypoxia-inducible factor-1{alpha}-dependent mechanisms. Am J Physiol Lung Cell Mol Physiol (2009) 0.78
Intracellular succinylation of 8-chloroadenosine and its effect on fumarate levels. J Biol Chem (2010) 0.78
Hypoxia-Inducible Histone Lysine Demethylases: Impact on the Aging Process and Age-Related Diseases. Aging Dis (2016) 0.77
TAp73 transcriptionally represses BNIP3 expression. Cell Cycle (2015) 0.77
Altered Hypoxic-Adenosine Axis and Metabolism in Group III Pulmonary Hypertension. Am J Respir Cell Mol Biol (2016) 0.77
Normoxic accumulation of HIF1α is associated with glutaminolysis. Clin Oral Investig (2016) 0.76
Competitive HIF Prolyl Hydroxylase Inhibitors Show Protection against Oxidative Stress by a Mechanism Partially Dependent on Glycolysis. ISRN Neurosci (2013) 0.76
Alpha-Ketoglutarate as a Molecule with Pleiotropic Activity: Well-Known and Novel Possibilities of Therapeutic Use. Arch Immunol Ther Exp (Warsz) (2016) 0.76
Role of Hypoxia Inducible Factor 1 in Hyperglycemia-Exacerbated Blood-Brain Barrier Disruption in Ischemic Stroke. Neurobiol Dis (2016) 0.76
The α-ketoglutarate dehydrogenase complex in cancer metabolic plasticity. Cancer Metab (2017) 0.75
A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD. Neuron (2011) 18.73
Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. Nature (2012) 5.47
Collagens, modifying enzymes and their mutations in humans, flies and worms. Trends Genet (2004) 5.47
Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study. Lancet Neurol (2012) 5.18
Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor. J Biol Chem (2003) 3.88
Inactivation of the lysyl oxidase gene Lox leads to aortic aneurysms, cardiovascular dysfunction, and perinatal death in mice. Circulation (2002) 3.57
Prolyl 4-hydroxylation regulates Argonaute 2 stability. Nature (2008) 2.51
Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy. Circ Res (2008) 2.15
Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases. J Biol Chem (2003) 2.11
Prevalence of the primary LHON mutations in Northern Finland associated with bilateral optic atrophy and tobacco-alcohol amblyopia. Acta Ophthalmol (2012) 2.00
Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor. Blood (2007) 1.84
Lysyl oxidase is essential for normal development and function of the respiratory system and for the integrity of elastic and collagen fibers in various tissues. Am J Pathol (2005) 1.79
A new endogenous ATP analog (ApppI) inhibits the mitochondrial adenine nucleotide translocase (ANT) and is responsible for the apoptosis induced by nitrogen-containing bisphosphonates. Br J Pharmacol (2006) 1.67
Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway. FASEB J (2005) 1.62
Molecular characterization of the principal substrate binding site of the ubiquitous folding catalyst protein disulfide isomerase. J Biol Chem (2003) 1.51
Further insight into mechanism of action of clodronate: inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite. Mol Pharmacol (2002) 1.38
The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases. J Biol Chem (2006) 1.35
Characterization of recombinant human prolyl 3-hydroxylase isoenzyme 2, an enzyme modifying the basement membrane collagen IV. J Biol Chem (2008) 1.28
Characterization of a second Arabidopsis thaliana prolyl 4-hydroxylase with distinct substrate specificity. J Biol Chem (2004) 1.26
Loss of assembly of the main basement membrane collagen, type IV, but not fibril-forming collagens and embryonic death in collagen prolyl 4-hydroxylase I null mice. J Biol Chem (2006) 1.23
Roles of the human hypoxia-inducible factor (HIF)-3α variants in the hypoxia response. Cell Mol Life Sci (2011) 1.23
A selective inhibitor and probe of the cellular functions of Jumonji C domain-containing histone demethylases. J Am Chem Soc (2011) 1.22
High myopia caused by a mutation in LEPREL1, encoding prolyl 3-hydroxylase 2. Am J Hum Genet (2011) 1.20
Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury. J Biol Chem (2010) 1.18
Collagen binding specificity of the discoidin domain receptors: binding sites on collagens II and III and molecular determinants for collagen IV recognition by DDR1. Matrix Biol (2010) 1.17
Identification and characterization of a third human, rat, and mouse collagen prolyl 4-hydroxylase isoenzyme. J Biol Chem (2003) 1.16
Tissue-specific changes in the hydroxylysine content and cross-links of collagens and alterations in fibril morphology in lysyl hydroxylase 1 knock-out mice. J Biol Chem (2006) 1.16
Premature aggregation of type IV collagen and early lethality in lysyl hydroxylase 3 null mice. Proc Natl Acad Sci U S A (2004) 1.15
The primary substrate binding site in the b' domain of ERp57 is adapted for endoplasmic reticulum lectin association. J Biol Chem (2004) 1.15
An endoplasmic reticulum transmembrane prolyl 4-hydroxylase is induced by hypoxia and acts on hypoxia-inducible factor alpha. J Biol Chem (2007) 1.11
Lysyl oxidase oxidizes cell membrane proteins and enhances the chemotactic response of vascular smooth muscle cells. J Biol Chem (2008) 1.06
The active site of an algal prolyl 4-hydroxylase has a large structural plasticity. J Biol Chem (2007) 1.06
Chlamydomonas reinhardtii has multiple prolyl 4-hydroxylases, one of which is essential for proper cell wall assembly. Plant Cell (2007) 1.04
Lysyl hydroxylase 2 is a specific telopeptide hydroxylase, while all three isoenzymes hydroxylate collagenous sequences. Matrix Biol (2007) 1.03
Hypoxia-inducible factor (HIF)-3alpha is subject to extensive alternative splicing in human tissues and cancer cells and is regulated by HIF-1 but not HIF-2. Int J Biochem Cell Biol (2010) 1.03
Homozygous W748S mutation in the POLG1 gene in patients with juvenile-onset Alpers syndrome and status epilepticus. Epilepsia (2008) 1.03
Improved production of human type II procollagen in the yeast Pichia pastoris in shake flasks by a wireless-controlled fed-batch system. BMC Biotechnol (2008) 1.03
Cardiac abnormalities in patients with mitochondrial DNA mutation 3243A>G. BMC Cardiovasc Disord (2002) 1.01
LOXL1 and LOXL4 are epigenetically silenced and can inhibit ras/extracellular signal-regulated kinase signaling pathway in human bladder cancer. Cancer Res (2007) 1.01
T-cell activation leads to reduced collagen maturation in atherosclerotic plaques of Apoe(-/-) mice. Am J Pathol (2009) 1.01
A pair of membrane-embedded acidic residues in the NuoK subunit of Escherichia coli NDH-1, a counterpart of the ND4L subunit of the mitochondrial complex I, are required for high ubiquinone reductase activity. Biochemistry (2004) 1.01
Genetic loci associated with Alzheimer's disease and cerebrospinal fluid biomarkers in a Finnish case-control cohort. PLoS One (2013) 0.99
Characterization of three fragments that constitute the monomers of the human lysyl hydroxylase isoenzymes 1-3. The 30-kDa N-terminal fragment is not required for lysyl hydroxylase activity. J Biol Chem (2002) 0.99
The crystal structure of an algal prolyl 4-hydroxylase complexed with a proline-rich peptide reveals a novel buried tripeptide binding motif. J Biol Chem (2009) 0.96
Fermentation process for tetrameric human collagen prolyl 4-hydroxylase in Escherichia coli: improvement by gene optimisation of the PDI/beta subunit and repeated addition of the inducer anhydrotetracycline. J Biotechnol (2006) 0.95
The peptide-substrate-binding domain of human collagen prolyl 4-hydroxylases. Backbone assignments, secondary structure, and binding of proline-rich peptides. J Biol Chem (2003) 0.95
GroupICA dual regression analysis of resting state networks in a behavioral variant of frontotemporal dementia. Front Hum Neurosci (2013) 0.94
Identification and characterization of structural domains of human ERp57: association with calreticulin requires several domains. J Biol Chem (2004) 0.94
Assembly of stable human type I and III collagen molecules from hydroxylated recombinant chains in the yeast Pichia pastoris. Effect of an engineered C-terminal oligomerization domain foldon. J Biol Chem (2003) 0.94
Missense mutations that cause Bruck syndrome affect enzymatic activity, folding, and oligomerization of lysyl hydroxylase 2. J Biol Chem (2009) 0.94
Relevance of posttranslational modifications for the arthritogenicity of type II collagen. J Immunol (2004) 0.93
Cortical thickness in frontotemporal dementia, mild cognitive impairment, and Alzheimer's disease. J Alzheimers Dis (2012) 0.93
Cerebrospinal fluid antibodies to oxidized LDL are increased in Alzheimer's disease. Neurobiol Dis (2008) 0.92
Hypoxia-inducible factor-1 (HIF-1) but not HIF-2 is essential for hypoxic induction of collagen prolyl 4-hydroxylases in primary newborn mouse epiphyseal growth plate chondrocytes. J Biol Chem (2012) 0.92
The peptide-substrate-binding domain of collagen prolyl 4-hydroxylases is a tetratricopeptide repeat domain with functional aromatic residues. J Biol Chem (2004) 0.91
Three binding sites in protein-disulfide isomerase cooperate in collagen prolyl 4-hydroxylase tetramer assembly. J Biol Chem (2004) 0.90
Connective tissue growth factor inhibition attenuates left ventricular remodeling and dysfunction in pressure overload-induced heart failure. Hypertension (2014) 0.90
Role of MAPT mutations and haplotype in frontotemporal lobar degeneration in Northern Finland. BMC Neurol (2008) 0.89
Mitochondrial function determines the viability and osteogenic potency of human mesenchymal stem cells. Tissue Eng Part C Methods (2010) 0.88
The Ras signaling inhibitor LOX-PP interacts with Hsp70 and c-Raf to reduce Erk activation and transformed phenotype of breast cancer cells. Mol Cell Biol (2011) 0.88
Transmembrane prolyl 4-hydroxylase is a fourth prolyl 4-hydroxylase regulating EPO production and erythropoiesis. Blood (2012) 0.87
The MELAS mutations 3946 and 3949 perturb the critical structure in a conserved loop of the ND1 subunit of mitochondrial complex I. Hum Mol Genet (2006) 0.87
Myocardial overexpression of Mecr, a gene of mitochondrial FAS II leads to cardiac dysfunction in mouse. PLoS One (2009) 0.86
Mitochondrial DNA haplogroups in early-onset Alzheimer's disease and frontotemporal lobar degeneration. Mol Neurodegener (2010) 0.86
Differential metabolic consequences of fumarate hydratase and respiratory chain defects. Biochim Biophys Acta (2008) 0.86
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Novel TARDBP sequence variant and C9ORF72 repeat expansion in a family with frontotemporal dementia. Alzheimer Dis Assoc Disord (2014) 0.85
High-level production of human collagen prolyl 4-hydroxylase in Escherichia coli. Matrix Biol (2004) 0.85
Egg shell collagen formation in Caenorhabditis elegans involves a novel prolyl 4-hydroxylase expressed in spermatheca and embryos and possessing many unique properties. J Biol Chem (2002) 0.85