Published in Toxicon on November 28, 2006
Molecular biology of insect sodium channels and pyrethroid resistance. Insect Biochem Mol Biol (2014) 1.28
Scorpion venom components that affect ion-channels function. Toxicon (2013) 1.23
Proteases as insecticidal agents. Toxins (Basel) (2010) 1.01
Elucidation of the molecular basis of selective recognition uncovers the interaction site for the core domain of scorpion alpha-toxins on sodium channels. J Biol Chem (2011) 1.00
Computational methods of studying the binding of toxins from venomous animals to biological ion channels: theory and applications. Physiol Rev (2013) 0.99
Sea anemone toxins affecting voltage-gated sodium channels--molecular and evolutionary features. Toxicon (2009) 0.94
Molecular requirements for recognition of brain voltage-gated sodium channels by scorpion alpha-toxins. J Biol Chem (2009) 0.92
Synthesis, solution structure, and phylum selectivity of a spider delta-toxin that slows inactivation of specific voltage-gated sodium channel subtypes. J Biol Chem (2009) 0.91
Molecular analysis of the sea anemone toxin Av3 reveals selectivity to insects and demonstrates the heterogeneity of receptor site-3 on voltage-gated Na+ channels. Biochem J (2007) 0.89
Evolutionary diversification of Mesobuthus α-scorpion toxins affecting sodium channels. Mol Cell Proteomics (2011) 0.89
Partial agonist and antagonist activities of a mutant scorpion beta-toxin on sodium channels. J Biol Chem (2010) 0.83
Miniaturization of scorpion beta-toxins uncovers a putative ancestral surface of interaction with voltage-gated sodium channels. J Biol Chem (2008) 0.81
Nervous System of Periplaneta americana Cockroach as a Model in Toxinological Studies: A Short Historical and Actual View. J Toxicol (2012) 0.80
Target-Driven Evolution of Scorpion Toxins. Sci Rep (2015) 0.78
Modular organization of α-toxins from scorpion venom mirrors domain structure of their targets, sodium channels. J Biol Chem (2013) 0.78
Identification and phylogenetic analysis of Tityus pachyurus and Tityus obscurus novel putative Na+-channel scorpion toxins. PLoS One (2012) 0.78
Substitutions in the domain III voltage-sensing module enhance the sensitivity of an insect sodium channel to a scorpion beta-toxin. J Biol Chem (2011) 0.77
Theoretical and simulation studies on voltage-gated sodium channels. Protein Cell (2015) 0.77
The Mediterranean scorpion Mesobuthus gibbosus (Scorpiones, Buthidae): transcriptome analysis and organization of the genome encoding chlorotoxin-like peptides. BMC Genomics (2014) 0.77
A Combinational Strategy upon RNA Sequencing and Peptidomics Unravels a Set of Novel Toxin Peptides in Scorpion Mesobuthus martensii. Toxins (Basel) (2016) 0.76
The unfulfilled promises of scorpion insectotoxins. J Venom Anim Toxins Incl Trop Dis (2015) 0.75
Exposure to 50 Hz electromagnetic field changes the efficiency of the scorpion alpha toxin. J Venom Anim Toxins Incl Trop Dis (2015) 0.75
Direct evidence that scorpion α-toxins (site-3) modulate sodium channel inactivation by hindrance of voltage-sensor movements. PLoS One (2013) 0.75
A first exploration of the venom of the Buthus occitanus scorpion found in southern France. Toxicon (2014) 0.75
From Mollusks to Medicine: A Venomics Approach for the Discovery and Characterization of Therapeutics from Terebridae Peptide Toxins. Toxins (Basel) (2016) 0.75
The role of glycine residues at the C-terminal peptide segment in antinociceptive activity: a molecular dynamics simulation. J Mol Model (2012) 0.75
WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion. Nat Genet (2003) 4.08
International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacol Rev (2005) 3.50
Chronic administration of anticholinergics in rats induces a shift from muscarinic to purinergic transmission in the bladder wall. Eur Urol (2013) 2.15
Alternative splicing of an insect sodium channel gene generates pharmacologically distinct sodium channels. J Neurosci (2002) 1.80
Overexpression of Eag1 potassium channels in clinical tumours. Mol Cancer (2006) 1.78
Altered trafficking and stability of polycystins underlie polycystic kidney disease. J Clin Invest (2014) 1.71
Arthropod and mollusk defensins--evolution by exon-shuffling. Trends Genet (2003) 1.66
TxXIIIA, an atypical homodimeric conotoxin found in the Conus textile venom. J Proteomics (2009) 1.61
Identification of amino acid residues in the insect sodium channel critical for pyrethroid binding. Mol Pharmacol (2004) 1.57
Knockdown of RCK/p54 expression by RNAi inhibits proliferation of human colorectal cancer cells in vitro and in vivo. Cancer Biol Ther (2008) 1.50
RNA editing generates tissue-specific sodium channels with distinct gating properties. J Biol Chem (2004) 1.50
Absence of small conductance K+ channel (SK) activity in apical membranes of thick ascending limb and cortical collecting duct in ROMK (Bartter's) knockout mice. J Biol Chem (2002) 1.49
Monoclonal antibody blockade of the human Eag1 potassium channel function exerts antitumor activity. Cancer Res (2007) 1.47
Molecular evidence for dual pyrethroid-receptor sites on a mosquito sodium channel. Proc Natl Acad Sci U S A (2013) 1.44
Silencing the activity and proliferative properties of the human EagI Potassium Channel by RNA Interference. J Biol Chem (2006) 1.43
Ether à go-go potassium channel expression in soft tissue sarcoma patients. Mol Cancer (2006) 1.42
Eag1 expression interferes with hypoxia homeostasis and induces angiogenesis in tumors. J Biol Chem (2008) 1.41
Diversity and Convergence of Sodium Channel Mutations Involved in Resistance to Pyrethroids. Pestic Biochem Physiol (2013) 1.38
Mapping the receptor site for alpha-scorpion toxins on a Na+ channel voltage sensor. Proc Natl Acad Sci U S A (2011) 1.36
Calcium regulates exocytosis at the level of single vesicles. Nat Neurosci (2003) 1.34
C-terminal domains implicated in the functional surface expression of potassium channels. EMBO J (2003) 1.32
Inhibition of protein-tyrosine phosphatase stimulates the dynamin-dependent endocytosis of ROMK1. J Biol Chem (2001) 1.32
Evolutionary origin of inhibitor cystine knot peptides. FASEB J (2003) 1.31
Mechanism of block of hEag1 K+ channels by imipramine and astemizole. J Gen Physiol (2004) 1.31
Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes. Mol Pharmacol (2005) 1.31
An overview of toxins and genes from the venom of the Asian scorpion Buthus martensi Karsch. Toxicon (2002) 1.29
Potassium channels in cell cycle and cell proliferation. Philos Trans R Soc Lond B Biol Sci (2014) 1.29
Inducing apoptosis and enhancing chemosensitivity to gemcitabine via RNA interference targeting Mcl-1 gene in pancreatic carcinoma cell. Cancer Chemother Pharmacol (2008) 1.24
A voltage-gated calcium-selective channel encoded by a sodium channel-like gene. Neuron (2004) 1.24
Nucleotides and phospholipids compete for binding to the C terminus of KATP channels. Proc Natl Acad Sci U S A (2002) 1.23
A sodium channel mutation identified in Aedes aegypti selectively reduces cockroach sodium channel sensitivity to type I, but not type II pyrethroids. Insect Biochem Mol Biol (2010) 1.23
Drosophila as a model for epilepsy: bss is a gain-of-function mutation in the para sodium channel gene that leads to seizures. Genetics (2010) 1.23
The insecticidal potential of scorpion beta-toxins. Toxicon (2006) 1.23
Multisite binding of a general anesthetic to the prokaryotic pentameric Erwinia chrysanthemi ligand-gated ion channel (ELIC). J Biol Chem (2013) 1.22
Identification of a cluster of residues in transmembrane segment 6 of domain III of the cockroach sodium channel essential for the action of pyrethroid insecticides. Biochem J (2009) 1.21
Crystal structures of a cysteine-modified mutant in loop D of acetylcholine-binding protein. J Biol Chem (2010) 1.18
Use of non-mammalian alternative models for neurotoxicological study. Neurotoxicology (2008) 1.17
Eag1: an emerging oncological target. Cancer Res (2008) 1.17
kappa-Hefutoxin1, a novel toxin from the scorpion Heterometrus fulvipes with unique structure and function. Importance of the functional diad in potassium channel selectivity. J Biol Chem (2002) 1.17
The nicotinic acetylcholine receptor gene family of the silkworm, Bombyx mori. BMC Genomics (2007) 1.16
Phosphorylation-regulated endoplasmic reticulum retention signal in the renal outer-medullary K+ channel (ROMK). Proc Natl Acad Sci U S A (2005) 1.15
Neurotoxins and their binding areas on voltage-gated sodium channels. Front Pharmacol (2011) 1.15
Common features in the functional surface of scorpion beta-toxins and elements that confer specificity for insect and mammalian voltage-gated sodium channels. J Biol Chem (2004) 1.14
The potassium channel Ether à go-go is a novel prognostic factor with functional relevance in acute myeloid leukemia. Mol Cancer (2010) 1.13
Voltage-gated sodium channel modulation by scorpion alpha-toxins. Toxicon (2006) 1.12
Animal peptides targeting voltage-activated sodium channels. Curr Pharm Des (2008) 1.11
The cross-sectional GRAS sample: a comprehensive phenotypical data collection of schizophrenic patients. BMC Psychiatry (2010) 1.10
Antibacterial and antifungal properties of alpha-helical, cationic peptides in the venom of scorpions from southern Africa. Eur J Biochem (2002) 1.09
Calcium microdomains in regulated exocytosis. Cell Calcium (2006) 1.09
Potent modulation of the voltage-gated sodium channel Nav1.7 by OD1, a toxin from the scorpion Odonthobuthus doriae. Mol Pharmacol (2006) 1.08
Persistent tetrodotoxin-sensitive sodium current resulting from U-to-C RNA editing of an insect sodium channel. Proc Natl Acad Sci U S A (2004) 1.08
Convergent evolution of sodium ion selectivity in metazoan neuronal signaling. Cell Rep (2012) 1.07
Functional K(v)10.1 channels localize to the inner nuclear membrane. PLoS One (2011) 1.06
Molecular and functional characterization of voltage-gated sodium channel variants from Drosophila melanogaster. Insect Biochem Mol Biol (2008) 1.06
Induction of HIV neutralizing antibodies against the MPER of the HIV envelope protein by HA/gp41 chimeric protein-based DNA and VLP vaccines. PLoS One (2011) 1.06
Structure-function map of the receptor site for β-scorpion toxins in domain II of voltage-gated sodium channels. J Biol Chem (2011) 1.05
Molecular basis of the high insecticidal potency of scorpion alpha-toxins. J Biol Chem (2004) 1.04
Characterization of Eag1 channel lateral mobility in rat hippocampal cultures by single-particle-tracking with quantum dots. PLoS One (2010) 1.03
Distinct primary structures of the major peptide toxins from the venom of the spider Macrothele gigas that bind to sites 3 and 4 in the sodium channel. FEBS Lett (2003) 1.02
Subunit-subunit interactions are critical for proton sensitivity of ROMK: evidence in support of an intermolecular gating mechanism. Proc Natl Acad Sci U S A (2006) 1.01
Inhibiting proliferation and enhancing chemosensitivity to taxanes in osteosarcoma cells by RNA interference-mediated downregulation of stathmin expression. Mol Med (2007) 1.01
A CAG repeat polymorphism of KCNN3 predicts SK3 channel function and cognitive performance in schizophrenia. EMBO Mol Med (2011) 1.00
Identification of new batrachotoxin-sensing residues in segment IIIS6 of the sodium channel. J Biol Chem (2011) 1.00
Function and solution structure of hainantoxin-I, a novel insect sodium channel inhibitor from the Chinese bird spider Selenocosmia hainana. FEBS Lett (2003) 1.00
Jellyfish and other cnidarian envenomations cause pain by affecting TRPV1 channels. FEBS Lett (2006) 1.00
Elucidation of the molecular basis of selective recognition uncovers the interaction site for the core domain of scorpion alpha-toxins on sodium channels. J Biol Chem (2011) 1.00
X-ray structure and mutagenesis of the scorpion depressant toxin LqhIT2 reveals key determinants crucial for activity and anti-insect selectivity. J Mol Biol (2006) 0.99
Glycosylation of Eag1 (Kv10.1) potassium channels: intracellular trafficking and functional consequences. J Biol Chem (2005) 0.99
Adaptive evolution of scorpion sodium channel toxins. J Mol Evol (2004) 0.99
Mapping the interaction site for a β-scorpion toxin in the pore module of domain III of voltage-gated Na(+) channels. J Biol Chem (2012) 0.99
Morphologic changes of mammary carcinomas in mice over time as monitored by flat-panel detector volume computed tomography. Neoplasia (2008) 0.99
ROMK1 channel activity is regulated by monoubiquitination. Proc Natl Acad Sci U S A (2005) 0.98
Quantifying axial secretory-granule motion with variable-angle evanescent-field excitation. J Neurosci Methods (2002) 0.98
A bifunctional sea anemone peptide with Kunitz type protease and potassium channel inhibiting properties. Biochem Pharmacol (2011) 0.98
Molecular determinants on the insect sodium channel for the specific action of type II pyrethroid insecticides. Toxicol Appl Pharmacol (2008) 0.98
Neurotoxin localization to ectodermal gland cells uncovers an alternative mechanism of venom delivery in sea anemones. Proc Biol Sci (2011) 0.98
Immunization by influenza virus-like particles protects aged mice against lethal influenza virus challenge. Antiviral Res (2009) 0.98
Molecular characterization of an arachnid sodium channel gene from the varroa mite (Varroa destructor). Insect Biochem Mol Biol (2003) 0.98
Randomized controlled trial of calcaneal taping, sham taping, and plantar fascia stretching for the short-term management of plantar heel pain. J Orthop Sports Phys Ther (2006) 0.97
Positions under positive selection--key for selectivity and potency of scorpion alpha-toxins. Mol Biol Evol (2009) 0.97