Plasmacytoid dendritic cells prime IL-10-producing T regulatory cells by inducible costimulator ligand.

PubWeight™: 3.78‹?› | Rank: Top 1%

🔗 View Article (PMC 2118437)

Published in J Exp Med on January 02, 2007

Authors

Tomoki Ito1, Maria Yang, Yui-Hsi Wang, Roberto Lande, Josh Gregorio, Olivia A Perng, Xiao-Feng Qin, Yong-Jun Liu, Michel Gilliet

Author Affiliations

1: Department of Immunology, M.D. Anderson Cancer Center, Graduate School of Biomedical Sciences at Houston, The University of Texas, Houston, TX 77030, USA.

Articles citing this

(truncated to the top 100)

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20

The regulation of IL-10 production by immune cells. Nat Rev Immunol (2010) 9.18

The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells. Nat Immunol (2008) 5.92

Plasmacytoid dendritic cells: recent progress and open questions. Annu Rev Immunol (2011) 3.32

CTLA-4 blockade increases IFNgamma-producing CD4+ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patients. Proc Natl Acad Sci U S A (2008) 3.04

Direct proteasome-independent cross-presentation of viral antigen by plasmacytoid dendritic cells on major histocompatibility complex class I. Nat Immunol (2008) 2.82

Two functional subsets of FOXP3+ regulatory T cells in human thymus and periphery. Immunity (2008) 2.78

Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose. Immunity (2009) 2.61

Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and tolerance. Immunol Rev (2010) 2.55

The indoleamine 2,3-dioxygenase pathway is essential for human plasmacytoid dendritic cell-induced adaptive T regulatory cell generation. J Immunol (2008) 2.55

Interleukin-10 production by effector T cells: Th1 cells show self control. J Exp Med (2007) 2.18

Dendritic cells and cytokines in human inflammatory and autoimmune diseases. Cytokine Growth Factor Rev (2008) 2.13

How tolerogenic dendritic cells induce regulatory T cells. Adv Immunol (2010) 2.11

HIV-activated human plasmacytoid DCs induce Tregs through an indoleamine 2,3-dioxygenase-dependent mechanism. J Clin Invest (2008) 2.06

Designing vaccines based on biology of human dendritic cell subsets. Immunity (2010) 2.04

IL-10 from CD4CD25Foxp3CD127 adaptive regulatory T cells modulates parasite clearance and pathology during malaria infection. PLoS Pathog (2008) 2.01

Diversity in the contribution of interleukin-10 to T-cell-mediated immune regulation. Immunol Rev (2008) 1.88

Plasmacytoid dendritic cells mediate anti-inflammatory responses to a gut commensal molecule via both innate and adaptive mechanisms. Cell Host Microbe (2014) 1.84

IRAK-4- and MyD88-dependent pathways are essential for the removal of developing autoreactive B cells in humans. Immunity (2008) 1.83

Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymus. J Exp Med (2009) 1.81

Interferon-alpha promotes abnormal vasculogenesis in lupus: a potential pathway for premature atherosclerosis. Blood (2007) 1.79

IL-10 production by CD4+ effector T cells: a mechanism for self-regulation. Mucosal Immunol (2010) 1.59

A Regulatory Feedback between Plasmacytoid Dendritic Cells and Regulatory B Cells Is Aberrant in Systemic Lupus Erythematosus. Immunity (2016) 1.59

The multifaceted biology of plasmacytoid dendritic cells. Nat Rev Immunol (2015) 1.52

Targeting self- and foreign antigens to dendritic cells via DC-ASGPR generates IL-10-producing suppressive CD4+ T cells. J Exp Med (2012) 1.50

Human dendritic cell subsets. Immunology (2013) 1.49

Tolerogenic plasmacytoid DC. Eur J Immunol (2010) 1.48

Harnessing human dendritic cell subsets for medicine. Immunol Rev (2010) 1.46

Role of dendritic cells in the induction of regulatory T cells. Cell Biosci (2011) 1.27

Contrasting roles for all-trans retinoic acid in TGF-beta-mediated induction of Foxp3 and Il10 genes in developing regulatory T cells. J Exp Med (2009) 1.27

Tolerogenic dendritic cells and their role in transplantation. Semin Immunol (2011) 1.26

Plasmacytoid dendritic cells promote immunosuppression in ovarian cancer via ICOS costimulation of Foxp3(+) T-regulatory cells. Cancer Res (2012) 1.25

CD2 distinguishes two subsets of human plasmacytoid dendritic cells with distinct phenotype and functions. J Immunol (2009) 1.23

Plasmacytoid dendritic cells: one-trick ponies or workhorses of the immune system? Nat Rev Immunol (2011) 1.23

Peripheral virus-specific T-cell interleukin-10 responses develop early in acute hepatitis C infection and become dominant in chronic hepatitis. J Hepatol (2008) 1.22

Follicular lymphoma B cells induce the conversion of conventional CD4+ T cells to T-regulatory cells. Int J Cancer (2009) 1.19

The role of dendritic cells in CNS autoimmunity. J Mol Med (Berl) (2010) 1.19

Chronic helminth infection promotes immune regulation in vivo through dominance of CD11cloCD103- dendritic cells. J Immunol (2011) 1.16

Tissue engineering tools for modulation of the immune response. Biotechniques (2011) 1.12

IL-2 therapy promotes suppressive ICOS+ Treg expansion in melanoma patients. J Clin Invest (2014) 1.12

Mechanisms of immune tolerance relevant to food allergy. J Allergy Clin Immunol (2011) 1.11

Preferential costimulation by CD80 results in IL-10-dependent TGF-beta1(+) -adaptive regulatory T cell generation. J Immunol (2008) 1.11

Complexity of dendritic cell subsets and their function in the host immune system. Immunology (2011) 1.11

Poor allostimulatory function of liver plasmacytoid DC is associated with pro-apoptotic activity, dependent on regulatory T cells. J Hepatol (2008) 1.10

Targeting human dendritic cell subsets for improved vaccines. Semin Immunol (2011) 1.09

T-cell subset regulation in atopy. Curr Allergy Asthma Rep (2011) 1.09

Plasmacytoid dendritic cells capture and cross-present viral antigens from influenza-virus exposed cells. PLoS One (2009) 1.09

Tumor associated regulatory dendritic cells. Semin Cancer Biol (2012) 1.08

CD8α+ plasmacytoid precursor DCs induce antigen-specific regulatory T cells that enhance HSC engraftment in vivo. Blood (2010) 1.07

Activation of the noncanonical NF-κB pathway by HIV controls a dendritic cell immunoregulatory phenotype. Proc Natl Acad Sci U S A (2012) 1.05

Regulatory T cells and immune regulation of allergic diseases: roles of IL-10 and TGF-β. Genes Immun (2014) 1.05

CD40-activated B cells are more potent than immature dendritic cells to induce and expand CD4(+) regulatory T cells. Cell Mol Immunol (2010) 1.04

Paradigm Shift in Dendritic Cell-Based Immunotherapy: From in vitro Generated Monocyte-Derived DCs to Naturally Circulating DC Subsets. Front Immunol (2014) 1.04

Advancing islet transplantation: from engraftment to the immune response. Diabetologia (2011) 1.04

Lung dendritic cells at the innate-adaptive immune interface. J Leukoc Biol (2011) 1.03

Exhaustion of bacteria-specific CD4 T cells and microbial translocation in common variable immunodeficiency disorders. J Exp Med (2014) 1.02

HIV type 1 gp120-induced expansion of myeloid derived suppressor cells is dependent on interleukin 6 and suppresses immunity. J Infect Dis (2013) 1.02

Costimulatory molecules on immunogenic versus tolerogenic human dendritic cells. Front Immunol (2013) 1.02

North American porcine reproductive and respiratory syndrome viruses inhibit type I interferon production by plasmacytoid dendritic cells. J Virol (2010) 1.00

Synergy between rapamycin and FLT3 ligand enhances plasmacytoid dendritic cell-dependent induction of CD4+CD25+FoxP3+ Treg. Blood (2015) 0.99

Human plasmacytoid dendritic cells: from molecules to intercellular communication network. Front Immunol (2013) 0.99

Dendritic cells: a critical player in cancer therapy? J Immunother (2008) 0.99

Functional crosstalk between dendritic cells and Foxp3(+) regulatory T cells in the maintenance of immune tolerance. Front Immunol (2012) 0.99

Viral infection prevents diabetes by inducing regulatory T cells through NKT cell-plasmacytoid dendritic cell interplay. J Exp Med (2011) 0.97

In situ-targeting of dendritic cells with donor-derived apoptotic cells restrains indirect allorecognition and ameliorates allograft vasculopathy. PLoS One (2009) 0.97

Role of dendritic cell maturity/costimulation for generation, homeostasis, and suppressive activity of regulatory T cells. Front Immunol (2011) 0.96

Mechanisms underlying the induction of regulatory T cells and its relevance in the adaptive immune response in parasitic infections. Int J Biol Sci (2011) 0.95

Tolerogenic and activatory plasmacytoid dendritic cells in autoimmunity. Front Immunol (2013) 0.95

Peptidoglycan recognition protein 1 enhances experimental asthma by promoting Th2 and Th17 and limiting regulatory T cell and plasmacytoid dendritic cell responses. J Immunol (2013) 0.95

ICOS controls Foxp3(+) regulatory T-cell expansion, maintenance and IL-10 production during helminth infection. Eur J Immunol (2013) 0.94

Enforced IL-10 expression confers type 1 regulatory T cell (Tr1) phenotype and function to human CD4(+) T cells. Mol Ther (2012) 0.93

From Q Fever to Coxiella burnetii Infection: a Paradigm Change. Clin Microbiol Rev (2017) 0.93

Anticandidal immunity and vaginitis: novel opportunities for immune intervention. Infect Immun (2007) 0.93

Spherical lactic acid bacteria activate plasmacytoid dendritic cells immunomodulatory function via TLR9-dependent crosstalk with myeloid dendritic cells. PLoS One (2012) 0.93

Plasmacytoid dendritic cells in antiviral immunity and autoimmunity. Sci China Life Sci (2010) 0.93

Concurrent decrease in IL-10 with development of immune-related adverse events in a patient treated with anti-CTLA-4 therapy. Cancer Immun (2008) 0.93

The four types of Tregs in malignant lymphomas. J Hematol Oncol (2011) 0.93

Priming of T follicular helper cells by dendritic cells. Immunol Cell Biol (2013) 0.92

Accumulation of plasmacytoid DC: Roles in disease pathogenesis and targets for immunotherapy. Eur J Immunol (2010) 0.92

The hepatitis B virus-associated tumor microenvironment in hepatocellular carcinoma. Natl Sci Rev (2014) 0.91

Evidence for significant overlap between common risk variants for Crohn's disease and ankylosing spondylitis. PLoS One (2010) 0.91

Molecular characterization of human plasmacytoid dendritic cells. J Clin Immunol (2009) 0.91

Dendritic cells: are they clinically relevant? Cancer J (2010) 0.90

Generation and maturation of bone marrow-derived DCs under serum-free conditions. J Immunol Methods (2007) 0.89

Genetic variants of the IL22 promoter associate to onset of psoriasis before puberty and increased IL-22 production in T cells. J Invest Dermatol (2013) 0.88

Plasmacytoid dendritic cells: no longer an enigma and now key to transplant tolerance? Am J Transplant (2013) 0.87

Why functional pre-erythrocytic and bloodstage malaria vaccines fail: a meta-analysis of fully protective immunizations and novel immunological model. PLoS One (2010) 0.87

Tonsillar application of AT-2 SIV affords partial protection against rectal challenge with SIVmac239. J Acquir Immune Defic Syndr (2009) 0.87

Innate immunity and resistance to tolerogenesis in allotransplantation. Front Immunol (2012) 0.85

Allostimulatory activity of bone marrow-derived plasmacytoid dendritic cells is independent of indoleamine dioxygenase but regulated by inducible costimulator ligand expression. Hum Immunol (2009) 0.85

Thymic Crosstalk Coordinates Medulla Organization and T-Cell Tolerance Induction. Front Immunol (2015) 0.85

Plasmacytoid dendritic cells in tolerance. Methods Mol Biol (2011) 0.84

Modulating intestinal immune responses by lipoteichoic acid-deficient Lactobacillus acidophilus. Immunotherapy (2012) 0.84

Ethanol inhibits antigen presentation by dendritic cells. Clin Vaccine Immunol (2011) 0.84

Tolerogenic dendritic cells and their applications in transplantation. Cell Mol Immunol (2014) 0.84

Interleukin-6 Induced "Acute" Phenotypic Microenvironment Promotes Th1 Anti-Tumor Immunity in Cryo-Thermal Therapy Revealed By Shotgun and Parallel Reaction Monitoring Proteomics. Theranostics (2016) 0.83

The dark side of dendritic cells: development and exploitation of tolerogenic activity that favor tumor outgrowth and immune escape. Front Immunol (2013) 0.83

Dendritic cells as gatekeepers of tolerance. Semin Immunopathol (2016) 0.83

Successful granulocyte-colony stimulating factor treatment of Crohn's disease is associated with the appearance of circulating interleukin-10-producing T cells and increased lamina propria plasmacytoid dendritic cells. Clin Exp Immunol (2008) 0.83

Targeting human dendritic cells in situ to improve vaccines. Immunol Lett (2014) 0.83

Articles cited by this

TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol (1989) 31.72

B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat Med (1999) 16.91

A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature (1997) 16.28

Dendritic cell subsets and lineages, and their functions in innate and adaptive immunity. Cell (2001) 13.24

Plasmacytoid dendritic cells in immunity. Nat Immunol (2004) 9.11

Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J Exp Med (2001) 8.60

Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus. Science (2001) 8.14

Reciprocal control of T helper cell and dendritic cell differentiation. Science (1999) 7.28

Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection. J Exp Med (2005) 6.59

Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J Exp Med (2000) 6.45

Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction. Nature (2005) 6.14

In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha. J Immunol (1996) 5.79

TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand. J Exp Med (2005) 5.77

ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature (1999) 5.76

Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity (1998) 5.75

Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat Immunol (2004) 5.71

The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand. J Exp Med (1997) 5.23

Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts. Nat Immunol (2006) 5.00

Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6. Immunity (2003) 4.93

Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells. J Exp Med (2001) 4.78

TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function. Immunity (2004) 4.50

Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen. J Exp Med (2004) 4.34

Natural interferon alpha/beta-producing cells link innate and adaptive immunity. J Exp Med (2000) 4.33

Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells. Eur J Immunol (2001) 4.23

Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity. Nat Med (2002) 3.80

Maturation, activation, and protection of dendritic cells induced by double-stranded RNA. J Exp Med (1999) 3.64

CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion. J Exp Med (2004) 3.57

Human immunodeficiency virus type 1 activates plasmacytoid dendritic cells and concomitantly induces the bystander maturation of myeloid dendritic cells. J Virol (2004) 3.12

Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+CD25+ regulatory T cells. J Immunol (2004) 3.10

Generation of human CD8 T regulatory cells by CD40 ligand-activated plasmacytoid dendritic cells. J Exp Med (2002) 3.02

Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction. J Exp Med (2005) 2.90

Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+ Tr cells. Blood (2004) 2.76

Interleukin-10 regulation in normal subjects and patients with asthma. J Allergy Clin Immunol (1996) 2.55

Dendritic cell lineage, plasticity and cross-regulation. Nat Immunol (2001) 2.43

Plasmacytoid DCs help lymph node DCs to induce anti-HSV CTLs. J Exp Med (2005) 2.23

Plasmacytoid dendritic cells inhibit pulmonary immunopathology and promote clearance of respiratory syncytial virus. J Exp Med (2006) 2.14

Plasmacytoid dendritic cells induce CD8+ regulatory T cells in human ovarian carcinoma. Cancer Res (2005) 2.06

Expression of ICOS in vivo defines CD4+ effector T cells with high inflammatory potential and a strong bias for secretion of interleukin 10. J Exp Med (2003) 1.89

Specialization, kinetics, and repertoire of type 1 interferon responses by human plasmacytoid predendritic cells. Blood (2005) 1.79

Human ICOS deficiency abrogates the germinal center reaction and provides a monogenic model for common variable immunodeficiency. Blood (2005) 1.63

GATA-3 directly remodels the IL-10 locus independently of IL-4 in CD4+ T cells. J Immunol (2006) 1.59

CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammation. J Allergy Clin Immunol (2002) 1.56

Plasmacytoid precursor dendritic cells facilitate allogeneic hematopoietic stem cell engraftment. J Exp Med (2005) 1.53

Plasmacytoid dendritic cells regulate Th cell responses through OX40 ligand and type I IFNs. J Immunol (2004) 1.48

Induction, binding specificity and function of human ICOS. Eur J Immunol (2000) 1.30

Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL). Blood (2006) 1.27

ICOS and CD28 reversely regulate IL-10 on re-activation of human effector T cells with mature dendritic cells. Eur J Immunol (2002) 1.19

The ICOS molecule plays a crucial role in the development of mucosal tolerance. J Immunol (2005) 1.13

Retracted Blockade of allergic airway inflammation following systemic treatment with a B7-dendritic cell (PD-L2) cross-linking human antibody. J Immunol (2004) 1.09

The diabetes susceptibility locus Idd5.1 on mouse chromosome 1 regulates ICOS expression and modulates murine experimental autoimmune encephalomyelitis. J Immunol (2004) 1.03

Human T cell activation by costimulatory signal-deficient allogeneic cells induces inducible costimulator-expressing anergic T cells with regulatory cell activity. J Immunol (2004) 1.03

Dendritic cell populations in Leishmania major-infected skin and draining lymph nodes. Infect Immun (2004) 1.02

Human recombinant B7-H3 expressed in E. coli enhances T lymphocyte proliferation and IL-10 secretion in vitro. Acta Biochim Biophys Sin (Shanghai) (2004) 0.93

Eminent role of ICOS costimulation for T cells interacting with plasmacytoid dendritic cells. Immunology (2006) 0.93

Articles by these authors

Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat Immunol (2002) 10.15

Mouse and human dendritic cell subtypes. Nat Rev Immunol (2002) 10.01

Plasmacytoid dendritic cells in immunity. Nat Immunol (2004) 9.11

Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature (2007) 8.88

Nomenclature of monocytes and dendritic cells in blood. Blood (2010) 6.63

Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases. Nat Rev Immunol (2008) 6.17

TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand. J Exp Med (2005) 5.77

Neutrophils activate plasmacytoid dendritic cells by releasing self-DNA-peptide complexes in systemic lupus erythematosus. Sci Transl Med (2011) 5.60

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells. Nat Immunol (2011) 5.34

Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus. J Exp Med (2005) 4.92

Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus. Nature (2005) 4.60

TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation. Annu Rev Immunol (2007) 4.39

Identification of IL-17-producing FOXP3+ regulatory T cells in humans. Proc Natl Acad Sci U S A (2009) 4.10

Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production. J Exp Med (2005) 4.04

The development of murine plasmacytoid dendritic cell precursors is differentially regulated by FLT3-ligand and granulocyte/macrophage colony-stimulating factor. J Exp Med (2002) 3.91

Interleukin 25 promotes the initiation of proallergic type 2 responses. J Exp Med (2007) 3.91

The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens. Nat Immunol (2006) 3.76

IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells. J Exp Med (2007) 3.66

Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: dependency on antigen dose and differential toll-like receptor ligation. J Exp Med (2003) 3.41

Dendritic cell apoptosis in the maintenance of immune tolerance. Science (2006) 3.33

Viral infection and Toll-like receptor agonists induce a differential expression of type I and lambda interferons in human plasmacytoid and monocyte-derived dendritic cells. Eur J Immunol (2004) 3.25

Thymic stromal lymphopoietin fosters human breast tumor growth by promoting type 2 inflammation. J Exp Med (2011) 3.12

Human immunodeficiency virus type 1 activates plasmacytoid dendritic cells and concomitantly induces the bystander maturation of myeloid dendritic cells. J Virol (2004) 3.12

Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+CD25+ regulatory T cells. J Immunol (2004) 3.10

Antagonistic nature of T helper 1/2 developmental programs in opposing peripheral induction of Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A (2007) 3.09

Generation of human CD8 T regulatory cells by CD40 ligand-activated plasmacytoid dendritic cells. J Exp Med (2002) 3.02

DDX1, DDX21, and DHX36 helicases form a complex with the adaptor molecule TRIF to sense dsRNA in dendritic cells. Immunity (2011) 3.01

Maintenance and polarization of human TH2 central memory T cells by thymic stromal lymphopoietin-activated dendritic cells. Immunity (2006) 2.95

Two functional subsets of FOXP3+ regulatory T cells in human thymus and periphery. Immunity (2008) 2.78

Isolation and characterization of human umbilical cord mesenchymal stem cells with hematopoiesis-supportive function and other potentials. Haematologica (2006) 2.75

Relationship of obesity with osteoporosis. J Clin Endocrinol Metab (2007) 2.71

Thymic stromal lymphopoietin in normal and pathogenic T cell development and function. Nat Immunol (2006) 2.69

Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8. J Exp Med (2009) 2.66

Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction. J Exp Med (2009) 2.63

TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells. Nat Med (2005) 2.62

The signal transducer STAT5 inhibits plasmacytoid dendritic cell development by suppressing transcription factor IRF8. Immunity (2008) 2.55

A novel subset of CD4(+) T(H)2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma. J Exp Med (2010) 2.53

Development of dendritic-cell lineages. Immunity (2007) 2.53

Stress-related mediators stimulate vascular endothelial growth factor secretion by two ovarian cancer cell lines. Clin Cancer Res (2003) 2.50

Biliary repair and carcinogenesis are mediated by IL-33-dependent cholangiocyte proliferation. J Clin Invest (2014) 2.31

Activation of influenza virus-specific CD4+ and CD8+ T cells: a new role for plasmacytoid dendritic cells in adaptive immunity. Blood (2003) 2.29

Human thymic stromal lymphopoietin promotes dendritic cell-mediated CD4+ T cell homeostatic expansion. Nat Immunol (2004) 2.27

Plasmacytoid dendritic cell-specific receptor ILT7-Fc epsilonRI gamma inhibits Toll-like receptor-induced interferon production. J Exp Med (2006) 2.26

Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells. Proc Natl Acad Sci U S A (2010) 2.25

Human immunoglobulin selection associated with class switch and possible tolerogenic origins for C delta class-switched B cells. J Clin Invest (2004) 2.21

Genome-wide association and follow-up replication studies identified ADAMTS18 and TGFBR3 as bone mass candidate genes in different ethnic groups. Am J Hum Genet (2009) 2.14

Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF-dependent TLR signals, and TLR-independent signals. J Immunol (2006) 2.11

Cutting edge: direct action of thymic stromal lymphopoietin on activated human CD4+ T cells. J Immunol (2007) 2.03

Bone marrow stromal cells transduced with human hemangiopoietin gene support hematopoiesis in vitro. Haematologica (2005) 2.03

PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation. J Exp Med (2008) 2.02

OX40 ligand shuts down IL-10-producing regulatory T cells. Proc Natl Acad Sci U S A (2006) 1.92

A genomewide linkage scan for quantitative-trait loci for obesity phenotypes. Am J Hum Genet (2002) 1.91

Plasmacytoid dendritic cells induce NK cell-dependent, tumor antigen-specific T cell cross-priming and tumor regression in mice. J Clin Invest (2008) 1.91

Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons. J Exp Med (2010) 1.85

Specialization, kinetics, and repertoire of type 1 interferon responses by human plasmacytoid predendritic cells. Blood (2005) 1.79

The DHX33 RNA helicase senses cytosolic RNA and activates the NLRP3 inflammasome. Immunity (2013) 1.78

Plasmacytoid dendritic cell precursors/type I interferon-producing cells sense viral infection by Toll-like receptor (TLR) 7 and TLR9. Springer Semin Immunopathol (2004) 1.72

Mutation patterns at dinucleotide microsatellite loci in humans. Am J Hum Genet (2002) 1.71

Vorinostat inhibits STAT6-mediated TH2 cytokine and TARC production and induces cell death in Hodgkin lymphoma cell lines. Blood (2008) 1.69

Circulating tumor antigen-specific regulatory T cells in patients with metastatic melanoma. Proc Natl Acad Sci U S A (2007) 1.66

From interleukin-23 to T-helper 17 cells: human T-helper cell differentiation revisited. Immunol Rev (2008) 1.65

Identification of a novel CpG DNA class and motif that optimally stimulate B cell and plasmacytoid dendritic cell functions. J Leukoc Biol (2003) 1.65

Plasmacytoid dendritic cells: key players in the initiation and regulation of immune responses. Ann N Y Acad Sci (2010) 1.61

CD34+ hemopoietic progenitor cells are potent effectors of allergic inflammation. J Allergy Clin Immunol (2008) 1.56

Drosophila melanogaster as a model host to dissect the immunopathogenesis of zygomycosis. Proc Natl Acad Sci U S A (2008) 1.54

Heterogeneity of dendritic cells in the mouse liver: identification and characterization of four distinct populations. J Immunol (2003) 1.53

Human dendritic cells activated by TSLP and CD40L induce proallergic cytotoxic T cells. J Exp Med (2003) 1.53

Thymic stromal lymphopoietin-activated plasmacytoid dendritic cells induce the generation of FOXP3+ regulatory T cells in human thymus. J Immunol (2010) 1.51

BDCA2/Fc epsilon RI gamma complex signals through a novel BCR-like pathway in human plasmacytoid dendritic cells. PLoS Biol (2007) 1.49

Molecular studies of identification of genes for osteoporosis: the 2002 update. J Endocrinol (2003) 1.48

Disease-independent skin recruitment and activation of plasmacytoid predendritic cells following imiquimod treatment. J Natl Cancer Inst (2005) 1.46

Natural type I interferon-producing cells as a link between innate and adaptive immunity. Hum Immunol (2002) 1.46

Functional consequences of interactions between human NKR-P1A and its ligand LLT1 expressed on activated dendritic cells and B cells. J Immunol (2008) 1.45

The E3 ubiquitin ligase TRIM21 negatively regulates the innate immune response to intracellular double-stranded DNA. Nat Immunol (2012) 1.45