Published in N Engl J Med on February 01, 2007
Gynaecomastia and breast cancer in men. BMJ (2008) 2.22
Endocrine disruptors and asthma-associated chemicals in consumer products. Environ Health Perspect (2012) 1.90
Fifteen years after "Wingspread"--environmental endocrine disrupters and human and wildlife health: where we are today and where we need to go. Toxicol Sci (2008) 1.71
What is in our environment that effects puberty? Reprod Toxicol (2013) 1.13
A systematic review of the reporting of adverse events associated with medical herb use among children. Glob Adv Health Med (2013) 1.05
Complementary and alternative medicine for the allergist-immunologist: where do I start? J Allergy Clin Immunol (2009) 1.00
Physiological effects and mechanisms of action of endocrine disrupting chemicals that alter estrogen signaling. Hormones (Athens) (2010) 0.94
Environmental assessment and exposure control of dust mites: a practice parameter. Ann Allergy Asthma Immunol (2013) 0.93
Lavender and the nervous system. Evid Based Complement Alternat Med (2013) 0.92
A new highly specific and robust yeast androgen bioassay for the detection of agonists and antagonists. Anal Bioanal Chem (2007) 0.88
Gynecomastia: what the surgeon needs to know. Eplasty (2009) 0.88
Prepubertal unilateral gynecomastia: a report of two cases. Eur J Plast Surg (2010) 0.88
Aromatherapy as an adjuvant treatment in cancer care--a descriptive systematic review. Afr J Tradit Complement Altern Med (2012) 0.87
Drug-induced gynecomastia in children and adolescents. Can Fam Physician (2010) 0.87
Seborrheic dermatitis. P T (2010) 0.86
Approach to the girl with early onset of pubic hair. J Clin Endocrinol Metab (2011) 0.82
An aroma of complexity: how the unique genetics of aromatase (CYP19A1) explain diverse phenotypes from hens and hyenas to human gynecomastia, and testicular and other tumors. J Clin Endocrinol Metab (2013) 0.80
Estrogenic and anti-estrogenic activity of off-the-shelf hair and skin care products. J Expo Sci Environ Epidemiol (2014) 0.79
Efavirenz-induced gynecomastia in a prepubertal girl with human immunodeficiency virus infection: a case report. BMC Pediatr (2013) 0.76
Prepubertal unilateral gynecomastia: report of 2 cases. J Clin Res Pediatr Endocrinol (2014) 0.75
Prepubertal gynecomastia linked to lavender and tea tree oils. N Engl J Med (2007) 0.75
Prepubertal gynecomastia linked to lavender and tea tree oils. N Engl J Med (2007) 0.75
Complementary and Alternative Medicine Familiarization: What's happening in Medical Schools in Wales? Evid Based Complement Alternat Med (2008) 0.75
Prepubertal gynecomastia linked to lavender and tea tree oils. N Engl J Med (2007) 0.75
Natural personal care products-analysis of ingredient lists and legal situation. Environ Sci Eur (2016) 0.75
Prepubertal unilateral gynecomastia in the absence of endocrine abnormalities. Ann Pediatr Endocrinol Metab (2014) 0.75
Lack of evidence that essential oils affect puberty. Reprod Toxicol (2014) 0.75
Prepubertal gynecomastia linked to lavender and tea tree oils. N Engl J Med (2007) 0.75
Estrogen receptors and human disease. J Clin Invest (2006) 4.91
Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature (2007) 4.12
Definition of estrogen receptor pathway critical for estrogen positive feedback to gonadotropin-releasing hormone neurons and fertility. Neuron (2006) 3.04
Estrogens protect pancreatic beta-cells from apoptosis and prevent insulin-deficient diabetes mellitus in mice. Proc Natl Acad Sci U S A (2006) 2.59
A G-protein-coupled estrogen receptor is involved in hypothalamic control of energy homeostasis. J Neurosci (2006) 2.40
Critical in vivo roles for classical estrogen receptors in rapid estrogen actions on intracellular signaling in mouse brain. Endocrinology (2004) 2.26
27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen. Nat Med (2007) 2.18
International Union of Pharmacology. LXIV. Estrogen receptors. Pharmacol Rev (2006) 2.15
Estrogen receptor-beta is critical to granulosa cell differentiation and the ovulatory response to gonadotropins. Endocrinology (2005) 2.15
Estrogen receptor-dependent genomic responses in the uterus mirror the biphasic physiological response to estrogen. Mol Endocrinol (2003) 2.12
Characterization of the hypothalamic-pituitary-gonadal axis in estrogen receptor (ER) Null mice reveals hypergonadism and endocrine sex reversal in females lacking ERalpha but not ERbeta. Mol Endocrinol (2003) 2.11
Stromal cell-derived factor 1, a novel target of estrogen receptor action, mediates the mitogenic effects of estradiol in ovarian and breast cancer cells. Mol Endocrinol (2003) 2.03
Lessons in estrogen biology from knockout and transgenic animals. Annu Rev Physiol (2005) 1.99
An estrogen-dependent four-gene micronet regulating social recognition: a study with oxytocin and estrogen receptor-alpha and -beta knockout mice. Proc Natl Acad Sci U S A (2003) 1.93
Phytoestrogens and their human metabolites show distinct agonistic and antagonistic properties on estrogen receptor alpha (ERalpha) and ERbeta in human cells. Toxicol Sci (2004) 1.92
Non-nuclear estrogen receptor alpha signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice. J Clin Invest (2010) 1.90
Spontaneous airway hyperresponsiveness in estrogen receptor-alpha-deficient mice. Am J Respir Crit Care Med (2006) 1.86
FOXA1 is an essential determinant of ERalpha expression and mammary ductal morphogenesis. Development (2010) 1.86
Allosteric regulation of estrogen receptor structure, function, and coactivator recruitment by different estrogen response elements. Mol Endocrinol (2002) 1.78
The effect of hand hygiene on illness rate among students in university residence halls. Am J Infect Control (2003) 1.75
Estrogen increases locomotor activity in mice through estrogen receptor alpha: specificity for the type of activity. Endocrinology (2003) 1.73
It's all about sex: gender, lung development and lung disease. Trends Endocrinol Metab (2007) 1.72
Mammary gland development in adult mice requires epithelial and stromal estrogen receptor alpha. Endocrinology (2002) 1.67
Oestrogen receptor knockout mice: roles for oestrogen receptors alpha and beta in reproductive tissues. Reproduction (2003) 1.67
Requirement of estrogen receptor-alpha in insulin-like growth factor-1 (IGF-1)-induced uterine responses and in vivo evidence for IGF-1/estrogen receptor cross-talk. J Biol Chem (2001) 1.60
Estrogen-induced proliferation of uterine epithelial cells is independent of estrogen receptor alpha binding to classical estrogen response elements. J Biol Chem (2006) 1.60
Estrogen receptor beta mediates rapid estrogen actions on gonadotropin-releasing hormone neurons in vivo. J Neurosci (2003) 1.58
Estrogen receptor activation reduces lipid synthesis in pancreatic islets and prevents β cell failure in rodent models of type 2 diabetes. J Clin Invest (2011) 1.55
Uterine epithelial estrogen receptor α is dispensable for proliferation but essential for complete biological and biochemical responses. Proc Natl Acad Sci U S A (2010) 1.54
Importance of extranuclear estrogen receptor-alpha and membrane G protein-coupled estrogen receptor in pancreatic islet survival. Diabetes (2009) 1.53
Myeloid-specific estrogen receptor alpha deficiency impairs metabolic homeostasis and accelerates atherosclerotic lesion development. Proc Natl Acad Sci U S A (2011) 1.52
The intraovarian actions of estrogen receptor-alpha are necessary to repress the formation of morphological and functional Leydig-like cells in the female gonad. Endocrinology (2006) 1.48
Estrogen receptor beta mediates gender differences in ischemia/reperfusion injury. J Mol Cell Cardiol (2005) 1.47
The role of estrogens and estrogen receptors in normal prostate growth and disease. Steroids (2007) 1.46
Biological and biochemical consequences of global deletion of exon 3 from the ER alpha gene. FASEB J (2010) 1.42
Estrogen receptor-beta mediates male-female differences in the development of pressure overload hypertrophy. Am J Physiol Heart Circ Physiol (2004) 1.41
Estrogen-mediated regulation of Igf1 transcription and uterine growth involves direct binding of estrogen receptor alpha to estrogen-responsive elements. J Biol Chem (2009) 1.38
Signal transduction. A new mediator for an old hormone? Science (2005) 1.38
The impact of sex and sex hormones on lung physiology and disease: lessons from animal studies. Am J Physiol Lung Cell Mol Physiol (2007) 1.38
Estrogen/estrogen receptor alpha signaling in mouse posterofrontal cranial suture fusion. PLoS One (2009) 1.35
Neonatal exposure to genistein induces estrogen receptor (ER)alpha expression and multioocyte follicles in the maturing mouse ovary: evidence for ERbeta-mediated and nonestrogenic actions. Biol Reprod (2002) 1.32
Increased blood pressure in mice lacking cytochrome P450 2J5. FASEB J (2008) 1.30
Extranuclear estrogen receptor-alpha stimulates NeuroD1 binding to the insulin promoter and favors insulin synthesis. Proc Natl Acad Sci U S A (2010) 1.28
Estrogen receptor alpha mediates 17alpha-ethynylestradiol causing hepatotoxicity. J Biol Chem (2006) 1.26
Global uterine genomics in vivo: microarray evaluation of the estrogen receptor alpha-growth factor cross-talk mechanism. Mol Endocrinol (2004) 1.24
Estrogen receptors and human disease: an update. Arch Toxicol (2012) 1.22
Estren behaves as a weak estrogen rather than a nongenomic selective activator in the mouse uterus. Endocrinology (2006) 1.22
Requirement for estrogen receptor alpha in a mouse model for human papillomavirus-associated cervical cancer. Cancer Res (2008) 1.21
Estradiol regulates angiopoietin-1 mRNA expression through estrogen receptor-alpha in a rodent experimental stroke model. Stroke (2005) 1.20
Research resource: whole-genome estrogen receptor α binding in mouse uterine tissue revealed by ChIP-seq. Mol Endocrinol (2012) 1.20
In vitro growth and ovulation of follicles from ovaries of estrogen receptor (ER){alpha} and ER{beta} null mice indicate a role for ER{beta} in follicular maturation. Endocrinology (2005) 1.19
Lack of ductal development in the absence of functional estrogen receptor alpha delays mammary tumor formation induced by transgenic expression of ErbB2/neu. Cancer Res (2002) 1.18
Estrogen receptor-alpha gene deficiency enhances androgen biosynthesis in the mouse Leydig cell. Endocrinology (2003) 1.17
Selective disruption of ER{alpha} DNA-binding activity alters uterine responsiveness to estradiol. Mol Endocrinol (2009) 1.17
Increased mortality and aggravation of heart failure in estrogen receptor-beta knockout mice after myocardial infarction. Circulation (2005) 1.17
Estrogen induces estrogen receptor alpha-dependent cAMP response element-binding protein phosphorylation via mitogen activated protein kinase pathway in basal forebrain cholinergic neurons in vivo. J Neurosci (2006) 1.16
An estrogen receptor-alpha knock-in mutation provides evidence of ligand-independent signaling and allows modulation of ligand-induced pathways in vivo. Endocrinology (2008) 1.16
Critical role for estrogen receptor alpha in negative feedback regulation of gonadotropin-releasing hormone mRNA expression in the female mouse. Neuroendocrinology (2003) 1.14
Role of estrogen receptor signaling required for endometriosis-like lesion establishment in a mouse model. Endocrinology (2012) 1.13
Leuprolide acetate 1-month depot for central precocious puberty: hormonal suppression and recovery. Int J Pediatr Endocrinol (2011) 1.13
Estrogen receptors: structure, mechanisms and function. Rev Endocr Metab Disord (2002) 1.12
Endocrine-Disrupting Chemicals (EDCs): In Vitro Mechanism of Estrogenic Activation and Differential Effects on ER Target Genes. Environ Health Perspect (2013) 1.12
Impact on bone of an estrogen receptor-alpha gene loss of function mutation. J Clin Endocrinol Metab (2008) 1.12
Effect of ER-beta gene disruption on estrogenic regulation of anxiety in female mice. Physiol Behav (2008) 1.12
Differential estrogenic actions of endocrine-disrupting chemicals bisphenol A, bisphenol AF, and zearalenone through estrogen receptor α and β in vitro. Environ Health Perspect (2012) 1.11
Diarylheptanoid phytoestrogens isolated from the medicinal plant Curcuma comosa: biologic actions in vitro and in vivo indicate estrogen receptor-dependent mechanisms. Environ Health Perspect (2009) 1.11
Estrogen receptor-beta regulates transcript levels for oxytocin and arginine vasopressin in the hypothalamic paraventricular nucleus of male mice. Brain Res Mol Brain Res (2002) 1.10
Estrogen receptor knockout mice as a model for endocrine research. ILAR J (2004) 1.09
Estrogen receptor α AF-2 mutation results in antagonist reversal and reveals tissue selective function of estrogen receptor modulators. Proc Natl Acad Sci U S A (2011) 1.08
Endocrine-disrupting chemicals use distinct mechanisms of action to modulate endocrine system function. Endocrinology (2006) 1.06
The impact of a health campaign on hand hygiene and upper respiratory illness among college students living in residence halls. J Am Coll Health (2005) 1.04
Impact of estrogen receptor deficiency on disease expression in the NZM2410 lupus prone mouse. Clin Immunol (2008) 1.03
Estrogen receptor-alpha mediates the detrimental effects of neonatal diethylstilbestrol (DES) exposure in the murine reproductive tract. Toxicology (2004) 1.02
Genotype/age interactions on aggressive behavior in gonadally intact estrogen receptor beta knockout (betaERKO) male mice. Horm Behav (2002) 1.02
Estrogenic activity of bisphenol A and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE) demonstrated in mouse uterine gene profiles. Environ Health Perspect (2010) 1.02
Disruption of estrogen receptor signaling enhances intestinal neoplasia in Apc(Min/+) mice. Carcinogenesis (2009) 1.02
Selective mutations in estrogen receptor alpha D-domain alters nuclear translocation and non-estrogen response element gene regulatory mechanisms. J Biol Chem (2011) 1.01
Estradiol regulates the thioredoxin antioxidant system in the mouse uterus. Endocrinology (2004) 1.01
Estrogen receptor-beta gene disruption potentiates estrogen-inducible aggression but not sexual behaviour in male mice. Eur J Neurosci (2006) 1.01
Requirement for stromal estrogen receptor alpha in cervical neoplasia. Horm Cancer (2012) 1.00
Analysis of the molecular mechanisms of human estrogen receptors alpha and beta reveals differential specificity in target promoter regulation by xenoestrogens. J Biol Chem (2002) 1.00
Male sex hormones exacerbate lung function impairment after bleomycin-induced pulmonary fibrosis. Am J Respir Cell Mol Biol (2008) 0.98
Effect of exogenous epidermal-like growth factors on mammary gland development and differentiation in the estrogen receptor-alpha knockout (ERKO) mouse. Breast Cancer Res Treat (2003) 0.98
Formation of cystic ovarian follicles associated with elevated luteinizing hormone requires estrogen receptor-beta. Endocrinology (2004) 0.97
Studies using the estrogen receptor alpha knockout uterus demonstrate that implantation but not decidualization-associated signaling is estrogen dependent. Biol Reprod (2002) 0.96
Estrogen receptor alpha-mediated events promote sex-specific diabetic glomerular hypertrophy. Am J Physiol Renal Physiol (2004) 0.96
Estrogen receptor beta is required for optimal cAMP production in mouse granulosa cells. Mol Endocrinol (2009) 0.95
Regulation of mouse renal CYP2J5 expression by sex hormones. Mol Pharmacol (2004) 0.95
The natural estrogenic compound diarylheptanoid (D3): in vitro mechanisms of action and in vivo uterine responses via estrogen receptor α. Environ Health Perspect (2013) 0.95
Estrogen receptor-alpha dependency of estrogen's stimulatory action on cancellous bone formation in male mice. Endocrinology (2003) 0.95
Tamoxifen versus aromatase inhibitors for breast cancer prevention. Clin Cancer Res (2005) 0.94
Uterine gland formation in mice is a continuous process, requiring the ovary after puberty, but not after parturition. Biol Reprod (2011) 0.94
Physiological effects and mechanisms of action of endocrine disrupting chemicals that alter estrogen signaling. Hormones (Athens) (2010) 0.94
The bi-modal effects of estradiol on gonadotropin synthesis and secretion in female mice are dependent on estrogen receptor-alpha. J Endocrinol (2006) 0.94
Estrogen receptor beta (ERbeta) protein levels in neurons depend on estrogen receptor alpha (ERalpha) gene expression and on its ligand in a brain region-specific manner. Brain Res Mol Brain Res (2003) 0.94
Loss of estrogen receptor beta decreases mitochondrial energetic potential and increases thrombogenicity of platelets in aged female mice. Age (Dordr) (2009) 0.93
Potential biological functions emerging from the different estrogen receptors. Ann N Y Acad Sci (2006) 0.93
The short-chain fatty acid methoxyacetic acid disrupts endogenous estrogen receptor-alpha-mediated signaling. Environ Health Perspect (2009) 0.92