Alpha-ketoglutarate dehydrogenase and glutamate dehydrogenase work in tandem to modulate the antioxidant alpha-ketoglutarate during oxidative stress in Pseudomonas fluorescens.

PubWeight™: 0.97‹?› | Rank: Top 15%

🔗 View Article (PMC 2698380)

Published in J Bacteriol on April 17, 2009

Authors

Ryan J Mailloux1, Ranji Singh, Guy Brewer, Christopher Auger, Joseph Lemire, Vasu D Appanna

Author Affiliations

1: Department of Chemistry and Biochemistry, Laurentian University, Sudbury, Ontario, Canada.

Articles citing this

Gut microbial gene expression in mother-fed and formula-fed piglets. PLoS One (2010) 1.27

Reactive oxygen species mediate bactericidal killing elicited by carbon monoxide-releasing molecules. J Biol Chem (2011) 1.09

A systematic investigation of Escherichia coli central carbon metabolism in response to superoxide stress. BMC Syst Biol (2010) 1.02

An ATP and oxalate generating variant tricarboxylic acid cycle counters aluminum toxicity in Pseudomonas fluorescens. PLoS One (2009) 0.94

A mitocentric view of Alzheimer's disease suggests multi-faceted treatments. J Alzheimers Dis (2010) 0.93

Metaproteomics analysis reveals the adaptation process for the chicken gut microbiota. Appl Environ Microbiol (2013) 0.90

Genetic analysis of the assimilation of C5-dicarboxylic acids in Pseudomonas aeruginosa PAO1. J Bacteriol (2014) 0.85

Expanding antitumor therapeutic windows by targeting cancer-specific nicotinamide adenine dinucleotide phosphate-biogenesis pathways. Clin Pharmacol (2015) 0.80

Clostridium difficile glutamate dehydrogenase is a secreted enzyme that confers resistance to H2O2. Microbiology (2013) 0.80

The metabolic reprogramming evoked by nitrosative stress triggers the anaerobic utilization of citrate in Pseudomonas fluorescens. PLoS One (2011) 0.79

Early changes in apoplast composition associated with defence and disease in interactions between Phaseolus vulgaris and the halo blight pathogen Pseudomonas syringae Pv. phaseolicola. Plant Cell Environ (2016) 0.77

Colony morphology and transcriptome profiling of Pseudomonas putida KT2440 and its mutants deficient in alginate or all EPS synthesis under controlled matric potentials. Microbiologyopen (2014) 0.77

α -Ketoglutarate accumulation is not dependent on isocitrate dehydrogenase activity during tellurite detoxification in Escherichia coli. Biomed Res Int (2013) 0.77

Importance of Metabolic Adaptations in Francisella Pathogenesis. Front Cell Infect Microbiol (2017) 0.75

Involvement of proline oxidase (PutA) in programmed cell death of Xanthomonas. PLoS One (2014) 0.75

Articles cited by this

Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem (1976) 903.81

Reactive oxygen species: metabolism, oxidative stress, and signal transduction. Annu Rev Plant Biol (2004) 18.76

NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences. Antioxid Redox Signal (2008) 4.23

Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells. Mol Cell Biol (2007) 3.33

The power to reduce: pyridine nucleotides--small molecules with a multitude of functions. Biochem J (2007) 3.11

Regulation of hepatic glutathione synthesis: current concepts and controversies. FASEB J (1999) 2.96

Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF. J Biol Chem (2006) 2.86

Regulation of inducible peroxide stress responses. Mol Microbiol (2002) 2.43

Bioenergetics and the formation of mitochondrial reactive oxygen species. Trends Pharmacol Sci (2006) 2.22

Carnitine biosynthesis in mammals. Biochem J (2002) 2.13

Complex cellular responses to reactive oxygen species. Trends Cell Biol (2005) 2.09

Nonezymatic formation of succinate in mitochondria under oxidative stress. Free Radic Biol Med (2006) 2.01

Oxidative stress in cyanobacteria. FEMS Microbiol Rev (2008) 1.87

The tricarboxylic acid cycle, an ancient metabolic network with a novel twist. PLoS One (2007) 1.60

Alpha-ketoglutarate dehydrogenase: a target and generator of oxidative stress. Philos Trans R Soc Lond B Biol Sci (2005) 1.55

Is the mitochondrial free radical theory of aging intact? Antioxid Redox Signal (2006) 1.40

Oxidative stress evokes a metabolic adaptation that favors increased NADPH synthesis and decreased NADH production in Pseudomonas fluorescens. J Bacteriol (2007) 1.35

Mitochondrial dysfunction increases oxidative stress and decreases chronological life span in fission yeast. PLoS One (2008) 1.17

A novel strategy involved in [corrected] anti-oxidative defense: the conversion of NADH into NADPH by a metabolic network. PLoS One (2008) 1.14

Offering surprises: TCA cycle regulation in Corynebacterium glutamicum. Trends Microbiol (2007) 1.07

Purification and characterization of a catalase from the facultatively psychrophilic bacterium Vibrio rumoiensis S-1(T) exhibiting high catalase activity. J Bacteriol (2000) 1.03

Oxidative stress in Synechococcus sp. strain PCC 7942: various mechanisms for H2O2 detoxification with different physiological roles. J Bacteriol (2003) 1.01

Antioxidant properties of myocardial fuels. Mol Cell Biochem (2003) 1.01

Aluminum triggers decreased aconitase activity via Fe-S cluster disruption and the overexpression of isocitrate dehydrogenase and isocitrate lyase: a metabolic network mediating cellular survival. J Biol Chem (2004) 0.97

Aluminum toxicity elicits a dysfunctional TCA cycle and succinate accumulation in hepatocytes. J Biochem Mol Toxicol (2006) 0.95

Novel functions of the alpha-ketoglutarate dehydrogenase complex may mediate diverse oxidant-induced changes in mitochondrial enzymes associated with Alzheimer's disease. Biochim Biophys Acta (2007) 0.92

Histochemical visualization of oxidant stress. Free Radic Biol Med (2000) 0.90

Identification and characterization of 1-Cys peroxiredoxin from Sulfolobus solfataricus and its involvement in the response to oxidative stress. FEBS J (2006) 0.86

Alpha-ketoglutarate abrogates the nuclear localization of HIF-1alpha in aluminum-exposed hepatocytes. Biochimie (2008) 0.84

The effect of chronic restraint stress and sulfite on visual evoked potentials (VEPs): relation to lipid peroxidation. Food Chem Toxicol (2005) 0.81

Alpha-ketoglutarate and N-acetyl cysteine protect PC12 cells from cyanide-induced cytotoxicity and altered energy metabolism. Neurotoxicology (2007) 0.81

Resistance to vanadium in Pseudomonas fluorescens ATCC 17400 caused by mutations in TCA cycle enzymes. FEMS Microbiol Lett (2006) 0.80

A novel metabolic network leads to enhanced citrate biogenesis in Pseudomonas fluorescens exposed to aluminum toxicity. Extremophiles (2008) 0.78

Articles by these authors

The tricarboxylic acid cycle, an ancient metabolic network with a novel twist. PLoS One (2007) 1.60

Oxidative stress evokes a metabolic adaptation that favors increased NADPH synthesis and decreased NADH production in Pseudomonas fluorescens. J Bacteriol (2007) 1.35

Hypermethylation of Fads2 and altered hepatic fatty acid and phospholipid metabolism in mice with hyperhomocysteinemia. J Biol Chem (2007) 1.18

A novel strategy involved in [corrected] anti-oxidative defense: the conversion of NADH into NADPH by a metabolic network. PLoS One (2008) 1.14

Zinc toxicity alters mitochondrial metabolism and leads to decreased ATP production in hepatocytes. J Appl Toxicol (2008) 1.11

Mitochondrial lactate dehydrogenase is involved in oxidative-energy metabolism in human astrocytoma cells (CCF-STTG1). PLoS One (2008) 1.03

Aluminum triggers decreased aconitase activity via Fe-S cluster disruption and the overexpression of isocitrate dehydrogenase and isocitrate lyase: a metabolic network mediating cellular survival. J Biol Chem (2004) 0.97

Aluminum toxicity elicits a dysfunctional TCA cycle and succinate accumulation in hepatocytes. J Biochem Mol Toxicol (2006) 0.95

An ATP and oxalate generating variant tricarboxylic acid cycle counters aluminum toxicity in Pseudomonas fluorescens. PLoS One (2009) 0.94

Metabolic networks to combat oxidative stress in Pseudomonas fluorescens. Antonie Van Leeuwenhoek (2010) 0.92

Aluminum-induced mitochondrial dysfunction leads to lipid accumulation in human hepatocytes: a link to obesity. Cell Physiol Biochem (2007) 0.92

Aluminum-tolerant Pseudomonas fluorescens: ROS toxicity and enhanced NADPH production. Extremophiles (2005) 0.89

Involvement of fumarase C and NADH oxidase in metabolic adaptation of Pseudomonas fluorescens cells evoked by aluminum and gallium toxicity. Appl Environ Microbiol (2008) 0.88

Detoxification of selenite and mercury by reduction and mutual protection in the assimilation of both elements by Pseudomonas fluorescens. Sci Total Environ (2006) 0.86

How aluminum, an intracellular ROS generator promotes hepatic and neurological diseases: the metabolic tale. Cell Biol Toxicol (2013) 0.86

Aluminum toxicity triggers the nuclear translocation of HIF-1alpha and promotes anaerobiosis in hepatocytes. Toxicol In Vitro (2006) 0.86

In-gel activity staining of oxidized nicotinamide adenine dinucleotide kinase by blue native polyacrylamide gel electrophoresis. Anal Biochem (2006) 0.85

Pseudomonas fluorescens orchestrates a fine metabolic-balancing act to counter aluminium toxicity. Environ Microbiol (2010) 0.84

Alpha-ketoglutarate abrogates the nuclear localization of HIF-1alpha in aluminum-exposed hepatocytes. Biochimie (2008) 0.84

Aluminum detoxification in Pseudomonas fluorescens is mediated by oxalate and phosphatidylethanolamine. Biochim Biophys Acta (2003) 0.83

Detection and purification of glucose 6-phosphate dehydrogenase, malic enzyme, and NADP-dependent isocitrate dehydrogenase by blue native polyacrylamide gel electrophoresis. Electrophoresis (2005) 0.83

Histidine is a source of the antioxidant, alpha-ketoglutarate, in Pseudomonas fluorescens challenged by oxidative stress. FEMS Microbiol Lett (2010) 0.81

Epigenetic regulation of glucocorticoid receptor expression in aorta from mice with hyperhomocysteinemia. Epigenetics (2012) 0.80

Hepatic response to aluminum toxicity: dyslipidemia and liver diseases. Exp Cell Res (2011) 0.80

The monitoring of nucleotide diphosphate kinase activity by blue native polyacrylamide gel electrophoresis. Electrophoresis (2008) 0.80

The metabolic reprogramming evoked by nitrosative stress triggers the anaerobic utilization of citrate in Pseudomonas fluorescens. PLoS One (2011) 0.79

Hepatic acyl-coenzyme a:cholesterol acyltransferase-2 expression is decreased in mice with hyperhomocysteinemia. J Nutr (2009) 0.79

Mitochondrial lactate metabolism is involved in antioxidative defense in human astrocytoma cells. J Neurosci Res (2014) 0.79

Overexpression of isocitrate lyase is an important strategy in the survival of Pseudomonas fluorescens exposed to aluminum. Biochem Biophys Res Commun (2004) 0.79

Hydrogen peroxide stress provokes a metabolic reprogramming in Pseudomonas fluorescens: enhanced production of pyruvate. J Biotechnol (2013) 0.78

Aluminum toxicity and astrocyte dysfunction: a metabolic link to neurological disorders. J Inorg Biochem (2011) 0.78

Tellurite-exposed Escherichia coli exhibits increased intracellular α-ketoglutarate. Biochem Biophys Res Commun (2012) 0.78

The disruption of L-carnitine metabolism by aluminum toxicity and oxidative stress promotes dyslipidemia in human astrocytic and hepatic cells. Toxicol Lett (2011) 0.78

A blue native polyacrylamide gel electrophoretic technology to probe the functional proteomics mediating nitrogen homeostasis in Pseudomonas fluorescens. J Microbiol Methods (2012) 0.78

A novel metabolic network leads to enhanced citrate biogenesis in Pseudomonas fluorescens exposed to aluminum toxicity. Extremophiles (2008) 0.78

Metabolic reengineering invoked by microbial systems to decontaminate aluminum: implications for bioremediation technologies. Biotechnol Adv (2012) 0.76

Metabolic adaptation and oxaloacetate homeostasis in P. fluorescens exposed to aluminum toxicity. J Basic Microbiol (2008) 0.76

Mitochondrial biogenesis and energy production in differentiating murine stem cells: a functional metabolic study. Cell Reprogram (2013) 0.76

A facile electrophoretic technique to monitor phosphoenolpyruvate-dependent kinases. Electrophoresis (2012) 0.75

The unravelling of metabolic dysfunctions linked to metal-associated diseases by blue native polyacrylamide gel electrophoresis. Anal Bioanal Chem (2012) 0.75

Alternatively Activated Macrophages Drive Browning of White Adipose Tissue in Burns. Ann Surg (2017) 0.75

Fumarate metabolism and ATP production in Pseudomonas fluorescens exposed to nitrosative stress. Antonie Van Leeuwenhoek (2014) 0.75