PubRank

Randall T Moon

Author PubWeight™ 230.27‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling. Dev Cell 2003 7.93
2 Proximal events in Wnt signal transduction. Nat Rev Mol Cell Biol 2009 6.66
3 WNT signalling pathways as therapeutic targets in cancer. Nat Rev Cancer 2013 6.64
4 Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements. Curr Biol 2003 6.60
5 Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell 2009 5.34
6 Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling. Science 2007 5.08
7 Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. Nature 2006 4.96
8 Distinct Wnt signaling pathways have opposing roles in appendage regeneration. Development 2006 4.88
9 Functional genomic analysis of the Wnt-wingless signaling pathway. Science 2005 4.73
10 Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration. Cell 2009 4.69
11 A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected]. Proc Natl Acad Sci U S A 2004 3.95
12 Biphasic role for Wnt/beta-catenin signaling in cardiac specification in zebrafish and embryonic stem cells. Proc Natl Acad Sci U S A 2007 3.90
13 The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway. Cell Stem Cell 2007 3.54
14 The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling. Mol Cell Biol 2003 3.53
15 Wnt and calcium signaling: beta-catenin-independent pathways. Cell Calcium 2005 3.46
16 The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition. J Biol Chem 2007 3.24
17 The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation. Nat Cell Biol 2006 3.22
18 The planar cell-polarity gene stbm regulates cell behaviour and cell fate in vertebrate embryos. Nat Cell Biol 2002 3.13
19 A Wnt survival guide: from flies to human disease. J Invest Dermatol 2009 2.91
20 Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy. Nat Genet 2002 2.90
21 Kaiso/p120-catenin and TCF/beta-catenin complexes coordinately regulate canonical Wnt gene targets. Dev Cell 2005 2.86
22 A temporal chromatin signature in human embryonic stem cells identifies regulators of cardiac development. Cell 2012 2.81
23 Disruption of acvrl1 increases endothelial cell number in zebrafish cranial vessels. Development 2002 2.61
24 Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation. Nat Med 2005 2.60
25 A transgenic Lef1/beta-catenin-dependent reporter is expressed in spatially restricted domains throughout zebrafish development. Dev Biol 2002 2.46
26 Wnt-beta-catenin signaling initiates taste papilla development. Nat Genet 2006 2.43
27 Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway. Nature 2003 2.42
28 Activated Wnt/beta-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model. Proc Natl Acad Sci U S A 2009 2.41
29 Differential requirement for the dual functions of β-catenin in embryonic stem cell self-renewal and germ layer formation. Nat Cell Biol 2011 2.32
30 Advances in signaling in vertebrate regeneration as a prelude to regenerative medicine. Genes Dev 2007 2.31
31 Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation. Dev Cell 2002 2.28
32 Wnt5a control of cell polarity and directional movement by polarized redistribution of adhesion receptors. Science 2008 2.22
33 Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation. Cancer Res 2006 2.14
34 The Sp1-related transcription factors sp5 and sp5-like act downstream of Wnt/beta-catenin signaling in mesoderm and neuroectoderm patterning. Curr Biol 2005 2.09
35 Dishevelled activates Ca2+ flux, PKC, and CamKII in vertebrate embryos. J Cell Biol 2003 2.07
36 Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization. Nat Cell Biol 2003 1.96
37 Wnt/β-catenin signaling and AXIN1 regulate apoptosis triggered by inhibition of the mutant kinase BRAFV600E in human melanoma. Sci Signal 2012 1.95
38 Wnt/β-catenin signaling promotes differentiation, not self-renewal, of human embryonic stem cells and is repressed by Oct4. Proc Natl Acad Sci U S A 2012 1.93
39 APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development. Dev Biol 2008 1.90
40 New regulators of Wnt/beta-catenin signaling revealed by integrative molecular screening. Sci Signal 2008 1.88
41 Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease. Proc Natl Acad Sci U S A 2007 1.84
42 Wnt signaling promotes hematoendothelial cell development from human embryonic stem cells. Blood 2007 1.79
43 Assaying beta-catenin/TCF transcription with beta-catenin/TCF transcription-based reporter constructs. Methods Mol Biol 2008 1.77
44 Reiterated Wnt signaling during zebrafish neural crest development. Development 2004 1.75
45 Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cells in vivo. Proc Natl Acad Sci U S A 2003 1.72
46 Microenvironmental protection of CML stem and progenitor cells from tyrosine kinase inhibitors through N-cadherin and Wnt-β-catenin signaling. Blood 2013 1.70
47 Signaling of rat Frizzled-2 through phosphodiesterase and cyclic GMP. Science 2002 1.69
48 Crystal structures of the extracellular domain of LRP6 and its complex with DKK1. Nat Struct Mol Biol 2011 1.68
49 CTLA-4 is a direct target of Wnt/beta-catenin signaling and is expressed in human melanoma tumors. J Invest Dermatol 2008 1.60
50 Crystal structure of a full-length beta-catenin. Structure 2008 1.55
51 A re-evaluation of the "oncogenic" nature of Wnt/beta-catenin signaling in melanoma and other cancers. Curr Oncol Rep 2010 1.52
52 LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1. Proc Natl Acad Sci U S A 2013 1.51
53 Small-molecule synergist of the Wnt/beta-catenin signaling pathway. Proc Natl Acad Sci U S A 2007 1.39
54 Wnt/beta-catenin regulation of the Sp1-related transcription factor sp5l promotes tail development in zebrafish. Development 2005 1.38
55 Inactivation of Chibby affects function of motile airway cilia. J Cell Biol 2009 1.38
56 A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models. J Clin Invest 2013 1.37
57 Two tcf3 genes cooperate to pattern the zebrafish brain. Development 2003 1.36
58 Wnt/Fz signaling and the cytoskeleton: potential roles in tumorigenesis. Cell Res 2009 1.35
59 Zebrafish Dapper1 and Dapper2 play distinct roles in Wnt-mediated developmental processes. Development 2004 1.32
60 Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak. Nat Genet 2009 1.31
61 When Wnts antagonize Wnts. J Cell Biol 2003 1.29
62 Wnt/beta-catenin signaling has an essential role in the initiation of limb regeneration. Dev Biol 2007 1.25
63 Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling. J Cell Biol 2011 1.25
64 Stromelysin-1 and mesothelin are differentially regulated by Wnt-5a and Wnt-1 in C57mg mouse mammary epithelial cells. BMC Dev Biol 2003 1.22
65 Noncanonical Wnt signaling orchestrates early developmental events toward hematopoietic cell fate from human embryonic stem cells. Cell Stem Cell 2009 1.20
66 The tuberin-hamartin complex negatively regulates beta-catenin signaling activity. J Biol Chem 2003 1.20
67 Microfluidic device generating stable concentration gradients for long term cell culture: application to Wnt3a regulation of β-catenin signaling. Lab Chip 2010 1.20
68 The CCN family member Wisp3, mutant in progressive pseudorheumatoid dysplasia, modulates BMP and Wnt signaling. J Clin Invest 2007 1.19
69 Active beta-catenin signaling is an inhibitory pathway for human immunodeficiency virus replication in peripheral blood mononuclear cells. J Virol 2008 1.18
70 Beta-catenin signaling increases in proliferating NG2+ progenitors and astrocytes during post-traumatic gliogenesis in the adult brain. Stem Cells 2010 1.18
71 nemo-like kinase is an essential co-activator of Wnt signaling during early zebrafish development. Development 2004 1.18
72 Transcription-based reporters of Wnt/beta-catenin signaling. Cold Spring Harb Protoc 2009 1.16
73 WNT5A enhances resistance of melanoma cells to targeted BRAF inhibitors. J Clin Invest 2014 1.16
74 Porous implants modulate healing and induce shifts in local macrophage polarization in the foreign body reaction. Ann Biomed Eng 2013 1.14
75 TC1 (C8orf4) enhances the Wnt/beta-catenin pathway by relieving antagonistic activity of Chibby. Cancer Res 2006 1.13
76 Wnt signaling exerts an antiproliferative effect on adult cardiac progenitor cells through IGFBP3. Circ Res 2011 1.13
77 Targeting Wnt pathways in disease. Cold Spring Harb Perspect Biol 2012 1.11
78 WNTS and WNT receptors as therapeutic tools and targets in human disease processes. Front Biosci 2007 1.11
79 Adiponectin haploinsufficiency promotes mammary tumor development in MMTV-PyVT mice by modulation of phosphatase and tensin homolog activities. PLoS One 2009 1.10
80 Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling. Sci Signal 2009 1.10
81 Requirement of Wnt/beta-catenin signaling in pronephric kidney development. Mech Dev 2008 1.09
82 Chibby promotes adipocyte differentiation through inhibition of beta-catenin signaling. Mol Cell Biol 2007 1.09
83 Wnt5a and Wnt11 are essential for second heart field progenitor development. Development 2012 1.08
84 AKT kinase activity is required for lithium to modulate mood-related behaviors in mice. Neuropsychopharmacology 2011 1.08
85 Wnt/β-catenin signaling suppresses DUX4 expression and prevents apoptosis of FSHD muscle cells. Hum Mol Genet 2013 1.06
86 Chemical-genetic screen identifies riluzole as an enhancer of Wnt/β-catenin signaling in melanoma. Chem Biol 2010 1.05
87 High basal levels of functional toll-like receptor 3 (TLR3) and noncanonical Wnt5a are expressed in papillary thyroid cancer and are coordinately decreased by phenylmethimazole together with cell proliferation and migration. Endocrinology 2007 1.04
88 Phenylmethimazole decreases Toll-like receptor 3 and noncanonical Wnt5a expression in pancreatic cancer and melanoma together with tumor cell growth and migration. Clin Cancer Res 2009 1.03
89 Wnt signaling: it gets more humorous with age. Curr Biol 2007 1.01
90 Crystal structure of a Tankyrase-Axin complex and its implications for Axin turnover and Tankyrase substrate recruitment. Proc Natl Acad Sci U S A 2012 1.01
91 TC1(C8orf4) correlates with Wnt/beta-catenin target genes and aggressive biological behavior in gastric cancer. Clin Cancer Res 2006 1.01
92 Beta-catenin-independent Wnt pathways: signals, core proteins, and effectors. Methods Mol Biol 2008 1.01
93 Canonical Wnt3a modulates intracellular calcium and enhances excitatory neurotransmission in hippocampal neurons. J Biol Chem 2010 1.00
94 The interaction of the Wnt and Notch pathways modulates natural killer versus T cell differentiation. Stem Cells 2007 0.99
95 A plasmid-based system for expressing small interfering RNA libraries in mammalian cells. BMC Cell Biol 2004 0.98
96 Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells. J Clin Invest 2015 0.97
97 Wnt1 and wnt10b function redundantly at the zebrafish midbrain-hindbrain boundary. Dev Biol 2003 0.95
98 Wilms tumor gene on X chromosome (WTX) inhibits degradation of NRF2 protein through competitive binding to KEAP1 protein. J Biol Chem 2012 0.95
99 Altered splicing of ATP6AP2 causes X-linked parkinsonism with spasticity (XPDS). Hum Mol Genet 2013 0.95
100 Activation of Wnt/β-catenin signaling increases apoptosis in melanoma cells treated with trail. PLoS One 2013 0.95
101 Regulating the response to targeted MEK inhibition in melanoma: enhancing apoptosis in NRAS- and BRAF-mutant melanoma cells with Wnt/β-catenin activation. Cell Cycle 2012 0.94
102 Transmembrane protein 88: a Wnt regulatory protein that specifies cardiomyocyte development. Development 2013 0.94
103 Assessment of hypoxia inducible factor levels in cancer cell lines upon hypoxic induction using a novel reporter construct. PLoS One 2011 0.93
104 Wnt3a activates dormant c-Kit(-) bone marrow-derived cells with short-term multilineage hematopoietic reconstitution capacity. Stem Cells 2010 0.92
105 Adiponectin stimulates Wnt inhibitory factor-1 expression through epigenetic regulations involving the transcription factor specificity protein 1. Carcinogenesis 2008 0.92
106 Microfluidic bioreactor for dynamic regulation of early mesodermal commitment in human pluripotent stem cells. Lab Chip 2013 0.92
107 Protein kinase PKN1 represses Wnt/β-catenin signaling in human melanoma cells. J Biol Chem 2013 0.91
108 WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling. PLoS One 2012 0.91
109 Intrinsic and extrinsic modifiers of the regulative capacity of the developing liver. Mech Dev 2012 0.90
110 Bili inhibits Wnt/beta-catenin signaling by regulating the recruitment of axin to LRP6. PLoS One 2009 0.89
111 Hematopoietic stem cell biology: too much of a Wnt thing. Nat Immunol 2006 0.88
112 It takes a village to grow a tissue. Nat Biotechnol 2005 0.88
113 Overexpression of Wnt-1 in thyrocytes enhances cellular growth but suppresses transcription of the thyroperoxidase gene via different signaling mechanisms. J Endocrinol 2007 0.86
114 A lentivirus-mediated genetic screen identifies dihydrofolate reductase (DHFR) as a modulator of beta-catenin/GSK3 signaling. PLoS One 2009 0.86
115 Developmental biology: signalling polarity. Nature 2002 0.86
116 Modulation of the beta-catenin signaling pathway by the dishevelled-associated protein Hipk1. PLoS One 2009 0.85
117 Beta-catenin gets jaded and von Hippel-Lindau is to blame. Trends Biochem Sci 2009 0.85
118 Integrative analysis of genome-wide RNA interference screens. Sci Signal 2009 0.85
119 A 1,536-well ultra-high-throughput siRNA screen to identify regulators of the Wnt/beta-catenin pathway. Assay Drug Dev Technol 2010 0.84
120 Botulinum toxin induces muscle paralysis and inhibits bone regeneration in zebrafish. J Bone Miner Res 2014 0.84
121 Lymphoid enhancer factor-1 links two hereditary leukemia syndromes through core-binding factor alpha regulation of ELA2. J Biol Chem 2003 0.81
122 Prolonged in vivo gene silencing by electroporation-mediated plasmid delivery of small interfering RNA. Hum Gene Ther 2007 0.80
123 A PKC wave follows the calcium wave after activation of Xenopus eggs. Differentiation 2004 0.80
124 WLS inhibits melanoma cell proliferation through the β-catenin signalling pathway and induces spontaneous metastasis. EMBO Mol Med 2012 0.80
125 A novel functional low-density lipoprotein receptor-related protein 6 gene alternative splice variant is associated with Alzheimer's disease. Neurobiol Aging 2012 0.79
126 Lentiviral-mediated transgene expression can potentiate intestinal mesenchymal-epithelial signaling. Biol Proced Online 2009 0.77
127 "Omic" risk assessment. Sci Signal 2009 0.75
128 Wnt and related signaling pathways in melanomagenesis. Cancers (Basel) 2010 0.75