Published in Nature on November 18, 2004
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature (2007) 16.95
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature (2005) 15.83
Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell (2006) 12.72
The essence of senescence. Genes Dev (2010) 8.21
Cancer drug resistance: an evolving paradigm. Nat Rev Cancer (2013) 6.77
Senescence in tumours: evidence from mice and humans. Nat Rev Cancer (2010) 6.34
Tumor heterogeneity: causes and consequences. Biochim Biophys Acta (2009) 5.90
The hallmarks of cancer: a long non-coding RNA point of view. RNA Biol (2012) 5.60
microRNAs join the p53 network--another piece in the tumour-suppression puzzle. Nat Rev Cancer (2007) 5.38
Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance. Blood (2007) 4.91
The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence. Genes Dev (2007) 4.91
Growth arrest and autophagy are required for salivary gland cell degradation in Drosophila. Cell (2007) 4.55
Distinct thresholds govern Myc's biological output in vivo. Cancer Cell (2008) 4.16
Tumour suppression by p53: a role for the DNA damage response? Nat Rev Cancer (2009) 4.06
A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis. Science (2011) 3.49
A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence. Nature (2013) 3.46
WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature. Nature (2005) 3.44
Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation. Proc Natl Acad Sci U S A (2007) 3.37
BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution. Nucleic Acids Res (2006) 3.29
Short telomeres limit tumor progression in vivo by inducing senescence. Cancer Cell (2007) 3.23
To kill a tumor cell: the potential of proapoptotic receptor agonists. J Clin Invest (2008) 3.05
Loss of heterozygosity (LOH) profiles--validated risk predictors for progression to oral cancer. Cancer Prev Res (Phila) (2012) 3.03
Mouse models of human AML accurately predict chemotherapy response. Genes Dev (2009) 2.75
AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations. Mol Cell (2009) 2.75
Cellular stress responses: cell survival and cell death. Int J Cell Biol (2010) 2.74
Long-range enhancers on 8q24 regulate c-Myc. Proc Natl Acad Sci U S A (2010) 2.54
Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600. Proc Natl Acad Sci U S A (2005) 2.51
HIF1alpha delays premature senescence through the activation of MIF. Genes Dev (2006) 2.37
Mechanisms of programmed DNA lesions and genomic instability in the immune system. Cell (2013) 2.32
Synergistic response to oncogenic mutations defines gene class critical to cancer phenotype. Nature (2008) 2.32
Inhibitors of histone deacetylases target the Rb-E2F1 pathway for apoptosis induction through activation of proapoptotic protein Bim. Proc Natl Acad Sci U S A (2005) 2.07
Exquisite sensitivity of TP53 mutant and basal breast cancers to a dose-dense epirubicin-cyclophosphamide regimen. PLoS Med (2007) 2.00
Bcl-2 family proteins contribute to apoptotic resistance in lung cancer multicellular spheroids. Am J Respir Cell Mol Biol (2008) 1.99
Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence. EMBO Rep (2007) 1.96
Intrinsic tumor suppression and epithelial maintenance by endocytic activation of Eiger/TNF signaling in Drosophila. Dev Cell (2009) 1.95
MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition. J Exp Med (2012) 1.85
Expanded and fat regulate growth and differentiation in the Drosophila eye through multiple signaling pathways. Dev Biol (2007) 1.82
Mechanisms governing metastatic dormancy and reactivation. Cell (2013) 1.81
Small-molecule modulators of p53 family signaling and antitumor effects in p53-deficient human colon tumor xenografts. Proc Natl Acad Sci U S A (2006) 1.80
DNA damage signaling and p53-dependent senescence after prolonged beta-interferon stimulation. Mol Biol Cell (2006) 1.78
Loss of p53 impedes the antileukemic response to BCR-ABL inhibition. Proc Natl Acad Sci U S A (2006) 1.71
PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling. Mol Cell (2012) 1.71
Loss of linker histone H1 in cellular senescence. J Cell Biol (2006) 1.71
Cancer gene discovery in hepatocellular carcinoma. J Hepatol (2010) 1.68
Differential effects on ARF stability by normal versus oncogenic levels of c-Myc expression. Mol Cell (2013) 1.67
Real-time in vivo imaging of p16Ink4a reveals cross talk with p53. J Cell Biol (2009) 1.66
CPEB regulation of human cellular senescence, energy metabolism, and p53 mRNA translation. Genes Dev (2008) 1.66
Irradiation selects for p53-deficient hematopoietic progenitors. PLoS Biol (2010) 1.65
Stressin' Sestrins take an aging fight. EMBO Mol Med (2010) 1.65
Mitochondrial dysfunction contributes to oncogene-induced senescence. Mol Cell Biol (2009) 1.61
The miR-17-92 cluster of microRNAs confers tumorigenicity by inhibiting oncogene-induced senescence. Cancer Res (2010) 1.60
Oncogenic activities of human papillomaviruses. Virus Res (2009) 1.60
Hyperactivation of Ha-ras oncogene, but not Ink4a/Arf deficiency, triggers bladder tumorigenesis. J Clin Invest (2007) 1.59
A systematic search for downstream mediators of tumor suppressor function of p53 reveals a major role of BTG2 in suppression of Ras-induced transformation. Genes Dev (2006) 1.58
Oncogenic KRas suppresses inflammation-associated senescence of pancreatic ductal cells. Cancer Cell (2010) 1.58
Survival and death signals can predict tumor response to therapy after oncogene inactivation. Sci Transl Med (2011) 1.56
Dual autonomous mitochondrial cell death pathways are activated by Nix/BNip3L and induce cardiomyopathy. Proc Natl Acad Sci U S A (2010) 1.54
Dual roles for NFAT transcription factor genes as oncogenes and tumor suppressors. Mol Cell Biol (2008) 1.52
MYC activation is a hallmark of cancer initiation and maintenance. Cold Spring Harb Perspect Med (2014) 1.51
Oncogene-induced cellular senescence elicits an anti-Warburg effect. Proteomics (2013) 1.50
A threshold mechanism mediates p53 cell fate decision between growth arrest and apoptosis. Cell Death Differ (2013) 1.50
Mitochondrial outer membrane proteins assist Bid in Bax-mediated lipidic pore formation. Mol Biol Cell (2009) 1.48
Obligatory participation of macrophages in an angiopoietin 2-mediated cell death switch. Development (2007) 1.47
AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy. Oncogene (2011) 1.45
Mammalian target of rapamycin contributes to the acquired apoptotic resistance of human mesothelioma multicellular spheroids. J Biol Chem (2008) 1.45
Anti cancer effects of curcumin: cycle of life and death. Cell Div (2008) 1.45
PAC-1 activates procaspase-3 in vitro through relief of zinc-mediated inhibition. J Mol Biol (2009) 1.41
The p53-Bcl-2 connection. Cell Death Differ (2006) 1.39
Identifying tightly regulated and variably expressed networks by Differential Rank Conservation (DIRAC). PLoS Comput Biol (2010) 1.38
MYC through miR-17-92 suppresses specific target genes to maintain survival, autonomous proliferation, and a neoplastic state. Cancer Cell (2014) 1.36
Decoding and unlocking the BCL-2 dependency of cancer cells. Nat Rev Cancer (2013) 1.36
Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation. Proc Natl Acad Sci U S A (2009) 1.36
Increased vascular senescence and impaired endothelial progenitor cell function mediated by mutation of circadian gene Per2. Circulation (2008) 1.36
Myxoma virus M-T5 protects infected cells from the stress of cell cycle arrest through its interaction with host cell cullin-1. J Virol (2005) 1.33
Regulation of ploidy and senescence by the AMPK-related kinase NUAK1. EMBO J (2009) 1.33
mir-17-92: a polycistronic oncomir with pleiotropic functions. Immunol Rev (2013) 1.32
Explaining oscillations and variability in the p53-Mdm2 system. BMC Syst Biol (2008) 1.31
Tissue-specific p19Arf regulation dictates the response to oncogenic K-ras. Proc Natl Acad Sci U S A (2010) 1.28
The circadian clock in cancer development and therapy. Prog Mol Biol Transl Sci (2013) 1.28
Initiation of genome instability and preneoplastic processes through loss of Fhit expression. PLoS Genet (2012) 1.27
The p53-cathepsin axis cooperates with ROS to activate programmed necrotic death upon DNA damage. Proc Natl Acad Sci U S A (2009) 1.27
Apoptotic pathways in pancreatic ductal adenocarcinoma. Mol Cancer (2008) 1.26
CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner. EMBO J (2007) 1.25
p14ARF activates a Tip60-dependent and p53-independent ATM/ATR/CHK pathway in response to genotoxic stress. Mol Cell Biol (2006) 1.25
Catalytic, Enantioselective Synthesis of Stilbene cis-Diamines: A Concise Preparation of (-)-Nutlin-3, a Potent p53/MDM2 Inhibitor. Chem Sci (2011) 1.25
Esophageal cancer-related gene 4 is a secreted inducer of cell senescence expressed by aged CNS precursor cells. Proc Natl Acad Sci U S A (2010) 1.24
Apoptotic cell signaling in cancer progression and therapy. Integr Biol (Camb) (2011) 1.22
Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2. Proc Natl Acad Sci U S A (2008) 1.22
Mechanism of von Hippel-Lindau protein-mediated suppression of nuclear factor kappa B activity. Mol Cell Biol (2005) 1.22
The novel Aurora A kinase inhibitor MLN8237 is active in resistant chronic myeloid leukaemia and significantly increases the efficacy of nilotinib. J Cell Mol Med (2011) 1.22
Restoring expression of wild-type p53 suppresses tumor growth but does not cause tumor regression in mice with a p53 missense mutation. J Clin Invest (2011) 1.21
Selective inactivation of a Fas-associated death domain protein (FADD)-dependent apoptosis and autophagy pathway in immortal epithelial cells. Mol Biol Cell (2005) 1.21
Declining cellular fitness with age promotes cancer initiation by selecting for adaptive oncogenic mutations. Biochim Biophys Acta (2007) 1.21
Acute overexpression of Myc in intestinal epithelium recapitulates some but not all the changes elicited by Wnt/beta-catenin pathway activation. Mol Cell Biol (2009) 1.21
A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis. Elife (2013) 1.20
Akt versus p53 in a network of oncogenes and tumor suppressor genes regulating cell survival and death. Biophys J (2006) 1.20
Intrinsic sensor of oncogenic transformation induces a signal for innate immunosurveillance. Proc Natl Acad Sci U S A (2008) 1.20
Evolutionary determinants of cancer. Cancer Discov (2015) 1.19
Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation. Genes Dev (2013) 1.18
c-MYC: more than just a matter of life and death. Nat Rev Cancer (2002) 6.73
c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis. Oncogene (2003) 2.21
Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis. J Cell Biol (2002) 1.75
Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis. BMC Cell Biol (2013) 1.64
c-Myc functionally cooperates with Bax to induce apoptosis. Mol Cell Biol (2002) 1.43
Tumor angiogenesis: cause or consequence of cancer? Cancer Res (2007) 1.35
Upstream regulatory role for XIAP in receptor-mediated apoptosis. Mol Cell Biol (2004) 1.28
Minimal BH3 peptides promote cell death by antagonizing anti-apoptotic proteins. J Biol Chem (2003) 1.14
Myc-Is this the oncogene from Hell? Cancer Cell (2002) 1.10
c-Myc augments the apoptotic activity of cytosolic death receptor signaling proteins by engaging the mitochondrial apoptotic pathway. J Biol Chem (2002) 1.09
Oxidised lipoproteins may promote inflammation through the selective delay of engulfment but not binding of apoptotic cells by macrophages. Atherosclerosis (2003) 0.95
Differentiation-dependent sensitivity to apoptogenic factors in PC12 cells. J Biol Chem (2004) 0.89
Genetic analysis of myc and telomerase interactions in vivo. Mol Cell Biol (2006) 0.89
R115777 induces Ras-independent apoptosis of myeloma cells via multiple intrinsic pathways. Mol Cancer Ther (2004) 0.88
Wild type p53 transcriptionally represses the SALL2 transcription factor under genotoxic stress. PLoS One (2013) 0.79
The future of cancer therapy: an interview with Gerard Evan. Dis Model Mech (2008) 0.75
Corrigendum: A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers. Nat Genet (2017) 0.75