Published in Aging Cell on September 16, 2011
Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update. Arch Toxicol (2012) 2.04
Mechanism-based epigenetic chemosensitization therapy of diffuse large B-cell lymphoma. Cancer Discov (2013) 1.90
Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions. EMBO J (2012) 1.71
Immortalization of normal human mammary epithelial cells in two steps by direct targeting of senescence barriers does not require gross genomic alterations. Cell Cycle (2014) 1.05
Molecular chaperones in mammary cancer growth and breast tumor therapy. J Cell Biochem (2012) 1.05
Three steps to the immortality of cancer cells: senescence, polyploidy and self-renewal. Cancer Cell Int (2013) 1.01
Role of stress-activated OCT4A in the cell fate decisions of embryonal carcinoma cells treated with etoposide. Cell Cycle (2015) 0.95
HSF1, a versatile factor in tumorogenesis. Curr Mol Med (2012) 0.87
Disentangling the aneuploidy and senescence paradoxes: a study of triploid breast cancers non-responsive to neoadjuvant therapy. Histochem Cell Biol (2016) 0.84
Therapeutic targeting of replicative immortality. Semin Cancer Biol (2015) 0.83
Exome-wide mutation profile in benzo[a]pyrene-derived post-stasis and immortal human mammary epithelial cells. Mutat Res Genet Toxicol Environ Mutagen (2014) 0.83
Polyploidy Formation in Doxorubicin-Treated Cancer Cells Can Favor Escape from Senescence. Neoplasia (2015) 0.78
Epigenetic approaches for chemosensitization of refractory diffuse large B-cell lymphomas. Cancer Discov (2013) 0.78
Aging phenotypes in cultured normal human mammary epithelial cells are correlated with decreased telomerase activity independent of telomere length. Genome Integr (2013) 0.78
Oncogene-triggered suppression of DNA repair leads to DNA instability in cancer. Oncotarget (2014) 0.76
The role of nibrin in doxorubicin-induced apoptosis and cell senescence in Nijmegen Breakage Syndrome patients lymphocytes. PLoS One (2014) 0.75
The damaging effect of passenger mutations on cancer progression. Cancer Res (2017) 0.75
Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science (1989) 31.55
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell (1997) 29.13
The serial cultivation of human diploid cell strains. Exp Cell Res (1961) 25.11
Telomeres shorten during ageing of human fibroblasts. Nature (1990) 23.97
Extension of life-span by introduction of telomerase into normal human cells. Science (1998) 20.48
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature (2005) 18.30
BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature (2005) 16.87
Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol (2007) 16.55
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature (2005) 15.83
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature (2005) 14.65
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature (2006) 11.76
Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature (2006) 11.18
Visualizing spatiotemporal dynamics of multicellular cell-cycle progression. Cell (2008) 10.49
Tumour biology: senescence in premalignant tumours. Nature (2005) 10.15
High frequency of BRAF mutations in nevi. Nat Genet (2002) 9.95
Oncogene-induced senescence as an initial barrier in lymphoma development. Nature (2005) 9.16
Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene. Cell (1988) 7.50
A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Cell (2002) 6.76
Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes Dev (1998) 5.60
Senescence of human fibroblasts induced by oncogenic Raf. Genes Dev (1998) 5.14
The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence. Genes Dev (2007) 4.91
Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis. Nat Cell Biol (2007) 4.67
Induction of transformation and continuous cell lines from normal human mammary epithelial cells after exposure to benzo[a]pyrene. Proc Natl Acad Sci U S A (1985) 3.24
Chromatin in need of a fix: phosphorylation of H2AX connects chromatin to DNA repair. Mol Cell (2005) 2.54
DNA end joining becomes less efficient and more error-prone during cellular senescence. Proc Natl Acad Sci U S A (2004) 2.51
Cellular senescence: putting the paradoxes in perspective. Curr Opin Genet Dev (2010) 2.49
Increased p16 expression with first senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivation. Oncogene (1998) 2.28
Molecular distinctions between stasis and telomere attrition senescence barriers shown by long-term culture of normal human mammary epithelial cells. Cancer Res (2009) 2.28
TGF-beta signaling engages an ATM-CHK2-p53-independent RAS-induced senescence and prevents malignant transformation in human mammary epithelial cells. Proc Natl Acad Sci U S A (2011) 1.94
Expression of the telomerase catalytic subunit, hTERT, induces resistance to transforming growth factor beta growth inhibition in p16INK4A(-) human mammary epithelial cells. Proc Natl Acad Sci U S A (2001) 1.83
Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland. Mol Cell Biol (2005) 1.61
ATR and H2AX cooperate in maintaining genome stability under replication stress. J Biol Chem (2008) 1.55
Oncogene-induced senescence pathways weave an intricate tapestry. Cell (2007) 1.47
Complementary functions of ATM and H2AX in development and suppression of genomic instability. Proc Natl Acad Sci U S A (2008) 1.42
Human epithelial cell immortalization as a step in carcinogenesis. Cancer Lett (2003) 1.38
Heat shock protein Hsp72 controls oncogene-induced senescence pathways in cancer cells. Mol Cell Biol (2008) 1.37
Raf-1-induced growth arrest in human mammary epithelial cells is p16-independent and is overcome in immortal cells during conversion. Oncogene (2002) 1.32
Invasive phenotype of MCF10A cells overexpressing c-Ha-ras and c-erbB-2 oncogenes. Int J Cancer (1995) 1.27
High levels of heat shock protein Hsp72 in cancer cells suppress default senescence pathways. Cancer Res (2007) 1.24
Premature senescence is a primary fail-safe mechanism of ERBB2-driven tumorigenesis in breast carcinoma cells. Cancer Res (2005) 1.23
Genetic and phenotypic characteristics of pleomorphic lobular carcinoma in situ of the breast. Am J Surg Pathol (2009) 1.17
Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation. Proc Natl Acad Sci U S A (2010) 1.09
Jailbreak: oncogene-induced senescence and its evasion. Cell Signal (2010) 1.00
The ATR-Chk1 pathway plays a role in the generation of centrosome aberrations induced by Rad51C dysfunction. Nucleic Acids Res (2009) 0.96
Interleukin-1 alpha mediates the growth proliferative effects of transforming growth factor-beta in p21 null MCF-10A human mammary epithelial cells. Oncogene (2006) 0.96
Senescence and serration: a new twist to an old tale. J Pathol (2006) 0.95
Triggering senescence programs suppresses Chk1 kinase and sensitizes cells to genotoxic stresses. Cancer Res (2008) 0.95
Genetic cooperation between p21Cip1 and INK4 inhibitors in cellular senescence and tumor suppression. Oncogene (2007) 0.94
HSP72 depletion suppresses gammaH2AX activation by genotoxic stresses via p53/p21 signaling. Oncogene (2010) 0.91
Executing cell senescence. Cell Cycle (2004) 0.87
In situ analyses of genome instability in breast cancer. Nat Genet (2004) 4.32
Necrosis: a specific form of programmed cell death? Exp Cell Res (2003) 2.47
TGF-beta signaling engages an ATM-CHK2-p53-independent RAS-induced senescence and prevents malignant transformation in human mammary epithelial cells. Proc Natl Acad Sci U S A (2011) 1.94
Exon-level microarray analyses identify alternative splicing programs in breast cancer. Mol Cancer Res (2010) 1.84
Targeting heat shock response to sensitize cancer cells to proteasome and Hsp90 inhibitors. Cancer Res (2006) 1.64
Heat shock protein Hsp72 controls oncogene-induced senescence pathways in cancer cells. Mol Cell Biol (2008) 1.37
Zinc inhibits nuclear factor-kappa B activation and sensitizes prostate cancer cells to cytotoxic agents. Clin Cancer Res (2002) 1.28
Triggering aggresome formation. Dissecting aggresome-targeting and aggregation signals in synphilin 1. J Biol Chem (2008) 1.26
High levels of heat shock protein Hsp72 in cancer cells suppress default senescence pathways. Cancer Res (2007) 1.24
Hsp27 modulates p53 signaling and suppresses cellular senescence. Cancer Res (2007) 1.22
Immobilization of MP-11 into a mesoporous metal-organic framework, MP-11@mesoMOF: a new platform for enzymatic catalysis. J Am Chem Soc (2011) 1.11
Mechanisms of tumor cell necrosis. Curr Pharm Des (2010) 1.06
DNA repair gene patterns as prognostic and predictive factors in molecular breast cancer subtypes. Oncologist (2013) 1.04
Heat shock transcription factor Hsf1 is involved in tumor progression via regulation of hypoxia-inducible factor 1 and RNA-binding protein HuR. Mol Cell Biol (2012) 0.98
The heat shock transcription factor Hsf1 is downregulated in DNA damage-associated senescence, contributing to the maintenance of senescence phenotype. Aging Cell (2012) 0.96
Triggering senescence programs suppresses Chk1 kinase and sensitizes cells to genotoxic stresses. Cancer Res (2008) 0.95
Toxicity of influenza A virus matrix protein 2 for mammalian cells is associated with its intrinsic proton-channeling activity. Cell Cycle (2007) 0.95
Proteasome failure promotes positioning of lysosomes around the aggresome via local block of microtubule-dependent transport. Mol Cell Biol (2014) 0.92
Hsp90 inhibitors as promising agents for radiotherapy. J Mol Med (Berl) (2009) 0.91
Regulation of necrosis of H9c2 myogenic cells upon transient energy deprivation. Rapid deenergization of mitochondria precedes necrosis and is controlled by reactive oxygen species, stress kinase JNK, HSP72 and ARC. J Biol Chem (2003) 0.90
Constitutive CCND1/CDK2 activity substitutes for p53 loss, or MYC or oncogenic RAS expression in the transformation of human mammary epithelial cells. PLoS One (2013) 0.82
Determination of cell survival or death. Methods Mol Biol (2011) 0.80
Workflow for combined proteomics and glycomics profiling from histological tissues. Anal Chem (2014) 0.78
Graphene-based polyaniline arrays for deoxyribonucleic acid electrochemical sensor: effect of nanostructure on sensitivity. ACS Appl Mater Interfaces (2014) 0.77
Multiple thermometers in mammalian cells: why do cells from homeothermic organisms need to measure temperature? Sci STKE (2006) 0.77
Synchronous electrosynthesis of poly(xanthurenic acid)-reduced graphene oxide nanocomposite for highly sensitive impedimetric detection of DNA. ACS Appl Mater Interfaces (2013) 0.77
Three-dimensional porous metal-metalloporphyrin framework consisting of nanoscopic polyhedral cages. J Am Chem Soc (2011) 0.77
Porous double-walled metal triazolate framework based upon a bifunctional ligand and a pentanuclear zinc cluster exhibiting selective CO2 uptake. Inorg Chem (2012) 0.76
Direct and freely switchable detection of target genes engineered by reduced graphene oxide-poly(m-aminobenzenesulfonic acid) nanocomposite via synchronous pulse electrosynthesis. Anal Chem (2013) 0.76
Direct electrochemical DNA detection originated from the self-redox signal of sulfonated polyaniline enhanced by graphene oxide in neutral solution. ACS Appl Mater Interfaces (2013) 0.75
The proteosomal degradation of fusion proteins cannot be predicted from the proteosome susceptibility of their individual components. Protein Sci (2008) 0.75
Effective expression of recombinant cytotoxic protein via its attachment to a polyglutamine domain. OMICS (2009) 0.75
P62 plasmid can alleviate diet-induced obesity and metabolic dysfunctions. Oncotarget (2017) 0.75
Quest for a highly connected robust porous metal-organic framework on the basis of a bifunctional linear linker and a rare heptanuclear zinc cluster. Chem Commun (Camb) (2013) 0.75