Published in J Biol Chem on November 29, 2006
Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell (2008) 12.29
Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes. Nat Immunol (2008) 10.42
A MicroRNA feedback circuit in midbrain dopamine neurons. Science (2007) 8.33
miRiad roles for the miR-17-92 cluster in development and disease. Cell (2008) 8.02
MicroRNA-mediated feedback and feedforward loops are recurrent network motifs in mammals. Mol Cell (2007) 5.67
MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression. Mol Cell Biol (2008) 4.76
MicroRNAs in cancer. Annu Rev Pathol (2009) 4.47
Global and local architecture of the mammalian microRNA-transcription factor regulatory network. PLoS Comput Biol (2007) 4.31
A C. elegans genome-scale microRNA network contains composite feedback motifs with high flux capacity. Genes Dev (2008) 3.19
MicroRNA: implications for cancer. Virchows Arch (2007) 3.17
mir-17-92, a cluster of miRNAs in the midst of the cancer network. Int J Biochem Cell Biol (2010) 3.15
A GATA-1-regulated microRNA locus essential for erythropoiesis. Proc Natl Acad Sci U S A (2008) 3.10
A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation. J Cell Biol (2008) 3.02
MicroRNA: Biogenesis, Function and Role in Cancer. Curr Genomics (2010) 2.80
MicroRNA MiR-17 retards tissue growth and represses fibronectin expression. Nat Cell Biol (2009) 2.49
MicroRNA and cancer--focus on apoptosis. J Cell Mol Med (2009) 2.44
The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease. Cell Death Differ (2013) 2.41
The MUC1 and galectin-3 oncoproteins function in a microRNA-dependent regulatory loop. Mol Cell (2007) 2.35
Identification of a microRNA signature of renal ischemia reperfusion injury. Proc Natl Acad Sci U S A (2010) 2.31
Flow-Dependent Regulation of Kruppel-Like Factor 2 Is Mediated by MicroRNA-92a. Circulation (2011) 2.29
The miR-17-5p microRNA is a key regulator of the G1/S phase cell cycle transition. Genome Biol (2008) 2.29
Estradiol-regulated microRNAs control estradiol response in breast cancer cells. Nucleic Acids Res (2009) 2.27
Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia. Blood (2009) 2.26
MicroRNA regulation of a cancer network: consequences of the feedback loops involving miR-17-92, E2F, and Myc. Proc Natl Acad Sci U S A (2008) 2.24
Retracted Differential expression of microRNAs in myometrium and leiomyomas and regulation by ovarian steroids. J Cell Mol Med (2007) 2.24
Leukaemogenesis: more than mutant genes. Nat Rev Cancer (2010) 2.16
Modulation of the osteosarcoma expression phenotype by microRNAs. PLoS One (2012) 2.06
p53-Repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation. Mol Syst Biol (2008) 2.04
Elevated expression of the miR-17-92 polycistron and miR-21 in hepadnavirus-associated hepatocellular carcinoma contributes to the malignant phenotype. Am J Pathol (2008) 2.03
MicroRNA-17~92 plays a causative role in lymphomagenesis by coordinating multiple oncogenic pathways. EMBO J (2013) 2.01
Hypoxia response and microRNAs: no longer two separate worlds. J Cell Mol Med (2008) 1.93
miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A. Genes Dev (2009) 1.91
The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression. Cancer Res (2010) 1.88
MiR-17-92 cluster is associated with 13q gain and c-myc expression during colorectal adenoma to adenocarcinoma progression. Br J Cancer (2009) 1.87
miR-17 and miR-20a temper an E2F1-induced G1 checkpoint to regulate cell cycle progression. Oncogene (2008) 1.86
miR-145 participates with TP53 in a death-promoting regulatory loop and targets estrogen receptor-alpha in human breast cancer cells. Cell Death Differ (2009) 1.82
MiR-93 enhances angiogenesis and metastasis by targeting LATS2. Cell Cycle (2012) 1.74
The role of miRNAs in regulating gene expression networks. J Mol Biol (2013) 1.74
The interplay between transcription factors and microRNAs in genome-scale regulatory networks. Bioessays (2009) 1.72
Evolution under canalization and the dual roles of microRNAs: a hypothesis. Genome Res (2009) 1.72
MicroRNA-127 modulates fetal lung development. Physiol Genomics (2009) 1.68
miR-17~92 cooperates with RB pathway mutations to promote retinoblastoma. Genes Dev (2011) 1.66
Lung development: orchestrating the generation and regeneration of a complex organ. Development (2014) 1.66
The miR-17-92 cluster of microRNAs confers tumorigenicity by inhibiting oncogene-induced senescence. Cancer Res (2010) 1.60
Myc: Maestro of MicroRNAs. Genes Cancer (2010) 1.58
The inhibition of the highly expressed miR-221 and miR-222 impairs the growth of prostate carcinoma xenografts in mice. PLoS One (2008) 1.56
An overview of microRNAs. Adv Drug Deliv Rev (2015) 1.48
Inter- and intra-combinatorial regulation by transcription factors and microRNAs. BMC Genomics (2007) 1.45
"Myc'ed messages": myc induces transcription of E2F1 while inhibiting its translation via a microRNA polycistron. PLoS Genet (2007) 1.45
Both mature miR-17-5p and passenger strand miR-17-3p target TIMP3 and induce prostate tumor growth and invasion. Nucleic Acids Res (2013) 1.44
Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia. Proc Natl Acad Sci U S A (2010) 1.43
A feed-forward loop involving protein kinase Calpha and microRNAs regulates tumor cell cycle. Cancer Res (2009) 1.43
Uncoupling of expression of an intronic microRNA and its myosin host gene by exon skipping. Mol Cell Biol (2010) 1.43
The microRNA-17-92 family of microRNA clusters in development and disease. Cancer J (2012) 1.42
Circular reasoning: microRNAs and cell-cycle control. Trends Biochem Sci (2008) 1.41
MicroRNAs MiR-17, MiR-20a, and MiR-106b act in concert to modulate E2F activity on cell cycle arrest during neuronal lineage differentiation of USSC. PLoS One (2011) 1.40
MicroRNAome genome: a treasure for cancer diagnosis and therapy. CA Cancer J Clin (2014) 1.40
A novel microRNA and transcription factor mediated regulatory network in schizophrenia. BMC Syst Biol (2010) 1.40
miRNA regulation of cytokine genes. Cytokine (2009) 1.39
Dysregulation of circulating microRNAs and prediction of aggressive prostate cancer. Prostate (2012) 1.39
MicroRNAs of the immune system: roles in inflammation and cancer. Ann N Y Acad Sci (2010) 1.37
Pumilio facilitates miRNA regulation of the E2F3 oncogene. Genes Dev (2012) 1.36
MicroRNAs and prostate cancer. J Cell Mol Med (2008) 1.33
Functional integration of microRNAs into oncogenic and tumor suppressor pathways. Cell Cycle (2008) 1.33
MIR@NT@N: a framework integrating transcription factors, microRNAs and their targets to identify sub-network motifs in a meta-regulation network model. BMC Bioinformatics (2011) 1.33
Towards computational prediction of microRNA function and activity. Nucleic Acids Res (2010) 1.32
miRNA response to DNA damage. Trends Biochem Sci (2011) 1.32
Epigenetic silencing of the oncogenic miR-17-92 cluster during PU.1-directed macrophage differentiation. EMBO J (2011) 1.30
MicroRNA networks in mouse lung organogenesis. PLoS One (2010) 1.28
Diagnostic, prognostic and therapeutic implications of microRNAs in urologic tumors. Nat Rev Urol (2010) 1.28
Exosome mimetics: a novel class of drug delivery systems. Int J Nanomedicine (2012) 1.27
microRNAs are biomarkers of oncogenic human papillomavirus infections. Proc Natl Acad Sci U S A (2014) 1.25
Network calisthenics: control of E2F dynamics in cell cycle entry. Cell Cycle (2011) 1.25
MiRNAs confer phenotypic robustness to gene networks by suppressing biological noise. Nat Commun (2013) 1.24
MiR-19a/b modulate the metastasis of gastric cancer cells by targeting the tumour suppressor MXD1. Cell Death Dis (2014) 1.24
A high throughput experimental approach to identify miRNA targets in human cells. Nucleic Acids Res (2009) 1.24
Tumorigenicity of the miR-17-92 cluster distilled. Genes Dev (2010) 1.22
The Roles of MicroRNAs in the Cancer Invasion-Metastasis Cascade. Cancer Microenviron (2010) 1.21
MicroRNA signature and regulatory functions in the endometrium during normal and disease states. Semin Reprod Med (2008) 1.20
miR-18a impairs DNA damage response through downregulation of ataxia telangiectasia mutated (ATM) kinase. PLoS One (2011) 1.20
Estrogen Regulation of MicroRNA Expression. Curr Genomics (2009) 1.20
Temporal expression of microRNA cluster miR-17-92 regulates effector and memory CD8+ T-cell differentiation. Proc Natl Acad Sci U S A (2012) 1.20
A microRNA-dependent circuit controlling p63/p73 homeostasis: p53 family cross-talk meets therapeutic opportunity. Oncotarget (2011) 1.19
MicroRNAs in the pathogenesis of Lung Cancer. J Thorac Oncol (2009) 1.17
Deciphering the transcriptional circuitry of microRNA genes expressed during human monocytic differentiation. BMC Genomics (2009) 1.14
Glucocorticoid-mediated repression of the oncogenic microRNA cluster miR-17~92 contributes to the induction of Bim and initiation of apoptosis. Mol Endocrinol (2011) 1.13
Shielding the messenger (RNA): microRNA-based anticancer therapies. Pharmacol Ther (2011) 1.12
Feud or Friend? The Role of the miR-17-92 Cluster in Tumorigenesis. Curr Genomics (2010) 1.09
miR-17-92 expression in differentiated T cells - implications for cancer immunotherapy. J Transl Med (2010) 1.07
The role of microRNAs in glioma initiation and progression. Front Biosci (Landmark Ed) (2012) 1.07
MicroRNAs in hepatocellular carcinoma: carcinogenesis, progression, and therapeutic target. Biomed Res Int (2014) 1.07
MicroRNAs in immune regulation--opportunities for cancer immunotherapy. Int J Biochem Cell Biol (2010) 1.06
MicroRNAs and the cancer phenotype: profiling, signatures and clinical implications. Genome Med (2013) 1.05
miR-106b-25/miR-17-92 clusters: polycistrons with oncogenic roles in hepatocellular carcinoma. World J Gastroenterol (2014) 1.03
MicroRNA and ovarian cancer. Histol Histopathol (2008) 1.03
The roles of microRNAs in tumorigenesis and angiogenesis. Int J Physiol Pathophysiol Pharmacol (2010) 1.03
MicroRNA-18a is elevated in prostate cancer and promotes tumorigenesis through suppressing STK4 in vitro and in vivo. Oncogenesis (2014) 1.03
microRNAs and lung cancer: tumors and 22-mers. Cancer Metastasis Rev (2010) 1.01
miR-200c inhibits invasion, migration and proliferation of bladder cancer cells through down-regulation of BMI-1 and E2F3. J Transl Med (2014) 1.01
MicroRNAs and lung cancers: from pathogenesis to clinical implications. Front Med (2012) 1.00
Cutting edge: 1,25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression. J Immunol (2004) 6.35
The MC-Fold and MC-Sym pipeline infers RNA structure from sequence data. Nature (2008) 5.67
RNAML: a standard syntax for exchanging RNA information. RNA (2002) 5.34
The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence. Genes Dev (2007) 4.91
The RNA Ontology Consortium: an open invitation to the RNA community. RNA (2006) 3.60
Autism-related deficits via dysregulated eIF4E-dependent translational control. Nature (2012) 3.13
Oncogenic ras and p53 cooperate to induce cellular senescence. Mol Cell Biol (2002) 2.61
PML is a direct p53 target that modulates p53 effector functions. Mol Cell (2004) 2.40
Staufen1 regulates diverse classes of mammalian transcripts. EMBO J (2007) 2.18
Metformin reduces endogenous reactive oxygen species and associated DNA damage. Cancer Prev Res (Phila) (2012) 2.10
RNA canonical and non-canonical base pairing types: a recognition method and complete repertoire. Nucleic Acids Res (2002) 2.03
Telomeric noncoding RNA TERRA is induced by telomere shortening to nucleate telomerase molecules at short telomeres. Mol Cell (2013) 1.89
RNA-Puzzles: a CASP-like evaluation of RNA three-dimensional structure prediction. RNA (2012) 1.88
New metrics for comparing and assessing discrepancies between RNA 3D structures and models. RNA (2009) 1.78
DNA damage signaling and p53-dependent senescence after prolonged beta-interferon stimulation. Mol Biol Cell (2006) 1.78
Mitochondrial dysfunction contributes to oncogene-induced senescence. Mol Cell Biol (2009) 1.61
Local activation of yeast ASH1 mRNA translation through phosphorylation of Khd1p by the casein kinase Yck1p. Mol Cell (2007) 1.54
Local regulation of mRNA translation: new insights from the bud. Trends Cell Biol (2008) 1.52
Identification of a conserved RNA motif essential for She2p recognition and mRNA localization to the yeast bud. Mol Cell Biol (2005) 1.46
Regulation of GREB1 transcription by estrogen receptor alpha through a multipartite enhancer spread over 20 kb of upstream flanking sequences. J Biol Chem (2007) 1.38
ERKs in cancer: friends or foes? Cancer Res (2014) 1.37
Live cell imaging of telomerase RNA dynamics reveals cell cycle-dependent clustering of telomerase at elongating telomeres. Mol Cell (2011) 1.33
Identification of hammerhead ribozymes in all domains of life reveals novel structural variations. PLoS Comput Biol (2011) 1.29
The DNA damage signaling pathway connects oncogenic stress to cellular senescence. Cell Cycle (2007) 1.28
Regulation of chronological aging in Schizosaccharomyces pombe by the protein kinases Pka1 and Sck2. Aging Cell (2006) 1.26
Regulation of E2Fs and senescence by PML nuclear bodies. Genes Dev (2011) 1.25
TLC1 RNA nucleo-cytoplasmic trafficking links telomerase biogenesis to its recruitment to telomeres. EMBO J (2008) 1.24
Cotranscriptional recruitment of She2p by RNA pol II elongation factor Spt4-Spt5/DSIF promotes mRNA localization to the yeast bud. Genes Dev (2010) 1.24
Genetic mapping of activity determinants within cellular prion proteins: N-terminal modules in PrPC offset pro-apoptotic activity of the Doppel helix B/B' region. J Biol Chem (2004) 1.23
RNA silencing of checkpoint regulators sensitizes p53-defective prostate cancer cells to chemotherapy while sparing normal cells. Cancer Res (2005) 1.23
Nuclear shuttling of She2p couples ASH1 mRNA localization to its translational repression by recruiting Loc1p and Puf6p. Mol Biol Cell (2009) 1.21
Human fibroblasts require the Rb family of tumor suppressors, but not p53, for PML-induced senescence. Oncogene (2004) 1.19
Pro-aging effects of glucose signaling through a G protein-coupled glucose receptor in fission yeast. PLoS Genet (2009) 1.19
SOCS1 links cytokine signaling to p53 and senescence. Mol Cell (2009) 1.18
Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation. Genes Dev (2013) 1.18
Automated extraction and classification of RNA tertiary structure cyclic motifs. Nucleic Acids Res (2006) 1.15
PEA-15 is inhibited by adenovirus E1A and plays a role in ERK nuclear export and Ras-induced senescence. J Biol Chem (2004) 1.15
Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation. Aging Cell (2013) 1.13
Histone deacetylase inhibitors globally enhance h3/h4 tail acetylation without affecting h3 lysine 56 acetylation. Sci Rep (2012) 1.11
The price of tumour suppression? Nature (2002) 1.10
Mutually exclusive binding of telomerase RNA and DNA by Ku alters telomerase recruitment model. Cell (2012) 1.08
Cdc42-interacting protein 4 is a Src substrate that regulates invadopodia and invasiveness of breast tumors by promoting MT1-MMP endocytosis. J Cell Sci (2011) 1.08
Convergence of vitamin D and retinoic acid signalling at a common hormone response element. EMBO Rep (2006) 1.04
Recognition and coupling of A-to-I edited sites are determined by the tertiary structure of the RNA. Nucleic Acids Res (2009) 1.04
Neuron-derived semaphorin 3A is an early inducer of vascular permeability in diabetic retinopathy via neuropilin-1. Cell Metab (2013) 1.03
Fission yeast and other yeasts as emergent models to unravel cellular aging in eukaryotes. J Gerontol A Biol Sci Med Sci (2009) 1.03
The activity of the HIV-1 IRES is stimulated by oxidative stress and controlled by a negative regulatory element. Nucleic Acids Res (2010) 1.00
Role of SLV in SLI substrate recognition by the Neurospora VS ribozyme. RNA (2008) 1.00
RNA structure determination using SAXS data. J Phys Chem B (2010) 0.99
The presence of the TAR RNA structure alters the programmed -1 ribosomal frameshift efficiency of the human immunodeficiency virus type 1 (HIV-1) by modifying the rate of translation initiation. Nucleic Acids Res (2007) 0.98
SOCS1, a novel interaction partner of p53 controlling oncogene-induced senescence. Aging (Albany NY) (2010) 0.98
A comparative analysis of the triloops in all high-resolution RNA structures reveals sequence structure relationships. RNA (2007) 0.95
Using fluorescent proteins to study mRNA trafficking in living cells. Methods Cell Biol (2008) 0.95
Urodele p53 tolerates amino acid changes found in p53 variants linked to human cancer. BMC Evol Biol (2007) 0.94
Metformin, aging and cancer. Aging (Albany NY) (2013) 0.93
RNA G-Quadruplexes in the model plant species Arabidopsis thaliana: prevalence and possible functional roles. Nucleic Acids Res (2010) 0.92
Myc down-regulation as a mechanism to activate the Rb pathway in STAT5A-induced senescence. J Biol Chem (2007) 0.91
Stochastic and reversible aggregation of mRNA with expanded CUG-triplet repeats. J Cell Sci (2011) 0.90
Barriers to Ras transformation. Nat Cell Biol (2007) 0.90
Towards 3D structure prediction of large RNA molecules: an integer programming framework to insert local 3D motifs in RNA secondary structure. Bioinformatics (2012) 0.90
The ERPIN server: an interface to profile-based RNA motif identification. Nucleic Acids Res (2004) 0.89
Endogenous oxidative stress prevents telomerase-dependent immortalization of human endothelial cells. Mech Ageing Dev (2010) 0.88
PML links aberrant cytokine signaling and oncogenic stress to cellular senescence. Front Biosci (Landmark Ed) (2009) 0.88
SOCS1 controls liver regeneration by regulating HGF signaling in hepatocytes. J Hepatol (2011) 0.88
Designing small multiple-target artificial RNAs. Nucleic Acids Res (2010) 0.88
Telomerase biogenesis: The long road before getting to the end. RNA Biol (2008) 0.88
Mutant lamin A links prophase to a p53 independent senescence program. Cell Cycle (2015) 0.88
Novel multiplex PCR approaches for the simultaneous detection of human pathogens: Escherichia coli 0157:H7 and Listeria monocytogenes. J Microbiol Methods (2006) 0.87
Determining RNA three-dimensional structures using low-resolution data. J Struct Biol (2012) 0.87
Retinoblastoma-independent regulation of cell proliferation and senescence by the p53-p21 axis in lamin A /C-depleted cells. Aging Cell (2011) 0.87
Modeling RNA tertiary structure motifs by graph-grammars. Nucleic Acids Res (2007) 0.86
Molecular basis of TRAP-5'SL RNA interaction in the Bacillus subtilis trp operon transcription attenuation mechanism. RNA (2008) 0.86
Control of cytoplasmic mRNA localization. Cell Mol Life Sci (2011) 0.85
RKB: a Semantic Web knowledge base for RNA. J Biomed Semantics (2010) 0.85
The 5' UTR of HIV-1 full-length mRNA and the Tat viral protein modulate the programmed -1 ribosomal frameshift that generates HIV-1 enzymes. RNA (2012) 0.84
Ranking the factors that contribute to protein beta-sheet folding. Proteins (2007) 0.84
A 6374 unigene set corresponding to low abundance transcripts expressed following fertilization in Solanum chacoense Bitt, and characterization of 30 receptor-like kinases. Plant Mol Biol (2005) 0.83
eIF2α phosphorylation bypasses premature senescence caused by oxidative stress and pro-oxidant antitumor therapies. Aging (Albany NY) (2013) 0.83
p53: is the guardian of the genome also a suppressor of cell invasion? Cell Cycle (2009) 0.83
CHES1/FOXN3 regulates cell proliferation by repressing PIM2 and protein biosynthesis. Mol Biol Cell (2014) 0.82
A screen for genes involved in respiration control and longevity in Schizosaccharomyces pombe. Ann N Y Acad Sci (2010) 0.82