Published in Am J Respir Crit Care Med on June 17, 2010
Population burden of long-term survivorship after severe sepsis in older Americans. J Am Geriatr Soc (2012) 2.78
Impact of critical care nursing on 30-day mortality of mechanically ventilated older adults. Crit Care Med (2014) 1.60
Symptoms of depression in survivors of severe sepsis: a prospective cohort study of older Americans. Am J Geriatr Psychiatry (2013) 1.09
A prognostic model for 6-month mortality in elderly survivors of critical illness. Chest (2013) 1.00
Epidemiology and recent trends of severe sepsis in Spain: a nationwide population-based analysis (2006-2011). BMC Infect Dis (2014) 0.90
Presepsis depressive symptoms are associated with incident cognitive impairment in survivors of severe sepsis: a prospective cohort study of older Americans. J Am Geriatr Soc (2012) 0.83
Transforming PICU Culture to Facilitate Early Rehabilitation. J Pediatr Intensive Care (2015) 0.82
Age-related differences in biomarkers of acute inflammation during hospitalization for sepsis. Shock (2014) 0.80
The brain after critical illness: effect of illness and aging on cognitive function. Crit Care (2013) 0.77
Sleep fragmentation and sepsis differentially impact blood-brain barrier integrity and transport of tumor necrosis factor-α in aging. Brain Behav Immun (2015) 0.76
The relationship between executive dysfunction, depression, and mental health-related quality of life in survivors of critical illness: Results from the BRAIN-ICU investigation. J Crit Care (2016) 0.75
Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med (2001) 51.99
Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med (2001) 46.58
Intensive versus conventional glucose control in critically ill patients. N Engl J Med (2009) 26.30
An intervention to decrease catheter-related bloodstream infections in the ICU. N Engl J Med (2006) 24.54
One-year outcomes in survivors of the acute respiratory distress syndrome. N Engl J Med (2003) 11.77
Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med (2000) 11.54
Understanding the treatment preferences of seriously ill patients. N Engl J Med (2002) 10.84
Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial. JAMA (2009) 10.24
Physician staffing patterns and clinical outcomes in critically ill patients: a systematic review. JAMA (2002) 9.89
Use of intensive care at the end of life in the United States: an epidemiologic study. Crit Care Med (2004) 9.06
Patterns of functional decline at the end of life. JAMA (2003) 7.79
Advance directives and outcomes of surrogate decision making before death. N Engl J Med (2010) 7.09
Supine body position as a risk factor for nosocomial pneumonia in mechanically ventilated patients: a randomised trial. Lancet (1999) 6.38
Improvement in process of care and outcome after a multicenter severe sepsis educational program in Spain. JAMA (2008) 6.29
Safety of patients isolated for infection control. JAMA (2003) 5.90
Loss of independence in activities of daily living in older adults hospitalized with medical illnesses: increased vulnerability with age. J Am Geriatr Soc (2003) 5.71
Efficacy and safety of epoetin alfa in critically ill patients. N Engl J Med (2007) 5.63
Blood transfusion in elderly patients with acute myocardial infarction. N Engl J Med (2001) 5.43
Are regional variations in end-of-life care intensity explained by patient preferences?: A Study of the US Medicare Population. Med Care (2007) 5.42
Early intensive care unit mobility therapy in the treatment of acute respiratory failure. Crit Care Med (2008) 5.28
Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial. Ann Intern Med (2008) 4.85
Patient preferences for communication with physicians about end-of-life decisions. SUPPORT Investigators. Study to Understand Prognoses and Preference for Outcomes and Risks of Treatment. Ann Intern Med (1997) 4.56
Association between acute care and critical illness hospitalization and cognitive function in older adults. JAMA (2010) 4.36
Evidence-based quality improvement: the state of the science. Health Aff (Millwood) (2005) 4.32
Two-year cognitive, emotional, and quality-of-life outcomes in acute respiratory distress syndrome. Am J Respir Crit Care Med (2004) 4.09
The FDA critical path initiative and its influence on new drug development. Annu Rev Med (2008) 4.08
Early activity is feasible and safe in respiratory failure patients. Crit Care Med (2007) 3.70
Recovery of activities of daily living in older adults after hospitalization for acute medical illness. J Am Geriatr Soc (2008) 3.53
Long-term outcome of critically ill elderly patients requiring intensive care. JAMA (1993) 3.27
Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis. Crit Care Med (2003) 3.18
Acute kidney injury in non-severe pneumonia is associated with an increased immune response and lower survival. Kidney Int (2009) 2.97
Recovery of kidney function after acute kidney injury in the elderly: a systematic review and meta-analysis. Am J Kidney Dis (2008) 2.85
The long-term psychological effects of daily sedative interruption on critically ill patients. Am J Respir Crit Care Med (2003) 2.80
Underuse of lung protective ventilation: analysis of potential factors to explain physician behavior. Crit Care Med (2006) 2.64
ICU-acquired weakness. Chest (2007) 2.61
Effect of 10 days of bed rest on skeletal muscle in healthy older adults. JAMA (2007) 2.60
Quality of life in adult survivors of critical illness: a systematic review of the literature. Intensive Care Med (2005) 2.55
Delirium in the intensive care unit: occurrence and clinical course in older patients. J Am Geriatr Soc (2003) 2.53
Rehabilitation after critical illness: a randomized, controlled trial. Crit Care Med (2003) 2.43
Is survival better at hospitals with higher "end-of-life" treatment intensity? Med Care (2010) 2.35
Long-term enhancement of skeletal muscle mass and strength by single gene administration of myostatin inhibitors. Proc Natl Acad Sci U S A (2008) 2.31
Impact of intensive insulin therapy on neuromuscular complications and ventilator dependency in the medical intensive care unit. Am J Respir Crit Care Med (2006) 2.22
The Mini Nutritional Assessment (MNA) review of the literature--What does it tell us? J Nutr Health Aging (2006) 2.16
Targeted ablation of IKK2 improves skeletal muscle strength, maintains mass, and promotes regeneration. J Clin Invest (2006) 2.13
Effect of anemia and comorbidity on functional status and mortality in old age: results from the Leiden 85-plus Study. CMAJ (2009) 2.11
Accuracy and feasibility of point-of-care and continuous blood glucose analysis in critically ill ICU patients. Crit Care (2006) 2.01
Use of intensive care services during terminal hospitalizations in England and the United States. Am J Respir Crit Care Med (2009) 2.00
Selection of intensive care unit admission criteria for patients aged 80 years and over and compliance of emergency and intensive care unit physicians with the selected criteria: An observational, multicenter, prospective study. Crit Care Med (2009) 1.88
End-of-life care in the ICU: treatments provided when life support was or was not withdrawn. Chest (2000) 1.84
Evidence-based decision making: global evidence, local decisions. Health Aff (Millwood) (2005) 1.74
Ability of pulse power, esophageal Doppler, and arterial pulse pressure to estimate rapid changes in stroke volume in humans. Crit Care Med (2008) 1.74
Critical illness outcomes in specialty versus general intensive care units. Am J Respir Crit Care Med (2009) 1.73
Consciousness monitoring in ventilated patients: bispectral EEG monitors arousal not delirium. Intensive Care Med (2004) 1.68
Short-term outcomes in older intensive care unit patients with dementia. Crit Care Med (2005) 1.65
Informal caregiver burden among survivors of prolonged mechanical ventilation. Am J Respir Crit Care Med (2006) 1.64
IGF-I restores satellite cell proliferative potential in immobilized old skeletal muscle. J Appl Physiol (1985) (2000) 1.61
Anti-inflammatory properties of omega-3 fatty acids in critical illness: novel mechanisms and an integrative perspective. Intensive Care Med (2008) 1.57
Should elderly patients be admitted to the intensive care unit? Intensive Care Med (2007) 1.55
Patients with respiratory failure increase ambulation after transfer to an intensive care unit where early activity is a priority. Crit Care Med (2008) 1.50
Recovery rate and prognosis in older persons who develop acute lung injury and the acute respiratory distress syndrome. Ann Intern Med (2002) 1.49
Non-invasive stroke volume measurement and passive leg raising predict volume responsiveness in medical ICU patients: an observational cohort study. Crit Care (2009) 1.47
Effects of a fish oil containing lipid emulsion on plasma phospholipid fatty acids, inflammatory markers, and clinical outcomes in septic patients: a randomized, controlled clinical trial. Crit Care (2010) 1.47
Nonlinear dynamics, complex systems, and the pathobiology of critical illness. Curr Opin Crit Care (2004) 1.45
Essential amino acid and carbohydrate supplementation ameliorates muscle protein loss in humans during 28 days bedrest. J Clin Endocrinol Metab (2004) 1.43
The Fourth National Institutes of Health Symposium on the Functional Genomics of Critical Injury: Surviving stress from organ systems to molecules. Crit Care Med (2008) 1.42
Anemia in the elderly: a public health crisis in hematology. Hematology Am Soc Hematol Educ Program (2005) 1.38
Factors that predict outcome of intensive care treatment in very elderly patients: a review. Crit Care (2005) 1.37
Age-related differences in care preferences, treatment decisions, and clinical outcomes of seriously ill hospitalized adults: lessons from SUPPORT. J Am Geriatr Soc (2000) 1.34
Predicting volume responsiveness by using the end-expiratory occlusion in mechanically ventilated intensive care unit patients. Crit Care Med (2009) 1.29
Immune remodeling: lessons from repertoire alterations during chronological aging and in immune-mediated disease. Trends Mol Med (2007) 1.21
Aging increases the susceptibility to injurious mechanical ventilation. Intensive Care Med (2008) 1.16
Risk factors for death due to nosocomial infection in intensive care unit patients: findings from the Krankenhaus Infektions Surveillance System. Infect Control Hosp Epidemiol (2007) 1.13
Antioxidant supplementation in sepsis and systemic inflammatory response syndrome. Crit Care Med (2007) 1.08
Exogenous arginine in sepsis. Crit Care Med (2007) 1.07
Angiotensin-converting enzyme inhibition intervention in elderly persons: effects on body composition and physical performance. J Gerontol A Biol Sci Med Sci (2005) 1.06
Methodology and baseline characteristics for the Sarcopenia and Hip Fracture study: a 5-year prospective study. J Gerontol A Biol Sci Med Sci (2009) 1.01
Epidemiology and treatment of psychiatric conditions that develop after critical illness. Curr Opin Crit Care (2005) 1.01
Glutamine: mode of action in critical illness. Crit Care Med (2007) 0.99
A prospective, randomized trial of intravenous fat emulsion administration in trauma victims requiring total parenteral nutrition. J Trauma (1997) 0.99
Cognitive functioning, mental health, and quality of life in ICU survivors: an overview. Crit Care Clin (2009) 0.98
Outcome of older patients receiving mechanical ventilation. Intensive Care Med (2004) 0.97
Outcome of intensive care of the "oldest-old" critically ill patients. Crit Care Med (1992) 0.92
Mobilizing the patient in the intensive care unit: the role of early tracheotomy. Crit Care Clin (2007) 0.90
Polar bears (Ursus maritimus), the most evolutionary advanced hibernators, avoid significant bone loss during hibernation. Comp Biochem Physiol A Mol Integr Physiol (2008) 0.90
Loss of muscle strength during aging studied at the gene level. Rejuvenation Res (2007) 0.88
Nutrition in the elderly. Gastroenterol Clin North Am (2001) 0.87
Bench-to-bedside review: critical illness-associated cognitive dysfunction--mechanisms, markers, and emerging therapeutics. Crit Care (2006) 0.86
Towards a new standard of perioperative fluid management. Ther Clin Risk Manag (2008) 0.85
The effects of MK-0677, an oral growth hormone secretagogue, in patients with hip fracture. J Am Geriatr Soc (2004) 0.80
Do gene variants really explain the heterogeneous outcomes in sepsis? Crit Care Med (2001) 0.76
Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med (2013) 39.56
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med (2008) 31.57
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med (2013) 17.37
A randomized trial of protocol-based care for early septic shock. N Engl J Med (2014) 16.05
Physician staffing patterns and clinical outcomes in critically ill patients: a systematic review. JAMA (2002) 9.89
RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis. Crit Care (2006) 9.29
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med (2007) 8.33
The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Crit Care Med (2010) 6.69
National estimates of severe sepsis in United States emergency departments. Crit Care Med (2007) 5.99
Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study. Arch Intern Med (2007) 5.65
Nighttime intensivist staffing and mortality among critically ill patients. N Engl J Med (2012) 5.22
Variation in critical care services across North America and Western Europe. Crit Care Med (2008) 5.00
The epidemiology of severe sepsis in children in the United States. Am J Respir Crit Care Med (2002) 4.72
The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Intensive Care Med (2010) 4.64
The effect of multidisciplinary care teams on intensive care unit mortality. Arch Intern Med (2010) 4.41
Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial. JAMA (2013) 3.78
Risk prediction with procalcitonin and clinical rules in community-acquired pneumonia. Ann Emerg Med (2008) 3.44
Severe sepsis in pre-hospital emergency care: analysis of incidence, care, and outcome. Am J Respir Crit Care Med (2012) 3.36
The epidemiology of mechanical ventilation use in the United States. Crit Care Med (2010) 3.28
Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis. Crit Care Med (2003) 3.18
Racial variation in the incidence, care, and outcomes of severe sepsis: analysis of population, patient, and hospital characteristics. Am J Respir Crit Care Med (2007) 3.17
The next generation of sepsis clinical trial designs: what is next after the demise of recombinant human activated protein C?*. Crit Care Med (2014) 3.17
Intensive care unit quality improvement: a "how-to" guide for the interdisciplinary team. Crit Care Med (2006) 3.15
Pneumonia: still the old man's friend? Arch Intern Med (2003) 3.12
Renal failure in the ICU: comparison of the impact of acute renal failure and end-stage renal disease on ICU outcomes. Kidney Int (2002) 3.07
Hospitalized community-acquired pneumonia in the elderly: age- and sex-related patterns of care and outcome in the United States. Am J Respir Crit Care Med (2002) 3.02
Acute kidney injury in non-severe pneumonia is associated with an increased immune response and lower survival. Kidney Int (2009) 2.97
Prospective meta-analysis using individual patient data in intensive care medicine. Intensive Care Med (2009) 2.93
Organizational characteristics, outcomes, and resource use in 78 Brazilian intensive care units: the ORCHESTRA study. Intensive Care Med (2015) 2.92
Three-year outcomes for Medicare beneficiaries who survive intensive care. JAMA (2010) 2.87
The association of sepsis syndrome and organ dysfunction with mortality in emergency department patients with suspected infection. Ann Emerg Med (2006) 2.84
The adult respiratory distress syndrome cognitive outcomes study: long-term neuropsychological function in survivors of acute lung injury. Am J Respir Crit Care Med (2012) 2.72
Trends in the epidemiology of pediatric severe sepsis*. Pediatr Crit Care Med (2013) 2.67
Critical care medicine training and certification for emergency physicians. Ann Emerg Med (2005) 2.67
End-of-life care for the critically ill: A national intensive care unit survey. Crit Care Med (2006) 2.61
Disability among elderly survivors of mechanical ventilation. Am J Respir Crit Care Med (2010) 2.50
Effects of drotrecogin alfa (activated) on organ dysfunction in the PROWESS trial. Crit Care Med (2003) 2.44
Harmonizing international trials of early goal-directed resuscitation for severe sepsis and septic shock: methodology of ProCESS, ARISE, and ProMISe. Intensive Care Med (2013) 2.44
Prioritizing the organization and management of intensive care services in the United States: the PrOMIS Conference. Crit Care Med (2007) 2.42
Relationship between staff perceptions of hospital norms and hospital-level end-of-life treatment intensity. J Palliat Med (2007) 2.39
Long-term mortality and medical care charges in patients with severe sepsis. Crit Care Med (2003) 2.39
Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsis. Am J Respir Crit Care Med (2008) 2.37
Is survival better at hospitals with higher "end-of-life" treatment intensity? Med Care (2010) 2.35
Survival after liver transplantation in the United States: a disease-specific analysis of the UNOS database. Liver Transpl (2004) 2.31
A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis. Crit Care Med (2010) 2.31
Growth of intensive care unit resource use and its estimated cost in Medicare. Crit Care Med (2008) 2.31
Severe sepsis epidemiology: sampling, selection, and society. Crit Care (2004) 2.28
Infection rate and acute organ dysfunction risk as explanations for racial differences in severe sepsis. JAMA (2010) 2.27
The Lifestyle Interventions and Independence for Elders Study: design and methods. J Gerontol A Biol Sci Med Sci (2011) 2.26
Perceptions of safety culture vary across the intensive care units of a single institution. Crit Care Med (2007) 2.24
Hospital deaths in patients with sepsis from 2 independent cohorts. JAMA (2014) 2.23
Plasma neutrophil gelatinase-associated lipocalin predicts recovery from acute kidney injury following community-acquired pneumonia. Kidney Int (2011) 2.22
Posttraumatic stress and complicated grief in family members of patients in the intensive care unit. J Gen Intern Med (2008) 2.12
Critical care medicine training and certification for emergency physicians. Crit Care Med (2005) 2.12
Haloperidol use is associated with lower hospital mortality in mechanically ventilated patients. Crit Care Med (2005) 2.11
Severe sepsis and septic shock. N Engl J Med (2013) 2.10
A comparison of critical care research funding and the financial burden of critical illness in the United States. Crit Care Med (2012) 2.07
Do hospitals provide lower quality of care to black patients for pneumonia? Crit Care Med (2010) 2.07
Forging a critical alliance: Addressing the research needs of the United States critical illness and injury community. Crit Care Med (2009) 2.03
Use of intensive care services during terminal hospitalizations in England and the United States. Am J Respir Crit Care Med (2009) 2.00
Fatigue in a representative population of older persons and its association with functional impairment, functional limitation, and disability. J Gerontol A Biol Sci Med Sci (2009) 1.96
Assessing the feasibility of the American College of Surgeons' benchmarks for the triage of trauma patients. Arch Surg (2011) 1.95
Critical care bed growth in the United States. A comparison of regional and national trends. Am J Respir Crit Care Med (2015) 1.93
How does lack of insurance affect use of intensive care? A population-based study. Crit Care Med (2006) 1.92
Temporal changes in management and outcome of septic shock in patients with malignancies in the intensive care unit. Crit Care Med (2008) 1.89
The first international consensus conference on continuous renal replacement therapy. Kidney Int (2002) 1.89
The effects of trauma center care, admission volume, and surgical volume on paralysis after traumatic spinal cord injury. Ann Surg (2009) 1.86
Using simulation to isolate physician variation in intensive care unit admission decision making for critically ill elders with end-stage cancer: a pilot feasibility study. Crit Care Med (2008) 1.81
Influence of comorbid conditions on long-term mortality after pneumonia in older people. J Am Geriatr Soc (2007) 1.79
Physician attitudes toward regionalization of adult critical care: a national survey. Crit Care Med (2009) 1.79
Outcome measures for clinical research in sepsis: a report of the 2nd Cambridge Colloquium of the International Sepsis Forum. Crit Care Med (2005) 1.77
Understanding the potential role of statins in pneumonia and sepsis. Crit Care Med (2011) 1.77
Variability in management of early severe sepsis. Emerg Med J (2010) 1.76
Racial variation in end-of-life intensive care use: a race or hospital effect? Health Serv Res (2006) 1.76
Quality of death: assessing the importance placed on end-of-life treatment in the intensive-care unit. Med Care (2004) 1.76
A randomized trial of the effect of patient race on physicians' intensive care unit and life-sustaining treatment decisions for an acutely unstable elder with end-stage cancer. Crit Care Med (2011) 1.75
Health and function of participants in the Long Life Family Study: A comparison with other cohorts. Aging (Albany NY) (2011) 1.74
Hospital mortality and resource use in subgroups of the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) trial. Crit Care Med (2004) 1.73
Comparison of Cox and Gray's survival models in severe sepsis. Crit Care Med (2004) 1.72
Differences in immune response may explain lower survival among older men with pneumonia. Crit Care Med (2009) 1.71
Association between supine hypertension and orthostatic hypotension in autonomic failure. Hypertension (2003) 1.69
Comparison of medical admissions to intensive care units in the United States and United Kingdom. Am J Respir Crit Care Med (2011) 1.69
The lingering consequences of sepsis: a hidden public health disaster? JAMA (2010) 1.67
Informal caregiver burden among survivors of prolonged mechanical ventilation. Am J Respir Crit Care Med (2006) 1.64
Access to urban acute care services in high- vs. middle-income countries: an analysis of seven cities. Intensive Care Med (2013) 1.64
The Cancer Genetics Network: recruitment results and pilot studies. Community Genet (2003) 1.61
Long-term outcomes from sepsis. Curr Infect Dis Rep (2007) 1.59
Development and validation of hospital "end-of-life" treatment intensity measures. Med Care (2009) 1.58
Reassessing the value of short-term mortality in sepsis: comparing conventional approaches to modeling. Crit Care Med (2003) 1.57
No child left behind: Enrolling children and adults simultaneously in critical care randomized trials. Crit Care Med (2009) 1.56
Accuracy of prehospital transport time estimation. Acad Emerg Med (2014) 1.56
Acute kidney injury in older adults. J Am Soc Nephrol (2011) 1.54
Drotrecogin alfa (activated) treatment of older patients with severe sepsis. Clin Infect Dis (2003) 1.54
Mortality among patients admitted to strained intensive care units. Am J Respir Crit Care Med (2013) 1.53
Serum biomarkers of brain injury to classify outcome after pediatric cardiac arrest*. Crit Care Med (2014) 1.52
Testing protocols in the intensive care unit: complex trials of complex interventions for complex patients. JAMA (2008) 1.51
Trial of shift scheduling with standardized sign-out to improve continuity of care in intensive care units. Crit Care Med (2012) 1.51
Intensive care unit safety culture and outcomes: a US multicenter study. Int J Qual Health Care (2010) 1.50
Potential value of regionalized intensive care for mechanically ventilated medical patients. Am J Respir Crit Care Med (2007) 1.47