Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth.

PubWeight™: 4.11‹?› | Rank: Top 1%

🔗 View Article (PMID 17222790)

Published in Cancer Cell on January 01, 2007

Authors

Qi Pan1, Yvan Chanthery, Wei-Ching Liang, Scott Stawicki, Judy Mak, Nisha Rathore, Raymond K Tong, Joe Kowalski, Sharon Fong Yee, Glenn Pacheco, Sarajane Ross, Zhiyong Cheng, Jennifer Le Couter, Greg Plowman, Franklin Peale, Alexander W Koch, Yan Wu, Anil Bagri, Marc Tessier-Lavigne, Ryan J Watts

Author Affiliations

1: Tumor Biology and Angiogenesis, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

Articles citing this

(truncated to the top 100)

Tumor angiogenesis. N Engl J Med (2008) 11.30

Normalization of the vasculature for treatment of cancer and other diseases. Physiol Rev (2011) 5.64

Molecular control of endothelial cell behaviour during blood vessel morphogenesis. Nat Rev Mol Cell Biol (2011) 3.25

A vascular niche and a VEGF-Nrp1 loop regulate the initiation and stemness of skin tumours. Nature (2011) 3.25

ERbeta impedes prostate cancer EMT by destabilizing HIF-1alpha and inhibiting VEGF-mediated snail nuclear localization: implications for Gleason grading. Cancer Cell (2010) 3.25

Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis. Proc Natl Acad Sci U S A (2009) 3.17

VEGF targets the tumour cell. Nat Rev Cancer (2013) 2.71

Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma. Cell (2013) 2.64

Axon guidance molecules in vascular patterning. Cold Spring Harb Perspect Biol (2010) 2.37

Autocrine VEGF-VEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth. J Exp Med (2012) 2.21

Anti-angiogenic therapy for cancer: current progress, unresolved questions and future directions. Angiogenesis (2014) 2.07

Neuropilin-1 promotes cirrhosis of the rodent and human liver by enhancing PDGF/TGF-beta signaling in hepatic stellate cells. J Clin Invest (2010) 2.06

Signal transduction by vascular endothelial growth factor receptors. Cold Spring Harb Perspect Med (2012) 1.99

Semaphorin 3A suppresses VEGF-mediated angiogenesis yet acts as a vascular permeability factor. Blood (2008) 1.93

VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis. Proc Natl Acad Sci U S A (2009) 1.91

Semaphorin 3A is an endogenous angiogenesis inhibitor that blocks tumor growth and normalizes tumor vasculature in transgenic mouse models. J Clin Invest (2009) 1.56

Mechanisms of resistance to anti-angiogenic therapy and development of third-generation anti-angiogenic drug candidates. Genes Cancer (2010) 1.54

Vascular endothelial growth factor regulates myeloid cell leukemia-1 expression through neuropilin-1-dependent activation of c-MET signaling in human prostate cancer cells. Mol Cancer (2010) 1.51

VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration, complex formation between NRP1 and VEGFR2, and signaling via FAK Tyr407 phosphorylation. Mol Biol Cell (2011) 1.47

Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding. EMBO J (2007) 1.43

Branching morphogenesis and antiangiogenesis candidates: tip cells lead the way. Nat Rev Clin Oncol (2009) 1.43

Vascular endothelial growth factor and semaphorin induce neuropilin-1 endocytosis via separate pathways. Circ Res (2008) 1.43

Successful inhibition of tumor development by specific class-3 semaphorins is associated with expression of appropriate semaphorin receptors by tumor cells. PLoS One (2008) 1.42

Neuropilin-1 in regulation of VEGF-induced activation of p38MAPK and endothelial cell organization. Blood (2008) 1.38

Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth. J Exp Med (2012) 1.38

Neuropilins are multifunctional coreceptors involved in tumor initiation, growth, metastasis and immunity. Oncotarget (2012) 1.37

GLI1 regulates a novel neuropilin-2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation. EMBO Mol Med (2013) 1.33

Neuropilin-1 modulates p53/caspases axis to promote endothelial cell survival. PLoS One (2007) 1.32

Impact of exploratory biomarkers on the treatment effect of bevacizumab in metastatic breast cancer. Clin Cancer Res (2011) 1.31

Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells. Mol Cell Biol (2011) 1.30

Tie2Cre-mediated inactivation of plexinD1 results in congenital heart, vascular and skeletal defects. Dev Biol (2008) 1.29

Anti-vascular endothelial growth factor therapies as a novel therapeutic approach to treating neurofibromatosis-related tumors. Cancer Res (2010) 1.24

Clinical advances in the development of novel VEGFR2 inhibitors. Ann Transl Med (2014) 1.24

Neuropilin-1 expression identifies a subset of regulatory T cells in human lymph nodes that is modulated by preoperative chemoradiation therapy in cervical cancer. Immunology (2007) 1.22

Expression of delta-like ligand 4 (Dll4) and markers of hypoxia in colon cancer. Br J Cancer (2009) 1.22

Regulation of vascular endothelial growth factor receptor 2 trafficking and angiogenesis by Golgi localized t-SNARE syntaxin 6. Blood (2010) 1.21

Neuropilin-1 upholds dedifferentiation and propagation phenotypes of renal cell carcinoma cells by activating Akt and sonic hedgehog axes. Cancer Res (2008) 1.19

Neuropilin-1 stimulates tumor growth by increasing fibronectin fibril assembly in the tumor microenvironment. Cancer Res (2012) 1.19

Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction. J Med Chem (2010) 1.18

Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells. J Exp Med (2014) 1.17

Lymphangiogenesis and cancer. Genes Cancer (2011) 1.16

Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis. Development (2014) 1.16

An unexpected role of semaphorin3a-neuropilin-1 signaling in lymphatic vessel maturation and valve formation. Circ Res (2012) 1.15

Alphav beta3 integrin limits the contribution of neuropilin-1 to vascular endothelial growth factor-induced angiogenesis. J Biol Chem (2009) 1.15

Targeting vascular and leukocyte communication in angiogenesis, inflammation and fibrosis. Nat Rev Drug Discov (2015) 1.14

Autocrine functions of VEGF in breast tumor cells: adhesion, survival, migration and invasion. Cell Adh Migr (2012) 1.14

Neuropilin-1 mediates PDGF stimulation of vascular smooth muscle cell migration and signalling via p130Cas. Biochem J (2011) 1.14

Metabolic stress induces the lysosomal degradation of neuropilin-1 but not neuropilin-2. J Biol Chem (2008) 1.14

Quantification and cell-to-cell variation of vascular endothelial growth factor receptors. Exp Cell Res (2010) 1.14

Neuropilin-2 expression in breast cancer: correlation with lymph node metastasis, poor prognosis, and regulation of CXCR4 expression. BMC Cancer (2009) 1.12

Overexpression of vascular endothelial growth factor 189 in breast cancer cells leads to delayed tumor uptake with dilated intratumoral vessels. Am J Pathol (2007) 1.12

Semaphorin3A, Neuropilin-1, and PlexinA1 are required for lymphatic valve formation. Circ Res (2012) 1.12

Chondroitin sulphate-modified neuropilin 1 is expressed in human tumour cells and modulates 3D invasion in the U87MG human glioblastoma cell line through a p130Cas-mediated pathway. EMBO Rep (2008) 1.12

Differentiation of human pluripotent stem cells to cells similar to cord-blood endothelial colony-forming cells. Nat Biotechnol (2014) 1.09

Defective retinal vascular endothelial cell development as a consequence of impaired integrin αVβ8-mediated activation of transforming growth factor-β. J Neurosci (2012) 1.08

Malignant cell-derived PlGF promotes normalization and remodeling of the tumor vasculature. Proc Natl Acad Sci U S A (2009) 1.08

Neuropilins: novel targets for anti-angiogenesis therapies. Cell Adh Migr (2007) 1.07

The role of semaphorins and their receptors in vascular development and cancer. Exp Cell Res (2013) 1.07

VEGF/neuropilin-2 regulation of Bmi-1 and consequent repression of IGF-IR define a novel mechanism of aggressive prostate cancer. Cancer Discov (2012) 1.06

Semaphorin 3A suppresses tumor growth and metastasis in mice melanoma model. PLoS One (2012) 1.05

Guidance from above: common cues direct distinct signaling outcomes in vascular and neural patterning. Trends Cell Biol (2009) 1.05

Overcoming resistance to antiangiogenic therapies. Oncologist (2012) 1.05

Extracellular regulation of VEGF: isoforms, proteolysis, and vascular patterning. Cytokine Growth Factor Rev (2013) 1.05

Regulation of VEGF signaling by membrane traffic. Cell Signal (2012) 1.04

Proteoglycan signaling co-receptors: roles in cell adhesion, migration and invasion. Cell Signal (2009) 1.04

Neuropilin-1 antagonism in human carcinoma cells inhibits migration and enhances chemosensitivity. Br J Cancer (2010) 1.04

Transmembrane domain interactions control biological functions of neuropilin-1. Mol Biol Cell (2007) 1.03

Targeting neuropilin-1 in human leukemia and lymphoma. Blood (2010) 1.03

Semaphorins and their receptors in lung cancer. Cancer Lett (2008) 1.02

Receptor tyrosine kinase-mediated angiogenesis. Cold Spring Harb Perspect Biol (2013) 1.01

Biomarkers in tumor angiogenesis and anti-angiogenic therapy. Int J Mol Sci (2011) 1.01

Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch. Nat Commun (2015) 0.99

Semaphorin 4D cooperates with VEGF to promote angiogenesis and tumor progression. Angiogenesis (2012) 0.99

Neuropilins: expression and roles in the epithelium. Int J Exp Pathol (2012) 0.98

Neuropilin-2 regulates α6β1 integrin in the formation of focal adhesions and signaling. J Cell Sci (2012) 0.98

Sulfated polysaccharides identified as inducers of neuropilin-1 internalization and functional inhibition of VEGF165 and semaphorin3A. Blood (2008) 0.98

Heparan sulfate signaling in cancer. Trends Biochem Sci (2014) 0.97

Guidance molecules in lung cancer. Cell Adh Migr (2010) 0.97

Cancer prevention and therapy through the modulation of the tumor microenvironment. Semin Cancer Biol (2015) 0.97

Molecular mechanisms of tumor angiogenesis. Genes Cancer (2011) 0.96

Neuropilin-1 functions as a VEGFR2 co-receptor to guide developmental angiogenesis independent of ligand binding. Elife (2014) 0.95

A mutated soluble neuropilin-2 B domain antagonizes vascular endothelial growth factor bioactivity and inhibits tumor progression. Mol Cancer Res (2010) 0.94

Emerging antibody combinations in oncology. MAbs (2011) 0.94

Location, location, location: macrophage positioning within tumors determines pro- or antitumor activity. Cancer Cell (2013) 0.93

Angiogenesis and liver fibrosis. World J Hepatol (2015) 0.93

From combinatorial peptide selection to drug prototype (I): targeting the vascular endothelial growth factor receptor pathway. Proc Natl Acad Sci U S A (2010) 0.92

Semaphorin, neuropilin and VEGF expression in glial tumours: SEMA3G, a prognostic marker? Br J Cancer (2008) 0.92

Effect of C-terminal sequence on competitive semaphorin binding to neuropilin-1. J Mol Biol (2013) 0.92

Angiogenesis and melanoma - from basic science to clinical trials. Am J Cancer Res (2011) 0.92

Bevacizumab-based therapies in the first-line treatment of metastatic colorectal cancer. Oncologist (2012) 0.92

Maximizing tumour exposure to anti-neuropilin-1 antibody requires saturation of non-tumour tissue antigenic sinks in mice. Br J Pharmacol (2012) 0.92

A graph theoretic approach to utilizing protein structure to identify non-random somatic mutations. BMC Bioinformatics (2014) 0.91

Bevacizumab treatment for advanced breast cancer. Oncologist (2011) 0.90

к Opioids inhibit tumor angiogenesis by suppressing VEGF signaling. Sci Rep (2013) 0.90

Differential expression of vascular endothelial growth factor A, its receptors VEGFR-1, -2, and -3 and co-receptors neuropilin-1 and -2 does not predict bevacizumab response in human astrocytomas. Neuro Oncol (2015) 0.90

Protein kinase LKB1 promotes RAB7-mediated neuropilin-1 degradation to inhibit angiogenesis. J Clin Invest (2014) 0.90

Predictive and prognostic biomarkers with therapeutic targets in advanced colorectal cancer. World J Gastroenterol (2014) 0.90

Neuropilins: a new target for cancer therapy. Cancers (Basel) (2011) 0.90

Insufficient OPC migration into demyelinated lesions is a cause of poor remyelination in MS and mouse models. Acta Neuropathol (2013) 0.89

VEGF receptor signaling in vertebrate development. Organogenesis (2010) 0.87

Articles by these authors

VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature (2005) 15.57

A mutation in APP protects against Alzheimer's disease and age-related cognitive decline. Nature (2012) 8.10

Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis. Nature (2006) 6.56

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature (2009) 6.17

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index. Nat Biotechnol (2008) 5.54

Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Nat Med (2002) 5.50

Common mechanisms of nerve and blood vessel wiring. Nature (2005) 5.46

IMGT, the international ImMunoGeneTics information system. Nucleic Acids Res (2008) 5.42

Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes. Nat Med (2006) 5.22

Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons. Cell Metab (2007) 5.04

Therapeutic antibody targeting of individual Notch receptors. Nature (2010) 4.56

Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells. Cell Stem Cell (2009) 4.52

Anterior-posterior guidance of commissural axons by Wnt-frizzled signaling. Science (2003) 4.18

The Drosophila cell corpse engulfment receptor Draper mediates glial clearance of severed axons. Neuron (2006) 4.13

Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment. Nat Med (2002) 4.00

Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL. Nat Med (2007) 3.99

New neurons follow the flow of cerebrospinal fluid in the adult brain. Science (2006) 3.98

A public gene trap resource for mouse functional genomics. Nat Genet (2004) 3.96

Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site. Science (2009) 3.87

PirB is a functional receptor for myelin inhibitors of axonal regeneration. Science (2008) 3.86

The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature (2004) 3.77

dSarm/Sarm1 is required for activation of an injury-induced axon death pathway. Science (2012) 3.72

The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance. Cell (2003) 3.66

Complete and specific inhibition of adult lymphatic regeneration by a novel VEGFR-3 neutralizing antibody. J Natl Cancer Inst (2005) 3.58

Class 3 semaphorins control vascular morphogenesis by inhibiting integrin function. Nature (2003) 3.42

Kinetic analysis of epidermal growth factor receptor somatic mutant proteins shows increased sensitivity to the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib. Cancer Res (2006) 3.34

Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin. J Clin Oncol (2011) 3.23

Lack of enhanced spinal regeneration in Nogo-deficient mice. Neuron (2003) 3.22

The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons. Cell (2004) 3.19

A specificity map for the PDZ domain family. PLoS Biol (2008) 3.16

Wlds protection distinguishes axon degeneration following injury from naturally occurring developmental pruning. Neuron (2006) 3.15

PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates. Nature (2004) 3.10

Importance of cellular microenvironment and circulatory dynamics in B cell immunotherapy. J Immunol (2005) 3.00

Conserved roles for Slit and Robo proteins in midline commissural axon guidance. Neuron (2004) 2.94

Regeneration of sensory axons within the injured spinal cord induced by intraganglionic cAMP elevation. Neuron (2002) 2.84

Slit1 and Slit2 cooperate to prevent premature midline crossing of retinal axons in the mouse visual system. Neuron (2002) 2.77

SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site. Dev Cell (2004) 2.74

Peritumoral neutrophils link inflammatory response to disease progression by fostering angiogenesis in hepatocellular carcinoma. J Hepatol (2010) 2.71

Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain. Neuron (2002) 2.71

Limb remote ischemic preconditioning attenuates lung injury after pulmonary resection under propofol-remifentanil anesthesia: a randomized controlled study. Anesthesiology (2014) 2.66

Mechanisms and molecules of neuronal wiring: a primer. Cold Spring Harb Perspect Biol (2011) 2.62

Regulation of cortical dendrite development by Slit-Robo interactions. Neuron (2002) 2.55

Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons. Cell (2003) 2.54

Mammalian brain morphogenesis and midline axon guidance require heparan sulfate. Science (2003) 2.53

Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target. Sci Transl Med (2011) 2.51

EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans. Science (2005) 2.50

Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China. Cancer Epidemiol Biomarkers Prev (2005) 2.45

Inhibition of VEGFR-3 activation with the antagonistic antibody more potently suppresses lymph node and distant metastases than inactivation of VEGFR-2. Cancer Res (2006) 2.40

Engaging neuroscience to advance translational research in brain barrier biology. Nat Rev Neurosci (2011) 2.40

Induction of cutaneous delayed-type hypersensitivity reactions in VEGF-A transgenic mice results in chronic skin inflammation associated with persistent lymphatic hyperplasia. Blood (2004) 2.37

Blocking neuropilin-2 function inhibits tumor cell metastasis. Cancer Cell (2008) 2.35

The chemokine SDF1 regulates migration of dentate granule cells. Development (2002) 2.34

False resurrections: distinguishing regenerated from spared axons in the injured central nervous system. J Comp Neurol (2003) 2.34

MetMAb, the one-armed 5D5 anti-c-Met antibody, inhibits orthotopic pancreatic tumor growth and improves survival. Cancer Res (2008) 2.33

Alternative splicing of the Robo3 axon guidance receptor governs the midline switch from attraction to repulsion. Neuron (2008) 2.33

Boc is a receptor for sonic hedgehog in the guidance of commissural axons. Nature (2006) 2.29

Genetic deletion of the Nogo receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo. Proc Natl Acad Sci U S A (2005) 2.27

Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells. Oncogene (2005) 2.24

VEGF-null cells require PDGFR alpha signaling-mediated stromal fibroblast recruitment for tumorigenesis. EMBO J (2004) 2.22

Registry and survival study in chinese patients with idiopathic and familial pulmonary arterial hypertension. Chest (2007) 2.19

Cyclic AMP/GMP-dependent modulation of Ca2+ channels sets the polarity of nerve growth-cone turning. Nature (2003) 2.18

An Fcγ receptor-dependent mechanism drives antibody-mediated target-receptor signaling in cancer cells. Cancer Cell (2011) 2.14

High-affinity human antibodies from phage-displayed synthetic Fab libraries with a single framework scaffold. J Mol Biol (2004) 2.14

A two-in-one antibody against HER3 and EGFR has superior inhibitory activity compared with monospecific antibodies. Cancer Cell (2011) 2.14

The human herpes virus 8-encoded viral FLICE inhibitory protein physically associates with and persistently activates the Ikappa B kinase complex. J Biol Chem (2002) 2.13

New neurons clear the path of astrocytic processes for their rapid migration in the adult brain. Neuron (2010) 2.12

Regeneration of the adult central nervous system. Curr Biol (2005) 2.11

Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1. Sci Transl Med (2011) 2.10

Recognition of the neural chemoattractant Netrin-1 by integrins alpha6beta4 and alpha3beta1 regulates epithelial cell adhesion and migration. Dev Cell (2003) 2.08

Neuropilin-1 promotes cirrhosis of the rodent and human liver by enhancing PDGF/TGF-beta signaling in hepatic stellate cells. J Clin Invest (2010) 2.06

Structure of the Nogo receptor ectodomain: a recognition module implicated in myelin inhibition. Neuron (2003) 2.06

The Nogo-66 receptor NgR1 is required only for the acute growth cone-collapsing but not the chronic growth-inhibitory actions of myelin inhibitors. J Neurosci (2007) 2.06

Effects of anti-VEGF on pharmacokinetics, biodistribution, and tumor penetration of trastuzumab in a preclinical breast cancer model. Mol Cancer Ther (2012) 2.03