Published in Mol Cell Biol on January 01, 2003
Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. PLoS Biol (2006) 7.36
Proximal events in Wnt signal transduction. Nat Rev Mol Cell Biol (2009) 6.66
Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation. J Cell Biol (2003) 4.70
Histone methylation-dependent mechanisms impose ligand dependency for gene activation by nuclear receptors. Cell (2007) 4.45
Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells. Hepatology (2009) 3.92
Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis. Nat Med (2012) 3.46
Wnt5a potentiates TGF-β signaling to promote colonic crypt regeneration after tissue injury. Science (2012) 3.45
A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration. Nat Genet (2008) 3.37
Tetraspanins: push and pull in suppressing and promoting metastasis. Nat Rev Cancer (2008) 3.04
Wnt and PPARgamma signaling in osteoblastogenesis and adipogenesis. Nat Rev Rheumatol (2009) 2.50
Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors. Genes Dev (2010) 2.28
Wnt-5/pipetail functions in vertebrate axis formation as a negative regulator of Wnt/beta-catenin activity. J Cell Biol (2003) 2.27
Wnt5a inhibits canonical Wnt signaling in hematopoietic stem cells and enhances repopulation. Proc Natl Acad Sci U S A (2007) 2.25
The opposing roles of Wnt-5a in cancer. Br J Cancer (2009) 2.07
Wnt5a regulates distinct signalling pathways by binding to Frizzled2. EMBO J (2009) 1.97
Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling. Biochem J (2007) 1.95
Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK. Genes Dev (2004) 1.87
Wnt6, Wnt10a and Wnt10b inhibit adipogenesis and stimulate osteoblastogenesis through a β-catenin-dependent mechanism. Bone (2011) 1.83
Wnt5a signaling induces proliferation and survival of endothelial cells in vitro and expression of MMP-1 and Tie-2. Mol Biol Cell (2006) 1.81
TCF/LEFs and Wnt signaling in the nucleus. Cold Spring Harb Perspect Biol (2012) 1.78
Wnt signaling regulates mitochondrial physiology and insulin sensitivity. Genes Dev (2010) 1.71
Parallels between global transcriptional programs of polarizing Caco-2 intestinal epithelial cells in vitro and gene expression programs in normal colon and colon cancer. Mol Biol Cell (2007) 1.69
Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis. J Immunol (2008) 1.68
CaMKII in the cardiovascular system: sensing redox states. Physiol Rev (2011) 1.67
Early stages of zebrafish eye formation require the coordinated activity of Wnt11, Fz5, and the Wnt/beta-catenin pathway. Neuron (2005) 1.62
Calmodulin-dependent protein kinase II: linking heart failure and arrhythmias. Circ Res (2012) 1.61
Integration of BMP, Wnt, and notch signaling pathways in osteoblast differentiation. J Cell Biochem (2011) 1.59
Uterine Wnt/beta-catenin signaling is required for implantation. Proc Natl Acad Sci U S A (2005) 1.57
Wnt signalling in lung development and diseases. Respir Res (2006) 1.55
NLK functions to maintain proliferation and stemness of NSCLC and is a target of metformin. J Hematol Oncol (2015) 1.46
Canonical Wnt signaling is antagonized by noncanonical Wnt5a in hepatocellular carcinoma cells. Mol Cancer (2009) 1.44
Wnt signaling and colon carcinogenesis: beyond APC. J Carcinog (2011) 1.44
Wnt5a is essential for intestinal elongation in mice. Dev Biol (2008) 1.41
The mechanism of endogenous receptor activation functionally distinguishes prototype canonical and noncanonical Wnts. Mol Cell Biol (2005) 1.39
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Role of the TAK1-NLK-STAT3 pathway in TGF-beta-mediated mesoderm induction. Genes Dev (2004) 1.34
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Loss of TGF-beta or Wnt5a results in an increase in Wnt/beta-catenin activity and redirects mammary tumour phenotype. Breast Cancer Res (2009) 1.29
When Wnts antagonize Wnts. J Cell Biol (2003) 1.29
Wnt4 induces nephronic tubules in metanephric mesenchyme by a non-canonical mechanism. Dev Biol (2011) 1.27
Distinct Wnt members regulate the hierarchical morphogenesis of skin regions (spinal tract) and individual feathers. Mech Dev (2004) 1.26
Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation. Neural Dev (2008) 1.23
STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation. Proc Natl Acad Sci U S A (2005) 1.22
Wnt11 signaling promotes proliferation, transformation, and migration of IEC6 intestinal epithelial cells. J Biol Chem (2004) 1.22
Stromelysin-1 and mesothelin are differentially regulated by Wnt-5a and Wnt-1 in C57mg mouse mammary epithelial cells. BMC Dev Biol (2003) 1.22
Array-based profiling of reference-independent methylation status (aPRIMES) identifies frequent promoter methylation and consecutive downregulation of ZIC2 in pediatric medulloblastoma. Nucleic Acids Res (2007) 1.19
Frizzled7 as an emerging target for cancer therapy. Cell Signal (2011) 1.16
Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo. PLoS Genet (2010) 1.16
Expression of secreted Wnt antagonists in gastrointestinal tissues: potential role in stem cell homeostasis. J Clin Pathol (2005) 1.15
Calcium signaling in vertebrate embryonic patterning and morphogenesis. Dev Biol (2007) 1.14
Phosphorylation of TCF proteins by homeodomain-interacting protein kinase 2. J Biol Chem (2011) 1.11
Transcriptional silencing of Dickkopf gene family by CpG island hypermethylation in human gastrointestinal cancer. World J Gastroenterol (2008) 1.11
Canonical Wnt pathway signaling suppresses VCAM-1 expression by marrow stromal and hematopoietic cells. Exp Hematol (2008) 1.10
Loss of Wnt5a and Ror2 protein in hepatocellular carcinoma associated with poor prognosis. World J Gastroenterol (2012) 1.10
Cell-context dependent TCF/LEF expression and function: alternative tales of repression, de-repression and activation potentials. Crit Rev Eukaryot Gene Expr (2011) 1.09
Wnt5a and Wnt11 are essential for second heart field progenitor development. Development (2012) 1.08
A Wnt kinase network alters nuclear localization of TCF-1 in colon cancer. Oncogene (2009) 1.07
Integrin regulation of beta-catenin signaling in ovarian carcinoma. J Biol Chem (2011) 1.06
Diverse mechanisms for activation of Wnt signalling in the ovarian tumour microenvironment. Biochem J (2011) 1.05
NLK positively regulates Wnt/β-catenin signalling by phosphorylating LEF1 in neural progenitor cells. EMBO J (2012) 1.05
The role of Ryk and Ror receptor tyrosine kinases in Wnt signal transduction. Cold Spring Harb Perspect Biol (2014) 1.03
Regulation of FOXO1 by TAK1-Nemo-like kinase pathway. J Biol Chem (2010) 1.02
ROR1 and ROR2 in Human Malignancies: Potentials for Targeted Therapy. Front Oncol (2012) 1.01
Wnt to build a tube: contributions of Wnt signaling to epithelial tubulogenesis. Dev Dyn (2010) 1.00
Mesodermal fate decisions of a stem cell: the Wnt switch. Cell Mol Life Sci (2008) 0.99
WNT signaling: an emerging mediator of cancer cell metabolism? Mol Cell Biol (2014) 0.99
miR-92b controls glioma proliferation and invasion through regulating Wnt/beta-catenin signaling via Nemo-like kinase. Neuro Oncol (2013) 0.97
Wnt5a as an effector of TGFβ in mammary development and cancer. J Mammary Gland Biol Neoplasia (2011) 0.96
Role and regulation of β-catenin signaling during physiological liver growth. Gene Expr (2014) 0.95
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Homodimerization of Nemo-like kinase is essential for activation and nuclear localization. Mol Biol Cell (2010) 0.94
Estrogenic environmental chemicals and drugs: mechanisms for effects on the developing male urogenital system. J Steroid Biochem Mol Biol (2011) 0.94
Elevating calcium in Th2 cells activates multiple pathways to induce IL-4 transcription and mRNA stabilization. J Immunol (2008) 0.93
TAB2 scaffolds TAK1 and NLK in repressing canonical Wnt signaling. J Biol Chem (2010) 0.93
The Wnt-dependent signaling pathways as target in oncology drug discovery. Invest New Drugs (2006) 0.93
Nemo-like kinase-myocyte enhancer factor 2A signaling regulates anterior formation in Xenopus development. Mol Cell Biol (2007) 0.93
CaMKII represses transcriptionally active β-catenin to mediate acute ethanol neurodegeneration and can phosphorylate β-catenin. J Neurochem (2013) 0.92
Noncanonical Wnt signaling promotes obesity-induced adipose tissue inflammation and metabolic dysfunction independent of adipose tissue expansion. Diabetes (2014) 0.92
Noncanonical Wnt5a enhances Wnt/β-catenin signaling during osteoblastogenesis. Sci Rep (2014) 0.91
A review of crosstalk between MAPK and Wnt signals and its impact on cartilage regeneration. Cell Tissue Res (2014) 0.91
The mitogen-activated protein kinase kinase kinase kinase GCKR positively regulates canonical and noncanonical Wnt signaling in B lymphocytes. Mol Cell Biol (2006) 0.91
Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling. Elife (2015) 0.90
Expression of the novel Wnt receptor ROR2 is increased in breast cancer and may regulate both β-catenin dependent and independent Wnt signalling. J Cancer Res Clin Oncol (2014) 0.90
The complex roles of Wnt antagonists in RCC. Nat Rev Urol (2011) 0.89
Receptor tyrosine kinase-like orphan receptor 2 (ROR2) and Indian hedgehog regulate digit outgrowth mediated by the phalanx-forming region. Proc Natl Acad Sci U S A (2010) 0.89
Wnt pathway antagonists and angiogenesis. Protein Cell (2010) 0.89
Nemo-like kinase, an essential effector of anterior formation, functions downstream of p38 mitogen-activated protein kinase. Mol Cell Biol (2009) 0.88
Hmga2 is required for canonical WNT signaling during lung development. BMC Biol (2014) 0.87
Wnt signaling through T-cell factor phosphorylation. Cell Res (2011) 0.87
The lysosome rupture-activated TAK1-JNK pathway regulates NLRP3 inflammasome activation. J Biol Chem (2014) 0.86
Loss of FTO antagonises Wnt signaling and leads to developmental defects associated with ciliopathies. PLoS One (2014) 0.86
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Generating a Wnt switch: it's all about the right dosage. J Cell Biol (2011) 0.85
Wnt5a controls Notch1 signaling through CaMKII-mediated degradation of the SMRT corepressor protein. J Biol Chem (2012) 0.85
Nuclear LEF1/TCF4 correlate with poor prognosis but not with nuclear β-catenin in cerebral metastasis of lung adenocarcinomas. Clin Exp Metastasis (2012) 0.85
microRNA regulation of Wnt signaling pathways in development and disease. Cell Signal (2015) 0.84
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Distinct Wnt signaling pathways have opposing roles in appendage regeneration. Development (2006) 4.88
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The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway. Genes Cells (2003) 4.11
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WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1. J Biol Chem (2005) 3.26
The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition. J Biol Chem (2007) 3.24
The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation. Nat Cell Biol (2006) 3.22
A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase. J Biol Chem (2003) 3.19
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Kaiso/p120-catenin and TCF/beta-catenin complexes coordinately regulate canonical Wnt gene targets. Dev Cell (2005) 2.86
The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response. Genes Dev (2005) 2.81
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A transgenic Lef1/beta-catenin-dependent reporter is expressed in spatially restricted domains throughout zebrafish development. Dev Biol (2002) 2.46
Inflammatory breast cancer: the disease, the biology, the treatment. CA Cancer J Clin (2010) 2.45
Wnt-beta-catenin signaling initiates taste papilla development. Nat Genet (2006) 2.43
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Prickle 1 regulates cell movements during gastrulation and neuronal migration in zebrafish. Development (2003) 2.26
Manipulation of alternative splicing by a newly developed inhibitor of Clks. J Biol Chem (2004) 2.26
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TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis. J Biol Chem (2006) 2.19
Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation. Cancer Res (2006) 2.14
The Sp1-related transcription factors sp5 and sp5-like act downstream of Wnt/beta-catenin signaling in mesoderm and neuroectoderm patterning. Curr Biol (2005) 2.09
Retracted Cytokines suppress adipogenesis and PPAR-gamma function through the TAK1/TAB1/NIK cascade. Nat Cell Biol (2003) 2.08
Dishevelled activates Ca2+ flux, PKC, and CamKII in vertebrate embryos. J Cell Biol (2003) 2.07
Regulation of the Caenorhabditis elegans oxidative stress defense protein SKN-1 by glycogen synthase kinase-3. Proc Natl Acad Sci U S A (2005) 2.04
Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling. Mol Cell Biol (2003) 2.03
AMP-activated protein kinase activates p38 mitogen-activated protein kinase by increasing recruitment of p38 MAPK to TAB1 in the ischemic heart. Circ Res (2005) 2.02
Integration of Caenorhabditis elegans MAPK pathways mediating immunity and stress resistance by MEK-1 MAPK kinase and VHP-1 MAPK phosphatase. Proc Natl Acad Sci U S A (2004) 1.99
Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization. Nat Cell Biol (2003) 1.96
Wnt/β-catenin signaling and AXIN1 regulate apoptosis triggered by inhibition of the mutant kinase BRAFV600E in human melanoma. Sci Signal (2012) 1.95
Expression profiling in ovarian clear cell carcinoma: identification of hepatocyte nuclear factor-1 beta as a molecular marker and a possible molecular target for therapy of ovarian clear cell carcinoma. Am J Pathol (2003) 1.94
Wnt/β-catenin signaling promotes differentiation, not self-renewal, of human embryonic stem cells and is repressed by Oct4. Proc Natl Acad Sci U S A (2012) 1.93
APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development. Dev Biol (2008) 1.90
New regulators of Wnt/beta-catenin signaling revealed by integrative molecular screening. Sci Signal (2008) 1.88
Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK. Genes Dev (2004) 1.87
The C. elegans thermosensory neuron AFD responds to warming. Curr Biol (2004) 1.87
Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease. Proc Natl Acad Sci U S A (2007) 1.84
Wnt signaling promotes hematoendothelial cell development from human embryonic stem cells. Blood (2007) 1.79
XGAP, an ArfGAP, is required for polarized localization of PAR proteins and cell polarity in Xenopus gastrulation. Dev Cell (2006) 1.79
Identification of guanylyl cyclases that function in thermosensory neurons of Caenorhabditis elegans. Genetics (2006) 1.79
PKC delta is essential for Dishevelled function in a noncanonical Wnt pathway that regulates Xenopus convergent extension movements. Genes Dev (2003) 1.79
Assaying beta-catenin/TCF transcription with beta-catenin/TCF transcription-based reporter constructs. Methods Mol Biol (2008) 1.77
LRK-1, a C. elegans PARK8-related kinase, regulates axonal-dendritic polarity of SV proteins. Curr Biol (2007) 1.76
The Caenorhabditis elegans MAPK phosphatase VHP-1 mediates a novel JNK-like signaling pathway in stress response. EMBO J (2004) 1.76
The prickle-related gene in vertebrates is essential for gastrulation cell movements. Curr Biol (2003) 1.76
Reiterated Wnt signaling during zebrafish neural crest development. Development (2004) 1.75
Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cells in vivo. Proc Natl Acad Sci U S A (2003) 1.72
TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells. Int Immunol (2006) 1.70
Microenvironmental protection of CML stem and progenitor cells from tyrosine kinase inhibitors through N-cadherin and Wnt-β-catenin signaling. Blood (2013) 1.70
MiR-107 and MiR-185 can induce cell cycle arrest in human non small cell lung cancer cell lines. PLoS One (2009) 1.70
Signaling of rat Frizzled-2 through phosphodiesterase and cyclic GMP. Science (2002) 1.69