Published in Cell on May 30, 2003
GSK3 signalling in neural development. Nat Rev Neurosci (2010) 3.29
Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation. J Neurosci (2010) 2.46
The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease. Nat Immunol (2011) 2.42
Communication between the synapse and the nucleus in neuronal development, plasticity, and disease. Annu Rev Cell Dev Biol (2008) 2.40
DCDC2 is associated with reading disability and modulates neuronal development in the brain. Proc Natl Acad Sci U S A (2005) 2.35
Neuronal activity-regulated gene transcription in synapse development and cognitive function. Cold Spring Harb Perspect Biol (2011) 2.27
Overexpression of c-myc in pancreatic cancer caused by ectopic activation of NFATc1 and the Ca2+/calcineurin signaling pathway. EMBO J (2006) 2.06
Signals to promote myelin formation and repair. Nat Rev Neurol (2010) 1.95
Activation of FAK and Src are receptor-proximal events required for netrin signaling. Nat Neurosci (2004) 1.89
A frazzled/DCC-dependent transcriptional switch regulates midline axon guidance. Science (2009) 1.79
Intracellular control of developmental and regenerative axon growth. Philos Trans R Soc Lond B Biol Sci (2006) 1.70
Inhibition of the NFAT pathway alleviates amyloid β neurotoxicity in a mouse model of Alzheimer's disease. J Neurosci (2012) 1.64
NFATc1 and NFATc2 repress spontaneous osteoarthritis. Proc Natl Acad Sci U S A (2013) 1.61
Serum response factor mediates NGF-dependent target innervation by embryonic DRG sensory neurons. Neuron (2008) 1.52
Mechanisms of specificity in neuronal activity-regulated gene transcription. Prog Neurobiol (2011) 1.49
Phosphorylation meets nuclear import: a review. Cell Commun Signal (2010) 1.49
Netrins and neogenin promote myotube formation. J Cell Biol (2004) 1.47
Negative regulation of calcineurin signaling by Hrr25p, a yeast homolog of casein kinase I. Genes Dev (2003) 1.46
A novel microRNA and transcription factor mediated regulatory network in schizophrenia. BMC Syst Biol (2010) 1.40
Long-distance retrograde neurotrophic factor signalling in neurons. Nat Rev Neurosci (2013) 1.30
NFAT signaling in neural development and axon growth. Int J Dev Neurosci (2007) 1.30
Nuclear factor of activated T cells balances angiogenesis activation and inhibition. J Exp Med (2004) 1.30
Hph1p and Hph2p, novel components of calcineurin-mediated stress responses in Saccharomyces cerevisiae. Eukaryot Cell (2004) 1.28
The DnaJ-related factor Mrj interacts with nuclear factor of activated T cells c3 and mediates transcriptional repression through class II histone deacetylase recruitment. Mol Cell Biol (2005) 1.25
Initiating and growing an axon. Cold Spring Harb Perspect Biol (2010) 1.24
A calcium-dependent switch in a CREST-BRG1 complex regulates activity-dependent gene expression. Neuron (2008) 1.21
Transcriptional regulation of neuronal polarity and morphogenesis in the mammalian brain. Neuron (2011) 1.19
A retrograde neuronal survival response: target-derived neurotrophins regulate MEF2D and bcl-w. J Neurosci (2009) 1.19
RSK2 mediates muscle cell differentiation through regulation of NFAT3. J Biol Chem (2007) 1.19
Spatial and temporal second messenger codes for growth cone turning. Proc Natl Acad Sci U S A (2011) 1.18
Phosphorylation of DCC by Fyn mediates Netrin-1 signaling in growth cone guidance. J Cell Biol (2004) 1.16
Multiple transcription factor families regulate axon growth and regeneration. Dev Neurobiol (2011) 1.13
NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins. Science (2008) 1.12
Synaptic vesicle clustering requires a distinct MIG-10/Lamellipodin isoform and ABI-1 downstream from Netrin. Genes Dev (2012) 1.12
Alternative splicing and expression of human and mouse NFAT genes. Genomics (2008) 1.12
Activity-dependent transcriptional regulation of M-Type (Kv7) K(+) channels by AKAP79/150-mediated NFAT actions. Neuron (2012) 1.11
Nuclear factor of activated T-cells isoform c4 (NFATc4/NFAT3) as a mediator of antiapoptotic transcription in NMDA receptor-stimulated cortical neurons. J Neurosci (2009) 1.11
Regulation of transcription factor NFAT by ADP-ribosylation. Mol Cell Biol (2008) 1.09
Requirement for balanced Ca/NFAT signaling in hematopoietic and embryonic development. Proc Natl Acad Sci U S A (2009) 1.09
Wnt5a mediates nerve growth factor-dependent axonal branching and growth in developing sympathetic neurons. J Neurosci (2009) 1.09
Mitochondrial Ca2+ cycling facilitates activation of the transcription factor NFAT in sensory neurons. J Neurosci (2009) 1.02
Role of transcription factor NFAT in glucose and insulin homeostasis. Mol Cell Biol (2006) 1.02
Endocytic trafficking of neurotrophins in neural development. Trends Cell Biol (2012) 1.01
Cooperative synergy between NFAT and MyoD regulates myogenin expression and myogenesis. J Biol Chem (2008) 1.01
Store-operated CRAC channels regulate gene expression and proliferation in neural progenitor cells. J Neurosci (2014) 1.01
Microglial phenotype is regulated by activity of the transcription factor, NFAT (nuclear factor of activated T cells). J Neurosci (2010) 1.00
Isoform-specific dephosphorylation of dynamin1 by calcineurin couples neurotrophin receptor endocytosis to axonal growth. Neuron (2011) 1.00
Calcineurin-Crz1 signaling in lower eukaryotes. Eukaryot Cell (2014) 1.00
Ca2+ signal summation and NFATc1 nuclear translocation in sympathetic ganglion neurons during repetitive action potentials. Cell Calcium (2006) 0.99
Tox: a multifunctional transcription factor and novel regulator of mammalian corticogenesis. EMBO J (2014) 0.96
Temporal regulation of nuclear factor one occupancy by calcineurin/NFAT governs a voltage-sensitive developmental switch in late maturing neurons. J Neurosci (2013) 0.95
Sex differences in the effects of acute and chronic stress and recovery after long-term stress on stress-related brain regions of rats. Cereb Cortex (2008) 0.94
A gene network perspective on axonal regeneration. Front Mol Neurosci (2011) 0.94
NFAT-3 is a transcriptional repressor of the growth-associated protein 43 during neuronal maturation. J Biol Chem (2009) 0.94
Spatial and temporal regulation of coronary vessel formation by calcineurin-NFAT signaling. Development (2009) 0.93
Nuclear factor of activated T cells (NFATc4) is required for BDNF-dependent survival of adult-born neurons and spatial memory formation in the hippocampus. Proc Natl Acad Sci U S A (2012) 0.93
NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy. J Clin Invest (2010) 0.92
Distinct activation properties of the nuclear factor of activated T-cells (NFAT) isoforms NFATc3 and NFATc4 in neurons. J Biol Chem (2012) 0.91
NFAT as cancer target: mission possible? Biochim Biophys Acta (2014) 0.91
Regulation of dendritic development by BDNF requires activation of CRTC1 by glutamate. J Biol Chem (2010) 0.90
Regulator of calcineurin 1 mediates pathological vascular wall remodeling. J Exp Med (2011) 0.90
The neogenin intracellular domain regulates gene transcription via nuclear translocation. Mol Cell Biol (2008) 0.89
Role of calcineurin in neurodegeneration produced by misfolded proteins and endoplasmic reticulum stress. Curr Opin Cell Biol (2011) 0.88
Coordinating Gene Expression and Axon Assembly to Control Axon Growth: Potential Role of GSK3 Signaling. Front Mol Neurosci (2012) 0.88
Selective role of calcineurin in haematopoiesis and lymphopoiesis. EMBO Rep (2008) 0.87
Gestational zinc deficiency affects the regulation of transcription factors AP-1, NF-κB and NFAT in fetal brain. J Nutr Biochem (2010) 0.87
Phosphorylation of Stim1 at serine 575 via netrin-2/Cdo-activated ERK1/2 is critical for the promyogenic function of Stim1. Mol Biol Cell (2012) 0.86
Doxorubicin-mediated apoptosis in glioma cells requires NFAT3. Cell Mol Life Sci (2009) 0.85
NFAT regulates pre-synaptic development and activity-dependent plasticity in Drosophila. Mol Cell Neurosci (2010) 0.85
Correlations between gene expression and mercury levels in blood of boys with and without autism. Neurotox Res (2009) 0.84
NGF upregulates the plasminogen activation inhibitor-1 in neurons via the calcineurin/NFAT pathway and the Down syndrome-related proteins DYRK1A and RCAN1 attenuate this effect. PLoS One (2013) 0.83
The Role of Methionine Oxidation/Reduction in the Regulation of Immune Response. Curr Signal Transduct Ther (2009) 0.83
Signaling involved in neurite outgrowth of postnatally born subventricular zone neurons in vitro. BMC Neurosci (2010) 0.83
Nerve growth factor (NGF) regulates activity of nuclear factor of activated T-cells (NFAT) in neurons via the phosphatidylinositol 3-kinase (PI3K)-Akt-glycogen synthase kinase 3β (GSK3β) pathway. J Biol Chem (2014) 0.83
Distinct roles of Ca2+ mobilization and G protein usage on regulation of Toll-like receptor function in human and murine mast cells. Immunology (2006) 0.83
Neuronal calcium sensor proteins are unable to modulate NFAT activation in mammalian cells. Biochim Biophys Acta (2007) 0.82
Upregulation of nuclear factor of activated T-cells by nerve injury contributes to development of neuropathic pain. J Pharmacol Exp Ther (2013) 0.82
Foxd3 suppresses NFAT-mediated differentiation to maintain self-renewal of embryonic stem cells. EMBO Rep (2014) 0.81
Prolonged infusion of inhibitors of calcineurin or L-type calcium channels does not block mossy fiber sprouting in a model of temporal lobe epilepsy. Epilepsia (2008) 0.81
A calcineurin- and NFAT-dependent pathway is involved in α-synuclein-induced degeneration of midbrain dopaminergic neurons. Hum Mol Genet (2014) 0.81
No association with the calcineurin A gamma subunit gene (PPP3CC) haplotype to Japanese schizophrenia. J Neural Transm (Vienna) (2005) 0.81
Calcineurin signaling regulates neural induction through antagonizing the BMP pathway. Neuron (2014) 0.80
Differential effect of traumatic brain injury on the nuclear factor of activated T Cells C3 and C4 isoforms in the rat hippocampus. Brain Res (2013) 0.80
Calcineurin regulation of cytoskeleton organization: a new paradigm to analyse the effects of calcineurin inhibitors on the kidney. J Cell Mol Med (2012) 0.80
The Drosophila transcription factor Adf-1 (nalyot) regulates dendrite growth by controlling FasII and Staufen expression downstream of CaMKII and neural activity. J Neurosci (2013) 0.80
Regulation of neurogenesis by calcium signaling. Cell Calcium (2016) 0.79
Positional differences of axon growth rates between sensory neurons encoded by Runx3. EMBO J (2012) 0.79
Nuclear factor of activated T cells regulates neutrophil recruitment, systemic inflammation, and T-cell dysfunction in abdominal sepsis. Infect Immun (2014) 0.79
Transcriptional Profiling of Hypoxic Neural Stem Cells Identifies Calcineurin-NFATc4 Signaling as a Major Regulator of Neural Stem Cell Biology. Stem Cell Reports (2015) 0.79
Extracellular ATP activates NFAT-dependent gene expression in neuronal PC12 cells via P2X receptors. BMC Neurosci (2011) 0.79
Neurotrophin signaling endosomes: biogenesis, regulation, and functions. Curr Opin Neurobiol (2016) 0.78
The Emerging Roles of the Calcineurin-Nuclear Factor of Activated T-Lymphocytes Pathway in Nervous System Functions and Diseases. J Aging Res (2016) 0.78
Control of neuronal apoptosis by reciprocal regulation of NFATc3 and Trim17. Cell Death Differ (2014) 0.78
Mechanisms and dynamics of AKAP79/150-orchestrated multi-protein signalling complexes in brain and peripheral nerve. J Physiol (2015) 0.77
Mechanism of nuclear factor of activated T-cells mediated FasL expression in corticosterone -treated mouse Leydig tumor cells. BMC Cell Biol (2008) 0.77
Novel fluorescence resonance energy transfer-based reporter reveals differential calcineurin activation in neonatal and adult cardiomyocytes. J Physiol (2015) 0.77
Tau accumulation induces synaptic impairment and memory deficit by calcineurin-mediated inactivation of nuclear CaMKIV/CREB signaling. Proc Natl Acad Sci U S A (2016) 0.77
Neuroblast differentiation during development and in neuroblastoma requires KIF1Bβ-mediated transport of TRKA. Genes Dev (2017) 0.76
The complete genome of an individual by massively parallel DNA sequencing. Nature (2008) 52.81
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Genome remodelling in a basal-like breast cancer metastasis and xenograft. Nature (2010) 19.68
Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study. Lancet Oncol (2011) 18.34
A catalog of reference genomes from the human microbiome. Science (2010) 8.10
The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium. Cell Stem Cell (2009) 6.44
APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature (2009) 6.17
Chromatin remodelling during development. Nature (2010) 5.86
MicroRNA-mediated conversion of human fibroblasts to neurons. Nature (2011) 5.59
Common mechanisms of nerve and blood vessel wiring. Nature (2005) 5.46
An essential switch in subunit composition of a chromatin remodeling complex during neural development. Neuron (2007) 5.35
Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations. Nature (2012) 5.23
Single-cell exome sequencing and monoclonal evolution of a JAK2-negative myeloproliferative neoplasm. Cell (2012) 5.16
ATP-dependent chromatin remodeling: genetics, genomics and mechanisms. Cell Res (2011) 4.91
NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21. Nature (2006) 4.80
A SNP discovery method to assess variant allele probability from next-generation resequencing data. Genome Res (2009) 4.78
Anterior-posterior guidance of commissural axons by Wnt-frizzled signaling. Science (2003) 4.18
How does intensity-modulated radiotherapy versus conventional two-dimensional radiotherapy influence the treatment results in nasopharyngeal carcinoma patients? Int J Radiat Oncol Biol Phys (2010) 4.14
Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth. Cancer Cell (2007) 4.11
An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network. Proc Natl Acad Sci U S A (2009) 4.07
New neurons follow the flow of cerebrospinal fluid in the adult brain. Science (2006) 3.98
A public gene trap resource for mouse functional genomics. Nat Genet (2004) 3.96
Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility. Proc Natl Acad Sci U S A (2009) 3.92
Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus. Science (2013) 3.90
PirB is a functional receptor for myelin inhibitors of axonal regeneration. Science (2008) 3.86
An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency. Proc Natl Acad Sci U S A (2009) 3.82
The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature (2004) 3.77
Dynamics and memory of heterochromatin in living cells. Cell (2012) 3.75
dSarm/Sarm1 is required for activation of an injury-induced axon death pathway. Science (2012) 3.72
A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis. Cell (2004) 3.71
Understanding the words of chromatin regulation. Cell (2009) 3.67
The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance. Cell (2003) 3.66
MicroRNA-mediated switching of chromatin-remodelling complexes in neural development. Nature (2009) 3.66
Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy. Nat Genet (2013) 3.51
Class 3 semaphorins control vascular morphogenesis by inhibiting integrin function. Nature (2003) 3.42
Genomic analyses identify distinct patterns of selection in domesticated pigs and Tibetan wild boars. Nat Genet (2013) 3.41
Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation. Proc Natl Acad Sci U S A (2002) 3.28
MicroRNA-mediated control of oligodendrocyte differentiation. Neuron (2010) 3.24
Lack of enhanced spinal regeneration in Nogo-deficient mice. Neuron (2003) 3.22
The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons. Cell (2004) 3.19
PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates. Nature (2004) 3.10
Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and function. Nature (2006) 2.96
Conserved roles for Slit and Robo proteins in midline commissural axon guidance. Neuron (2004) 2.94
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Regulation of dendritic development by neuron-specific chromatin remodeling complexes. Neuron (2007) 2.89
Regeneration of sensory axons within the injured spinal cord induced by intraganglionic cAMP elevation. Neuron (2002) 2.84
Slit1 and Slit2 cooperate to prevent premature midline crossing of retinal axons in the mouse visual system. Neuron (2002) 2.77
SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site. Dev Cell (2004) 2.74
Nuclear actin and actin-related proteins in chromatin remodeling. Annu Rev Biochem (2001) 2.74
Large scale variation in Enterococcus faecalis illustrated by the genome analysis of strain OG1RF. Genome Biol (2008) 2.71
Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain. Neuron (2002) 2.71
Diverse gene expression and DNA methylation profiles correlate with differential adaptation of breast cancer cells to the antiestrogens tamoxifen and fulvestrant. Cancer Res (2006) 2.63
Mechanisms and molecules of neuronal wiring: a primer. Cold Spring Harb Perspect Biol (2011) 2.62
Sequential roles of Brg, the ATPase subunit of BAF chromatin remodeling complexes, in thymocyte development. Immunity (2003) 2.56
Regulation of cortical dendrite development by Slit-Robo interactions. Neuron (2002) 2.55
Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway. Proc Natl Acad Sci U S A (2010) 2.53
Mammalian brain morphogenesis and midline axon guidance require heparan sulfate. Science (2003) 2.53
EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans. Science (2005) 2.50
From neural development to cognition: unexpected roles for chromatin. Nat Rev Genet (2013) 2.42
Comparison between 1-needle technique versus 2-needle technique for bone marrow aspiration and biopsy procedures. Arch Pathol Lab Med (2013) 2.41
Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes. Nature (2002) 2.41
Universal approximation using incremental constructive feedforward networks with random hidden nodes. IEEE Trans Neural Netw (2006) 2.41
Blocking neuropilin-2 function inhibits tumor cell metastasis. Cancer Cell (2008) 2.35
The chemokine SDF1 regulates migration of dentate granule cells. Development (2002) 2.34
False resurrections: distinguishing regenerated from spared axons in the injured central nervous system. J Comp Neurol (2003) 2.34
Alternative splicing of the Robo3 axon guidance receptor governs the midline switch from attraction to repulsion. Neuron (2008) 2.33
Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin. FASEB J (2007) 2.30
Boc is a receptor for sonic hedgehog in the guidance of commissural axons. Nature (2006) 2.29
esBAF facilitates pluripotency by conditioning the genome for LIF/STAT3 signalling and by regulating polycomb function. Nat Cell Biol (2011) 2.29
The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons. Nat Neurosci (2012) 2.28
Genetic deletion of the Nogo receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo. Proc Natl Acad Sci U S A (2005) 2.27
Integration of Notch 1 and calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation control. Dev Cell (2005) 2.21
Association between the various mutations in viral core promoter region to different stages of hepatitis B, ranging of asymptomatic carrier state to hepatocellular carcinoma. Am J Gastroenterol (2010) 2.20
Calcineurin B1 is essential for positive but not negative selection during thymocyte development. Immunity (2004) 2.20
Conditional protein alleles using knockin mice and a chemical inducer of dimerization. Mol Cell (2003) 2.20
Cyclic AMP/GMP-dependent modulation of Ca2+ channels sets the polarity of nerve growth-cone turning. Nature (2003) 2.18
Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development. Genome Biol (2011) 2.18
Computation-guided backbone grafting of a discontinuous motif onto a protein scaffold. Science (2011) 2.17
Harnessing chaperones to generate small-molecule inhibitors of amyloid beta aggregation. Science (2004) 2.14
Nuclear factor high-mobility group box1 mediating the activation of Toll-like receptor 4 signaling in hepatocytes in the early stage of nonalcoholic fatty liver disease in mice. Hepatology (2011) 2.13
New neurons clear the path of astrocytic processes for their rapid migration in the adult brain. Neuron (2010) 2.12
Regeneration of the adult central nervous system. Curr Biol (2005) 2.11
Mesothelium contributes to vascular smooth muscle and mesenchyme during lung development. Proc Natl Acad Sci U S A (2008) 2.08
Recognition of the neural chemoattractant Netrin-1 by integrins alpha6beta4 and alpha3beta1 regulates epithelial cell adhesion and migration. Dev Cell (2003) 2.08
Regulation of CXCR4 expression in human mesenchymal stem cells by cytokine treatment: role in homing efficiency in NOD/SCID mice. Haematologica (2007) 2.07
Structure of the Nogo receptor ectodomain: a recognition module implicated in myelin inhibition. Neuron (2003) 2.06
The Nogo-66 receptor NgR1 is required only for the acute growth cone-collapsing but not the chronic growth-inhibitory actions of myelin inhibitors. J Neurosci (2007) 2.06
Reversible disruption of mSWI/SNF (BAF) complexes by the SS18-SSX oncogenic fusion in synovial sarcoma. Cell (2013) 2.05
Lymphocyte calcium signaling from membrane to nucleus. Nat Immunol (2006) 2.03
Isolation of mesenchymal stem cells from human placenta: comparison with human bone marrow mesenchymal stem cells. Cell Biol Int (2006) 2.01
Dynamic changes in transcription factor complexes during erythroid differentiation revealed by quantitative proteomics. Nat Struct Mol Biol (2003) 2.00
Calcium signalling in lymphocytes. Curr Opin Immunol (2003) 2.00
The mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channel. Nature (2002) 2.00
Baseline serum lactate dehydrogenase levels for patients treated with intensity-modulated radiotherapy for nasopharyngeal carcinoma: a predictor of poor prognosis and subsequent liver metastasis. Int J Radiat Oncol Biol Phys (2011) 1.99