Published in BMC Cell Biol on April 30, 2004
RNAi screen in mouse astrocytes identifies phosphatases that regulate NF-kappaB signaling. Mol Cell (2006) 1.47
Gene modulation for treating liver fibrosis. Crit Rev Ther Drug Carrier Syst (2007) 0.99
Pol III Promoters to Express Small RNAs: Delineation of Transcription Initiation. Mol Ther Nucleic Acids (2014) 0.99
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Functional mapping of disease susceptibility loci using cell biology. Proc Natl Acad Sci U S A (2006) 0.89
Identification of GAS1 as an epirubicin resistance-related gene in human gastric cancer cells with a partially randomized small interfering RNA library. J Biol Chem (2009) 0.86
Dazap2 modulates transcription driven by the Wnt effector TCF-4. Nucleic Acids Res (2009) 0.85
Forward and robust selection of the most potent and noncellular toxic siRNAs from RNAi libraries. Nucleic Acids Res (2008) 0.84
Downregulation of IGF-IR expression by RNAi inhibits proliferation and enhances chemosensitization of human colon cancer cells. Int J Colorectal Dis (2009) 0.81
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Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization. Nat Cell Biol (2003) 1.96
Enzymatic production of RNAi libraries from cDNAs. Nat Genet (2004) 1.54
Wnt/Wingless signaling through beta-catenin requires the function of both LRP/Arrow and frizzled classes of receptors. BMC Cell Biol (2003) 1.54
Restriction enzyme-generated siRNA (REGS) vectors and libraries. Nat Genet (2004) 1.40
Expressing functional siRNAs in mammalian cells using convergent transcription. BMC Biotechnol (2003) 1.11
Blocking oligonucleotides improve sequencing through inverted repeats. Biotechniques (2003) 0.99
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling. Dev Cell (2003) 7.93
Proximal events in Wnt signal transduction. Nat Rev Mol Cell Biol (2009) 6.66
WNT signalling pathways as therapeutic targets in cancer. Nat Rev Cancer (2013) 6.64
Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements. Curr Biol (2003) 6.60
Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell (2009) 5.34
Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling. Science (2007) 5.08
Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. Nature (2006) 4.96
Distinct Wnt signaling pathways have opposing roles in appendage regeneration. Development (2006) 4.88
Functional genomic analysis of the Wnt-wingless signaling pathway. Science (2005) 4.73
Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration. Cell (2009) 4.69
A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected]. Proc Natl Acad Sci U S A (2004) 3.95
Biphasic role for Wnt/beta-catenin signaling in cardiac specification in zebrafish and embryonic stem cells. Proc Natl Acad Sci U S A (2007) 3.90
The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway. Cell Stem Cell (2007) 3.54
The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling. Mol Cell Biol (2003) 3.53
Wnt and calcium signaling: beta-catenin-independent pathways. Cell Calcium (2005) 3.46
The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition. J Biol Chem (2007) 3.24
The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation. Nat Cell Biol (2006) 3.22
The planar cell-polarity gene stbm regulates cell behaviour and cell fate in vertebrate embryos. Nat Cell Biol (2002) 3.13
A Wnt survival guide: from flies to human disease. J Invest Dermatol (2009) 2.91
Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy. Nat Genet (2002) 2.90
Kaiso/p120-catenin and TCF/beta-catenin complexes coordinately regulate canonical Wnt gene targets. Dev Cell (2005) 2.86
A temporal chromatin signature in human embryonic stem cells identifies regulators of cardiac development. Cell (2012) 2.81
Disruption of acvrl1 increases endothelial cell number in zebrafish cranial vessels. Development (2002) 2.61
Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation. Nat Med (2005) 2.60
A transgenic Lef1/beta-catenin-dependent reporter is expressed in spatially restricted domains throughout zebrafish development. Dev Biol (2002) 2.46
Wnt-beta-catenin signaling initiates taste papilla development. Nat Genet (2006) 2.43
Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway. Nature (2003) 2.42
Activated Wnt/beta-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model. Proc Natl Acad Sci U S A (2009) 2.41
Differential requirement for the dual functions of β-catenin in embryonic stem cell self-renewal and germ layer formation. Nat Cell Biol (2011) 2.32
Advances in signaling in vertebrate regeneration as a prelude to regenerative medicine. Genes Dev (2007) 2.31
Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation. Dev Cell (2002) 2.28
Wnt5a control of cell polarity and directional movement by polarized redistribution of adhesion receptors. Science (2008) 2.22
Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation. Cancer Res (2006) 2.14
The Sp1-related transcription factors sp5 and sp5-like act downstream of Wnt/beta-catenin signaling in mesoderm and neuroectoderm patterning. Curr Biol (2005) 2.09
Dishevelled activates Ca2+ flux, PKC, and CamKII in vertebrate embryos. J Cell Biol (2003) 2.07
Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization. Nat Cell Biol (2003) 1.96
Wnt/β-catenin signaling and AXIN1 regulate apoptosis triggered by inhibition of the mutant kinase BRAFV600E in human melanoma. Sci Signal (2012) 1.95
Wnt/β-catenin signaling promotes differentiation, not self-renewal, of human embryonic stem cells and is repressed by Oct4. Proc Natl Acad Sci U S A (2012) 1.93
APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development. Dev Biol (2008) 1.90
New regulators of Wnt/beta-catenin signaling revealed by integrative molecular screening. Sci Signal (2008) 1.88
Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease. Proc Natl Acad Sci U S A (2007) 1.84
Wnt signaling promotes hematoendothelial cell development from human embryonic stem cells. Blood (2007) 1.79
Assaying beta-catenin/TCF transcription with beta-catenin/TCF transcription-based reporter constructs. Methods Mol Biol (2008) 1.77
Reiterated Wnt signaling during zebrafish neural crest development. Development (2004) 1.75
Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cells in vivo. Proc Natl Acad Sci U S A (2003) 1.72
Microenvironmental protection of CML stem and progenitor cells from tyrosine kinase inhibitors through N-cadherin and Wnt-β-catenin signaling. Blood (2013) 1.70
Signaling of rat Frizzled-2 through phosphodiesterase and cyclic GMP. Science (2002) 1.69
Crystal structures of the extracellular domain of LRP6 and its complex with DKK1. Nat Struct Mol Biol (2011) 1.68
CTLA-4 is a direct target of Wnt/beta-catenin signaling and is expressed in human melanoma tumors. J Invest Dermatol (2008) 1.60
Crystal structure of a full-length beta-catenin. Structure (2008) 1.55
A re-evaluation of the "oncogenic" nature of Wnt/beta-catenin signaling in melanoma and other cancers. Curr Oncol Rep (2010) 1.52
LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1. Proc Natl Acad Sci U S A (2013) 1.51
Small-molecule synergist of the Wnt/beta-catenin signaling pathway. Proc Natl Acad Sci U S A (2007) 1.39
Inactivation of Chibby affects function of motile airway cilia. J Cell Biol (2009) 1.38
Wnt/beta-catenin regulation of the Sp1-related transcription factor sp5l promotes tail development in zebrafish. Development (2005) 1.38
A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models. J Clin Invest (2013) 1.37
Two tcf3 genes cooperate to pattern the zebrafish brain. Development (2003) 1.36
Wnt/Fz signaling and the cytoskeleton: potential roles in tumorigenesis. Cell Res (2009) 1.35
Zebrafish Dapper1 and Dapper2 play distinct roles in Wnt-mediated developmental processes. Development (2004) 1.32
Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak. Nat Genet (2009) 1.31
When Wnts antagonize Wnts. J Cell Biol (2003) 1.29
Wnt/beta-catenin signaling has an essential role in the initiation of limb regeneration. Dev Biol (2007) 1.25
Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling. J Cell Biol (2011) 1.25
Stromelysin-1 and mesothelin are differentially regulated by Wnt-5a and Wnt-1 in C57mg mouse mammary epithelial cells. BMC Dev Biol (2003) 1.22
Noncanonical Wnt signaling orchestrates early developmental events toward hematopoietic cell fate from human embryonic stem cells. Cell Stem Cell (2009) 1.20
The tuberin-hamartin complex negatively regulates beta-catenin signaling activity. J Biol Chem (2003) 1.20
Microfluidic device generating stable concentration gradients for long term cell culture: application to Wnt3a regulation of β-catenin signaling. Lab Chip (2010) 1.20
The CCN family member Wisp3, mutant in progressive pseudorheumatoid dysplasia, modulates BMP and Wnt signaling. J Clin Invest (2007) 1.19
Active beta-catenin signaling is an inhibitory pathway for human immunodeficiency virus replication in peripheral blood mononuclear cells. J Virol (2008) 1.18
Beta-catenin signaling increases in proliferating NG2+ progenitors and astrocytes during post-traumatic gliogenesis in the adult brain. Stem Cells (2010) 1.18
nemo-like kinase is an essential co-activator of Wnt signaling during early zebrafish development. Development (2004) 1.18
Transcription-based reporters of Wnt/beta-catenin signaling. Cold Spring Harb Protoc (2009) 1.16
WNT5A enhances resistance of melanoma cells to targeted BRAF inhibitors. J Clin Invest (2014) 1.16
Porous implants modulate healing and induce shifts in local macrophage polarization in the foreign body reaction. Ann Biomed Eng (2013) 1.14
TC1 (C8orf4) enhances the Wnt/beta-catenin pathway by relieving antagonistic activity of Chibby. Cancer Res (2006) 1.13
Wnt signaling exerts an antiproliferative effect on adult cardiac progenitor cells through IGFBP3. Circ Res (2011) 1.13
Targeting Wnt pathways in disease. Cold Spring Harb Perspect Biol (2012) 1.11
WNTS and WNT receptors as therapeutic tools and targets in human disease processes. Front Biosci (2007) 1.11
Adiponectin haploinsufficiency promotes mammary tumor development in MMTV-PyVT mice by modulation of phosphatase and tensin homolog activities. PLoS One (2009) 1.10
Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling. Sci Signal (2009) 1.10
Requirement of Wnt/beta-catenin signaling in pronephric kidney development. Mech Dev (2008) 1.09
Chibby promotes adipocyte differentiation through inhibition of beta-catenin signaling. Mol Cell Biol (2007) 1.09
AKT kinase activity is required for lithium to modulate mood-related behaviors in mice. Neuropsychopharmacology (2011) 1.08
Wnt5a and Wnt11 are essential for second heart field progenitor development. Development (2012) 1.08
Wnt/β-catenin signaling suppresses DUX4 expression and prevents apoptosis of FSHD muscle cells. Hum Mol Genet (2013) 1.06
Chemical-genetic screen identifies riluzole as an enhancer of Wnt/β-catenin signaling in melanoma. Chem Biol (2010) 1.05
High basal levels of functional toll-like receptor 3 (TLR3) and noncanonical Wnt5a are expressed in papillary thyroid cancer and are coordinately decreased by phenylmethimazole together with cell proliferation and migration. Endocrinology (2007) 1.04
Phenylmethimazole decreases Toll-like receptor 3 and noncanonical Wnt5a expression in pancreatic cancer and melanoma together with tumor cell growth and migration. Clin Cancer Res (2009) 1.03
Wnt signaling: it gets more humorous with age. Curr Biol (2007) 1.01
Crystal structure of a Tankyrase-Axin complex and its implications for Axin turnover and Tankyrase substrate recruitment. Proc Natl Acad Sci U S A (2012) 1.01
TC1(C8orf4) correlates with Wnt/beta-catenin target genes and aggressive biological behavior in gastric cancer. Clin Cancer Res (2006) 1.01
Beta-catenin-independent Wnt pathways: signals, core proteins, and effectors. Methods Mol Biol (2008) 1.01
Canonical Wnt3a modulates intracellular calcium and enhances excitatory neurotransmission in hippocampal neurons. J Biol Chem (2010) 1.00
The interaction of the Wnt and Notch pathways modulates natural killer versus T cell differentiation. Stem Cells (2007) 0.99
Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells. J Clin Invest (2015) 0.97
Wilms tumor gene on X chromosome (WTX) inhibits degradation of NRF2 protein through competitive binding to KEAP1 protein. J Biol Chem (2012) 0.95
Altered splicing of ATP6AP2 causes X-linked parkinsonism with spasticity (XPDS). Hum Mol Genet (2013) 0.95
Wnt1 and wnt10b function redundantly at the zebrafish midbrain-hindbrain boundary. Dev Biol (2003) 0.95
Activation of Wnt/β-catenin signaling increases apoptosis in melanoma cells treated with trail. PLoS One (2013) 0.95
Transmembrane protein 88: a Wnt regulatory protein that specifies cardiomyocyte development. Development (2013) 0.94