Published in Genes Dev on January 01, 2007
Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol (2008) 11.43
Senescence of activated stellate cells limits liver fibrosis. Cell (2008) 8.98
The essence of senescence. Genes Dev (2010) 8.21
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat Cell Biol (2009) 7.74
Four faces of cellular senescence. J Cell Biol (2011) 6.86
Autophagy mediates the mitotic senescence transition. Genes Dev (2009) 6.80
Aging, cellular senescence, and cancer. Annu Rev Physiol (2012) 5.08
A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis. J Clin Invest (2010) 3.47
A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations. Nat Struct Mol Biol (2011) 3.10
Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence. Nature (2010) 3.09
JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia. Blood (2010) 2.83
Two faces of p53: aging and tumor suppression. Nucleic Acids Res (2007) 2.78
Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer. Nat Cell Biol (2011) 2.69
Therapy-induced senescence in cancer. J Natl Cancer Inst (2010) 2.45
PR-Set7-dependent lysine methylation ensures genome replication and stability through S phase. J Cell Biol (2007) 2.39
Cellular senescence and its effector programs. Genes Dev (2014) 2.37
RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites. EMBO J (2012) 2.34
DNA damage, cellular senescence and organismal ageing: causal or correlative? Nucleic Acids Res (2007) 2.09
Lamin B1 loss is a senescence-associated biomarker. Mol Biol Cell (2012) 2.03
Metformin: multi-faceted protection against cancer. Oncotarget (2011) 2.00
Oncogenic PIK3CA mutations occur in epidermal nevi and seborrheic keratoses with a characteristic mutation pattern. Proc Natl Acad Sci U S A (2007) 1.97
TGF-beta signaling engages an ATM-CHK2-p53-independent RAS-induced senescence and prevents malignant transformation in human mammary epithelial cells. Proc Natl Acad Sci U S A (2011) 1.94
F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage. Nature (2009) 1.93
Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging. Gene (2007) 1.92
Downregulation of Wnt signaling is a trigger for formation of facultative heterochromatin and onset of cell senescence in primary human cells. Mol Cell (2007) 1.87
Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence. Cell Cycle (2012) 1.67
Real-time in vivo imaging of p16Ink4a reveals cross talk with p53. J Cell Biol (2009) 1.66
Mitochondrial dysfunction contributes to oncogene-induced senescence. Mol Cell Biol (2009) 1.61
Transcriptional patterns, biomarkers and pathways characterizing nasopharyngeal carcinoma of Southern China. J Transl Med (2008) 1.57
Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin. Aging (Albany NY) (2012) 1.57
Elucidating distinct roles for NF1 in melanomagenesis. Cancer Discov (2012) 1.53
MacroH2A1 and ATM Play Opposing Roles in Paracrine Senescence and the Senescence-Associated Secretory Phenotype. Mol Cell (2015) 1.53
The ATR barrier to replication-born DNA damage. DNA Repair (Amst) (2010) 1.50
ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence. Oncogene (2011) 1.45
AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy. Oncogene (2011) 1.45
Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status. Aging Cell (2010) 1.43
A mouse PRMT1 null allele defines an essential role for arginine methylation in genome maintenance and cell proliferation. Mol Cell Biol (2009) 1.40
Functional genomic screens identify CINP as a genome maintenance protein. Proc Natl Acad Sci U S A (2009) 1.38
DDB1-CUL4 and MLL1 mediate oncogene-induced p16INK4a activation. Cancer Res (2009) 1.34
Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage response. Cancer Res (2010) 1.34
Maximal STAT5-induced proliferation and self-renewal at intermediate STAT5 activity levels. Mol Cell Biol (2008) 1.33
Cellular features of senescence during the evolution of human and murine ductal pancreatic cancer. Oncogene (2011) 1.32
The role of BRAF mutation and p53 inactivation during transformation of a subpopulation of primary human melanocytes. Am J Pathol (2009) 1.31
Molecular damage in cancer: an argument for mTOR-driven aging. Aging (Albany NY) (2011) 1.29
Cellular senescence and chromatin structure. Chromosoma (2007) 1.26
UVB-induced senescence in human keratinocytes requires a functional insulin-like growth factor-1 receptor and p53. Mol Biol Cell (2008) 1.26
Regulation of E2Fs and senescence by PML nuclear bodies. Genes Dev (2011) 1.25
Regulation of the Wip1 phosphatase and its effects on the stress response. Front Biosci (Landmark Ed) (2012) 1.24
Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression. PLoS One (2009) 1.22
Beta-catenin expression results in p53-independent DNA damage and oncogene-induced senescence in prelymphomagenic thymocytes in vivo. Mol Cell Biol (2007) 1.21
Senescent cells communicate via intercellular protein transfer. Genes Dev (2015) 1.21
The relative contributions of the p53 and pRb pathways in oncogene-induced melanocyte senescence. Aging (Albany NY) (2009) 1.19
Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation. Genes Dev (2013) 1.18
Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways. Mol Biol Cell (2009) 1.18
DNA damage response to the Mdm2 inhibitor nutlin-3. Biochem Pharmacol (2010) 1.17
Assessing cell and organ senescence biomarkers. Circ Res (2012) 1.17
Senescence and the pro-tumorigenic stroma. Crit Rev Oncog (2013) 1.16
Physiological and pathological consequences of cellular senescence. Cell Mol Life Sci (2014) 1.15
The regulation of p53 by phosphorylation: a model for how distinct signals integrate into the p53 pathway. Aging (Albany NY) (2009) 1.12
p53 mediates senescence-like arrest induced by chronic replicational stress. Mol Cell Biol (2007) 1.11
CENP-A reduction induces a p53-dependent cellular senescence response to protect cells from executing defective mitoses. Mol Cell Biol (2010) 1.11
Cyclin-dependent kinase subunit (Cks) 1 or Cks2 overexpression overrides the DNA damage response barrier triggered by activated oncoproteins. Proc Natl Acad Sci U S A (2011) 1.11
The ATM signaling network in development and disease. Front Genet (2013) 1.09
Growth hormone-STAT5 regulation of growth, hepatocellular carcinoma, and liver metabolism. Ann N Y Acad Sci (2011) 1.09
Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation. Proc Natl Acad Sci U S A (2010) 1.09
Gerosuppressant metformin: less is more. Aging (Albany NY) (2011) 1.08
Ablation of PRMT6 reveals a role as a negative transcriptional regulator of the p53 tumor suppressor. Nucleic Acids Res (2012) 1.07
Proline, glutamic acid and leucine-rich protein-1 is essential for optimal p53-mediated DNA damage response. Cell Death Differ (2014) 1.06
Silencing of the Lats2 tumor suppressor overrides a p53-dependent oncogenic stress checkpoint and enables mutant H-Ras-driven cell transformation. Oncogene (2009) 1.06
A screen for suppressors of gross chromosomal rearrangements identifies a conserved role for PLP in preventing DNA lesions. PLoS Genet (2007) 1.06
Oncogenes and senescence: breaking down in the fast lane. Genes Dev (2007) 1.05
The different functions of Stat5 and chromatin alteration through Stat5 proteins. Front Biosci (2008) 1.05
Unexpected pieces to the senescence puzzle. Cell (2008) 1.04
ATMIN is required for maintenance of genomic stability and suppression of B cell lymphoma. Cancer Cell (2011) 1.03
The autophagy-senescence connection in chemotherapy: must tumor cells (self) eat before they sleep? J Pharmacol Exp Ther (2012) 1.03
Metformin and the ATM DNA damage response (DDR): accelerating the onset of stress-induced senescence to boost protection against cancer. Aging (Albany NY) (2011) 1.01
MutT Homolog 1 (MTH1) maintains multiple KRAS-driven pro-malignant pathways. Oncogene (2014) 1.01
Three steps to the immortality of cancer cells: senescence, polyploidy and self-renewal. Cancer Cell Int (2013) 1.01
Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo. EMBO J (2010) 1.00
DNA double-strand break signaling and human disorders. Genome Integr (2010) 1.00
DNA-damage response network at the crossroads of cell-cycle checkpoints, cellular senescence and apoptosis. J Zhejiang Univ Sci B (2007) 0.99
Oncogenes induce senescence with incomplete growth arrest and suppress the DNA damage response in immortalized cells. Aging Cell (2011) 0.99
Ras-induced senescence and its physiological relevance in cancer. Curr Cancer Drug Targets (2010) 0.99
SOCS1, a novel interaction partner of p53 controlling oncogene-induced senescence. Aging (Albany NY) (2010) 0.98
Modulation of the E2F1-driven cancer cell fate by the DNA damage response machinery and potential novel E2F1 targets in osteosarcomas. Am J Pathol (2009) 0.97
Thresholds of replication stress signaling in cancer development and treatment. Nat Struct Mol Biol (2012) 0.97
Tumor suppression by p53: making cells senescent. Histol Histopathol (2010) 0.96
Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression. Nat Commun (2012) 0.95
The JAK-STAT transcriptional regulator, STAT-5, activates the ATM DNA damage pathway to induce HPV 31 genome amplification upon epithelial differentiation. PLoS Pathog (2013) 0.95
c-MYC functions as a molecular switch to alter the response of human mammary epithelial cells to oncostatin M. Cancer Res (2011) 0.95
Ataxia-telangiectasia: future prospects. Appl Clin Genet (2014) 0.94
Nucleotide metabolism, oncogene-induced senescence and cancer. Cancer Lett (2014) 0.94
The liver-specific tumor suppressor STAT5 controls expression of the reactive oxygen species-generating enzyme NOX4 and the proapoptotic proteins PUMA and BIM in mice. Hepatology (2012) 0.94
Interferon-β induces cellular senescence in cutaneous human papilloma virus-transformed human keratinocytes by affecting p53 transactivating activity. PLoS One (2012) 0.94
Hepatic growth hormone and glucocorticoid receptor signaling in body growth, steatosis and metabolic liver cancer development. Mol Cell Endocrinol (2012) 0.93
IL-6-STAT3 signaling and premature senescence. JAKSTAT (2013) 0.93
Ras-induced ROS upregulation affecting cell proliferation is connected with cell type-specific alterations of HSF1/SESN3/p21Cip1/WAF1 pathways. Cell Cycle (2013) 0.93
Tug of war between survival and death: exploring ATM function in cancer. Int J Mol Sci (2014) 0.92
Lack of TRF2 in ALT cells causes PML-dependent p53 activation and loss of telomeric DNA. J Cell Biol (2007) 0.92
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell (1997) 29.13
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature (2003) 20.13
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature (2005) 18.30
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature (2005) 14.65
A DNA damage checkpoint response in telomere-initiated senescence. Nature (2003) 12.55
Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. Genes Dev (1998) 9.03
Intrinsic tumour suppression. Nature (2004) 8.73
STATs in oncogenesis. Oncogene (2000) 8.60
ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol Cell Biol (2001) 7.26
Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. Proc Natl Acad Sci U S A (2000) 5.64
c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability. Mol Cell (2002) 5.47
Interfaces between the detection, signaling, and repair of DNA damage. Science (2002) 5.33
53BP1, a mediator of the DNA damage checkpoint. Science (2002) 5.00
PML regulates p53 acetylation and premature senescence induced by oncogenic Ras. Nature (2000) 4.90
p19ARF links the tumour suppressor p53 to Ras. Nature (1998) 4.89
E1A signaling to p53 involves the p19(ARF) tumor suppressor. Genes Dev (1998) 4.60
53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer. Nat Cell Biol (2002) 4.45
Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species. J Biol Chem (1999) 4.38
Absence of cancer-associated changes in human fibroblasts immortalized with telomerase. Nat Genet (1999) 4.22
Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions. Genes Dev (2000) 3.74
Checking on the fork: the DNA-replication stress-response pathway. Trends Cell Biol (2002) 3.66
Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor. Mol Cell Biol (2000) 3.37
PML is induced by oncogenic ras and promotes premature senescence. Genes Dev (2000) 3.35
Identification and characterization of a constitutively active STAT5 mutant that promotes cell proliferation. Mol Cell Biol (1998) 3.23
Defective S phase chromatin assembly causes DNA damage, activation of the S phase checkpoint, and S phase arrest. Mol Cell (2003) 3.23
Oncogenic ras and p53 cooperate to induce cellular senescence. Mol Cell Biol (2002) 2.61
Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation. J Biol Chem (2003) 2.54
Chromatin assembly factor 1 is essential and couples chromatin assembly to DNA replication in vivo. Proc Natl Acad Sci U S A (2003) 2.36
Role of p14(ARF) in replicative and induced senescence of human fibroblasts. Mol Cell Biol (2001) 2.27
Arf tumor suppressor promoter monitors latent oncogenic signals in vivo. Proc Natl Acad Sci U S A (2003) 2.07
Chk2 activation and phosphorylation-dependent oligomerization. Mol Cell Biol (2002) 1.88
Expression of catalytically active telomerase does not prevent premature senescence caused by overexpression of oncogenic Ha-Ras in normal human fibroblasts. Cancer Res (1999) 1.86
Regulation of cellular response to oncogenic and oxidative stress by Seladin-1. Nature (2004) 1.80
Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation. Proc Natl Acad Sci U S A (2001) 1.79
DNA damage signaling and p53-dependent senescence after prolonged beta-interferon stimulation. Mol Biol Cell (2006) 1.78
High intensity ras signaling induces premature senescence by activating p38 pathway in primary human fibroblasts. J Biol Chem (2003) 1.76
Chk1 is activated transiently and targets Cdc25A for degradation at the Xenopus midblastula transition. EMBO J (2002) 1.58
Escape from premature senescence is not sufficient for oncogenic transformation by Ras. Nat Cell Biol (2001) 1.36
RNA silencing of checkpoint regulators sensitizes p53-defective prostate cancer cells to chemotherapy while sparing normal cells. Cancer Res (2005) 1.23
Human fibroblasts require the Rb family of tumor suppressors, but not p53, for PML-induced senescence. Oncogene (2004) 1.19
PEA-15 is inhibited by adenovirus E1A and plays a role in ERK nuclear export and Ras-induced senescence. J Biol Chem (2004) 1.15
p19(ARF) is dispensable for oncogenic stress-induced p53-mediated apoptosis and tumor suppression in vivo. Mol Cell Biol (2002) 1.12
An E2F/miR-20a autoregulatory feedback loop. J Biol Chem (2006) 5.20
PML is a direct p53 target that modulates p53 effector functions. Mol Cell (2004) 2.40
Metformin reduces endogenous reactive oxygen species and associated DNA damage. Cancer Prev Res (Phila) (2012) 2.10
DNA damage signaling and p53-dependent senescence after prolonged beta-interferon stimulation. Mol Biol Cell (2006) 1.78
Mitochondrial dysfunction contributes to oncogene-induced senescence. Mol Cell Biol (2009) 1.61
ERKs in cancer: friends or foes? Cancer Res (2014) 1.37
Identification of hammerhead ribozymes in all domains of life reveals novel structural variations. PLoS Comput Biol (2011) 1.29
The DNA damage signaling pathway connects oncogenic stress to cellular senescence. Cell Cycle (2007) 1.28
Regulation of chronological aging in Schizosaccharomyces pombe by the protein kinases Pka1 and Sck2. Aging Cell (2006) 1.26
Regulation of E2Fs and senescence by PML nuclear bodies. Genes Dev (2011) 1.25
RNA silencing of checkpoint regulators sensitizes p53-defective prostate cancer cells to chemotherapy while sparing normal cells. Cancer Res (2005) 1.23
Human fibroblasts require the Rb family of tumor suppressors, but not p53, for PML-induced senescence. Oncogene (2004) 1.19
Pro-aging effects of glucose signaling through a G protein-coupled glucose receptor in fission yeast. PLoS Genet (2009) 1.19
Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation. Genes Dev (2013) 1.18
SOCS1 links cytokine signaling to p53 and senescence. Mol Cell (2009) 1.18
PEA-15 is inhibited by adenovirus E1A and plays a role in ERK nuclear export and Ras-induced senescence. J Biol Chem (2004) 1.15
Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation. Aging Cell (2013) 1.13
Histone deacetylase inhibitors globally enhance h3/h4 tail acetylation without affecting h3 lysine 56 acetylation. Sci Rep (2012) 1.11
The price of tumour suppression? Nature (2002) 1.10
Fission yeast and other yeasts as emergent models to unravel cellular aging in eukaryotes. J Gerontol A Biol Sci Med Sci (2009) 1.03
The activity of the HIV-1 IRES is stimulated by oxidative stress and controlled by a negative regulatory element. Nucleic Acids Res (2010) 1.00
The presence of the TAR RNA structure alters the programmed -1 ribosomal frameshift efficiency of the human immunodeficiency virus type 1 (HIV-1) by modifying the rate of translation initiation. Nucleic Acids Res (2007) 0.98
SOCS1, a novel interaction partner of p53 controlling oncogene-induced senescence. Aging (Albany NY) (2010) 0.98
Urodele p53 tolerates amino acid changes found in p53 variants linked to human cancer. BMC Evol Biol (2007) 0.94
Metformin, aging and cancer. Aging (Albany NY) (2013) 0.93
Myc down-regulation as a mechanism to activate the Rb pathway in STAT5A-induced senescence. J Biol Chem (2007) 0.91
Barriers to Ras transformation. Nat Cell Biol (2007) 0.90
Designing small multiple-target artificial RNAs. Nucleic Acids Res (2010) 0.88
Endogenous oxidative stress prevents telomerase-dependent immortalization of human endothelial cells. Mech Ageing Dev (2010) 0.88
SOCS1 controls liver regeneration by regulating HGF signaling in hepatocytes. J Hepatol (2011) 0.88
PML links aberrant cytokine signaling and oncogenic stress to cellular senescence. Front Biosci (Landmark Ed) (2009) 0.88
Mutant lamin A links prophase to a p53 independent senescence program. Cell Cycle (2015) 0.88
Retinoblastoma-independent regulation of cell proliferation and senescence by the p53-p21 axis in lamin A /C-depleted cells. Aging Cell (2011) 0.87
The 5' UTR of HIV-1 full-length mRNA and the Tat viral protein modulate the programmed -1 ribosomal frameshift that generates HIV-1 enzymes. RNA (2012) 0.84
eIF2α phosphorylation bypasses premature senescence caused by oxidative stress and pro-oxidant antitumor therapies. Aging (Albany NY) (2013) 0.83
CHES1/FOXN3 regulates cell proliferation by repressing PIM2 and protein biosynthesis. Mol Biol Cell (2014) 0.82
A screen for genes involved in respiration control and longevity in Schizosaccharomyces pombe. Ann N Y Acad Sci (2010) 0.82
Transcriptome analysis and tumor suppressor requirements of STAT5-induced senescence. Ann N Y Acad Sci (2010) 0.78
Correction: Deficiency of Interleukin-15 Confers Resistance to Obesity by Diminishing Inflammation and Enhancing the Thermogenic Function of Adipose Tissues. PLoS One (2016) 0.75
[Cytokines prevent tumors via a cell senescence mechanism]. Med Sci (Paris) (2009) 0.75
[The DNA damage response contributes to tumor suppression by sensing oncogenic activity]. Med Sci (Paris) (2008) 0.75