Published in N Engl J Med on April 20, 2006
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med (2007) 8.33
The acute respiratory distress syndrome. J Clin Invest (2012) 5.61
Nonventilatory treatments for acute lung injury and ARDS. Chest (2007) 3.02
Effects of interventions on survival in acute respiratory distress syndrome: an umbrella review of 159 published randomized trials and 29 meta-analyses. Intensive Care Med (2014) 2.51
Prehospital statin and aspirin use and the prevalence of severe sepsis and acute lung injury/acute respiratory distress syndrome. Crit Care Med (2011) 2.40
Corticosteroids and transition to delirium in patients with acute lung injury. Crit Care Med (2014) 2.33
Essential role of MMP-12 in Fas-induced lung fibrosis. Am J Respir Cell Mol Biol (2007) 2.16
Therapeutic strategies for severe acute lung injury. Crit Care Med (2010) 2.12
Acute lung injury: epidemiology, pathogenesis, and treatment. J Aerosol Med Pulm Drug Deliv (2010) 1.78
Intensive care unit-acquired neuromyopathy and corticosteroids in survivors of persistent ARDS. Intensive Care Med (2008) 1.76
Protection against sepsis-induced lung injury by selective inhibition of protein kinase C-δ (δ-PKC). J Leukoc Biol (2010) 1.62
Acute respiratory distress syndrome after trauma: development and validation of a predictive model. Crit Care Med (2012) 1.62
Microarray-based analysis of ventilator-induced lung injury. Proc Am Thorac Soc (2007) 1.58
Utilization patterns and patient outcomes associated with use of rescue therapies in acute lung injury. Crit Care Med (2011) 1.46
Exploring the heterogeneity of effects of corticosteroids on acute respiratory distress syndrome: a systematic review and meta-analysis. Crit Care (2014) 1.43
Steroids in fibroproliferative acute respiratory distress syndrome: approach with care. Can J Anaesth (2007) 1.39
Steroid treatment in ARDS: a critical appraisal of the ARDS network trial and the recent literature. Intensive Care Med (2007) 1.36
Leptin promotes fibroproliferative acute respiratory distress syndrome by inhibiting peroxisome proliferator-activated receptor-γ. Am J Respir Crit Care Med (2011) 1.34
Perioperative organ injury. Anesthesiology (2013) 1.27
Lower tidal volume at initiation of mechanical ventilation may reduce progression to acute respiratory distress syndrome: a systematic review. Crit Care (2013) 1.25
Do corticosteroids reduce the risk of fat embolism syndrome in patients with long-bone fractures? A meta-analysis. Can J Surg (2009) 1.24
Invasive aspergillosis after pandemic (H1N1) 2009. Emerg Infect Dis (2010) 1.23
Macrolide antibiotics and survival in patients with acute lung injury. Chest (2011) 1.23
Effects of a clinical trial on mechanical ventilation practices in patients with acute lung injury. Am J Respir Crit Care Med (2008) 1.21
The Sick and the Weak: Neuropathies/Myopathies in the Critically Ill. Physiol Rev (2015) 1.20
Open lung biopsy in early-stage acute respiratory distress syndrome. Crit Care (2006) 1.20
Acute respiratory distress syndrome. BMJ (2007) 1.18
Assessment of lung inflammation with 18F-FDG PET during acute lung injury. AJR Am J Roentgenol (2010) 1.17
Risk factors for physical impairment after acute lung injury in a national, multicenter study. Am J Respir Crit Care Med (2014) 1.14
Pharmacotherapy of acute lung injury and acute respiratory distress syndrome. Curr Med Chem (2008) 1.13
Biomarkers in acute lung injury. Transl Res (2012) 1.11
The physical basis of ventilator-induced lung injury. Expert Rev Respir Med (2010) 1.11
Role of the pulmonary epithelium and inflammatory signals in acute lung injury. Expert Rev Clin Immunol (2009) 1.10
Delta inflation: a bias in the design of randomized controlled trials in critical care medicine. Crit Care (2010) 1.09
Acute respiratory distress syndrome: epidemiology and management approaches. Clin Epidemiol (2012) 1.07
Clinical review: Early treatment of acute lung injury--paradigm shift toward prevention and treatment prior to respiratory failure. Crit Care (2012) 1.07
Update in acute respiratory distress syndrome. J Intensive Care (2014) 1.06
Steroids in late ARDS? Crit Care (2007) 1.03
Evidence-based medicine: classifying the evidence from clinical trials--the need to consider other dimensions. Crit Care (2006) 1.02
Acute respiratory distress syndrome: A clinical review. Pulm Circ (2011) 1.02
An alternative method of acute lung injury classification for use in observational studies. Chest (2010) 1.02
Always cleave up your mess: targeting collagen degradation to treat tissue fibrosis. Am J Physiol Lung Cell Mol Physiol (2013) 1.02
PAI-1 promotes the accumulation of exudate macrophages and worsens pulmonary fibrosis following type II alveolar epithelial cell injury. J Pathol (2012) 1.02
Clinical review: intensive care unit acquired weakness. Crit Care (2015) 1.01
Acute respiratory distress syndrome: pathophysiology and therapeutic options. J Clin Med Res (2012) 1.01
Critical illness polyneuropathy and myopathy in the intensive care unit. Nat Rev Neurol (2009) 1.01
Toward Smarter Lumping and Smarter Splitting: Rethinking Strategies for Sepsis and Acute Respiratory Distress Syndrome Clinical Trial Design. Am J Respir Crit Care Med (2016) 1.01
Landmark survival as an end-point for trials in critically ill patients--comparison of alternative durations of follow-up: an exploratory analysis. Crit Care (2009) 1.00
Pharmacological treatments in ARDS; a state-of-the-art update. BMC Med (2013) 0.99
Improving therapeutic strategies for secondary bacterial pneumonia following influenza. Future Microbiol (2008) 0.99
Corticosteroids influence the mortality and morbidity of acute critical illness. Crit Care (2006) 0.99
Fasudil, a Rho-kinase inhibitor, attenuates bleomycin-induced pulmonary fibrosis in mice. Int J Mol Sci (2012) 0.98
Clinical review: Acute respiratory distress syndrome - clinical ventilator management and adjunct therapy. Crit Care (2013) 0.96
The fibroproliferative response in acute respiratory distress syndrome: mechanisms and clinical significance. Eur Respir J (2013) 0.95
Clinical review: primary influenza viral pneumonia. Crit Care (2009) 0.95
Risk factors for underuse of lung-protective ventilation in acute lung injury. J Crit Care (2011) 0.94
Pulmonary complications in patients with severe brain injury. Crit Care Res Pract (2012) 0.93
Steroids for acute respiratory distress syndrome? Clin Chest Med (2014) 0.93
Design and implementation of the START (STem cells for ARDS Treatment) trial, a phase 1/2 trial of human mesenchymal stem/stromal cells for the treatment of moderate-severe acute respiratory distress syndrome. Ann Intensive Care (2014) 0.93
Lung Inflammation in ARDS--friend or foe? N Engl J Med (2006) 0.93
Emerging role of anticoagulants and fibrinolytics in the treatment of acute respiratory distress syndrome. Pharmacotherapy (2007) 0.92
High-dose intravenous methylprednisolone for hantavirus cardiopulmonary syndrome in Chile: a double-blind, randomized controlled clinical trial. Clin Infect Dis (2013) 0.92
Immunodetection of occult eosinophils in lung tissue biopsies may help predict survival in acute lung injury. Respir Res (2011) 0.92
The acute respiratory distress syndrome. Proc (Bayl Univ Med Cent) (2015) 0.90
Decreased respiratory system compliance on the sixth day of mechanical ventilation is a predictor of death in patients with established acute lung injury. Respir Res (2011) 0.90
Fibroproliferative changes on high-resolution CT in the acute respiratory distress syndrome predict mortality and ventilator dependency: a prospective observational cohort study. BMJ Open (2012) 0.90
An assessment of H1N1 influenza-associated acute respiratory distress syndrome severity after adjustment for treatment characteristics. PLoS One (2011) 0.90
Therapeutic targeting of acute lung injury and acute respiratory distress syndrome. Transl Res (2015) 0.90
Wogonin prevents lipopolysaccharide-induced acute lung injury and inflammation in mice via peroxisome proliferator-activated receptor gamma-mediated attenuation of the nuclear factor-kappaB pathway. Immunology (2014) 0.89
Growth differentiation factor-15 and prognosis in acute respiratory distress syndrome: a retrospective cohort study. Crit Care (2013) 0.89
Anti-inflammatory effects of novel curcumin analogs in experimental acute lung injury. Respir Res (2015) 0.89
Aspirin as a potential treatment in sepsis or acute respiratory distress syndrome. Crit Care (2015) 0.88
The plasma mitochondrial DNA is an independent predictor for post-traumatic systemic inflammatory response syndrome. PLoS One (2013) 0.88
Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1. Nat Commun (2015) 0.87
ARDS Network (NHLBI) studies: successes and challenges in ARDS clinical research. Crit Care Clin (2011) 0.86
Modulation of LPS-stimulated pulmonary inflammation by Borneol in murine acute lung injury model. Inflammation (2014) 0.86
Mechanical ventilation-associated lung fibrosis in acute respiratory distress syndrome: a significant contributor to poor outcome. Anesthesiology (2014) 0.85
Pulmonary administration of a water-soluble curcumin complex reduces severity of acute lung injury. Am J Respir Cell Mol Biol (2012) 0.85
Inhibition of chlorine-induced pulmonary inflammation and edema by mometasone and budesonide. Toxicol Appl Pharmacol (2013) 0.85
Inhaled NO contributes to lung repair in piglets with acute respiratory distress syndrome via increasing circulating endothelial progenitor cells. PLoS One (2012) 0.84
Oroxylin-A rescues LPS-induced acute lung injury via regulation of NF-κB signaling pathway in rodents. PLoS One (2012) 0.84
The effectiveness of Corticosteroids on mortality in patients with acute respiratory distress syndrome or acute lung injury: a secondary analysis. Sci Rep (2015) 0.83
Inhalation of activated protein C: A possible new adjunctive intervention in acute respiratory distress syndrome. Biologics (2007) 0.83
Pulmonary endothelial protein kinase C-delta (PKCδ) regulates neutrophil migration in acute lung inflammation. Am J Pathol (2013) 0.83
The influence of prehospital systemic corticosteroid use on development of acute respiratory distress syndrome and hospital outcomes. Crit Care Med (2013) 0.83
Sepsis and Acute Respiratory Distress Syndrome: Recent Update. Tuberc Respir Dis (Seoul) (2016) 0.83
The pharmacology of acute lung injury in sepsis. Adv Pharmacol Sci (2011) 0.82
Goal-oriented respiratory management for critically ill patients with acute respiratory distress syndrome. Crit Care Res Pract (2012) 0.82
Protein kinase C and acute respiratory distress syndrome. Shock (2013) 0.82
Key mechanisms governing resolution of lung inflammation. Semin Immunopathol (2016) 0.81
Protein-based therapies for acute lung injury: targeting neutrophil extracellular traps. Expert Opin Ther Targets (2014) 0.81
Hemagglutinin from the H5N1 virus activates Janus kinase 3 to dysregulate innate immunity. PLoS One (2012) 0.81
Detection of fibroproliferation by chest high-resolution CT scan in resolving ARDS. Chest (2014) 0.81
Prehospital use of inhaled steroids and incidence of acute lung injury among patients at risk. J Crit Care (2013) 0.81
Acute exacerbation of idiopathic pulmonary fibrosis-a review of current and novel pharmacotherapies. J Thorac Dis (2015) 0.80
Corticosteroids for acute respiratory distress syndrome. BMJ (2008) 0.80
Corticosteroid therapy in acute respiratory distress syndrome. CMAJ (2012) 0.80
The need to reform our assessment of evidence from clinical trials: a commentary. Philos Ethics Humanit Med (2008) 0.80
Comparison of community-acquired, hospital-acquired, and intensive care unit-acquired acute respiratory distress syndrome: a prospective observational cohort study. Crit Care (2015) 0.80
Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med (2000) 48.03
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med (2008) 31.57
An intervention to decrease catheter-related bloodstream infections in the ICU. N Engl J Med (2006) 24.54
Incidence and outcomes of acute lung injury. N Engl J Med (2005) 21.56
Acute respiratory distress syndrome: the Berlin Definition. JAMA (2012) 21.04
Comparison of two fluid-management strategies in acute lung injury. N Engl J Med (2006) 19.54
Intensity of renal support in critically ill patients with acute kidney injury. N Engl J Med (2008) 14.40
AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell (2007) 12.52
Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med (2004) 11.78
Drotrecogin alfa (activated) in adults with septic shock. N Engl J Med (2012) 9.19
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med (2007) 8.33
Pulmonary-artery versus central venous catheter to guide treatment of acute lung injury. N Engl J Med (2006) 7.97
Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury. Crit Care Med (2005) 5.76
Vitamin D therapy and cardiac structure and function in patients with chronic kidney disease: the PRIMO randomized controlled trial. JAMA (2012) 5.27
Randomized, placebo-controlled clinical trial of an aerosolized β₂-agonist for treatment of acute lung injury. Am J Respir Crit Care Med (2011) 5.24
Clinical predictors of and mortality in acute respiratory distress syndrome: potential role of red cell transfusion. Crit Care Med (2005) 5.16
Enteral omega-3 fatty acid, gamma-linolenic acid, and antioxidant supplementation in acute lung injury. JAMA (2011) 5.08
Initial trophic vs full enteral feeding in patients with acute lung injury: the EDEN randomized trial. JAMA (2012) 4.67
Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: a phase II study. J Clin Oncol (2009) 4.54
Design, conduct, analysis and reporting of a multi-national placebo-controlled trial of activated protein C for persistent septic shock. Intensive Care Med (2008) 4.21
An official American Thoracic Society clinical policy statement: palliative care for patients with respiratory diseases and critical illnesses. Am J Respir Crit Care Med (2008) 3.98
The role of open-lung biopsy in ARDS. Chest (2004) 3.46
Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma. J Clin Oncol (2010) 3.43
Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study. J Clin Oncol (2009) 3.39
Rosuvastatin for sepsis-associated acute respiratory distress syndrome. N Engl J Med (2014) 3.39
Urine IL-18 is an early diagnostic marker for acute kidney injury and predicts mortality in the intensive care unit. J Am Soc Nephrol (2005) 3.38
Pathogenetic and prognostic significance of altered coagulation and fibrinolysis in acute lung injury/acute respiratory distress syndrome. Crit Care Med (2007) 3.31
Randomized clinical trial of activated protein C for the treatment of acute lung injury. Am J Respir Crit Care Med (2008) 3.28
Relative biological effectiveness (RBE) values for proton beam therapy. Int J Radiat Oncol Biol Phys (2002) 3.21
The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material. Intensive Care Med (2012) 3.18
Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping. Oncologist (2011) 3.05
A "vascular normalization index" as potential mechanistic biomarker to predict survival after a single dose of cediranib in recurrent glioblastoma patients. Cancer Res (2009) 3.00
Challenges in end-of-life care in the ICU: statement of the 5th International Consensus Conference in Critical Care: Brussels, Belgium, April 2003: executive summary. Crit Care Med (2004) 2.95
Incidence of acute lung injury in the United States. Crit Care Med (2003) 2.93
Excess body weight is not independently associated with outcome in mechanically ventilated patients with acute lung injury. Ann Intern Med (2004) 2.80
Trauma-associated lung injury differs clinically and biologically from acute lung injury due to other clinical disorders. Crit Care Med (2007) 2.79
Causes and timing of death in patients with ARDS. Chest (2005) 2.72
The adult respiratory distress syndrome cognitive outcomes study: long-term neuropsychological function in survivors of acute lung injury. Am J Respir Crit Care Med (2012) 2.72
Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury. FASEB J (2007) 2.65
Underuse of lung protective ventilation: analysis of potential factors to explain physician behavior. Crit Care Med (2006) 2.64
Effects of recruitment maneuvers in patients with acute lung injury and acute respiratory distress syndrome ventilated with high positive end-expiratory pressure. Crit Care Med (2003) 2.63
Higher urine nitric oxide is associated with improved outcomes in patients with acute lung injury. Am J Respir Crit Care Med (2006) 2.61
Acute kidney injury in patients with acute lung injury: impact of fluid accumulation on classification of acute kidney injury and associated outcomes. Crit Care Med (2011) 2.55
Association of RBC transfusion with mortality in patients with acute lung injury. Chest (2007) 2.55
Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy. Proc Natl Acad Sci U S A (2012) 2.50
Significance of von Willebrand factor in septic and nonseptic patients with acute lung injury. Am J Respir Crit Care Med (2004) 2.49
Vitamin D reduces left atrial volume in patients with left ventricular hypertrophy and chronic kidney disease. Am Heart J (2012) 2.42
Increased survival of glioblastoma patients who respond to antiangiogenic therapy with elevated blood perfusion. Cancer Res (2011) 2.40
A protocol for high-frequency oscillatory ventilation in adults: results from a roundtable discussion. Crit Care Med (2007) 2.38
Improving patient safety in intensive care units in Michigan. J Crit Care (2008) 2.31
Polymorphisms in the mannose binding lectin-2 gene and acute respiratory distress syndrome. Crit Care Med (2007) 2.31
Beyond mortality: future clinical research in acute lung injury. Am J Respir Crit Care Med (2010) 2.28
Chronic alcohol abuse is associated with an increased incidence of acute respiratory distress syndrome and severity of multiple organ dysfunction in patients with septic shock. Crit Care Med (2003) 2.27
Effect of acute lung injury and acute respiratory distress syndrome on outcome in critically ill trauma patients. Crit Care Med (2004) 2.20
Barriers to providing lung-protective ventilation to patients with acute lung injury. Crit Care Med (2004) 2.20
Hemodynamic monitoring in shock and implications for management. International Consensus Conference, Paris, France, 27-28 April 2006. Intensive Care Med (2007) 2.18
Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury. Chest (2009) 2.17
Racial and ethnic disparities in mortality from acute lung injury. Crit Care Med (2009) 2.14
Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation. Proc Natl Acad Sci U S A (2013) 2.14
Predictors of hospital mortality in a population-based cohort of patients with acute lung injury. Crit Care Med (2008) 2.09
Pre-B-cell colony-enhancing factor gene polymorphisms and risk of acute respiratory distress syndrome. Crit Care Med (2007) 2.08
Accelerated partial breast irradiation with low-dose-rate interstitial implant brachytherapy after wide local excision: 12-year outcomes from a prospective trial. Int J Radiat Oncol Biol Phys (2011) 2.06
Critical illness from 2009 pandemic influenza A virus and bacterial coinfection in the United States. Crit Care Med (2012) 2.00
The association between body mass index and clinical outcomes in acute lung injury. Chest (2007) 1.96
Hypercapnic acidosis and mortality in acute lung injury. Crit Care Med (2006) 1.93
Utility of B-type natriuretic peptide for the evaluation of intensive care unit shock. Crit Care Med (2004) 1.92
A simple clinical predictive index for objective estimates of mortality in acute lung injury. Crit Care Med (2009) 1.91
Design of clinical trials in acute kidney injury: report from an NIDDK workshop on trial methodology. Clin J Am Soc Nephrol (2012) 1.90
Heme oxygenase-1 microsatellite polymorphism and haplotypes are associated with the development of acute respiratory distress syndrome. Intensive Care Med (2009) 1.87
Plasma angiopoietin-2 in clinical acute lung injury: prognostic and pathogenetic significance. Crit Care Med (2012) 1.81
Team training of medical students in the 21st century: would Flexner approve? Acad Med (2010) 1.77
Intensive care unit-acquired neuromyopathy and corticosteroids in survivors of persistent ARDS. Intensive Care Med (2008) 1.76
Critically ill children during the 2009-2010 influenza pandemic in the United States. Pediatrics (2011) 1.74
Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injury. Crit Care Med (2007) 1.73
Relationship of pulmonary artery catheter use to mortality and resource utilization in patients with severe sepsis. Crit Care Med (2003) 1.72
Neutrophil elastase inhibition in acute lung injury: results of the STRIVE study. Crit Care Med (2004) 1.72
Inhibitor kappaB-alpha haplotype GTC is associated with susceptibility to acute respiratory distress syndrome in Caucasians. Crit Care Med (2007) 1.71
Age-, sex-, and race-based differences among patients enrolled versus not enrolled in acute lung injury clinical trials. Crit Care Med (2010) 1.71
Use of sedatives, opioids, and neuromuscular blocking agents in patients with acute lung injury and acute respiratory distress syndrome. Crit Care Med (2008) 1.71
Acute effects of tidal volume strategy on hemodynamics, fluid balance, and sedation in acute lung injury. Crit Care Med (2005) 1.70
ARDSNet lower tidal volume ventilatory strategy may generate intrinsic positive end-expiratory pressure in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med (2002) 1.65
The value of positive end-expiratory pressure and Fio₂ criteria in the definition of the acute respiratory distress syndrome. Crit Care Med (2011) 1.64
Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer. Cancer Res (2009) 1.64
ANGPT2 genetic variant is associated with trauma-associated acute lung injury and altered plasma angiopoietin-2 isoform ratio. Am J Respir Crit Care Med (2011) 1.62
Role of diabetes in the development of acute respiratory distress syndrome. Crit Care Med (2013) 1.62
Duffy antigen facilitates movement of chemokine across the endothelium in vitro and promotes neutrophil transmigration in vitro and in vivo. J Immunol (2003) 1.62
Soluble intercellular adhesion molecule-1 and clinical outcomes in patients with acute lung injury. Intensive Care Med (2008) 1.61
BCL2 genetic variants are associated with acute kidney injury in septic shock*. Crit Care Med (2012) 1.61
Performance of an automated electronic acute lung injury screening system in intensive care unit patients. Crit Care Med (2011) 1.61
Recommendations for informed consent forms for critical care clinical trials. Crit Care Med (2005) 1.60