Published in N Engl J Med on December 28, 2006
Protocolized Care for Early Septic Shock (ProCESS) | NCT00510835
Critical Illness Outcomes Study (CIOS) | NCT01109719
Web-based Implementation for the Science of Enhancing Resilience Study (WISER) | NCT02603133
Developing and Maintaining a Central Venous Catheter Registry | NCT01165411
ED Residents MBP During CVC Placement: Sim Lab Based Training (EM CVC MBP) | NCT00791583
Simulation-based Training for Surgery Residents in Aseptic Techniques (CVC) | NCT00787345
Multistate point-prevalence survey of health care-associated infections. N Engl J Med (2014) 8.78
Hospital-acquired infections due to gram-negative bacteria. N Engl J Med (2010) 6.61
Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. JAMA (2014) 5.33
Systematic review of the application of the plan-do-study-act method to improve quality in healthcare. BMJ Qual Saf (2013) 5.30
Guidelines for preventing infectious complications among hematopoietic cell transplantation recipients: a global perspective. Biol Blood Marrow Transplant (2009) 5.10
The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Intensive Care Med (2010) 4.64
The SQUIRE (Standards for QUality Improvement Reporting Excellence) guidelines for quality improvement reporting: explanation and elaboration. Qual Saf Health Care (2008) 4.59
Explaining Michigan: developing an ex post theory of a quality improvement program. Milbank Q (2011) 4.58
The effect of multidisciplinary care teams on intensive care unit mortality. Arch Intern Med (2010) 4.41
Guidelines for the prevention of intravascular catheter-related infections. Clin Infect Dis (2011) 4.09
Chlorhexidine-impregnated dressing for prevention of catheter-related bloodstream infection: a meta-analysis*. Crit Care Med (2014) 3.79
Sustaining reductions in catheter related bloodstream infections in Michigan intensive care units: observational study. BMJ (2010) 2.63
Hemodynamic monitoring and management in patients undergoing high risk surgery: a survey among North American and European anesthesiologists. Crit Care (2011) 2.59
The influence of context on quality improvement success in health care: a systematic review of the literature. Milbank Q (2010) 2.59
Bundled care for septic shock: an analysis of clinical trials. Crit Care Med (2010) 2.57
Summary of recommendations: Guidelines for the Prevention of Intravascular Catheter-related Infections. Clin Infect Dis (2011) 2.49
Models for structuring a clinical initiative to enhance palliative care in the intensive care unit: a report from the IPAL-ICU Project (Improving Palliative Care in the ICU). Crit Care Med (2010) 2.49
Catheter-associated urinary tract infection and the Medicare rule changes. Ann Intern Med (2009) 2.47
'Matching Michigan': a 2-year stepped interventional programme to minimise central venous catheter-blood stream infections in intensive care units in England. BMJ Qual Saf (2012) 2.44
Ethical issues posed by cluster randomized trials in health research. Trials (2011) 2.43
Chronic critical illness. Am J Respir Crit Care Med (2010) 2.42
Louder than words: power and conflict in interprofessional education articles, 1954-2013. Med Educ (2015) 2.42
Implementing an Antibiotic Stewardship Program: Guidelines by the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America. Clin Infect Dis (2016) 2.32
Reducing iatrogenic risks: ICU-acquired delirium and weakness--crossing the quality chasm. Chest (2010) 2.28
Variation in use of intensive care for adults with diabetic ketoacidosis*. Crit Care Med (2012) 2.24
Hospital epidemiology and infection control in acute-care settings. Clin Microbiol Rev (2011) 2.22
Understanding the conditions for improvement: research to discover which context influences affect improvement success. BMJ Qual Saf (2011) 2.18
Improved outcomes in a quality improvement collaborative for pediatric inflammatory bowel disease. Pediatrics (2012) 2.16
Adopting a surgical safety checklist could save money and improve the quality of care in U.S. hospitals. Health Aff (Millwood) (2010) 2.01
The effect of a quality improvement intervention on perceived sleep quality and cognition in a medical ICU. Crit Care Med (2013) 2.00
Central line bundle implementation in US intensive care units and impact on bloodstream infections. PLoS One (2011) 1.99
Daily chlorhexidine bathing to reduce bacteraemia in critically ill children: a multicentre, cluster-randomised, crossover trial. Lancet (2013) 1.94
Changes in incidence and antifungal drug resistance in candidemia: results from population-based laboratory surveillance in Atlanta and Baltimore, 2008-2011. Clin Infect Dis (2012) 1.91
Promoting a culture of safety as a patient safety strategy: a systematic review. Ann Intern Med (2013) 1.90
Management practices and major infections after cardiac surgery. J Am Coll Cardiol (2014) 1.85
Lessons from the Johns Hopkins Multi-Disciplinary Venous Thromboembolism (VTE) Prevention Collaborative. BMJ (2012) 1.78
Prompting physicians to address a daily checklist and process of care and clinical outcomes: a single-site study. Am J Respir Crit Care Med (2011) 1.77
Preventing catheter-associated urinary tract infection in the United States: a national comparative study. JAMA Intern Med (2013) 1.77
Women of child-bearing age have better inhospital cardiac arrest survival outcomes than do equal-aged men. Crit Care Med (2010) 1.73
Implementation science: how to jump‐start infection prevention. Infect Control Hosp Epidemiol (2010) 1.72
Hospital checklists are meant to save lives - so why do they often fail? Nature (2015) 1.71
What counts? An ethnographic study of infection data reported to a patient safety program. Milbank Q (2012) 1.68
Increases in mortality, length of stay, and cost associated with hospital-acquired infections in trauma patients. Arch Surg (2011) 1.68
Explaining Matching Michigan: an ethnographic study of a patient safety program. Implement Sci (2013) 1.64
Six components necessary for effective public health program implementation. Am J Public Health (2013) 1.62
Association of Anaesthetists of Great Britain and Ireland: Safe vascular access 2016. Anaesthesia (2016) 1.62
Evaluation Following Staggered Implementation of the "Rethinking Critical Care" ICU Care Bundle in a Multicenter Community Setting. Crit Care Med (2016) 1.61
Optimizing practice through research: a new perspective to solve an old problem. Ann Fam Med (2008) 1.60
Nurse staffing, burnout, and health care-associated infection. Am J Infect Control (2012) 1.56
No child left behind: Enrolling children and adults simultaneously in critical care randomized trials. Crit Care Med (2009) 1.56
A checklist-based intervention to improve surgical outcomes in Michigan: evaluation of the Keystone Surgery program. JAMA Surg (2015) 1.56
Enhancing patient safety by reducing healthcare-associated infections: the role of discovery and dissemination. Infect Control Hosp Epidemiol (2010) 1.55
Improving quality of care for maternal and newborn health: prospective pilot study of the WHO safe childbirth checklist program. PLoS One (2012) 1.55
CMS changes in reimbursement for HAIs: setting a research agenda. Med Care (2010) 1.54
Meeting standards of high-quality intensive care unit palliative care: clinical performance and predictors. Crit Care Med (2012) 1.52
Structure, process, and annual ICU mortality across 69 centers: United States Critical Illness and Injury Trials Group Critical Illness Outcomes Study. Crit Care Med (2014) 1.48
Diverse attitudes to and understandings of spontaneous awakening trials: results from a statewide quality improvement collaborative*. Crit Care Med (2013) 1.48
Hospital safety culture in Taiwan: a nationwide survey using Chinese version Safety Attitude Questionnaire. BMC Health Serv Res (2010) 1.43
Towards safer, better healthcare: harnessing the natural properties of complex sociotechnical systems. Qual Saf Health Care (2009) 1.41
Introducing the Comprehensive Unit-based Safety Program for mechanically ventilated patients in Saudi Arabian Intensive Care Units. Ann Thorac Med (2017) 1.39
Do clinicians know which of their patients have central venous catheters?: a multicenter observational study. Ann Intern Med (2014) 1.39
Web-based training improves knowledge about central line bloodstream infections. Infect Control Hosp Epidemiol (2011) 1.39
A clinical guidance tool to improve the care of children hospitalized with severe pneumonia in Lusaka, Zambia. BMC Pediatr (2016) 1.39
A cluster randomized trial of a multifaceted quality improvement intervention in Brazilian intensive care units: study protocol. Implement Sci (2015) 1.38
Uncharted paths: hospital networks in critical care. Chest (2009) 1.37
How variability in the institutional review board review process affects minimal-risk multisite health services research. Ann Intern Med (2012) 1.37
Declining incidence of candidemia and the shifting epidemiology of Candida resistance in two US metropolitan areas, 2008-2013: results from population-based surveillance. PLoS One (2015) 1.30
Late-onset sepsis in very low birth weight infants from singleton and multiple-gestation births. J Pediatr (2013) 1.29
Clinical review: checklists - translating evidence into practice. Crit Care (2009) 1.29
Developing a science of improvement. J R Soc Med (2013) 1.28
Translating health care-associated urinary tract infection prevention research into practice via the bladder bundle. Jt Comm J Qual Patient Saf (2009) 1.27
Translational educational research: a necessity for effective health-care improvement. Chest (2012) 1.24
High-reliability health care: getting there from here. Milbank Q (2013) 1.23
The relationship between case volume, care quality, and outcomes of complex cancer surgery. J Am Coll Surg (2010) 1.23
Preventing hospital-acquired infections: a national survey of practices reported by U.S. hospitals in 2005 and 2009. J Gen Intern Med (2011) 1.23
Prolonged acute mechanical ventilation and hospital bed utilization in 2020 in the United States: implications for budgets, plant and personnel planning. BMC Health Serv Res (2008) 1.23
A national infection control evaluation of drug-resistant tuberculosis hospitals in South Africa. Int J Tuberc Lung Dis (2012) 1.21
Totally implantable vascular access devices 30 years after the first procedure. What has changed and what is still unsolved? Support Care Cancer (2014) 1.20
The forgotten role of alcohol: a systematic review and meta-analysis of the clinical efficacy and perceived role of chlorhexidine in skin antisepsis. PLoS One (2012) 1.20
Prevention of central venous catheter-related infection in the intensive care unit. Crit Care (2010) 1.19
Impact of the ventilator bundle on ventilator-associated pneumonia in intensive care unit. Int J Qual Health Care (2011) 1.18
Defensive medicine and tort reform: a wide view. J Gen Intern Med (2010) 1.17
Evaluating the impact of simulation on translational patient outcomes. Simul Healthc (2011) 1.17
California hospitals response to state and federal policies related to health care-associated infections. Policy Polit Nurs Pract (2011) 1.17
Biofilm-related infections: bridging the gap between clinical management and fundamental aspects of recalcitrance toward antibiotics. Microbiol Mol Biol Rev (2014) 1.16
Integrating Palliative Care in the ICU: The Nurse in a Leading Role. J Hosp Palliat Nurs (2011) 1.15
Is patient safety improving? National trends in patient safety indicators: 1998-2007. Health Serv Res (2011) 1.15
State-mandated reporting of health care-associated infections in the United States: trends over time. Am J Med Qual (2014) 1.14
Effect of nosocomial bloodstream infections on mortality, length of stay, and hospital costs in older adults. J Am Geriatr Soc (2014) 1.12
The impact of central line insertion bundle on central line-associated bloodstream infection. BMC Infect Dis (2014) 1.12
Implementation of checklists in health care; learning from high-reliability organisations. Scand J Trauma Resusc Emerg Med (2011) 1.11
Advancing the research agenda for diagnostic error reduction. BMJ Qual Saf (2013) 1.10
Toward an integrated research agenda for critical illness in aging. Am J Respir Crit Care Med (2010) 1.10
Trends in acute kidney injury, associated use of dialysis, and mortality after cardiac surgery, 1999 to 2008. Ann Thorac Surg (2012) 1.10
Nurse staffing and NICU infection rates. JAMA Pediatr (2013) 1.09
Reduction of surgical site infections after implementation of a bundle of care. PLoS One (2012) 1.09
Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome. N Engl J Med (2006) 9.52
Parametric survival analysis and taxonomy of hazard functions for the generalized gamma distribution. Stat Med (2007) 3.96
Outcomes after stereotactic lung radiotherapy or wedge resection for stage I non-small-cell lung cancer. J Clin Oncol (2010) 3.59
Illustrating bias due to conditioning on a collider. Int J Epidemiol (2009) 3.54
Rapid response systems: a systematic review. Crit Care Med (2007) 3.51
Multiple-imputation for measurement-error correction. Int J Epidemiol (2006) 3.13
Improving communication in the ICU using daily goals. J Crit Care (2003) 2.96
Medication reconciliation: a practical tool to reduce the risk of medication errors. J Crit Care (2003) 2.94
A meta-analysis of the neuropsychological sequelae of HIV infection. J Int Neuropsychol Soc (2002) 2.64
Sustaining reductions in catheter related bloodstream infections in Michigan intensive care units: observational study. BMJ (2010) 2.63
Estimating efficacy of trivalent, cold-adapted, influenza virus vaccine (CAIV-T) against influenza A (H1N1) and B using surveillance cultures. Am J Epidemiol (2003) 2.50
Bivariate meta-analysis of sensitivity and specificity with sparse data: a generalized linear mixed model approach. J Clin Epidemiol (2006) 2.45
Basic concepts and methods for joint models of longitudinal and survival data. J Clin Oncol (2010) 2.41
Improving patient safety in intensive care units in Michigan. J Crit Care (2008) 2.31
Exercise training improves overall physical fitness and quality of life in older women with coronary artery disease. Chest (2004) 2.21
Neighborhood poverty and injection cessation in a sample of injection drug users. Am J Epidemiol (2010) 2.07
Missing data in clinical studies: issues and methods. J Clin Oncol (2012) 2.05
A statistical framework for Illumina DNA methylation arrays. Bioinformatics (2010) 1.92
Network meta-analysis of margin threshold for women with ductal carcinoma in situ. J Natl Cancer Inst (2012) 1.87
A call to action for antimicrobial stewardship in the emergency department: approaches and strategies. Ann Emerg Med (2012) 1.80
Effects of antibiotics on nosocomial epidemiology of vancomycin-resistant enterococci. Antimicrob Agents Chemother (2002) 1.71
Collaborative cohort study of an intervention to reduce ventilator-associated pneumonia in the intensive care unit. Infect Control Hosp Epidemiol (2011) 1.69
Linear regression with an independent variable subject to a detection limit. Epidemiology (2010) 1.61
Bayesian posterior distributions without Markov chains. Am J Epidemiol (2012) 1.54
Effect of acyclovir on herpetic ocular recurrence using a structural nested model. Contemp Clin Trials (2005) 1.52
Multicenter implementation of a consensus-developed, evidence-based, spontaneous breathing trial protocol. Crit Care Med (2008) 1.51
Systematic review and meta-analysis of the effect of various laser wavelengths in the treatment of peri-implantitis. J Periodontol (2014) 1.50
Confidence intervals for biomarker-based human immunodeficiency virus incidence estimates and differences using prevalent data. Am J Epidemiol (2006) 1.49
Relative adrenal insufficiency in patients with septic shock; a close look to practice patterns. J Crit Care (2006) 1.41
Estimating the odds ratio when exposure has a limit of detection. Int J Epidemiol (2009) 1.39
Variation in safety culture dimensions within and between US and Swiss Hospital Units: an exploratory study. BMJ Qual Saf (2012) 1.35
Revealing and resolving patient safety defects: the impact of leadership WalkRounds on frontline caregiver assessments of patient safety. Health Serv Res (2008) 1.31
How will we know patients are safer? An organization-wide approach to measuring and improving safety. Crit Care Med (2006) 1.28
On estimation of vaccine efficacy using validation samples with selection bias. Biostatistics (2006) 1.25
Hierarchical regression for analyses of multiple outcomes. Am J Epidemiol (2015) 1.22
An official American Thoracic Society/American Association of Critical-Care Nurses/American College of Chest Physicians/Society of Critical Care Medicine policy statement: the Choosing Wisely® Top 5 list in Critical Care Medicine. Am J Respir Crit Care Med (2014) 1.15
Analysis of occupational asbestos exposure and lung cancer mortality using the g formula. Am J Epidemiol (2013) 1.15
Exploring the scope of post-intensive care syndrome therapy and care: engagement of non-critical care providers and survivors in a second stakeholders meeting. Crit Care Med (2014) 1.14
Longitudinal increases in waist circumference are associated with HIV-serostatus, independent of antiretroviral therapy. AIDS (2007) 1.09
DNA-methylation profiling distinguishes malignant melanomas from benign nevi. Pigment Cell Melanoma Res (2011) 1.08
Longitudinal anthropometric changes in HIV-infected and HIV-uninfected men. J Acquir Immune Defic Syndr (2006) 1.07
Review of retention strategies in longitudinal studies and application to follow-up of ICU survivors. Intensive Care Med (2007) 1.06
Dogmatists cannot learn. Epidemiology (2016) 1.06
Oxytocin enhances resting-state connectivity between amygdala and medial frontal cortex. Int J Neuropsychopharmacol (2012) 1.05
Assessing the Safety Attitudes Questionnaire (SAQ), German language version in Swiss university hospitals--a validation study. BMC Health Serv Res (2013) 1.05
Sample size and power determination in joint modeling of longitudinal and survival data. Stat Med (2011) 1.04
Maximum likelihood, profile likelihood, and penalized likelihood: a primer. Am J Epidemiol (2013) 1.04
Content validity and internal consistency of the Dutch translation of the Safety Attitudes Questionnaire: an observational study. Int J Nurs Stud (2011) 1.02
Use of an indwelling pleural catheter compared with thorascopic talc pleurodesis in the management of malignant pleural effusions. Am Surg (2003) 1.02
Improving post-intensive care unit neuropsychiatric outcomes: understanding cognitive effects of physical activity. Am J Respir Crit Care Med (2012) 1.01
Network meta-analysis of randomized clinical trials: reporting the proper summaries. Clin Trials (2013) 1.00
Efficacy of NNRTI-based antiretroviral therapy initiated during acute HIV infection. AIDS (2011) 0.99
Variation in public reporting of central line-associated bloodstream infections by state. Am J Med Qual (2011) 0.98
DNA methylation profiling in the Carolina Breast Cancer Study defines cancer subclasses differing in clinicopathologic characteristics and survival. Breast Cancer Res (2014) 0.98
A unification of models for meta-analysis of diagnostic accuracy studies. Biostatistics (2008) 0.98
A prognostic signature of defective p53-dependent G1 checkpoint function in melanoma cell lines. Pigment Cell Melanoma Res (2012) 0.97
Team care: beyond open and closed intensive care units. Curr Opin Crit Care (2006) 0.97
Lagging exposure information in cumulative exposure-response analyses. Am J Epidemiol (2011) 0.96
NF-kB and Bcl-3 activation are prognostic in metastatic colorectal cancer. Oncology (2010) 0.95
Maximum likelihood estimation in generalized linear models with multiple covariates subject to detection limits. Stat Med (2011) 0.95
Pulmonary outcomes of off-pump vs on-pump coronary artery bypass surgery in a randomized trial. Chest (2005) 0.93
Manual muscle testing: a method of measuring extremity muscle strength applied to critically ill patients. J Vis Exp (2011) 0.93
Transcatheter aortic valve implantation: a Canadian Cardiovascular Society position statement. Can J Cardiol (2012) 0.93
Association of rear seat safety belt use with death in a traffic crash: a matched cohort study. Inj Prev (2007) 0.91
Improving safety culture results in Rhode Island ICUs: lessons learned from the development of action-oriented plans. Jt Comm J Qual Patient Saf (2011) 0.91
Effects of graduated driver licensing on licensure and traffic injury rates in Upstate New York. Accid Anal Prev (2009) 0.91
Cardiovascular adaptations to exercise training in postmenopausal women with type 2 diabetes mellitus. Cardiovasc Diabetol (2004) 0.91
Effect of exercise training on peak aerobic power, left ventricular morphology, and muscle strength in healthy older women. J Gerontol A Biol Sci Med Sci (2005) 0.90
Ventilator-associated pneumonia: overdiagnosis and treatment are common in medical and surgical intensive care units. Infect Control Hosp Epidemiol (2014) 0.90
Measuring clinical information technology in the ICU setting: application in a quality improvement collaborative. J Am Med Inform Assoc (2007) 0.89
Graduated driver licensing and motor vehicle crashes involving teenage drivers: an exploratory age-stratified meta-analysis. Inj Prev (2012) 0.89
Distributed effects of methylphenidate on the network structure of the resting brain: a connectomic pattern classification analysis. Neuroimage (2013) 0.88
Radiographic and metabolic response rates following image-guided stereotactic radiotherapy for lung tumors. Radiother Oncol (2011) 0.88
Relative excess risk due to interaction: resampling-based confidence intervals. Epidemiology (2010) 0.88
Monitoring and reducing central line-associated bloodstream infections: a national survey of state hospital associations. Am J Med Qual (2010) 0.88
A randomized double-blind trial of iseganan in prevention of ventilator-associated pneumonia. Am J Respir Crit Care Med (2005) 0.87
Catheter-related vs. catheter-associated blood stream infections in the intensive care unit: incidence, microbiology, and implications. Surg Infect (Larchmt) (2010) 0.87
Improving data quality control in quality improvement projects. Int J Qual Health Care (2009) 0.87
A prognostic signature of G(2) checkpoint function in melanoma cell lines. Cell Cycle (2013) 0.86
Bimodal virological response to antiretroviral therapy for HIV infection: an application using a mixture model with left censoring. J Epidemiol Community Health (2006) 0.86
Nitrogen dioxide and allergic sensitization in the 2005-2006 National Health and Nutrition Examination Survey. Respir Med (2013) 0.86
What is the role of antimicrobial stewardship in improving outcomes of patients with CAP? Infect Dis Clin North Am (2013) 0.85
Abasic sites preferentially form at regions undergoing DNA replication. FASEB J (2010) 0.84
Accounting for outcome misclassification in estimates of the effect of occupational asbestos exposure on lung cancer death. Am J Epidemiol (2013) 0.84
Survival attributable to an exposure. Stat Med (2009) 0.84
Advances in critical care hepatology. Am J Respir Crit Care Med (2003) 0.83
Sample size calculation using exact methods in diagnostic test studies. J Clin Epidemiol (2007) 0.83
A morning briefing: setting the stage for a clinically and operationally good day. Jt Comm J Qual Patient Saf (2005) 0.83
Reclassification of risk of death with the knowledge of D-dimer in a cohort of treated HIV-infected individuals. AIDS (2012) 0.82
Sample size determination in shared frailty models for multivariate time-to-event data. J Biopharm Stat (2014) 0.82