Published in Clin Exp Pharmacol Physiol on January 04, 2007
Ghrelin: structure and function. Physiol Rev (2005) 4.74
Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction. Nat Med (2006) 4.53
The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats. Gastroenterology (2002) 3.17
Transplantation of mesenchymal stem cells improves cardiac function in a rat model of dilated cardiomyopathy. Circulation (2005) 3.10
Cyclic AMP potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway. Mol Cell Biol (2005) 2.80
Intravenous administration of mesenchymal stem cells improves cardiac function in rats with acute myocardial infarction through angiogenesis and myogenesis. Am J Physiol Heart Circ Physiol (2004) 2.69
Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. J Clin Endocrinol Metab (2002) 2.62
Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca2+ signaling in beta-cells: implication in the glycemic control in rodents. Diabetes (2004) 2.04
Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion. Diabetes (2002) 1.95
Treatment of cachexia with ghrelin in patients with COPD. Chest (2005) 1.87
Hybrid cell-gene therapy for pulmonary hypertension based on phagocytosing action of endothelial progenitor cells. Circulation (2003) 1.86
Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure. Circulation (2004) 1.79
Weight loss increases circulating levels of ghrelin in human obesity. Clin Endocrinol (Oxf) (2002) 1.76
A combination of oral sildenafil and beraprost ameliorates pulmonary hypertension in rats. Am J Respir Crit Care Med (2003) 1.74
Des-acyl ghrelin induces food intake by a mechanism independent of the growth hormone secretagogue receptor. Endocrinology (2006) 1.67
Ghrelin, a novel growth hormone-releasing peptide, in the treatment of cardiopulmonary-associated cachexia. Intern Med (2006) 1.66
Adrenomedullin induces lymphangiogenesis and ameliorates secondary lymphoedema. Cardiovasc Res (2008) 1.64
Ghrelin concentration in cord and neonatal blood: relation to fetal growth and energy balance. J Clin Endocrinol Metab (2003) 1.56
Comparison of angiogenic potency between mesenchymal stem cells and mononuclear cells in a rat model of hindlimb ischemia. Cardiovasc Res (2005) 1.55
Hyperglycaemia suppresses the secretion of ghrelin, a novel growth-hormone-releasing peptide: responses to the intravenous and oral administration of glucose. Clin Sci (Lond) (2002) 1.54
Inhibitory effect of C-type natriuretic peptide (CNP) on cultured cardiac myocyte hypertrophy: interference between CNP and endothelin-1 signaling pathways. Endocrinology (2004) 1.53
Identification and characterization of a novel type of membrane-associated prostaglandin E synthase. Biochem Biophys Res Commun (2002) 1.52
Role of endogenous adrenomedullin in the regulation of vascular tone and ischemic renal injury: studies on transgenic/knockout mice of adrenomedullin gene. Circ Res (2002) 1.49
Role of Rho-kinase signaling and endothelial dysfunction in modulating blood flow distribution in pulmonary hypertension. J Appl Physiol (1985) (2011) 1.48
Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway. Nat Med (2004) 1.48
Beneficial effects of adrenomedullin on left ventricular remodeling after myocardial infarction in rats. Cardiovasc Res (2002) 1.47
Ghrelin directly regulates bone formation. J Bone Miner Res (2004) 1.44
Aldosterone augments adrenomedullin production without stimulating pro-adrenomedullin N-terminal 20 peptide secretion in vascular smooth muscle cells. J Hypertens (2002) 1.44
Postoperative weight loss does not resolve after esophagectomy despite normal serum ghrelin levels. Ann Thorac Surg (2011) 1.43
Endothelial Gab1 deletion accelerates angiotensin II-dependent vascular inflammation and atherosclerosis in apolipoprotein E knockout mice. Circ J (2012) 1.41
Gene expression, secretion, and autocrine action of C-type natriuretic peptide in cultured adult rat cardiac fibroblasts. Endocrinology (2003) 1.40
Ghrelin-induced food intake is mediated via the orexin pathway. Endocrinology (2003) 1.39
Ingested medium-chain fatty acids are directly utilized for the acyl modification of ghrelin. Endocrinology (2005) 1.38
Plasma ghrelin and desacyl ghrelin concentrations in renal failure. J Am Soc Nephrol (2002) 1.37
Central control of bone remodeling by neuromedin U. Nat Med (2007) 1.32
C-type natriuretic peptide, a novel antifibrotic and antihypertrophic agent, prevents cardiac remodeling after myocardial infarction. J Am Coll Cardiol (2005) 1.31
Structural divergence of human ghrelin. Identification of multiple ghrelin-derived molecules produced by post-translational processing. J Biol Chem (2002) 1.30
Biological, physiological, and pharmacological aspects of ghrelin. J Pharmacol Sci (2006) 1.30
Genomic structure and characterization of the 5'-flanking region of the human ghrelin gene. Endocrinology (2004) 1.30
Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance. Diabetes (2006) 1.29
Pharmacokinetics, safety, and endocrine and appetite effects of ghrelin administration in young healthy subjects. Eur J Endocrinol (2004) 1.29
Ghrelin modulates the downstream molecules of insulin signaling in hepatoma cells. J Biol Chem (2001) 1.28
Increased plasma ghrelin level in lung cancer cachexia. Clin Cancer Res (2003) 1.27
Peripheral ghrelin transmits orexigenic signals through the noradrenergic pathway from the hindbrain to the hypothalamus. Cell Metab (2006) 1.26
The GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity. J Clin Invest (2008) 1.26
Regulator of G-protein signaling subtype 4 mediates antihypertrophic effect of locally secreted natriuretic peptides in the heart. Circulation (2008) 1.23
Transplantation of mesenchymal stem cells attenuates myocardial injury and dysfunction in a rat model of acute myocarditis. J Mol Cell Cardiol (2006) 1.22
Diagnostic and prognostic value of plasma brain natriuretic peptide in non-dialysis-dependent CRF. Am J Kidney Dis (2004) 1.20
The role of ghrelin and growth hormone secretagogues receptor on rat adipogenesis. Endocrinology (2003) 1.19
Identification of ghrelin and its receptor in neurons of the rat arcuate nucleus. Regul Pept (2005) 1.19
Delayed short-term secretory regulation of ghrelin in obese animals: evidenced by a specific RIA for the active form of ghrelin. Endocrinology (2002) 1.19
Adrenomedullin infusion attenuates myocardial ischemia/reperfusion injury through the phosphatidylinositol 3-kinase/Akt-dependent pathway. Circulation (2003) 1.18
Ghrelin-producing cells exist as two types of cells, closed- and opened-type cells, in the rat gastrointestinal tract. Peptides (2002) 1.16
Structure and function of ghrelin. Results Probl Cell Differ (2008) 1.15
Transgenic mice overexpressing des-acyl ghrelin show small phenotype. Endocrinology (2004) 1.13
Optimum collection and storage conditions for ghrelin measurements: octanoyl modification of ghrelin is rapidly hydrolyzed to desacyl ghrelin in blood samples. Clin Chem (2004) 1.13
Postoperative ghrelin levels and delayed recovery from body weight loss after distal or total gastrectomy. J Surg Res (2005) 1.12
Peripheral interaction of ghrelin with cholecystokinin on feeding regulation. Endocrinology (2005) 1.12
Ghrelin for cachexia. J Cachexia Sarcopenia Muscle (2010) 1.12
Adrenomedullin, an endogenous peptide, counteracts cardiovascular damage. Circulation (2002) 1.12
Adrenomedullin ameliorates lipopolysaccharide-induced acute lung injury in rats. Am J Physiol Lung Cell Mol Physiol (2007) 1.11
Elevated plasma ghrelin level in underweight patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2004) 1.10
Ghrelin, an orexigenic signaling molecule from the gastrointestinal tract. Curr Opin Pharmacol (2002) 1.07
Effects of sustained length-dependent activation on in situ cross-bridge dynamics in rat hearts. Biophys J (2007) 1.07
Growth hormone secretagogue receptor expression in the cells of the stomach-projected afferent nerve in the rat nodose ganglion. Neurosci Lett (2003) 1.07
Imaging of the pulmonary circulation in the closed-chest rat using synchrotron radiation microangiography. J Appl Physiol (1985) (2006) 1.06
Structure, regulation and function of ghrelin. J Biochem (2011) 1.05
Separate measurement of plasma levels of acylated and desacyl ghrelin in healthy subjects using a new direct ELISA assay. J Clin Endocrinol Metab (2004) 1.04
Adrenomedullin: angiogenesis and gene therapy. Am J Physiol Regul Integr Comp Physiol (2005) 1.04
Adrenomedullin regenerates alveoli and vasculature in elastase-induced pulmonary emphysema in mice. Am J Respir Crit Care Med (2005) 1.04
Morphological analysis of ghrelin and its receptor distribution in the rat pancreas. Regul Pept (2005) 1.04
Ghrelin: more than endogenous growth hormone secretagogue. Ann N Y Acad Sci (2010) 1.03
Production and autocrine/paracrine effects of endogenous insulin-like growth factor-1 in rat cardiac fibroblasts. Regul Pept (2005) 1.03
Alterations of plasma ghrelin levels in rats with lipopolysaccharide-induced wasting syndrome and effects of ghrelin treatment on the syndrome. Endocrinology (2003) 1.03
Identification of neuromedin S and its possible role in the mammalian circadian oscillator system. EMBO J (2005) 1.02
Calcineurin-nuclear factor of activated T cells pathway-dependent cardiac remodeling in mice deficient in guanylyl cyclase A, a receptor for atrial and brain natriuretic peptides. Circulation (2005) 1.02
Anti-cachectic effect of ghrelin in nude mice bearing human melanoma cells. Biochem Biophys Res Commun (2003) 1.02
Ghrelin: a gastric peptide that regulates food intake and energy homeostasis. Regul Pept (2005) 1.01
Ghrelin: from gene to physiological function. Results Probl Cell Differ (2010) 1.01
Ghrelin improves endothelial dysfunction through growth hormone-independent mechanisms in rats. Biochem Biophys Res Commun (2003) 1.01
Enhanced gastric ghrelin production and secretion in rats with gastric outlet obstruction. Dig Dis Sci (2011) 1.01
Acylated ghrelin level in patients with OSA before and after nasal CPAP treatment. Respirology (2008) 1.00
Ghrelin: a multifunctional hormone in non-mammalian vertebrates. Comp Biochem Physiol A Mol Integr Physiol (2007) 1.00
Central actions of neuromedin U via corticotropin-releasing hormone. Biochem Biophys Res Commun (2003) 1.00
Effects of ghrelin administration during chemotherapy with advanced esophageal cancer patients: a prospective, randomized, placebo-controlled phase 2 study. Cancer (2012) 0.99
Somatostatin suppresses ghrelin secretion from the rat stomach. Biochem Biophys Res Commun (2003) 0.99
Transplantation of genetically engineered mesenchymal stem cells improves cardiac function in rats with myocardial infarction: benefit of a novel nonviral vector, cationized dextran. Tissue Eng (2007) 0.99
Establishment of a novel ghrelin-producing cell line. Endocrinology (2010) 0.99
Drug insight: The functions of ghrelin and its potential as a multitherapeutic hormone. Nat Clin Pract Endocrinol Metab (2006) 0.98
Docking protein Gab1 is an essential component of postnatal angiogenesis after ischemia via HGF/c-met signaling. Circ Res (2011) 0.98
Fasting plasma ghrelin levels are negatively correlated with insulin resistance and PAI-1, but not with leptin, in obese children and adolescents. Diabetes (2002) 0.98
The gut-brain peptide neuromedin U is involved in the mammalian circadian oscillator system. Biochem Biophys Res Commun (2004) 0.98
Selective rapid eye movement sleep deprivation impairs the maintenance of long-term potentiation in the rat hippocampus. Eur J Neurosci (2006) 0.98